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index.qmd
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---
title: ""
page-layout: full
format:
html:
html-math-method: katex
include-in-header:
text: |
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/animate.css/4.1.1/animate.min.css"/>
<link href="https://fonts.googleapis.com/css2?family=Inter:wght@300;400;500;600;700&display=swap" rel="stylesheet">
<style>
:root {
--primary: #4a6fa5;
--secondary: #166088;
--accent: #4fc3dc;
--light: #f8f9fa;
}
body {
font-family: 'Inter', sans-serif;
line-height: 1.6;
color: var(--dark);
}
.hero-section {
background: linear-gradient(135deg, var(--secondary) 0%, var(--primary) 100%);
color: white;
padding: 6rem 0;
margin-bottom: 3rem;
clip-path: polygon(0 0, 100% 0, 100% 90%, 0 100%);
}
.hero-section h1 {
font-weight: 700;
font-size: 3.5rem;
margin-bottom: 1.5rem;
}
.card {
border: none;
border-radius: 12px;
box-shadow: 0 10px 20px rgba(0,0,0,0.1);
transition: transform 0.3s ease, box-shadow 0.3s ease;
overflow: hidden;
}
.card:hover {
transform: translateY(-5px);
box-shadow: 0 15px 30px rgba(0,0,0,0.15);
}
.card-body {
padding: 2rem;
}
.btn {
border-radius: 50px;
padding: 0.6rem 1.5rem;
font-weight: 500;
transition: all 0.3s ease;
}
.btn-primary {
background-color: var(--primary);
border-color: var(--primary);
}
.btn-primary:hover {
background-color: var(--secondary);
border-color: var(--secondary);
transform: translateY(-2px);
}
.btn-outline-secondary {
border-color: var(--primary);
color: var(--primary);
}
.btn-outline-secondary:hover {
background-color: var(--primary);
color: white;
}
.publication {
background: white;
padding: 1.5rem;
border-radius: 8px;
margin-bottom: 1.5rem;
box-shadow: 0 5px 15px rgba(0,0,0,0.05);
border-left: 4px solid var(--accent);
}
.animate-delay-1 { animation-delay: 0.2s; }
.animate-delay-2 { animation-delay: 0.4s; }
.animate-delay-3 { animation-delay: 0.6s; }
footer {
background-color: var(--dark);
color: white;
padding: 3rem 0;
margin-top: 5rem;
}
</style>
---
::: {.hero-section .text-center .animate__animated .animate__fadeIn}
# Computational Oncology & Cancer Genomics
We develop computational tools and algorithms to understand cancer biology and improve treatment outcomes.
[Learn About Our Work](projects.html){.btn .btn-primary .btn-lg .mt-4 .animate__animated .animate__fadeInUp}
:::
:::::::::::::: {.row .mt-5}
:::::: {.col-md-4 .mb-4 .animate__animated .animate__fadeInUp .animate-delay-1}
::: {.card .h-100}
::: card-body
### Our Research
We specialize in developing algorithms for multi-modal analysis of cancer omics data, creating tools to discover insights into tumor evolution and treatment efficacy.
[Explore Projects](projects.html){.btn .btn-primary .mt-3}
:::
:::
::::::
:::::: {.col-md-4 .mb-4 .animate__animated .animate__fadeInUp .animate-delay-2}
::: {.card .h-100}
::: card-body
### Connected Data
We lead initiatives in federated cancer data infrastructure, working with global consortiums to build frameworks that improve cancer research and care.
[Learn More](Projects/eHealthHub.html){.btn .btn-primary .mt-3}
:::
:::
::::::
:::::: {.col-md-4 .mb-4 .animate__animated .animate__fadeInUp .animate-delay-3}
::: {.card .h-100}
::: card-body
### Open Science
We embrace open science principles, contributing to Bioconductor and sharing tools with the research community to accelerate cancer research globally.
[See Our Software](software.html){.btn .btn-primary .mt-3}
:::
:::
::::::
::::::::::::::
# Highlights
:::::::::::::: {.row .mt-5}
:::::: {.col-lg-6 .animate__animated .animate__fadeIn}
## Recent Publications
::: publication
#### Correspondence analysis for dimension reduction, batch integration, and visualization of single-cell RNA-seq data
**Hsu LL, Culhane AC** (2023) Scientific Reports
[Read Paper](https://doi.org/10.1038/s41598-022-26434-1){.btn .btn-sm .btn-outline-secondary}
:::
::: publication
#### Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model
**Wang Y, Buck A, Grimaud M, Culhane AC,** et al. (2022) Molecular Therapy Oncolytics
[Read Paper](https://doi.org/10.1016/j.omto.2021.12.019){.btn .btn-sm .btn-outline-secondary}
:::
[View All Publications](publications.html){.btn .btn-primary .mt-3}
::::::
:::::: {.col-lg-6 .animate__animated .animate__fadeIn}
## Latest News
::: {.card .mb-3}
::: card-body
### New Grant Award
Our lab has received funding for all-island eHealth research in cancer.
[Read More](News/22-04-04_LimerickPost.html){.btn .btn-sm .btn-outline-secondary}
:::
:::
::: {.card .mb-3}
::: card-body
### RTE Brainstorm Article
Prof Aedin Culhane and Prof Mark Lawler spoke with RTE Brainstorm about the pressing need for harmonization of clinical cancer health data.
[Read More](News/22_05_19_BrainStorm.html){.btn .btn-sm .btn-outline-secondary}
:::
:::
[View All News](news.html){.btn .btn-primary}
:::