@@ -15,18 +15,24 @@ Without further ado, here are some highlights!
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## Improved rendering of phased VCF in multi-variant view
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- Phased variants offer a unique opportunity to see "which parent" particular
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- parents came from
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+ Phased variants offer a unique opportunity to see which parent particular
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+ variants came from. To help this, we added a new "phased" rendering mode to the
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+ multi-variant renderings, that takes phased VCF and renders each phase as an
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+ individual row. This allows users to effectively see the entire row as a
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+ haplotype, and can be used to help visualize trio VCF to find parent of origin
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![ Screenshot From 2025-01-25 15-03-21] ( https://github.com/user-attachments/assets/a9308a40-ab74-48c0-9ab6-035b50a1ae0b )
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- Screenshot showing the "phased mode" for the multi-variant matrix display, here
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- showing a "trio VCF" with child and parents. You can visually see which blocks
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- the child inherited from which parents. This inspection can also be useful for
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- plant breeders to ensure regions that their crosses inherited particular gnomic
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- regions from a particular parent line
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+ Screenshot showing the "phased mode" for a trio VCF
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- We can also render "phased sets" if the VCF is not completely phased (detects PS
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- tag in genotypes)
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+ ![ image] ( https://github.com/user-attachments/assets/4198d6ba-05fd-4be7-829e-76f58499ad46 )
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+
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+ Screenshot showing how to access the phased rendering mode
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+
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+ ## Rendring of phase-sets
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+
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+ This could be more or less uncommon depending on your work, but for incompletely
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+ phased variant calls you will see "phased sets" (PS tag in genotypes). We color
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+ each set a random color
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![ image] ( https://github.com/user-attachments/assets/63fa9f59-d54b-4f66-852d-4d8592ff95ec )
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@@ -35,7 +41,7 @@ completely phased so just showing green, but each phase set would get a unique
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color. The black entries are unphased variants (which could be filtered out, but
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this is not done currently)
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- ## Improved rendering of polyploid VCF in multi-variant view
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+ ## Rendering polyploids in the multi-variant view
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![ image] ( https://github.com/user-attachments/assets/58138b02-4d20-487b-af77-68b2d038dedc )
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@@ -53,12 +59,25 @@ Each of these is a spectrum that increases in darkness, so darker blue indicates
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more ALT===1, darker red indicates more ALT!==1, darker yellow is more uncalled,
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etc.
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- ## Adding VCF sample metadata from TSV
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+ ## Adding sample metadata to VCF from an external TSV
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![ image] ( https://github.com/user-attachments/assets/ba7b99ab-53eb-4719-a6de-1cf9ff16511a )
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Screnshot showing multi-sample matrix display, with the population colors coming
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- from a "sample TSV" file
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+ from a "sample TSV" file. The below config shows the samplesTsvLocation config,
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+ the first column should match the sample name in the VCF
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+
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+ Example TSV
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+
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+ ```
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+ name population
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+ HG01879 ACB
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+ HG01880 ACB
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+ HG01881 ACB
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+ HG01882 ACB
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+ HG01883 ACB
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+ HG01884 ACB
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+ ```
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Config
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@@ -87,10 +106,12 @@ Config
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## Improved UI for opening synteny tracks
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- It has always been a little tricky to open synteny tracks
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+ It has always been challenging for end users to open synteny tracks
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- We now allow support adding synteny tracks via the default "Add track" workflow,
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- and make it easier to specify the query and target assembly names
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+ To help with this, we now support adding synteny tracks via the default "Add
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+ track" workflow, and make it easier to specify the query and target assembly
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+ names. We also added a similar UI change to the "Linear synteny view" import
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+ form
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![ image] ( https://github.com/user-attachments/assets/913fd8b9-9d4e-4d44-88d7-ba3e70fd54f4 )
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@@ -99,7 +120,7 @@ and query assemblies for PAF tracks
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![ image] ( https://github.com/user-attachments/assets/75da5058-50cc-413e-aee9-e57362d2d0c0 )
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- Screenshot showing the add track workflow in the Linear synteny view import
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+ Screenshot showing the add track workflow in the " Linear synteny view" import
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form, also showing new UI for choosing query and target assmblies
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## New "turbo zoom" buttons
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