diff --git a/.github/CODEOWNERS b/.github/CODEOWNERS
index 7a2cc956a..42b2977db 100644
--- a/.github/CODEOWNERS
+++ b/.github/CODEOWNERS
@@ -23,6 +23,7 @@
 
 /apps/agora/ @Sage-Bionetworks/sage-monorepo-agora
 /libs/agora/ @Sage-Bionetworks/sage-monorepo-agora
+/.github/workflows/e2e-agora.yaml @Sage-Bionetworks/sage-monorepo-agora
 
 /libs/shared/ @tschaffter
 
diff --git a/.github/workflows/e2e-agora.yaml b/.github/workflows/e2e-agora.yaml
new file mode 100644
index 000000000..e0103c2d7
--- /dev/null
+++ b/.github/workflows/e2e-agora.yaml
@@ -0,0 +1,75 @@
+name: Run e2e tests for Agora
+
+on: push
+
+jobs:
+  run-agora-e2e-tests:
+    # Run in Sage repo on main branch and on all branches in user-owned forks
+    if: ${{ github.ref_name == 'main' || github.actor == github.repository_owner }}
+    timeout-minutes: 60
+    runs-on: ubuntu-22.04
+    environment: agora
+    steps:
+      - uses: actions/checkout@v4
+        with:
+          # We need to fetch all branches and commits so that Nx affected has a base to compare
+          # against.
+          fetch-depth: 0
+
+      - name: Derive appropriate SHAs for base and head for `nx affected` commands
+        uses: nrwl/nx-set-shas@v4
+
+      - name: Set up the dev container
+        uses: ./.github/actions/setup-dev-container
+
+      - name: Check if Agora was affected
+        id: agora_affected
+        run: |
+          AFFECTED=$(devcontainer exec --workspace-folder ../sage-monorepo bash -c ". ./dev-env.sh \
+              && nx show projects --affected --with-target e2e | grep -q 'agora' && echo 'true' || echo 'false'")
+          echo "AFFECTED=${AFFECTED}" >> "${GITHUB_OUTPUT}"
+
+      - name: Install Playwright Browsers
+        if: steps.agora_affected.outputs.AFFECTED == 'true'
+        run: |
+          devcontainer exec --workspace-folder ../sage-monorepo bash -c ". ./dev-env.sh \
+              && npx playwright install --with-deps"
+
+      - name: Build Agora
+        if: steps.agora_affected.outputs.AFFECTED == 'true'
+        run: |
+          devcontainer exec --workspace-folder ../sage-monorepo bash -c ". ./dev-env.sh \
+              && agora-build-images"
+
+      - name: Write Synapse PAT for Agora
+        if: steps.agora_affected.outputs.AFFECTED == 'true'
+        run: |
+          sed -i "s/^SYNAPSE_AUTH_TOKEN=.*/SYNAPSE_AUTH_TOKEN=\"${{ secrets.AGORA_DATA_SYNAPSE_AUTH_TOKEN }}\"/" apps/agora/data/.env
+
+      - name: Start Agora
+        if: steps.agora_affected.outputs.AFFECTED == 'true'
+        run: |
+          devcontainer exec --workspace-folder ../sage-monorepo bash -c ". ./dev-env.sh \
+              && nx run agora-apex:serve-detach"
+
+      - name: Run Agora e2e tests
+        if: steps.agora_affected.outputs.AFFECTED == 'true'
+        run: |
+          devcontainer exec --workspace-folder ../sage-monorepo bash -c ". ./dev-env.sh \
+              && nx run agora-app:e2e"
+
+      - name: Stop Agora
+        if: steps.agora_affected.outputs.AFFECTED == 'true'
+        run: |
+          devcontainer exec --workspace-folder ../sage-monorepo bash -c ". ./dev-env.sh \
+              && workspace-docker-stop"
+
+      - uses: actions/upload-artifact@v4
+        if: ${{ !cancelled() && steps.agora_affected.outputs.AFFECTED == 'true'}}
+        with:
+          name: playwright-report
+          path: playwright-report/
+          retention-days: 5
+
+      - name: Remove the dev container
+        run: docker rm -f sage_devcontainer
diff --git a/apps/agora/app/playwright.config.ts b/apps/agora/app/playwright.config.ts
index 3cce18e49..d2af14447 100644
--- a/apps/agora/app/playwright.config.ts
+++ b/apps/agora/app/playwright.config.ts
@@ -6,12 +6,6 @@ import { workspaceRoot } from '@nx/devkit';
 const port = 8000;
 export const baseURL = process.env['BASE_URL'] || `http://localhost:${port}`;
 
-/**
- * Read environment variables from file.
- * https://github.com/motdotla/dotenv
- */
-// require('dotenv').config();
-
 /**
  * See https://playwright.dev/docs/test-configuration.
  */