diff --git a/dd-java-agent/src/main/java/datadog/trace/bootstrap/AgentBootstrap.java b/dd-java-agent/src/main/java/datadog/trace/bootstrap/AgentBootstrap.java
index 90f6f8279c5..ed0db2fc50a 100644
--- a/dd-java-agent/src/main/java/datadog/trace/bootstrap/AgentBootstrap.java
+++ b/dd-java-agent/src/main/java/datadog/trace/bootstrap/AgentBootstrap.java
@@ -291,32 +291,45 @@ static int parseJavaMajorVersion(String version) {
 
   @SuppressForbidden
   static boolean shouldAbortDueToOtherJavaAgents() {
-    // Simply considering having multiple agents
+    // We don't abort if either
+    // * We are not using SSI
+    // * Injection is forced
+    // * There is only one agent
+    if (!getConfig(LIB_INJECTION_ENABLED_ENV_VAR)
+        || getConfig(LIB_INJECTION_FORCE_SYS_PROP)
+        || getAgentFilesFromVMArguments().size() <= 1) {
+      return false;
+    }
 
-    if (getConfig(LIB_INJECTION_ENABLED_ENV_VAR)
-        && !getConfig(LIB_INJECTION_FORCE_SYS_PROP)
-        && getAgentFilesFromVMArguments().size() > 1) {
-      // Formatting agent file list, Java 7 style
-      StringBuilder agentFiles = new StringBuilder();
-      boolean first = true;
+    // If there are 2 agents and one of them is for patching log4j, it's fine
+    if (getAgentFilesFromVMArguments().size() == 2) {
       for (File agentFile : getAgentFilesFromVMArguments()) {
-        if (first) {
-          first = false;
-        } else {
-          agentFiles.append(", ");
+        if (agentFile.getName().toLowerCase().contains("log4j")) {
+          return false;
         }
-        agentFiles.append('"');
-        agentFiles.append(agentFile.getAbsolutePath());
-        agentFiles.append('"');
       }
-      System.err.println(
-          "Info: multiple JVM agents detected, found "
-              + agentFiles
-              + ". Loading multiple APM/Tracing agent is not a recommended or supported configuration."
-              + "Please set the environment variable DD_INJECT_FORCE or the system property dd.inject.force to TRUE to load Datadog APM/Tracing agent.");
-      return true;
     }
-    return false;
+
+    // Simply considering having multiple agents
+    // Formatting agent file list, Java 7 style
+    StringBuilder agentFiles = new StringBuilder();
+    boolean first = true;
+    for (File agentFile : getAgentFilesFromVMArguments()) {
+      if (first) {
+        first = false;
+      } else {
+        agentFiles.append(", ");
+      }
+      agentFiles.append('"');
+      agentFiles.append(agentFile.getAbsolutePath());
+      agentFiles.append('"');
+    }
+    System.err.println(
+        "Info: multiple JVM agents detected, found "
+            + agentFiles
+            + ". Loading multiple APM/Tracing agent is not a recommended or supported configuration."
+            + "Please set the environment variable DD_INJECT_FORCE or the system property dd.inject.force to TRUE to load Datadog APM/Tracing agent.");
+    return true;
   }
 
   public static void main(final String[] args) {
diff --git a/dd-smoke-tests/lib-injection/src/test/groovy/datadog/smoketest/MultipleAgentGuardrailsTest.groovy b/dd-smoke-tests/lib-injection/src/test/groovy/datadog/smoketest/MultipleAgentGuardrailsTest.groovy
index b644a87296a..c0e9350e468 100644
--- a/dd-smoke-tests/lib-injection/src/test/groovy/datadog/smoketest/MultipleAgentGuardrailsTest.groovy
+++ b/dd-smoke-tests/lib-injection/src/test/groovy/datadog/smoketest/MultipleAgentGuardrailsTest.groovy
@@ -1,16 +1,21 @@
 package datadog.smoketest
 
+import java.nio.file.Files
+import java.nio.file.Paths
+
+import static java.nio.file.StandardCopyOption.REPLACE_EXISTING
+
 abstract class MultipleAgentGuardrailsTest extends AbstractSmokeTest {
   static final String LIB_INJECTION_ENABLED_FLAG = 'DD_INJECTION_ENABLED'
   static final String LIB_INJECTION_FORCE_FLAG = 'DD_INJECT_FORCE'
 
   @Override
   ProcessBuilder createProcessBuilder() {
-    def jarPath = System.getProperty("datadog.smoketest.shadowJar.path")
+    def jarPath = System.getProperty('datadog.smoketest.shadowJar.path')
     def command = []
     command+= javaPath()
     command.addAll(defaultJavaProperties)
-    command+= "-javaagent:${jarPath}" as String // Happen the fake agent too
+    command+= "-javaagent:${getFakeAgentPath(jarPath)}" as String // Happen the fake agent too
     command+= '-Ddd.trace.otel.enabled=true'
     command+= '-jar'
     command+= jarPath
@@ -25,9 +30,23 @@ abstract class MultipleAgentGuardrailsTest extends AbstractSmokeTest {
     processBuilder.directory(new File(buildDirectory))
   }
 
+  String getFakeAgentPath(String jarPath) {
+    if (overriddenFakeAgentFilename() != null) {
+      def buildFakeAgentPath = Paths.get(jarPath)
+      def overriddenFakeAgentPath = buildFakeAgentPath.getParent().resolve(overriddenFakeAgentFilename())
+      Files.copy(buildFakeAgentPath, overriddenFakeAgentPath, REPLACE_EXISTING)
+      jarPath = overriddenFakeAgentPath.toString()
+    }
+    return jarPath
+  }
+
   abstract boolean isLibInjectionEnabled()
   abstract boolean isLibInjectionForced()
 
+  String overriddenFakeAgentFilename() {
+    return null
+  }
+
   boolean isExpectingTrace() {
     return !isLibInjectionEnabled() || isLibInjectionForced()
   }
@@ -78,3 +97,26 @@ class LibInjectionForcedTest extends MultipleAgentGuardrailsTest {
     return true
   }
 }
+
+// Test that injection still works if we have to agent if one of them is the aws emr log4j patcher
+class LibsInjectionLog4jExclusionTest extends MultipleAgentGuardrailsTest {
+  @Override
+  boolean isLibInjectionEnabled() {
+    return true
+  }
+
+  @Override
+  boolean isLibInjectionForced() {
+    return false
+  }
+
+  @Override
+  String overriddenFakeAgentFilename() {
+    return 'Log4jHotPatchFat.jar'
+  }
+
+  @Override
+  boolean isExpectingTrace() {
+    return true
+  }
+}