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Copy pathkinase_JAK.csv
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kinase_JAK.csv
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SMILES,measurement_type,measurement_value,Kinase_name
C#CCCOC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,6.81,JAK2
C#CCCOC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,8.05,JAK1
C#CCN(c1ccc(C#N)cn1)C1CCN(c2ncnc3[nH]ccc23)C1,pIC50,10.26,JAK2
C#CCN(c1ccc(C#N)cn1)C1CCN(c2ncnc3[nH]ccc23)C1,pIC50,10.26,JAK1
C#CCNCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.36,JAK2
C#CCNCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,8.07,JAK1
C#CCNCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.57,TYK2
C=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.57,JAK2
C=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,8.09,JAK1
C=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.92,TYK2
C=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.15,JAK3
C=C1Cn2c3ccccc3c3c4c(c5c6ccccc6n(c5c32)C1)C(=O)NC4,pIC50,7.14,JAK1
C=C1Cn2c3ccccc3c3c4c(c5c6ccccc6n(c5c32)C1)C(=O)NC4,pIC50,7.14,JAK3
C=CC(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,pIC50,7.98,JAK1
C=CC(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,pIC50,7.98,JAK3
C=CC(=O)Nc1ccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2Cl)cc1,pIC50,9.06,JAK1
C=CC(=O)Nc1ccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2Cl)cc1,pIC50,9.06,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCC(O)CC4)c(F)c3)ncc2Cl)c1,pIC50,8.13,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCC(O)CC4)c(F)c3)ncc2Cl)c1,pIC50,8.13,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCOCC4)c(F)c3)ncc2Cl)c1,pIC50,6.45,JAK2
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCOCC4)c(F)c3)ncc2Cl)c1,pIC50,7.7,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCOCC4)c(F)c3)ncc2Cl)c1,pIC50,7.7,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(OCCN4CCOCC4)c(F)c3)ncc2Cl)c1,pIC50,8.21,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(OCCN4CCOCC4)c(F)c3)ncc2Cl)c1,pIC50,8.21,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCOCC4)cc3F)ncc2Cl)c1,pIC50,8.28,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCOCC4)cc3F)ncc2Cl)c1,pIC50,8.28,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)c(F)c3)ncc2Cl)c1,pIC50,9.05,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)c(F)c3)ncc2Cl)c1,pIC50,9.05,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2Cl)c1,pIC50,7.75,JAK2
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2Cl)c1,pIC50,8.89,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2Cl)c1,pIC50,8.89,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3F)ncc2Cl)c1,pIC50,8.85,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3F)ncc2Cl)c1,pIC50,8.85,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C(F)F)c3)ncc2Cl)c1,pIC50,8.85,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C(F)F)c3)ncc2Cl)c1,pIC50,8.85,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C4CCOCC4)c3)ncc2Cl)c1,pIC50,9.15,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C4CCOCC4)c3)ncc2Cl)c1,pIC50,9.15,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(=O)N4CCOCC4)c3)ncc2Cl)c1,pIC50,9.22,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(=O)N4CCOCC4)c3)ncc2Cl)c1,pIC50,9.22,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(=O)NCC(F)(F)F)c3)ncc2Cl)c1,pIC50,9.3,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(=O)NCC(F)(F)F)c3)ncc2Cl)c1,pIC50,9.3,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCO)c3)ncc2Cl)c1,pIC50,7.49,JAK2
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCO)c3)ncc2Cl)c1,pIC50,7.96,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCO)c3)ncc2Cl)c1,pIC50,6.85,TYK2
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOC(F)F)c3)ncc2Cl)c1,pIC50,9.15,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOC(F)F)c3)ncc2Cl)c1,pIC50,9.15,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOCCOCCOCCNC(=O)CCCCC4SCC5NC(=O)NC54)c3)ncc2Cl)c1,pIC50,6.38,JAK2
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOCCOCCOCCNC(=O)CCCCC4SCC5NC(=O)NC54)c3)ncc2Cl)c1,pIC50,8.64,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOCCOCCOCCNC(=O)CCCCC4SCC5NC(=O)NC54)c3)ncc2Cl)c1,pIC50,8.64,JAK3
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnoc3)ncc2Cl)c1,pIC50,8.54,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnoc3)ncc2Cl)c1,pIC50,8.54,JAK3
C=CC(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccccc4)c23)c1,pIC50,10.8,JAK1
C=CC(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccccc4)c23)c1,pIC50,10.8,JAK3
C=CC(=O)Nc1cccc(-c2cnc3ccccc3n2)c1,pIC50,7.35,JAK1
C=CC(=O)Nc1cccc(-c2cnc3ccccc3n2)c1,pIC50,7.35,JAK3
C=CC(=O)Nc1cccc(-n2cnc3cnc(Nc4ccc(OCCCN5CCOCC5)cc4)nc32)c1,pIC50,7.14,JAK1
C=CC(=O)Nc1cccc(-n2cnc3cnc(Nc4ccc(OCCCN5CCOCC5)cc4)nc32)c1,pIC50,7.14,JAK3
C=CC1(O)CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,8.22,JAK2
C=CC1(O)CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,9.07,JAK1
C=CCOCCC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,7.33,JAK1
C=CCOCCC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,7.33,JAK3
CC#CC(=O)N1CCCC1c1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12,pIC50,6.0,JAK3
CC(C)=C(C)c1cccc2c(CCCOc3cccc(Cl)c3Cl)c(C(=O)O)[nH]c12,pKi,6.0,JAK2
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OC)c23)ccc1F,pIC50,9.4,JAK1
C=C(C)C(=O)Nc1cc(-c2ncnc3[nH]cc(C(=O)OC)c23)ccc1F,pIC50,9.4,JAK3
C=C(C)C(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOC)c3)ncc2Cl)c1,pIC50,8.11,JAK1
C=C(C)C(=O)Nc1cccc(CNc2nc(Nc3cnn(CCOC)c3)ncc2Cl)c1,pIC50,8.11,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OC)c23)c1,pIC50,8.7,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C(=O)OC)c23)c1,pIC50,8.7,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C4=CCOCC4)c23)c1,pIC50,8.3,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C4=CCOCC4)c23)c1,pIC50,8.3,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C4CCOCC4)c23)c1,pIC50,8.08,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(C4CCOCC4)c23)c1,pIC50,8.08,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccc(F)cc4)c23)c1,pIC50,8.82,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccc(F)cc4)c23)c1,pIC50,8.82,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccc(F)c4)c23)c1,pIC50,9.23,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccc(F)c4)c23)c1,pIC50,9.23,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccc(F)c4Cl)c23)c1,pIC50,8.82,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccc(F)c4Cl)c23)c1,pIC50,8.82,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccccc4F)c23)c1,pIC50,9.02,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ccccc4F)c23)c1,pIC50,9.02,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccnc4)c23)c1,pIC50,8.01,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cccnc4)c23)c1,pIC50,8.01,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cnc[nH]4)c23)c1,pIC50,8.12,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cnc[nH]4)c23)c1,pIC50,8.12,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cnco4)c23)c1,pIC50,8.3,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cnco4)c23)c1,pIC50,8.3,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cncs4)c23)c1,pIC50,8.74,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4cncs4)c23)c1,pIC50,8.74,JAK3
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ncco4)c23)c1,pIC50,8.1,JAK1
C=C(C)C(=O)Nc1cccc(-c2ncnc3[nH]cc(-c4ncco4)c23)c1,pIC50,8.1,JAK3
CC(C#N)=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.26,JAK2
CC(C#N)=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.7,JAK1
CC(C#N)=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.35,TYK2
CC(C#N)=C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.24,JAK3
CC(=NNC(=N)N)c1cc(NC(=O)NCCCCCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1,pKi,6.0,JAK2
CC(=NNC(=N)N)c1cc(NC(=O)NCCCCCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1,pKi,6.0,JAK3
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1,pKi,6.7,JAK2
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1,pKi,6.7,JAK3
COCc1nnn(-c2nonc2N)c1C(=O)NN=C(C)c1ccc(O)cc1O,pKi,6.1,JAK3
[C-]#[N+]C1CCCCC1n1cc(C(N)=O)c(Nc2ccc(C(C)=NOC)cc2)n1,pIC50,8.7,JAK2
[C-]#[N+]C1CCCCC1n1cc(C(N)=O)c(Nc2ccc(C(C)=NOC)cc2)n1,pIC50,9.46,JAK1
CC(=O)C1=CCn2c3ccccc3c3c4c(c5c6ccccc6n(c5c32)C1)C(=O)NC4=O,pIC50,8.15,JAK1
CC(=O)C1=CCn2c3ccccc3c3c4c(c5c6ccccc6n(c5c32)C1)C(=O)NC4=O,pIC50,8.15,JAK3
CC(=O)C1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,7.66,JAK2
CC(=O)C1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,8.15,JAK1
CC(=O)C1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,8.15,JAK3
CC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,6.29,JAK2
CC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,7.03,JAK1
CC(=O)N1CC2CC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2C1,pIC50,7.43,JAK2
CC(=O)N1CC2CC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2C1,pIC50,8.52,JAK1
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.4,JAK2
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,10.6,JAK1
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.4,JAK3
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,10.6,JAK3
C=CC(=O)Nc1cccc(CNc2nc(NC3CCN(C(C)=O)C3)ncc2Cl)c1,pIC50,7.0,JAK1
C=CC(=O)Nc1cccc(CNc2nc(NC3CCN(C(C)=O)C3)ncc2Cl)c1,pIC50,7.0,JAK3
CC(=O)N1CCC(CN2CC3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)CC3C2)CC1,pKi,9.02,JAK2
CC(=O)N1CCC(CN2CC3CN(C(=O)Cn4cc(NC(=O)c5cnn6cccnc56)c(-c5cc(Cl)ccc5OC(F)F)n4)CC3C2)CC1,pKi,9.03,JAK1
CC(=O)N1CCC(CN2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1,pKi,9.89,JAK2
CC(=O)N1CCC(CN2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1,pKi,9.24,JAK1
CC(=O)N1CCC(N2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1,pKi,9.77,JAK2
CC(=O)N1CCC(N2CCC(n3cc(NC(=O)c4c(N)nn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)CC1,pKi,9.27,JAK1
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1,pIC50,10.12,JAK2
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1,pKi,9.51,JAK1
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1,pIC50,10.12,JAK3
CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1,pKi,9.51,JAK3
CC(=O)N1CCC(Nc2c(C(N)=O)cnc3[nH]ccc23)CC1,pIC50,6.19,JAK2
CC(=O)N1CCC(Nc2c(C(N)=O)cnc3[nH]ccc23)CC1,pIC50,6.47,JAK1
CC(=O)N1CCC(Nc2c(C(N)=O)cnc3[nH]ccc23)CC1,pIC50,6.47,JAK3
CC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2)CC1,pIC50,8.4,JAK2
CC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2)CC1,pIC50,9.05,JAK1
CC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2)CC1,pIC50,8.4,TYK2
CC(=O)N1CCC2(CCC(Nc3nc(Nc4cnn(C)c4)ncc3Cl)CC2)CC1,pIC50,7.33,JAK3
CC(=O)N1CCC2CC(N(C)c3ncnc4[nH]ccc34)CC2C1,pIC50,7.8,JAK2
CC(=O)N1CCC2CC(N(C)c3ncnc4[nH]ccc34)CC2C1,pIC50,8.52,JAK1
CC(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,7.04,JAK2
CC(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,7.09,JAK1
CC(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,7.09,JAK3
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3nc[nH]c3n2)C1,pKi,8.63,JAK1
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3nc[nH]c3n2)C1,pIC50,8.33,JAK3
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3nc[nH]c3n2)C1,pKi,8.63,JAK3
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.64,JAK2
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,11.18,JAK1
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.89,JAK3
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,11.18,JAK3
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ncc3n2)C1,pIC50,8.0,JAK2
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ncc3n2)C1,pIC50,8.0,JAK1
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ncc3n2)C1,pIC50,8.0,JAK3
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3cc[nH]c3n2)C1,pIC50,8.0,JAK2
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3cc[nH]c3n2)C1,pIC50,8.0,JAK1
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3cc[nH]c3n2)C1,pIC50,8.0,JAK3
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3ccn(C)c3n2)C1,pIC50,8.0,JAK2
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3ccn(C)c3n2)C1,pIC50,8.0,JAK1
CC(=O)N1CCCC(Nc2ncccc2-c2cnc3ccn(C)c3n2)C1,pIC50,8.0,JAK3
CC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.6,JAK1
CC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.6,JAK3
CC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.72,JAK2
CC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,10.26,JAK1
CC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.72,JAK3
CC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,10.26,JAK3
CC(=O)N1CCCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.34,JAK1
CC(=O)N1CCCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.34,JAK3
CC(=O)N1CCCCC12CCN(c1ncnc3[nH]ccc13)C2,pIC50,6.82,JAK1
CC(=O)N1CCCCC12CCN(c1ncnc3[nH]ccc13)C2,pIC50,6.82,JAK3
CC(=O)N1CCN(C2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)CC1,pIC50,6.65,JAK2
CC(=O)N1CCN(C2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)CC1,pIC50,7.89,JAK1
CC(=O)N1CCN(Cc2ccc(-c3cccc4nc(NC(=O)C5CC5)nn34)cc2)CC1,pIC50,6.07,JAK2
CC(=O)N1CCN(Cc2ccc(-c3cccc4nc(NC(=O)C5CC5)nn34)cc2)CC1,pIC50,6.48,JAK1
CC(=O)N1CCN(S(=O)(=O)c2ccc(Nc3nn(C4CCCCC4C#N)cc3C(N)=O)cc2)CC1,pIC50,9.0,JAK2
CC(=O)N1CCN(S(=O)(=O)c2ccc(Nc3nn(C4CCCCC4C#N)cc3C(N)=O)cc2)CC1,pIC50,9.3,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCN(C(C)=O)CC4)c(F)c3)ncc2Cl)c1,pIC50,8.44,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cc(F)c(N4CCN(C(C)=O)CC4)c(F)c3)ncc2Cl)c1,pIC50,8.44,JAK3
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br,pKi,8.3,JAK2
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br,pKi,7.1,TYK2
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br,pKi,7.9,JAK3
CC(=O)N1CCN(c2ccc3cc2COCC=CCOCc2cccc(c2)-c2ccnc(n2)N3)CC1,pIC50,6.96,JAK2
CC(=O)N1CCN(c2ccc3cc2COCC=CCOCc2cccc(c2)-c2ccnc(n2)N3)CC1,pIC50,6.96,TYK2
CC(=O)NC1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,7.24,JAK2
CC(=O)NC1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,8.32,JAK1
CC(=O)NC1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,6.21,TYK2
CC(=O)NC1CCc2ccc(Oc3cnc4[nH]cc(C(=O)NC(C(=O)N5CC(C#N)C5)C(C)(C)C)c4n3)cc21,pIC50,6.35,JAK2
CC(=O)NC1CCc2ccc(Oc3cnc4[nH]cc(C(=O)NC(C(=O)N5CC(C#N)C5)C(C)(C)C)c4n3)cc21,pIC50,7.24,JAK1
CC(=O)NC1CCc2ccc(Oc3cnc4[nH]cc(C(=O)NC(C(=O)N5CC(C#N)C5)C(C)(C)C)c4n3)cc21,pIC50,7.24,JAK3
CC(=O)NC1CCc2ccc(Oc3cnc4[nH]cc(C(=O)NC(C(=O)N5CC(C#N)C5)C5CC5)c4n3)cc21,pIC50,7.41,JAK2
CC(=O)NC1CCc2ccc(Oc3cnc4[nH]cc(C(=O)NC(C(=O)N5CC(C#N)C5)C5CC5)c4n3)cc21,pIC50,8.3,JAK1
CC(=O)NC1CCc2ccc(Oc3cnc4[nH]cc(C(=O)NC(C(=O)N5CC(C#N)C5)C5CC5)c4n3)cc21,pIC50,8.3,JAK3
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12,pKi,8.4,JAK2
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12,pKi,7.9,TYK2
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12,pKi,7.6,JAK3
CC(=O)NCC1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,7.82,JAK2
CC(=O)NCC1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,8.78,JAK1
CC(=O)NCC1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,8.78,JAK3
CC(=O)NCCCN1CCC(n2cc(NC(=O)C(C(=N)N)=C3N=CC=CN3)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.77,JAK2
CC(=O)NCCCN1CCC(n2cc(NC(=O)C(C(=N)N)=C3N=CC=CN3)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.14,JAK1
CC(=O)NCCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.42,JAK2
CC(=O)NCCCN1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,8.78,JAK1
CC(=O)Nc1c(C(N)=O)sc2ccc(Cl)c(Cl)c12,pKi,6.1,JAK2
CC(=O)Nc1cc(NC(=O)c2c(Cl)cccc2Cl)ccn1,pKi,6.51,JAK2
CC(=O)Nc1cc(NC(=O)c2c(Cl)cccc2Cl)ccn1,pKi,7.02,TYK2
CC(=O)Nc1cc2c(NC3CCC(C)(O)C3(C)C)c(C(N)=O)cnn2c1,pIC50,9.05,JAK1
CC(=O)Nc1cc2c(NC3CCC(C)(O)C3(C)C)c(C(N)=O)cnn2c1,pIC50,9.05,JAK3
CC(=O)Nc1ccc(C=C2C(=O)Nc3ccc(C(=O)c4cccs4)cc32)cc1,pIC50,6.15,JAK1
CC(=O)Nc1ccc(C=C2C(=O)Nc3ccc(C(=O)c4cccs4)cc32)cc1,pIC50,6.15,JAK3
CC(=O)Nc1ccc(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)cc1,pIC50,6.89,JAK2
CC(=O)Nc1ccc(CN2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)CC2)cc1,pIC50,8.15,JAK1
CC(=O)Nc1ccc(Nc2nn(C(CC#N)C3CC3)cc2C(N)=O)cc1,pIC50,7.35,JAK2
CC(=O)Nc1ccc(Nc2nn(C(CC#N)C3CC3)cc2C(N)=O)cc1,pIC50,8.1,JAK1
CC(=O)Nc1cccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)c1,pKi,6.4,JAK2
CC(=O)Nc1cccc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)c1,pIC50,8.46,JAK2
CC(=O)Nc1cccc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)c1,pIC50,6.79,JAK1
CC(=O)Nc1cccc(Nc2nc3c(-c4ccc(S(C)(=O)=O)cc4)cccn3n2)c1,pIC50,6.79,JAK3
CC(=O)Nc1cccc(-c2cc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c3c2)c1,pIC50,7.57,JAK2
CC(=O)Nc1ccccc1-c1cc2c(NC3CCC(C)(N)C3(C)C)c(C(N)=O)cnn2c1,pIC50,7.52,JAK1
CC(=O)Nc1ccccc1-c1cc2c(NC3CCC(C)(N)C3(C)C)c(C(N)=O)cnn2c1,pIC50,7.43,JAK3
[C-]#[N+]C1CC(OC(C)=O)C(O)CC1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1,pIC50,6.74,JAK2
[C-]#[N+]C1CC(OC(C)=O)C(O)CC1n1cc(C(N)=O)c(Nc2ccc(C(F)(F)F)cc2)n1,pIC50,7.7,JAK1
CC(=O)OCC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.64,JAK1
CC(=O)OCC(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.64,JAK3
CC(=O)OCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,8.11,JAK2
CC(=O)OCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,8.68,JAK1
CC(=O)OCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.49,TYK2
CC(=O)OCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.32,JAK3
CC(=O)SCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,8.55,JAK2
CC(=O)SCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,9.03,JAK1
CC(=O)SCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.55,TYK2
CC(=O)SCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.26,JAK3
CC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,8.52,JAK2
CC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,9.7,JAK1
CC(=O)c1ccc(Nc2nn(C3CCC(N4CCC4)CC3C#N)cc2C(N)=O)cc1,pIC50,8.05,JAK2
CC(=O)c1ccc(Nc2nn(C3CCC(N4CCC4)CC3C#N)cc2C(N)=O)cc1,pIC50,9.52,JAK1
CC(=O)c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1,pIC50,8.7,JAK2
CC(=O)c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1,pIC50,9.52,JAK1
CC(=O)c1cccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)c1,pIC50,7.07,JAK2
CC(=O)c1cccc(NC(=O)N2CC(CC#N)(n3cc(C(N)=O)c(Nc4ccccc4)n3)C2)c1,pIC50,8.4,JAK1
CC(C#N)C(C)n1cc(C(N)=O)c(Nc2ccccc2)n1,pIC50,6.7,JAK2
CC(C#N)C(C)n1cc(C(N)=O)c(Nc2ccccc2)n1,pIC50,7.49,JAK1
CC(C#N)C1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC(C)(C)C)CC1,pIC50,6.79,JAK2
CC(C#N)C1(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CCN(C(=O)OC(C)(C)C)CC1,pIC50,7.47,JAK1
CC(C#N)C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,8.17,JAK2
CC(C#N)C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,8.51,JAK1
CC(C#N)C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.6,TYK2
CC(C#N)C1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.48,JAK3
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N(C)C,pIC50,6.64,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N(C)C,pIC50,6.98,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N(C)C,pIC50,6.98,JAK3
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1,pIC50,7.43,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1,pIC50,8.09,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1,pIC50,8.09,JAK3
CC(=O)NC1CCc2ccc(Oc3cnc4[nH]cc(C(=O)NC(C)C(=O)N5CC(C#N)C5)c4n3)cc21,pIC50,6.95,JAK1
CC(=O)NC1CCc2ccc(Oc3cnc4[nH]cc(C(=O)NC(C)C(=O)N5CC(C#N)C5)c4n3)cc21,pIC50,6.95,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)cc(F)c34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.25,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)cc(F)c34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.74,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)cc(F)c34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.74,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)cc(F)c34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.43,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)cc(F)c34)nc12)C(=O)N1CC(C#N)C1,pIC50,9.0,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)cc(F)c34)nc12)C(=O)N1CC(C#N)C1,pIC50,9.0,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4ccc(Cl)cc34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.55,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4ccc(Cl)cc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.52,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4ccc(Cl)cc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.52,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C#N)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.42,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C#N)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.64,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C#N)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.64,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C(C)(C)C)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.89,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C(C)(C)C)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.0,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C(C)(C)C)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.0,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C5CC5)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.82,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C5CC5)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.51,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(C5CC5)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.51,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.66,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.51,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.96,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.92,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,9.22,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,9.22,JAK3
COc1ccc2c(-c3cnc4[nH]cc(C(=O)NC(C)C(=O)N5CC(C#N)C5)c4n3)nn(C)c2c1,pIC50,7.8,JAK2
COc1ccc2c(-c3cnc4[nH]cc(C(=O)NC(C)C(=O)N5CC(C#N)C5)c4n3)nn(C)c2c1,pIC50,8.74,JAK1
COc1ccc2c(-c3cnc4[nH]cc(C(=O)NC(C)C(=O)N5CC(C#N)C5)c4n3)nn(C)c2c1,pIC50,8.74,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.23,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,9.52,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3ncn4cc(F)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,9.52,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4ccccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.7,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4ccccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.54,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3nn(C)c4ccccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.54,JAK3
COc1cc(-c2cnc3[nH]cc(C(=O)NC(C)C(=O)N4CC(C#N)C4)c3n2)cc(OC)c1OC,pIC50,9.1,JAK2
COc1cc(-c2cnc3[nH]cc(C(=O)NC(C)C(=O)N4CC(C#N)C4)c3n2)cc(OC)c1OC,pIC50,9.4,JAK1
COc1cc(-c2cnc3[nH]cc(C(=O)NC(C)C(=O)N4CC(C#N)C4)c3n2)cc(OC)c1OC,pIC50,9.4,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3cn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.48,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3cn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,9.1,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3cn(C)c4cc(Cl)ccc34)nc12)C(=O)N1CC(C#N)C1,pIC50,9.1,JAK3
CC(NC(=O)c1c[nH]c2ncc(-c3cnc4cc(Cl)ccn34)nc12)C(=O)N1CC(C#N)C1,pIC50,7.24,JAK2
CC(NC(=O)c1c[nH]c2ncc(-c3cnc4cc(Cl)ccn34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.47,JAK1
CC(NC(=O)c1c[nH]c2ncc(-c3cnc4cc(Cl)ccn34)nc12)C(=O)N1CC(C#N)C1,pIC50,8.47,JAK3
CC(NC(=O)c1c[nH]c2ncc(-n3ncc4cc(Cl)ccc43)nc12)C(=O)N1CC(C#N)C1,pIC50,7.08,JAK2
CC(NC(=O)c1c[nH]c2ncc(-n3ncc4cc(Cl)ccc43)nc12)C(=O)N1CC(C#N)C1,pIC50,7.96,JAK1
CC(NC(=O)c1c[nH]c2ncc(-n3ncc4cc(Cl)ccc43)nc12)C(=O)N1CC(C#N)C1,pIC50,7.98,JAK3
CC(O)C(=O)N1CC2CC(N(C)c3ncnc4[nH]ccc34)CC2C1,pIC50,8.52,JAK2
CC(O)C(=O)N1CC2CC(N(C)c3ncnc4[nH]ccc34)CC2C1,pIC50,9.7,JAK1
CC(O)C(=O)N1CC2CC(N(C)c3ncnc4[nH]ccc34)CC2C1,pIC50,9.52,JAK3
COc1ccc(-c2cc3c(NC4CCN(C(=O)C(C)O)CC4(C)C)c(C(N)=O)cnn3c2)cn1,pIC50,8.48,JAK1
COc1ccc(-c2cc3c(NC4CCN(C(=O)C(C)O)CC4(C)C)c(C(N)=O)cnn3c2)cn1,pIC50,8.48,JAK3
CC(F)(F)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)C(F)C1,pIC50,10.0,JAK2
CC(F)(F)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)C(F)C1,pIC50,10.3,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCC(C#N)C1,pIC50,7.64,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCC(C#N)C1,pIC50,8.06,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCC(C#N)C1,pIC50,8.06,JAK3
CC(F)(F)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,8.7,JAK2
CC(F)(F)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,10.0,JAK1
CC(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)(F)F,pIC50,7.89,JAK2
CC(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)(F)F,pIC50,9.52,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCC1,pIC50,6.46,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCC1,pIC50,6.83,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCC1,pIC50,6.83,JAK3
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCCC1,pIC50,6.92,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCCC1,pIC50,7.31,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCCC1,pIC50,7.31,JAK3
CC(O)C(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,7.4,JAK1
CC(O)C(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,7.4,JAK3
COC(C)C(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.57,JAK1
COC(C)C(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.57,JAK3
CC(=O)OC(C)C(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.96,JAK1
CC(=O)OC(C)C(=O)N1CCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.96,JAK3
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCCCC1,pIC50,6.91,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCCCC1,pIC50,7.16,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CCCCC1,pIC50,7.16,JAK3
CC(N)C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1,pIC50,8.77,JAK2
CC(N)C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1,pIC50,6.53,JAK1
CC(N)C(=O)Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1,pIC50,6.53,JAK3
CC(Cl)C(=O)Nc1cccc(-c2cnc3ccccc3n2)c1,pIC50,6.48,JAK1
CC(Cl)C(=O)Nc1cccc(-c2cnc3ccccc3n2)c1,pIC50,6.48,JAK3
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)C#N,pIC50,7.96,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)C#N,pIC50,8.74,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)C#N,pIC50,8.74,JAK3
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)C,pIC50,7.97,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)C,pIC50,8.85,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)C,pIC50,8.85,JAK3
C=CC(=O)N1CCCC1Cn1c(NC(=O)c2ccc(C(F)F)s2)nc2cc(CNC(C)C(C)(C)C)ccc21,pIC50,7.52,JAK3
CC(Nc1c(C(N)=O)cnn2cccc12)C(C)(C)C,pIC50,7.8,JAK2
CC(Nc1c(C(N)=O)cnn2cccc12)C(C)(C)C,pIC50,8.1,JAK1
CC(Nc1c(C(N)=O)cnn2cccc12)C(C)(C)C,pIC50,7.8,TYK2
CC(Nc1c(C(N)=O)cnn2cccc12)C(C)(C)C,pIC50,8.1,JAK3
CC(Nc1ccc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C(C)(C)C,pIC50,8.3,JAK2
CC(Nc1ccc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C(C)(C)C,pIC50,6.46,JAK1
CC(Nc1ccc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C(C)(C)C,pIC50,6.46,JAK3
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)O,pIC50,7.37,JAK2
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)O,pIC50,7.77,JAK1
CC(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(C)(C)O,pIC50,7.77,JAK3
CC(Nc1nc(-n2cnc3ccncc32)nc2c1cc(C(=O)N1CCN(C)CC1)n2C)C(C)(C)O,pIC50,6.68,JAK2
CC(Nc1nc(-n2cnc3ccncc32)nc2c1cc(C(=O)N1CCN(C)CC1)n2C)C(C)(C)O,pIC50,6.85,JAK1
CC(Nc1nc(-n2cnc3ccncc32)nc2c1cc(C(=O)N1CCN(C)CC1)n2C)C(C)(C)O,pIC50,6.85,JAK3
CC(NC(=O)c1cnn2ccc(N3CC(O)CC3c3cccc(F)c3)nc12)C(F)(F)F,pIC50,6.17,JAK2
CC(OC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1)C(F)(F)F,pIC50,6.41,JAK2
CC(OC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1)C(F)(F)F,pIC50,7.82,JAK1
CC(OC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1)C(F)(F)F,pIC50,6.87,JAK2
CC(OC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1)C(F)(F)F,pIC50,8.1,JAK1
CC(OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1)C(F)(F)F,pIC50,7.55,JAK2
CC(OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1)C(F)(F)F,pIC50,9.1,JAK1
CC(O)(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)F,pIC50,7.42,JAK2
CC(O)(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)F,pIC50,8.7,JAK1
CC(C)(C#N)C(=O)N1CC(CF)C(Nc2c(C(N)=O)cnn3cc(-c4cn[nH]c4)nc23)C1,pIC50,7.7,JAK1
CC(C)(C#N)C(=O)N1CC(CF)C(Nc2c(C(N)=O)cnn3cc(-c4cn[nH]c4)nc23)C1,pIC50,7.6,JAK3
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C#N)cc3)sc12,pIC50,8.4,JAK2
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C#N)cc3)sc12,pIC50,7.44,JAK1
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C#N)cc3)sc12,pIC50,6.84,TYK2
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C#N)cc3)sc12,pIC50,6.93,JAK3
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21,pIC50,6.0,JAK1
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21,pIC50,6.0,JAK3
CC(C)(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)(F)F,pIC50,7.55,JAK2
CC(C)(C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1)C(F)(F)F,pIC50,9.0,JAK1
CC(C)(O)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,6.63,JAK2
CC(C)(O)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,7.96,JAK1
CC(C)(O)C(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1,pIC50,9.3,JAK1
CC(C)(O)C(=O)N1CCN(c2ccc(C(F)(F)F)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1,pIC50,9.3,JAK3
CC(C)(C)C(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,6.24,JAK2
CC(C)(C)C(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,6.86,JAK1
CC(C)(C)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,7.04,JAK2
CC(C)(C)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,7.89,JAK1
Cn1c(C(=O)NCCCN2CCOCC2)cc2c(-c3ccc(NC(=O)C(C)(C)C)cc3)ncnc21,pIC50,8.22,JAK2
Cn1c(C(=O)NCCCN2CCOCC2)cc2c(-c3ccc(NC(=O)C(C)(C)C)cc3)ncnc21,pIC50,6.23,JAK1
Cn1c(C(=O)NCCCN2CCOCC2)cc2c(-c3ccc(NC(=O)C(C)(C)C)cc3)ncnc21,pIC50,6.23,JAK3
Cn1c(C(=O)NCCN2CCCC2)cc2c(-c3ccc(NC(=O)C(C)(C)C)cc3)ncnc21,pIC50,8.1,JAK2
Cn1c(C(=O)NCCN2CCCC2)cc2c(-c3ccc(NC(=O)C(C)(C)C)cc3)ncnc21,pIC50,6.02,JAK1
Cn1c(C(=O)NCCN2CCCC2)cc2c(-c3ccc(NC(=O)C(C)(C)C)cc3)ncnc21,pIC50,6.02,JAK3
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCCC(OC(=O)C(C)(C)C)C2)CC1,pIC50,9.89,JAK2
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCCC(OC(=O)C(C)(C)C)C2)CC1,pIC50,10.64,JAK1
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCCC(OC(=O)C(C)(C)C)C2)CC1,pIC50,10.64,JAK3
CC(C)(C)C(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1,pIC50,9.1,JAK2
CC(C)(C)C(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1,pIC50,8.49,JAK1
CC(C)(C)C(NC(=O)c1c[nH]c2ncc(C3CC3)nc12)C(=O)N1CC(C#N)C1,pIC50,9.59,JAK3
Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C(=O)N4CC(C#N)C4)C(C)(C)C)c3n2)c2ccc(Cl)cc21,pIC50,8.89,JAK2
Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C(=O)N4CC(C#N)C4)C(C)(C)C)c3n2)c2ccc(Cl)cc21,pIC50,9.1,JAK1
Cn1nc(-c2cnc3[nH]cc(C(=O)NC(C(=O)N4CC(C#N)C4)C(C)(C)C)c3n2)c2ccc(Cl)cc21,pIC50,9.1,JAK3
CC(C)(C)C(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1,pIC50,6.3,JAK2
CC(C)(C)C(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1,pIC50,7.27,JAK1
CC(C)(C)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,7.36,JAK2
CC(C)(C)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,9.22,JAK1
CC(C)(C)CCOC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,6.93,JAK2
CC(C)(C)CCOC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,8.1,JAK1
CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(NC3CCCN(S(=O)(=O)CCC(C)(C)C)C3)n2)CC1,pIC50,10.76,JAK2
CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(NC3CCCN(S(=O)(=O)CCC(C)(C)C)C3)n2)CC1,pKi,11.96,JAK1
CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(NC3CCCN(S(=O)(=O)CCC(C)(C)C)C3)n2)CC1,pIC50,11.66,JAK3
CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(NC3CCCN(S(=O)(=O)CCC(C)(C)C)C3)n2)CC1,pKi,11.96,JAK3
CSc1ncc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(=O)(=O)CCC(C)(C)C)C2)n1,pIC50,10.53,JAK2
CSc1ncc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(=O)(=O)CCC(C)(C)C)C2)n1,pKi,11.92,JAK1
CSc1ncc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(=O)(=O)CCC(C)(C)C)C2)n1,pIC50,11.62,JAK3
CSc1ncc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(=O)(=O)CCC(C)(C)C)C2)n1,pKi,11.92,JAK3
CC(C)(C)CNc1ncnc2c(=O)[nH]ccc12,pKi,6.42,JAK2
CC(C)(C)CNc1ncnc2c(=O)[nH]ccc12,pKi,6.15,JAK1
CC(C)(C)COC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,6.43,JAK2
CC(C)(C)COC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,7.74,JAK1
CC(C)(C)COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,6.84,JAK2
CC(C)(C)COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,8.22,JAK1
CC(C)(C)COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,6.6,JAK2
CC(C)(C)COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,8.22,JAK1
CC(C)(C)CS(=O)(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,7.8,JAK2
CC(C)(C)CS(=O)(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,8.7,JAK1
CC(C)(C)CS(=O)(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,8.7,JAK3
CC(C)(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.61,JAK2
CC(C)(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,11.92,JAK1
CC(C)(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,11.62,JAK3
CC(C)(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,11.92,JAK3
CN(C1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1)C(C)(C)C,pIC50,7.8,JAK2
CN(C1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1)C(C)(C)C,pIC50,9.26,JAK1
CC(C)(C)NC(=O)C1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,6.37,JAK2
CC(C)(C)NC(=O)C1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,7.33,JAK1
CC(C)(C)NC(=O)c1cncc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)c1,pIC50,6.55,JAK2
CC(C)(C)NC(=O)c1cncc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)c1,pIC50,7.22,JAK1
CC(C)(C)NC(=O)c1cnn2ccc(N3CCCC3c3cc(F)cnc3CO)nc12,pIC50,6.06,JAK2
CC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(C(O)C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,7.64,JAK2
CC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(C(O)C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,9.4,JAK1
CC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,7.59,JAK2
CC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,9.7,JAK1
CC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,7.74,JAK2
CC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,9.0,JAK1
CC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)C(C#N)C1,pIC50,7.55,JAK2
CC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)C(C#N)C1,pIC50,9.1,JAK1
CC(C)(C)NCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.35,JAK2
CC(C)(C)NCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.92,JAK1
CC(C)(C)NCC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.31,TYK2
CC(C)(C)NS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.65,JAK2
CC(C)(C)NS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,10.49,JAK1
CC(C)(C)NS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.19,JAK3
CC(C)(C)NS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,10.49,JAK3
CNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12,pIC50,9.0,JAK2
CNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12,pIC50,7.52,JAK1
CNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12,pIC50,6.58,TYK2
CNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12,pIC50,6.51,JAK3
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCCN4CCOCC4)c3s2)cc1,pIC50,8.3,JAK2
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCCN4CCOCC4)c3s2)cc1,pIC50,6.69,JAK1
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCCN4CCOCC4)c3s2)cc1,pIC50,6.19,JAK3
CN(C)CCNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12,pIC50,8.1,JAK2
CN(C)CCNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12,pIC50,6.15,JAK1
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCN4CCCCC4)c3s2)cc1,pIC50,8.3,JAK2
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCN4CCCCC4)c3s2)cc1,pIC50,6.18,JAK1
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCN4CCOCC4)c3s2)cc1,pIC50,8.7,JAK2
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCN4CCOCC4)c3s2)cc1,pIC50,6.75,JAK1
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCN4CCOCC4)c3s2)cc1,pIC50,6.12,TYK2
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCN4CCOCC4)c3s2)cc1,pIC50,6.02,JAK3
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCO)c3s2)cc1,pIC50,8.1,JAK2
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCO)c3s2)cc1,pIC50,7.11,JAK1
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCO)c3s2)cc1,pIC50,6.03,TYK2
CC(C)(C)NS(=O)(=O)c1ccc(-c2cc3c(N)ncc(C(=O)NCCO)c3s2)cc1,pIC50,6.36,JAK3
COCCNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12,pIC50,8.52,JAK2
COCCNC(=O)c1cnc(N)c2cc(-c3ccc(S(=O)(=O)NC(C)(C)C)cc3)sc12,pIC50,6.89,JAK1
CC(C)(C)NS(=O)(=O)c1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1,pIC50,9.19,JAK2
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O,pKi,6.04,JAK2
CN1CCN(C(=O)c2cc3c(NC(C)(C)C)nc(-n4cnc5ccncc54)nc3n2C)CC1,pIC50,6.49,JAK2
CN1CCN(C(=O)c2cc3c(NC(C)(C)C)nc(-n4cnc5ccncc54)nc3n2C)CC1,pIC50,6.7,JAK1
CN1CCN(C(=O)c2cc3c(NC(C)(C)C)nc(-n4cnc5ccncc54)nc3n2C)CC1,pIC50,6.7,JAK3
CC(C)(C)Nc1ncnc2c(=O)[nH]ccc12,pKi,6.91,JAK2
CC(C)(C)Nc1ncnc2c(=O)[nH]ccc12,pKi,7.01,JAK1
CC(C)(C)OC(=O)C1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,6.33,JAK2
CC(C)(C)OC(=O)C1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,7.77,JAK1
CC(C)(C)OC(=O)C1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,6.36,JAK2
CC(C)(C)OC(=O)C1CCC(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,7.64,JAK1
CC(C)(C)OC(=O)C1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,7.3,JAK2
CC(C)(C)OC(=O)C1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,8.15,JAK1
CC(C)(C)OC(=O)C1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,7.04,JAK2
CC(C)(C)OC(=O)C1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,8.52,JAK1
CC(C)(C)OC(=O)CN1Cc2cc(Nc3nn(C(CC#N)C4CC4)cc3C(N)=O)ccc2C1=O,pIC50,7.7,JAK2
CC(C)(C)OC(=O)CN1Cc2cc(Nc3nn(C(CC#N)C4CC4)cc3C(N)=O)ccc2C1=O,pIC50,8.7,JAK1
CN(C(=O)OC(C)(C)C)C1CCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,7.09,JAK2
CN(C(=O)OC(C)(C)C)C1CCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,8.16,JAK1
CN(C(=O)OC(C)(C)C)C1CCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,8.16,JAK3
CC(C)(C)OC(=O)N1CC(CC#N)(NCC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,6.12,JAK2
CC(C)(C)OC(=O)N1CC(CC#N)(NCC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,6.72,JAK1
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)n2)C1,pIC50,8.3,JAK2
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)n2)C1,pIC50,8.7,JAK1
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)C1,pIC50,8.15,JAK2
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)C1,pIC50,9.22,JAK1
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,7.24,JAK2
CC(C)(C)OC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,8.1,JAK1
CN(CC1C2CN(C(=O)OC(C)(C)C)CC21)c1ncnc2[nH]ccc12,pIC50,7.05,JAK1
CN(CC1C2CN(C(=O)OC(C)(C)C)CC21)c1ncnc2[nH]ccc12,pIC50,7.05,JAK3
CC(C)(C)OC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,6.44,JAK2
CC(C)(C)OC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,7.57,JAK1
CC(C)(C)OC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)C(C#N)C1,pIC50,6.3,JAK2
CC(C)(C)OC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)C(C#N)C1,pIC50,7.62,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(F)C1,pIC50,9.7,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(F)C1,pIC50,10.3,JAK1
CC(C)(C)OC(=O)N1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)C(O)C1,pIC50,8.87,JAK2
CC(C)(C)OC(=O)N1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)C(O)C1,pIC50,7.15,JAK1
CC(C)(C)OC(=O)N1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)C(O)C1,pIC50,7.15,JAK3
CC(C)(C)OC(=O)N1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C(O)C1,pKi,8.98,JAK2
CC(C)(C)OC(=O)N1CCC(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C(O)C1,pKi,9.14,JAK1
CC(C)(C)OC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,7.41,JAK2
CC(C)(C)OC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,8.22,JAK1
CC(C)(C)OC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,7.39,JAK2
CC(C)(C)OC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,8.3,JAK1
CC(C)(C)OC(=O)N1CCC(O)C(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1,pKi,8.97,JAK2
CC(C)(C)OC(=O)N1CCC(O)C(n2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)C1,pKi,8.91,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)C1,pIC50,8.7,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)C1,pIC50,9.7,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,7.57,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,8.7,JAK1
CN1CCN(c2ccc(Nc3nc4c(NCC5CCN(C(=O)OC(C)(C)C)C5)cccn4n3)cc2)CC1,pIC50,7.01,JAK2
CC(C)(C)OC(=O)N1CCC(NCC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,6.47,JAK2
CC(C)(C)OC(=O)N1CCC(NCC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,7.54,JAK1
CC(C)(C)OC(=O)N1CCC(NCC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,6.29,TYK2
CC(C)(C)OC(=O)N1CCC(C(C#N)C2CC2)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,6.13,JAK2
CC(C)(C)OC(=O)N1CCC(C(C#N)C2CC2)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,6.57,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(F)cc(F)c3)n2)CC1,pIC50,7.38,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(F)cc(F)c3)n2)CC1,pIC50,8.7,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(F)ccn3)n2)CC1,pIC50,6.04,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(F)ccn3)n2)CC1,pIC50,7.82,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cncc(Cl)c3)n2)CC1,pIC50,7.68,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cncc(Cl)c3)n2)CC1,pIC50,9.05,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cncc(F)c3)n2)CC1,pIC50,7.8,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cncc(F)c3)n2)CC1,pIC50,9.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(Cl)nc(Cl)c3)n2)CC1,pIC50,7.48,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(Cl)nc(Cl)c3)n2)CC1,pIC50,9.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(F)ncn3)n2)CC1,pIC50,7.8,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cc(F)ncn3)n2)CC1,pIC50,9.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)c(F)c3)n2)CC1,pIC50,8.15,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)c(F)c3)n2)CC1,pIC50,9.4,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)c(F)c3)n2)CC1,pIC50,9.15,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)c(F)c3)n2)CC1,pIC50,9.7,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)c(F)c3)n2)CC1,pIC50,7.62,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)c(F)c3)n2)CC1,pIC50,9.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(Br)cc3)n2)CC1,pIC50,7.64,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(Br)cc3)n2)CC1,pIC50,9.3,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)cc3)n2)CC1,pIC50,8.22,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)cc3)n2)CC1,pIC50,9.7,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)C(F)(F)F)cc3)n2)CC1,pIC50,8.52,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)C(F)(F)F)cc3)n2)CC1,pIC50,9.7,JAK1
CN(C)C(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,8.7,JAK2
CN(C)C(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,9.15,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)CC1,pIC50,9.15,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)CC1,pIC50,9.52,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)n2)CC1,pIC50,9.0,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)n2)CC1,pIC50,9.3,JAK1
CNC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,8.7,JAK2
CNC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,10.0,JAK1
COC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,8.05,JAK2
COC(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,9.52,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(C)(C)O)cc3)n2)CC1,pIC50,8.52,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(C)(C)O)cc3)n2)CC1,pIC50,9.52,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(CC(=O)O)cc3)n2)CC1,pIC50,8.0,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(CC(=O)O)cc3)n2)CC1,pIC50,10.0,JAK1
COC(=O)Cc1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,8.52,JAK2
COC(=O)Cc1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,9.7,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,7.68,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,9.1,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1,pIC50,7.89,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)n2)CC1,pIC50,8.7,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CC1,pIC50,9.22,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CC1,pIC50,10.05,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)CC1,pIC50,9.0,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(C)(=O)=O)cc3)n2)CC1,pIC50,10.0,JAK1
CN(C)S(=O)(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,9.1,JAK2
CN(C)S(=O)(=O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)cc1,pIC50,9.52,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(N)(=O)=O)cc3)n2)CC1,pIC50,9.0,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(S(N)(=O)=O)cc3)n2)CC1,pIC50,10.0,JAK1
Cn1ccc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)cc2)n1,pIC50,6.86,JAK2
Cn1ccc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)cc2)n1,pIC50,8.52,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cn3)n2)CC1,pIC50,6.74,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cn3)n2)CC1,pIC50,8.4,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)nc3)n2)CC1,pIC50,8.22,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C#N)nc3)n2)CC1,pIC50,9.3,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(C)(C)O)nc3)n2)CC1,pIC50,8.52,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(C(C)(C)O)nc3)n2)CC1,pIC50,9.1,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)CC1,pIC50,8.15,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)nc3)n2)CC1,pIC50,9.1,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(N4CCOCC4)nc3)n2)CC1,pIC50,8.52,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(N4CCOCC4)nc3)n2)CC1,pIC50,9.1,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc4c(c3)CNC4=O)n2)CC1,pIC50,8.7,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc4c(c3)CNC4=O)n2)CC1,pIC50,10.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Br)c3)n2)CC1,pIC50,7.43,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Br)c3)n2)CC1,pIC50,9.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Cn4nnc5ccccc54)c3)n2)CC1,pIC50,7.74,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Cn4nnc5ccccc54)c3)n2)CC1,pIC50,9.3,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Cn4ccnc4)c3)n2)CC1,pIC50,7.96,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(Cn4ccnc4)c3)n2)CC1,pIC50,9.22,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(-c4ccc(O)cc4)c3)n2)CC1,pIC50,6.53,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(-c4ccc(O)cc4)c3)n2)CC1,pIC50,7.85,JAK1
COc1ccc(-c2cccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)c2)cc1,pIC50,6.02,JAK2
COc1ccc(-c2cccc(Nc3nn(C4(CC#N)CCN(C(=O)OC(C)(C)C)CC4)cc3C(N)=O)c2)cc1,pIC50,7.39,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(-c4ccccc4F)c3)n2)CC1,pIC50,6.08,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(-c4ccccc4F)c3)n2)CC1,pIC50,7.51,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(-c4ccccc4O)c3)n2)CC1,pIC50,6.74,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccc(-c4ccccc4O)c3)n2)CC1,pIC50,7.89,JAK1
COc1cccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)n1,pIC50,6.73,JAK2
COc1cccc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)n1,pIC50,8.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,7.57,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,9.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccn3)n2)CC1,pIC50,6.33,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccn3)n2)CC1,pIC50,8.1,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccnc3)n2)CC1,pIC50,8.4,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccnc3)n2)CC1,pIC50,9.3,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccnn3)n2)CC1,pIC50,6.75,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cccnn3)n2)CC1,pIC50,7.59,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C#N)c3)n2)CC1,pIC50,8.22,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C#N)c3)n2)CC1,pIC50,9.7,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C(N)=O)c3)n2)CC1,pIC50,8.15,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C(N)=O)c3)n2)CC1,pIC50,9.4,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C(F)(F)F)c3)n2)CC1,pIC50,8.0,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(C(F)(F)F)c3)n2)CC1,pIC50,9.4,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(CO)c3)n2)CC1,pIC50,7.0,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(CO)c3)n2)CC1,pIC50,8.22,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(Cl)c3)n2)CC1,pIC50,8.52,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(Cl)c3)n2)CC1,pIC50,10.0,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,8.3,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,9.7,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(N)c3)n2)CC1,pIC50,8.52,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(N)c3)n2)CC1,pIC50,9.7,JAK1
COc1cc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)ccn1,pIC50,6.84,JAK2
COc1cc(Nc2nn(C3(CC#N)CCN(C(=O)OC(C)(C)C)CC3)cc2C(N)=O)ccn1,pIC50,8.22,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccncc3)n2)CC1,pIC50,8.0,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccncc3)n2)CC1,pIC50,9.52,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccncn3)n2)CC1,pIC50,6.86,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccncn3)n2)CC1,pIC50,8.52,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnnc3)n2)CC1,pIC50,7.82,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnnc3)n2)CC1,pIC50,9.4,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cnc(C#N)nc3)n2)CC1,pIC50,7.42,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cnc(C#N)nc3)n2)CC1,pIC50,8.52,JAK1
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cnccn3)n2)CC1,pIC50,6.68,JAK2
CC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3cnccn3)n2)CC1,pIC50,8.1,JAK1
CC(C)(C)OC(=O)N1CCC(C(C)(CC#N)n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,6.63,JAK2
CC(C)(C)OC(=O)N1CCC(C(C)(CC#N)n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,8.3,JAK1
CC(C)(C)OC(=O)N1CCC(C(CC#N)n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,6.04,JAK2
CC(C)(C)OC(=O)N1CCC(C(CC#N)n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,7.31,JAK1
CC(C)(C)OC(=O)N1CCC(C(CC#N)n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,6.64,JAK2
CC(C)(C)OC(=O)N1CCC(C(CC#N)n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,8.15,JAK1
CC(C)(C)OC(=O)N1CCC(CNCC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)CC1,pIC50,6.54,JAK2
CC(C)(C)OC(=O)N1CCC(CNCC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)CC1,pIC50,7.54,JAK1
CC(C)(C)OC(=O)N1CCC(CNCC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)CC1,pIC50,6.15,TYK2
CC(C)(C)OC(=O)N1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.29,JAK2
CC(C)(C)OC(=O)N1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.8,JAK1
CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3nc4c(-c5ccc(C#N)cc5)cccn4n3)cc2)CC1,pIC50,7.21,JAK2
CC(C)(C)OC(=O)N1CCC(c2ccc(Nc3nc4c(-c5ccc(F)cc5)cccn4n3)cc2)CC1,pIC50,6.44,JAK2
COc1ccc(-c2cccn3nc(Nc4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc4)nc23)c(F)c1,pIC50,6.79,JAK2
COc1ccc(-c2cccn3nc(Nc4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc4)nc23)c(F)c1,pIC50,6.0,JAK1
COc1ccc(-c2cccn3nc(Nc4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc4)nc23)c(F)c1,pIC50,6.0,JAK3
CN(C)c1cccc(-c2cccn3nc(Nc4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc4)nc23)c1,pIC50,6.71,JAK2
COc1cccc(-c2cccn3nc(Nc4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc4)nc23)c1F,pIC50,6.28,JAK2
COc1cccc(-c2cccn3nc(Nc4ccc(C5CCN(C(=O)OC(C)(C)C)CC5)cc4)nc23)c1OC,pIC50,6.49,JAK2
COc1ncccc1-c1cccn2nc(Nc3ccc(C4CCN(C(=O)OC(C)(C)C)CC4)cc3)nc12,pIC50,6.17,JAK2
CC(C)(C)OC(=O)N1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,8.72,JAK2
CC(C)(C)OC(=O)N1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,6.67,JAK1
CC(C)(C)OC(=O)N1CCC(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,6.67,JAK3
CC(C)(C)OC(=O)N1CCC(n2cc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cn2)CC1,pIC50,9.3,JAK2
CC(C)(C)OC(=O)N1CCC(n2cc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cn2)CC1,pIC50,7.68,JAK1
CC(C)(C)OC(=O)N1CCC(n2cc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)cn2)CC1,pIC50,7.68,JAK3
CN(Cc1ccccc1)C1CC2CCN(C(=O)OC(C)(C)C)CC2C1,pIC50,7.8,JAK2
CN(Cc1ccccc1)C1CC2CCN(C(=O)OC(C)(C)C)CC2C1,pIC50,8.52,JAK1
CC(C)(C)OC(=O)N1CCCC(c2nnn3cnc4[nH]ccc4c23)C1,pIC50,6.6,JAK2
CC(C)(C)OC(=O)N1CCCC(c2nnn3cnc4[nH]ccc4c23)C1,pIC50,6.92,JAK1
Cn1c(C(=O)NCCCN2CCOCC2)cc2c(-c3ccc(NC(=O)C4CCCN4C(=O)OC(C)(C)C)cc3)ncnc21,pIC50,8.0,JAK2
Cn1c(C(=O)NCCCN2CCOCC2)cc2c(-c3ccc(NC(=O)C4CCCN4C(=O)OC(C)(C)C)cc3)ncnc21,pIC50,6.29,JAK1
Cn1c(C(=O)NCCCN2CCOCC2)cc2c(-c3ccc(NC(=O)C4CCCN4C(=O)OC(C)(C)C)cc3)ncnc21,pIC50,6.29,JAK3
Cn1c(C(=O)NCCN2CCCC2)cc2c(-c3ccc(NC(=O)C4CCCN4C(=O)OC(C)(C)C)cc3)ncnc21,pIC50,8.05,JAK2
Cn1c(C(=O)NCCN2CCCC2)cc2c(-c3ccc(NC(=O)C4CCCN4C(=O)OC(C)(C)C)cc3)ncnc21,pIC50,6.15,JAK1
Cn1c(C(=O)NCCN2CCCC2)cc2c(-c3ccc(NC(=O)C4CCCN4C(=O)OC(C)(C)C)cc3)ncnc21,pIC50,6.15,JAK3
CC(C)(C)OC(=O)N1CCCCC12CCN(c1ncnc3[nH]ccc13)C2,pIC50,7.0,JAK1
CC(C)(C)OC(=O)N1CCCCC12CCN(c1ncnc3[nH]ccc13)C2,pIC50,7.0,JAK3
CC(C)(C)OC(=O)N1CCCCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.12,JAK1
CC(C)(C)OC(=O)N1CCCCCC12CCCN(c1ncnc3[nH]ccc13)C2,pIC50,6.12,JAK3
CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc4cccc(-c5ccc(S(C)(=O)=O)cc5)n4n3)cc2)CC1,pIC50,8.89,JAK2
CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc4cccc(-c5ccc(S(C)(=O)=O)cc5)n4n3)cc2)CC1,pIC50,7.3,JAK1
CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc4cccc(-c5ccc(S(C)(=O)=O)cc5)n4n3)cc2)CC1,pIC50,7.3,JAK3
CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc4cccc(-c5ccccc5)n4n3)cc2)CC1,pIC50,8.18,JAK2
CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc4cccc(-c5ccccc5)n4n3)cc2)CC1,pIC50,7.0,JAK1
CC(C)(C)OC(=O)N1CCN(c2ccc(Nc3nc4cccc(-c5ccccc5)n4n3)cc2)CC1,pIC50,7.0,JAK3
CC(C)(C)OC(=O)N1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,8.43,JAK2
CC(C)(C)OC(=O)N1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,6.53,JAK1
CC(C)(C)OC(=O)N1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,6.53,JAK3
CC(C)(C)OC(=O)N1CCc2ccc(Nc3nc4c(-c5cc(C(F)(F)F)ccc5F)cccn4n3)cc2CC1,pIC50,6.23,JAK2
Cn1ncc2c(-c3cccn4nc(Nc5ccc6c(c5)CCN(C(=O)OC(C)(C)C)CC6)nc34)cccc21,pIC50,7.78,JAK2
Cn1ncc2c(-c3cccn4nc(Nc5ccc6c(c5)CCN(C(=O)OC(C)(C)C)CC6)nc34)cccc21,pIC50,6.64,JAK1
Cn1ncc2c(-c3cccn4nc(Nc5ccc6c(c5)CCN(C(=O)OC(C)(C)C)CC6)nc34)cccc21,pIC50,6.64,JAK3
COCc1ccccc1-c1cccc2nc(Nc3ccc4c(c3)CCN(C(=O)OC(C)(C)C)CC4)nn12,pIC50,6.19,JAK2
CC(C)(C)OC(=O)N1Cc2cc(Nc3nn(C(CC#N)C4CC4)cc3C(N)=O)ccc2C1=O,pIC50,7.46,JAK2
CC(C)(C)OC(=O)N1Cc2cc(Nc3nn(C(CC#N)C4CC4)cc3C(N)=O)ccc2C1=O,pIC50,8.7,JAK1
CC(C)(C)OC(=O)NC1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,7.7,JAK2
CC(C)(C)OC(=O)NC1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,9.1,JAK1
CC(C)(C)OC(=O)NC1CCC(n2nnc3cnc4[nH]ccc4c32)C1,pKi,8.0,JAK2
CC(C)(C)OC(=O)NC1CCC(n2nnc3cnc4[nH]ccc4c32)C1,pKi,8.62,JAK1
CC(C)(C)OC(=O)NC1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,6.57,JAK2
CC(C)(C)OC(=O)NC1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,7.92,JAK1
CC(C)(C)OC(=O)NC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.74,JAK2
CC(C)(C)OC(=O)NC1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.49,JAK1
CC(C)(C)OC(=O)NC1CCC(n2nnc3cnc4[nH]ccc4c32)CC1,pKi,6.4,JAK2
CC(C)(C)OC(=O)NC1CCC(n2nnc3cnc4[nH]ccc4c32)CC1,pKi,6.92,JAK1
CC(C)(C)OC(=O)NC1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,6.77,JAK2
CC(C)(C)OC(=O)NC1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)C1,pIC50,8.18,JAK1
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCC(NC(=O)OC(C)(C)C)C2)CC1,pIC50,7.32,JAK2
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCC(NC(=O)OC(C)(C)C)C2)CC1,pIC50,8.84,JAK1
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCC(NC(=O)OC(C)(C)C)C2)CC1,pIC50,8.84,JAK3
CC(C)(C)OC(=O)NCC1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,6.36,JAK2
CC(C)(C)OC(=O)NCC1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,7.68,JAK1
CC(C)(C)OC(=O)NCC1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)CC1,pIC50,6.43,JAK2
CC(C)(C)OC(=O)NCC1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)CC1,pIC50,7.6,JAK1
CC(C)(C)OC(=O)NCCN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,6.03,JAK2
CC(C)(C)OC(=O)NCCN1CCC(c2nnn3cnc4[nH]ccc4c23)CC1,pIC50,7.0,JAK1
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1,pIC50,9.0,JAK2
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1,pKi,8.6,JAK2
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1,pIC50,8.4,JAK1
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1,pIC50,9.0,TYK2
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1,pIC50,8.3,JAK3
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1,pKi,7.4,JAK3
CC(C)(C)c1nc2c3cc[nH]c(=O)c3c3cc(F)ccc3c2[nH]1,pIC50,9.0,JAK2
CC(C)(C)c1nc2c3cc[nH]c(=O)c3c3cc(F)ccc3c2[nH]1,pKi,8.6,JAK2
CC(C)(C)c1nc2c3cc[nH]c(=O)c3c3cc(F)ccc3c2[nH]1,pIC50,8.4,JAK1
CC(C)(C)c1nc2c3cc[nH]c(=O)c3c3cc(F)ccc3c2[nH]1,pIC50,9.0,TYK2
CC(C)(C)c1nc2c3cc[nH]c(=O)c3c3cc(F)ccc3c2[nH]1,pIC50,8.3,JAK3
CC(C)(C)c1nc2c3cc[nH]c(=O)c3c3cc(F)ccc3c2[nH]1,pKi,7.4,JAK3
CN(Cc1ccc(C(C)(C)C)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.64,JAK2
CN(Cc1ccc(C(C)(C)C)cc1)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.52,JAK1
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C)cc3)sc12,pIC50,8.0,JAK2
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C)cc3)sc12,pIC50,7.41,JAK1
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C)cc3)sc12,pIC50,6.69,TYK2
CNC(=O)c1cnc(N)c2cc(-c3ccc(C(C)(C)C)cc3)sc12,pIC50,6.73,JAK3
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1,pKi,7.3,JAK2
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1,pKi,6.6,TYK2
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1,pKi,6.4,JAK3
CC(C)(C)c1ccc2[nH]c(-c3n[nH]c4ccccc34)nc2c1,pKi,7.3,JAK2
CC(C)(C)c1ccc2[nH]c(-c3n[nH]c4ccccc34)nc2c1,pKi,6.6,TYK2
CC(C)(C)c1ccc2[nH]c(-c3n[nH]c4ccccc34)nc2c1,pKi,6.4,JAK3
CC(C)(O)C1CC(CN2CCC(C#N)C(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)C1,pIC50,6.27,JAK2
CC(C)(O)C1CC(CN2CCC(C#N)C(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)C2)C1,pIC50,7.6,JAK1
CC(C)(O)C1CC(CNC2CCC(n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)C(C#N)C2)C1,pIC50,6.58,JAK2
CC(C)(O)C1CC(CNC2CCC(n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)C(C#N)C2)C1,pIC50,9.0,JAK1
CN(C1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1)C(C)(C)C1CC1,pIC50,7.42,JAK2
CN(C1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1)C(C)(C)C1CC1,pIC50,9.0,JAK1
CC(C)(NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1)C1CC1,pIC50,7.77,JAK2
CC(C)(NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1)C1CC1,pIC50,9.82,JAK1
CC(C)(NC1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)C(C#N)C1)C1CC1,pIC50,7.42,JAK2
CC(C)(NC1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)C(C#N)C1)C1CC1,pIC50,9.0,JAK1
[C-]#[N+]C1CC(C(C)(C)O)CCC1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1,pIC50,8.4,JAK2
[C-]#[N+]C1CC(C(C)(C)O)CCC1n1cc(C(N)=O)c(Nc2ccc(Cl)cc2)n1,pIC50,9.19,JAK1
CC(C)(O)C1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)CC1,pIC50,6.8,JAK2
CC(C)(O)C1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)CC1,pIC50,7.6,JAK1
CC(C)(O)C1CCN(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)CC1,pIC50,6.03,TYK2
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCC(C(C)(C)O)CC2)CC1,pIC50,7.16,JAK2
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCC(C(C)(C)O)CC2)CC1,pIC50,7.87,JAK1
CN(c1ncnc2[nH]ccc12)C1CCC(CS(=O)(=O)N2CCC(C(C)(C)O)CC2)CC1,pIC50,7.87,JAK3
CC(C)(O)C1CN(C(=O)C2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)C(C#N)C2)C1,pIC50,7.23,JAK2
CC(C)(O)C1CN(C(=O)C2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)C(C#N)C2)C1,pIC50,8.05,JAK1
CC(C)(O)C1CN(C2CCC(n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)C(C#N)C2)C1,pIC50,7.31,JAK2
CC(C)(O)C1CN(C2CCC(n3cc(C(N)=O)c(Nc4ccc(C(F)(F)F)cc4)n3)C(C#N)C2)C1,pIC50,9.4,JAK1
CC(C)(O)C1CN(C2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)C(C#N)C2)C1,pIC50,7.44,JAK2
CC(C)(O)C1CN(C2CCC(n3cc(C(N)=O)c(Nc4ccc(Cl)cc4)n3)C(C#N)C2)C1,pIC50,9.22,JAK1
CC(C)(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1,pIC50,6.99,JAK2
CC(C)(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1,pIC50,7.92,JAK1
CC(C)(O)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,8.1,JAK2
CC(C)(O)CC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,9.7,JAK1
CC(C)(O)CCN1CC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1,pKi,9.13,JAK2
CC(C)(O)CCN1CC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1,pKi,9.0,JAK1
CC(C)(CF)NC(=O)c1cnn2ccc(N3CCCC3c3cc(F)cnc3CO)nc12,pIC50,6.18,JAK2
CC(C)(CF)c1ccc(Nc2nn(C3CCC(O)CC3C#N)cc2C(N)=O)cc1,pIC50,8.22,JAK2
CC(C)(CF)c1ccc(Nc2nn(C3CCC(O)CC3C#N)cc2C(N)=O)cc1,pIC50,9.0,JAK1
CN(C)CC(C)(C)COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,6.35,JAK2
CN(C)CC(C)(C)COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,7.8,JAK1
CN(CC(C)(C)C#N)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.25,JAK2
CN(CC(C)(C)C#N)C1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.62,JAK1
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1,pKi,6.3,JAK3
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1,pKi,6.6,JAK3
CC(C)(O)CN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,8.58,JAK2
CC(C)(O)CN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,6.96,JAK1
CC(C)(O)CN1CCN(c2cccc(Nc3nc4c(-c5ccc(S(C)(=O)=O)cc5)cccn4n3)c2)CC1,pIC50,6.96,JAK3
CC(C)(O)CNC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,7.38,JAK2
CC(C)(O)CNC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,8.7,JAK1
COC(C)(C)CNC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,7.32,JAK2
COC(C)(C)CNC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,8.7,JAK1
CC(C)(C#N)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.13,JAK2
CC(C)(C#N)CNC1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.57,JAK1
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O,pKi,6.3,JAK3
CC(C)(O)CNc1ncc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(C)(=O)=O)C2)n1,pIC50,9.75,JAK2
CC(C)(O)CNc1ncc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(C)(=O)=O)C2)n1,pKi,10.7,JAK1
CC(C)(O)CNc1ncc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(C)(=O)=O)C2)n1,pIC50,10.4,JAK3
CC(C)(O)CNc1ncc(-c2cnc3[nH]ccc3n2)c(NC2CCCN(S(C)(=O)=O)C2)n1,pKi,10.7,JAK3
CC(C)(CO)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,7.39,JAK2
CC(C)(CO)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,9.0,JAK1
CC(C)(CO)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,7.02,JAK2
CC(C)(CO)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,8.7,JAK1
CC(C)(C#N)COC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,6.39,JAK2
CC(C)(C#N)COC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,7.82,JAK1
CC(C)(C#N)COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,7.39,JAK2
CC(C)(C#N)COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,9.0,JAK1
CC(C)(COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1)n1cccn1,pIC50,6.42,JAK2
CC(C)(COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1)n1cccn1,pIC50,7.57,JAK1
COCC(C)(C)N(C)C1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,7.2,JAK2
COCC(C)(C)N(C)C1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,8.7,JAK1
COCC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,7.37,JAK2
COCC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccc(Cl)cc3)n2)C(C#N)C1,pIC50,9.1,JAK1
COCC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)C(C#N)C1,pIC50,6.77,JAK2
COCC(C)(C)NC1CCC(n2cc(C(N)=O)c(Nc3ccccc3)n2)C(C#N)C1,pIC50,7.8,JAK1
COCC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,7.4,JAK2
COCC(C)(C)OC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)CC1,pIC50,9.0,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C(C)(C)COC)c3)ncc2Cl)c1,pIC50,9.22,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(C(C)(C)COC)c3)ncc2Cl)c1,pIC50,9.22,JAK3
CC(C)(O)COCc1cccc(Nc2nn(C(CC#N)C3CC3)cc2C(N)=O)c1,pIC50,6.94,JAK2
CC(C)(O)COCc1cccc(Nc2nn(C(CC#N)C3CC3)cc2C(N)=O)c1,pIC50,7.33,JAK1
CC(C)(O)COCc1cccc(Nc2sc(-c3c(F)cc(C(C)(C)O)cc3F)cc2C(N)=O)n1,pIC50,8.12,JAK2
CC(C)(O)COCc1cccc(Nc2sc(-c3c(F)cc(C(C)(C)O)cc3F)cc2C(N)=O)n1,pIC50,6.12,JAK1
CC(C)(O)COCc1cccc(Nc2sc(-c3c(F)cc(C(C)(C)O)cc3F)cc2C(N)=O)n1,pIC50,6.12,JAK3
CN(c1ncnc2[nH]ccc12)C1CC2CN(C(=O)Nc3nc(OCC(C)(C)O)ns3)CC2C1,pIC50,8.3,JAK2
CN(c1ncnc2[nH]ccc12)C1CC2CN(C(=O)Nc3nc(OCC(C)(C)O)ns3)CC2C1,pIC50,9.52,JAK1
CN(c1ncnc2[nH]ccc12)C1CC2CN(C(=O)Nc3nc(OCC(C)(C)O)ns3)CC2C1,pIC50,6.96,JAK3
CN(c1ncnc2[nH]ccc12)C1CC2CN(C(=O)Oc3nc(OCC(C)(C)O)ns3)CC2C1,pIC50,8.3,JAK2
CN(c1ncnc2[nH]ccc12)C1CC2CN(C(=O)Oc3nc(OCC(C)(C)O)ns3)CC2C1,pIC50,9.52,JAK1
CN(c1ncnc2[nH]ccc12)C1CC2CN(C(=O)Oc3nc(OCC(C)(C)O)ns3)CC2C1,pIC50,6.96,JAK3
CC(C)(O)Cc1cccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)n1,pIC50,6.83,JAK2
CC(C)(O)Cc1cccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)n1,pIC50,8.3,JAK1
COc1cnc(C(F)(F)F)cc1-c1nn(CC(C)(C)O)cc1NC(=O)c1cnn2cccnc12,pKi,7.41,JAK2
COc1cnc(C(F)(F)F)cc1-c1nn(CC(C)(C)O)cc1NC(=O)c1cnn2cccnc12,pKi,7.92,JAK1
COc1cnc(C(F)(F)F)cc1-c1nn(CC(C)(C)O)cc1NC(=O)c1cnn2cccnc12,pKi,6.46,TYK2
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(C)(C)O)c3)ncc2Cl)c1,pIC50,9.22,JAK1
C=CC(=O)Nc1cccc(CNc2nc(Nc3cnn(CC(C)(C)O)c3)ncc2Cl)c1,pIC50,9.22,JAK3
CC(C)(C(=O)O)c1ccc(Nc2nn(C3CCC(N4CC5(CCC5)C4)CC3C#N)cc2C(N)=O)cc1,pIC50,7.1,JAK2
CC(C)(C(=O)O)c1ccc(Nc2nn(C3CCC(N4CC5(CCC5)C4)CC3C#N)cc2C(N)=O)cc1,pIC50,9.6,JAK1
CC(C)(C(=O)O)c1ccc(Nc2nn(C3CCC(N4CCC4)CC3C#N)cc2C(N)=O)cc1,pIC50,7.01,JAK2
CC(C)(C(=O)O)c1ccc(Nc2nn(C3CCC(N4CCC4)CC3C#N)cc2C(N)=O)cc1,pIC50,9.52,JAK1
CC(C)(c1ccc(Nc2nn(C3CCC(O)CC3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F,pIC50,8.7,JAK2
CC(C)(c1ccc(Nc2nn(C3CCC(O)CC3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F,pIC50,9.3,JAK1
COC(C)(C)c1ccc(Nc2nn(C3CCC(O)CC3C#N)cc2C(N)=O)cc1,pIC50,8.7,JAK2
COC(C)(C)c1ccc(Nc2nn(C3CCC(O)CC3C#N)cc2C(N)=O)cc1,pIC50,9.35,JAK1
CC(C)(C(=O)NCC(F)(F)F)c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1,pIC50,9.18,JAK2
CC(C)(C(=O)NCC(F)(F)F)c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1,pIC50,9.7,JAK1
CC(C)(C(=O)O)c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1,pIC50,8.15,JAK2
CC(C)(C(=O)O)c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1,pIC50,9.92,JAK1
CC(C)(c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F,pIC50,9.0,JAK2
CC(C)(c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1)C(O)C(F)(F)F,pIC50,10.0,JAK1
COC(C)(C)c1ccc(Nc2nn(C3COCCC3C#N)cc2C(N)=O)cc1,pIC50,9.4,JAK2
COC(C)(C)c1ccc(Nc2nn(C3COCCC3C#N)cc2C(N)=O)cc1,pIC50,10.0,JAK1
CC(C)(c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1F)C(O)C(F)(F)F,pIC50,8.4,JAK2
CC(C)(c1ccc(Nc2nn(C3CCCCC3C#N)cc2C(N)=O)cc1F)C(O)C(F)(F)F,pIC50,8.7,JAK1
CC(C)(O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OCC(F)(F)F)CC3)cc2C(N)=O)cn1,pIC50,9.15,JAK2
CC(C)(O)c1ccc(Nc2nn(C3(CC#N)CCN(C(=O)OCC(F)(F)F)CC3)cc2C(N)=O)cn1,pIC50,10.0,JAK1
Cn1c(=O)n(-c2cccc(-c3c(Cl)cc(C(N)=O)c4[nH]c5cc(C(C)(C)O)ccc5c34)c2Cl)c(=O)c2cccc(F)c21,pIC50,6.15,JAK2
Cn1c(=O)n(-c2cccc(-c3c(F)cc(C(N)=O)c4[nH]c5cc(C(C)(C)O)ccc5c34)c2Cl)c(=O)c2cccc(F)c21,pIC50,6.57,JAK2
CC(C)(O)c1cccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)n1,pIC50,7.66,JAK2
CC(C)(O)c1cccc(N2CCC(CC#N)(n3cc(C(N)=O)c(Nc4ccc(F)cc4)n3)CC2)n1,pIC50,9.52,JAK1
CC(C)(O)c1cn(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)nn1,pIC50,7.01,JAK2
CC(C)(O)c1cn(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)nn1,pIC50,8.13,JAK1
CC(C)(O)c1cn(CC2CCC(c3nnn4cnc5[nH]ccc5c34)CC2)nn1,pIC50,6.23,JAK3
CC(C)(O)c1cn(Cc2cccc(Nc3nn(C(CC#N)C4CCCC4)cc3C(N)=O)c2)nn1,pIC50,6.0,JAK2
CC(C)(O)c1cn(Cc2cccc(Nc3nn(C(CC#N)C4CCCC4)cc3C(N)=O)c2)nn1,pIC50,6.71,JAK1
CC(C)(O)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1,pKi,7.12,JAK2
CC(C)(O)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1,pKi,7.89,JAK1
CC(C)C(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.77,JAK2
CC(C)C(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,9.75,JAK1
CC(C)C(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.77,JAK3
CC(C)C(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,9.75,JAK3
CC(C)C(=O)N1CCC2CC(N(C)c3ncnc4[nH]ccc34)CC2C1,pIC50,6.9,JAK2
CC(C)C(=O)N1CCC2CC(N(C)c3ncnc4[nH]ccc34)CC2C1,pIC50,6.97,JAK1
CC(C)C(=O)N1CCC2CC(N(C)c3ncnc4[nH]ccc34)CC2C1,pIC50,6.69,JAK3
CC(C)C(=O)N1CCCC12CCN(c1ncnc3[nH]ccc13)C2,pIC50,6.24,JAK1
CC(C)C(=O)N1CCCC12CCN(c1ncnc3[nH]ccc13)C2,pIC50,6.24,JAK3
CC(C)C(O)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,7.1,JAK2
CC(C)C(O)C(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CC1,pIC50,8.7,JAK1
CC(C)C(Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C(F)(F)F,pIC50,8.52,JAK2
CC(C)C(Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C(F)(F)F,pIC50,6.25,JAK1
CC(C)C(Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C(F)(F)F,pIC50,6.25,JAK3
CC(C)C(C)NC(=O)c1c[nH]c2ncc(C3CC3)nc12,pIC50,7.49,JAK2
CC(C)C(C)NC(=O)c1c[nH]c2ncc(C3CC3)nc12,pIC50,8.11,JAK1
CC(C)C(C)NC(=O)c1c[nH]c2ncc(C3CC3)nc12,pIC50,8.11,JAK3
CC(C)C(C)n1cc(-c2cc(C(C)(C)O)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.68,JAK2
CC(C)C(C)n1cc(-c2cc(C(C)(C)O)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.48,JAK1
CC(C)C(C)n1cc(-c2cc(C(C)(C)O)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.68,TYK2
CC(C)C(C)n1cc(-c2cc(C(C)(C)O)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.48,JAK3
CC(C)C(C)n1cc(-c2cc(C3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,9.01,JAK2
CC(C)C(C)n1cc(-c2cc(C3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.34,JAK1
CC(C)C(C)n1cc(-c2cc(C3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,9.01,TYK2
CC(C)C(C)n1cc(-c2cc(C3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.34,JAK3
CC(C)C(C)n1cc(-c2cc(N3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,9.26,JAK2
CC(C)C(C)n1cc(-c2cc(N3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.55,JAK1
CC(C)C(C)n1cc(-c2cc(N3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,9.26,TYK2
CC(C)C(C)n1cc(-c2cc(N3CCOCC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.55,JAK3
CC(C)C(C)n1cc(-c2cc(N3CCS(=O)(=O)CC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.92,JAK2
CC(C)C(C)n1cc(-c2cc(N3CCS(=O)(=O)CC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.4,JAK1
CC(C)C(C)n1cc(-c2cc(N3CCS(=O)(=O)CC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.92,TYK2
CC(C)C(C)n1cc(-c2cc(N3CCS(=O)(=O)CC3)n(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.4,JAK3
CC(C)C(C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O,pIC50,9.04,JAK2
CC(C)C(C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O,pIC50,8.28,JAK1
CC(C)C(C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O,pIC50,9.04,TYK2
CC(C)C(C)n1cc(-c2ccc(N3CCOCC3)cn2)c2[nH]nc(N)c2c1=O,pIC50,8.28,JAK3
CC(C)C(C)n1cc(-c2ccn(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.26,JAK2
CC(C)C(C)n1cc(-c2ccn(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.19,JAK1
CC(C)C(C)n1cc(-c2ccn(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.26,TYK2
CC(C)C(C)n1cc(-c2ccn(C)n2)c2[nH]nc(N)c2c1=O,pIC50,8.19,JAK3
CC(C)C(Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C1CC1,pIC50,8.52,JAK2
CC(C)C(Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C1CC1,pIC50,6.68,JAK1
CC(C)C(Nc1ncc(C(N)=O)c2[nH]c3cc(-c4cnn(C)c4)ccc3c12)C1CC1,pIC50,6.68,JAK3
CC(C)C(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1,pIC50,6.19,JAK2
CC(C)C(CC#N)n1cc(C(N)=O)c(Nc2ccccc2)n1,pIC50,7.19,JAK1
CC(C)C(CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1,pIC50,6.08,JAK2
CC(C)C(Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(F)cc1,pIC50,9.22,JAK2
CC(C)C(Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(F)cc1,pIC50,7.92,JAK1
CC(C)C(Nc1cc(-c2c(N)nn3cccnc23)ncn1)c1ccc(F)cc1,pIC50,7.92,JAK3
CC(C)CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.81,JAK2
CC(C)CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,8.0,JAK1
CC(C)CC(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.82,JAK3
CC(C)CC(=O)NC1CCC(n2nnc3cnc4[nH]ccc4c32)CC1,pKi,7.77,JAK2
CC(C)CC(=O)NC1CCC(n2nnc3cnc4[nH]ccc4c32)CC1,pKi,8.33,JAK1
CC(C)CCS(=O)(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.09,JAK2
CC(C)CCS(=O)(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,9.55,JAK1
CC(C)CCS(=O)(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.26,JAK3
CC(C)CCS(=O)(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,9.55,JAK3
CC(C)CN(CC1CC1)C1CCC(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,6.04,JAK2
CC(C)CN(CC1CC1)C1CCC(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,7.8,JAK1
CC(C)CN1CC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1,pKi,9.08,JAK2
CC(C)CN1CC2CN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2C1,pKi,9.09,JAK1
CC(C)CN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,10.05,JAK2
CC(C)CN1CCC(n2cc(NC(=O)c3c(N)nn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.17,JAK1
CC(C)CN1CCC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1,pKi,8.89,JAK2
CC(C)CN1CCC2(CCN(C(=O)Cn3cc(NC(=O)c4cnn5cccnc45)c(-c4cc(Cl)ccc4OC(F)F)n3)CC2)C1,pKi,9.41,JAK1
CC(C)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,8.94,JAK2
CC(C)CN1CCN(C(=O)Cn2cc(NC(=O)c3cnn4cccnc34)c(-c3cc(Cl)ccc3OC(F)F)n2)CC1,pKi,9.19,JAK1
CC(C)CNC1CCC(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,6.38,JAK2
CC(C)CNC1CCC(n2cc(C(N)=O)c(Nc3ccc(C(F)(F)F)cc3)n2)C(C#N)C1,pIC50,8.22,JAK1
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1,pKi,6.0,JAK3
CC(C)COC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,6.53,JAK2
CC(C)COC(=O)N1CC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)C1,pIC50,7.85,JAK1
CC(C)COC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,6.12,JAK2
CC(C)COC(=O)N1CCC(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C(C#N)C1,pIC50,7.48,JAK1
CC(C)COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,7.12,JAK2
CC(C)COC(=O)N1CCC(C#N)C(n2cc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1,pIC50,8.4,JAK1
CC(C)COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,6.99,JAK2
CC(C)COC(=O)N1CCC(CC#N)(n2cc(C(N)=O)c(Nc3ccccc3)n2)CC1,pIC50,8.52,JAK1
CC(C)COC1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,11.12,JAK2
CC(C)COC1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,11.88,JAK1
CC(C)COC1CCCN(S(=O)(=O)CC2CCC(N(C)c3ncnc4[nH]ccc34)CC2)C1,pIC50,11.88,JAK3
CC(C)COc1cccc(-c2cccn3nc(Nc4ccc5c(c4)CCNCC5)nc23)c1,pIC50,7.49,JAK2
CC(C)COc1cccc(-c2cccn3nc(Nc4ccc5c(c4)CCNCC5)nc23)c1,pIC50,6.47,JAK1
CC(C)COc1cccc(-c2cccn3nc(Nc4ccc5c(c4)CCNCC5)nc23)c1,pIC50,6.47,JAK3
CC(C)CS(=O)(=O)N1CC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC(C(F)(F)F)C1,pIC50,9.33,JAK2
CC(C)CS(=O)(=O)N1CC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC(C(F)(F)F)C1,pKi,10.17,JAK1
CC(C)CS(=O)(=O)N1CC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC(C(F)(F)F)C1,pIC50,9.87,JAK3
CC(C)CS(=O)(=O)N1CC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC(C(F)(F)F)C1,pKi,10.17,JAK3
CC(C)CS(=O)(=O)N1CCC(O)C(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.05,JAK2
CC(C)CS(=O)(=O)N1CCC(O)C(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,11.68,JAK1
CC(C)CS(=O)(=O)N1CCC(O)C(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,11.38,JAK3
CC(C)CS(=O)(=O)N1CCC(O)C(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,11.68,JAK3
CC(C)CS(=O)(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.18,JAK2
CC(C)CS(=O)(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,9.23,JAK1
CC(C)CS(=O)(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.18,JAK3
CC(C)CS(=O)(=O)N1CCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,9.23,JAK3
CC(C)CS(=O)(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,7.33,JAK2
CC(C)CS(=O)(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,8.15,JAK1
CC(C)CS(=O)(=O)N1CCCC(NC(=O)Nc2cnc3[nH]ccc3n2)C1,pIC50,8.15,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3nc[nH]c3n2)C1,pIC50,8.52,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3nc[nH]c3n2)C1,pIC50,9.0,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3nc[nH]c3n2)C1,pIC50,9.0,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,9.97,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,6.99,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,10.98,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.69,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1,pKi,10.98,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ncc3n2)C1,pIC50,9.0,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ncc3n2)C1,pKi,9.83,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ncc3n2)C1,pIC50,9.54,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ncc3n2)C1,pKi,9.83,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3cc[nH]c3n2)C1,pIC50,9.72,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3cc[nH]c3n2)C1,pKi,9.25,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3cc[nH]c3n2)C1,pIC50,9.72,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3cc[nH]c3n2)C1,pKi,9.25,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3ccn(C)c3n2)C1,pIC50,9.24,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3ccn(C)c3n2)C1,pKi,9.41,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3ccn(C)c3n2)C1,pIC50,9.24,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3ccn(C)c3n2)C1,pKi,9.41,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N(C)C)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.26,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N(C)C)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,11.61,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N(C)C)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,11.3,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N(C)C)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,11.61,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.71,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,12.24,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,11.94,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,12.24,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.23,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,11.47,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,11.17,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N3CCN(C)CC3)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,11.47,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N3CCOCC3)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.31,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N3CCOCC3)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,11.28,JAK1
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N3CCOCC3)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.98,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(N3CCOCC3)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,11.28,JAK3
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(S(C)(=O)=O)ncc2-c2cnc3[nH]ccc3n2)C1,pIC50,10.19,JAK2
CC(C)CS(=O)(=O)N1CCCC(Nc2nc(S(C)(=O)=O)ncc2-c2cnc3[nH]ccc3n2)C1,pKi,12.03,JAK1