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2021 Series 4 SAR Summary Figure 5 Short.cdxml
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><s font="3" size="10.15" color="0" face="1">MMV897698</s><s font="3" size="10.15" color="0"> (R</s><s font="3" size="10.15" color="0" face="32">1</s><s font="3" size="10.15" color="0"> = H, R</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0"> = OCHF</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0">):</s><s font="3" size="10.15" color="10"> 0.362
</s><s font="3" size="10.15" color="0" face="1">MMV663915 </s><s font="3" size="10.15" color="0">(R</s><s font="3" size="10.15" color="0" face="32">1</s><s font="3" size="10.15" color="0"> = H, R</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0"> = Cl): </s><s font="3" size="10.15" color="10">0.104
</s><s font="3" size="10.15" color="0" face="1">OSM-W-10 </s><s font="3" size="10.15" color="0">(R</s><s font="3" size="10.15" color="0" face="32">1</s><s font="3" size="10.15" color="0"> = 4-fluoro, R</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0"> = Cl): </s><s font="3" size="10.15" color="10">0.141
</s><s font="3" size="10.15" color="0" face="1">MMV675960</s><s font="3" size="10.15" color="0"> (R</s><s font="3" size="10.15" color="0" face="32">1</s><s font="3" size="10.15" color="0"> = 3,4-difluoro, R</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0"> = OCHF</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0">): </s><s font="3" size="10.15" color="10">0.281
</s><s font="3" size="10.15" color="0" face="1">MMV639565</s><s font="3" size="10.15" color="0"> (R</s><s font="3" size="10.15" color="0" face="32">1</s><s font="3" size="10.15" color="0"> = 3,4-difluoro, R</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0"> = Cl): </s><s font="3" size="10.15" color="10">0.079
</s><s font="3" size="10.15" color="0" face="1">MMV897711</s><s font="3" size="10.15" color="0"> (R</s><s font="3" size="10.15" color="0" face="32">1</s><s font="3" size="10.15" color="0"> = 3-OMe, R</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0"> = OCHF</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0">): </s><s font="3" size="10.15" color="10">0.136
</s><s font="3" size="10.15" color="0" face="1">MMV897712</s><s font="3" size="10.15" color="0"> (R</s><s font="3" size="10.15" color="0" face="32">1</s><s font="3" size="10.15" color="0"> = 4-OMe, R</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0"> = OCHF</s><s font="3" size="10.15" color="0" face="32">2</s><s font="3" size="10.15" color="0">): </s><s font="3" size="10.15" color="10">0.928</s></t></group></group></group><group
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id="12359"
p="343.41 125.42"
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Warning="Chemical Interpretation is not possible for this label"
CaptionJustification="Center"
Justification="Center"
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><s font="5" size="10.15" color="0" face="4">Potency</s><s font="3" size="10.15" color="0">
</s><s font="3" size="10.15" color="10"><1 µM = green</s><s font="3" size="10.15" color="0">
</s><s font="3" size="10.15" color="11">1-2.5 µM = orange</s><s font="3" size="10.15" color="0">
</s><s font="3" size="10.15" color="4">>2.5 µM = red</s></t><graphic
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id="13011"
p="452.56 143.99"
Z="626"
AS="N"
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AS="N"
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p="448.96 162.24"
BoundingBox="448.96 153.96 456.16 162.24"
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><s font="3" size="9.95" color="0" face="96">N</s></t></n><n
id="13013"
p="464.98 165.51"
Z="629"
AS="N"
/><n
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p="477.41 158.34"
Z="630"
AS="N"
/><n
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p="477.41 143.99"
Z="631"
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NeedsClean="yes"
AS="N"
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p="473.81 147.89"
BoundingBox="473.81 139.61 481.01 147.89"
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><s font="3" size="9.95" color="0" face="96">N</s></t></n><n
id="13016"
p="464.98 136.81"
Z="632"
AS="N"
/><n
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p="491.05 162.77"
Z="639"
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p="487.45 166.67"
BoundingBox="487.45 158.39 494.65 166.67"
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><s font="3" size="9.95" color="0" face="96">N</s></t></n><n
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p="499.50 151.16"
Z="640"
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NumHydrogens="0"
NeedsClean="yes"
AS="N"
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p="495.90 155.06"
BoundingBox="495.90 146.78 503.10 155.06"
LabelJustification="Left"
><s font="3" size="9.95" color="0" face="96">N</s></t></n><n
id="13019"
p="491.05 139.56"
Z="641"
AS="N"
/><n
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p="495.49 125.92"
Z="646"
AS="N"
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p="464.98 122.46"
Z="648"
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NumHydrogens="0"
NeedsClean="yes"
AS="N"
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p="461.11 126.36"
BoundingBox="461.11 117.96 468.86 126.46"
LabelJustification="Left"
><s font="3" size="9.95" color="0" face="96">O</s></t></n><n
id="13022"
p="509.53 122.93"
Z="650"
AS="N"
/><n
id="13023"
p="513.96 109.28"
Z="651"
AS="N"
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p="504.36 98.62"
Z="652"
AS="N"
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id="13025"
p="490.33 101.61"
Z="653"
AS="N"
/><n
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p="485.88 115.25"
Z="654"
AS="N"
/><n
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p="452.56 115.29"
Z="661"
AS="N"
/><n
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p="508.79 84.97"
Z="663"
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AS="N"
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p="508.79 84.97"
Z="617"
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NumHydrogens="0"
NeedsClean="yes"
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p="504.89 88.87"
BoundingBox="504.89 80.41 512.69 88.97"
LabelJustification="Left"
><s font="3" size="10" color="0" face="96">O</s></t></n><n
id="13031"
p="499.19 74.31"
Z="618"
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p="485.15 77.29"
Z="619"
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NumHydrogens="0"
NeedsClean="yes"
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p="482.10 81.19"
BoundingBox="482.10 72.85 488.21 81.19"
LabelJustification="Left"
><s font="3" size="10" color="0" face="96">F</s></t></n><n
id="13033"
p="503.62 60.66"
Z="620"
Element="9"
NumHydrogens="0"
NeedsClean="yes"
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p="500.57 64.56"
BoundingBox="500.57 56.22 506.68 64.56"
LabelJustification="Left"
><s font="3" size="10" color="0" face="96">F</s></t></n><n
id="13034"
p="504.36 98.62"
Z="621"
NodeType="ExternalConnectionPoint"
ExternalConnectionNum="1"
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id="13035"
Z="622"
B="13031"
E="13032"
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Z="623"
B="13031"
E="13033"
/><b
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Z="624"
B="13030"
E="13031"
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id="13038"
Z="625"
B="13034"
E="13030"
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p="504.89 88.87"
BoundingBox="504.89 80.41 537.41 91.07"
LabelJustification="Left"
LabelAlignment="Left"
><s font="3" size="10" color="0" face="96">OCHF2</s></t></n><n
id="13039"
p="452.56 100.94"
Z="665"
AS="N"
/><n
id="13293"
p="419 72.70"
Z="668"
Geometry="Tetrahedral"
AS="r"
BondOrdering="13301 13304 13309 0"
AtomNumber="0"
/><n
id="13294"
p="419 87.10"
Z="669"
AS="N"
AtomNumber="1"
/><n
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p="433.40 87.10"
Z="670"
AS="N"
AtomNumber="2"
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p="433.40 72.70"
Z="671"
Geometry="Tetrahedral"
AS="R"
BondOrdering="13304 13303 0 13310"
AtomNumber="3"
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p="426.20 79.90"
Z="672"
Geometry="Tetrahedral"
AS="S"
BondOrdering="13309 13305 13308 0"
AtomNumber="4"
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id="13298"
p="426.20 94.30"
Z="673"
AS="N"
AtomNumber="5"
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p="440.60 94.30"
Z="674"
AS="N"
AtomNumber="6"
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p="440.60 79.90"
Z="675"
Geometry="Tetrahedral"
AS="r"
BondOrdering="13310 13308 13307 0"
AtomNumber="7"
/><b
id="13050"
Z="633"
B="13011"
E="13012"
BS="N"
/><b
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Z="634"
B="13012"
E="13013"
Order="2"
BS="N"
BondCircularOrdering="13050 0 0 13052"
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Z="635"
B="13013"
E="13014"
BS="N"
/><b
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Z="636"
B="13014"
E="13015"
BS="N"
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Z="637"
B="13015"
E="13016"
BS="N"
/><b
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Z="638"
B="13016"
E="13011"
Order="2"
BS="N"
BondCircularOrdering="13054 13061 0 13050"
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Z="642"
B="13014"
E="13017"
Order="2"
BS="N"
BondCircularOrdering="13053 13052 0 13057"
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Z="643"
B="13017"
E="13018"
BS="N"
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B="13018"
E="13019"
Order="2"
BS="N"
BondCircularOrdering="13057 0 13060 13059"
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Z="645"
B="13019"
E="13015"
BS="N"
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Z="647"
B="13019"
E="13020"
BS="N"
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BS="N"
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B="13020"
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BS="N"
BondCircularOrdering="13067 13060 0 13063"
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BS="N"
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Order="2"
BS="N"
BondCircularOrdering="13063 0 13069 13065"
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B="13024"
E="13025"
BS="N"
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B="13025"
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Order="2"
BS="N"
BondCircularOrdering="13065 0 0 13067"
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Z="660"
B="13026"
E="13020"
BS="N"
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Z="662"
B="13021"
E="13027"
BS="N"
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Z="664"
B="13024"
E="13028"
BS="N"
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Z="666"
B="13027"
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BS="N"
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Z="676"
B="13293"
E="13294"
BS="N"
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Z="677"
B="13294"
E="13295"
BS="N"
CrossingBonds="13305"
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id="13303"
Z="678"
B="13295"
E="13296"
BS="N"
CrossingBonds="13308"
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id="13304"
Z="679"
B="13296"
E="13293"
BS="N"
/><b
id="13305"
Z="680"
B="13297"
E="13298"
BS="N"