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|**Plot System**| ggplot2 (Advanced plot system built on grid system) | grid | Matplotlib | ggplot2 (Advanced plot system built on grid system) | ggplot2 (Advanced plot system built on grid system) |
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|**Focus**| Composable Visualization | Heatmap | Composable Visualization | Heatmap | tree Data |
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|**Heatmap Layout**|Yes| Yes| Yes| Yes| No |
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|**Marginal Layout**|Yes| No |Yes| No|No|
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|**Stack Layout**|Yes| Yes| Yes| No|No|
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|**Circle Layout**|Yes| No|No|No|Yes|
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|**Cross Layout**|Yes| No|No|No|No|
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|**Group or Reorder Heatmap**|Yes| Yes| Yes| Yes| No|
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|**Group or Reorder Stack Only**|Yes| No|Yes| No|No|
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|**Separate Group into Slices**|Yes| Yes| Yes| No|No|
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|**Heatmap Layout**|✅| ✅| ✅| ✅ | No |
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|**Marginal Layout**|✅| No |✅| ❌|❌|
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|**Stack Layout**|✅| ✅| ✅| ❌|❌|
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|**Circle Layout**|✅| ❌|❌|❌|✅ |
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|**Cross Layout**|✅| ❌|❌|❌|❌|
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|**Group or Reorder Heatmap**|✅| ✅| ✅| ✅| ❌|
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|**Group or Reorder Stack Only**|✅| ❌|✅| ❌|❌|
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|**Separate Group into Slices**|✅| ✅| ✅| ❌|❌|
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|**Data input**| Various, and can be easily extended | fixed | fixed | fixed | Various, and can be easily extended |
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|**Visualization Type**| Wide variety, provided by ggplot2 | Many, but limited | Many, but limited | Limited | Limited Geometric layers support |
|**Legends Position**| Anywhere, can be controlled for a single plot | Four sides, can only be placed on one side at a time | ? | Four sides, can only be placed on one side at a time | Anywhere |
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|**Scientific Color Palettes**| Many | Limited | Limited | Many | Many |
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|**Tanglegram**|Yes| No|Yes| No|No|
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|**Tanglegram**|✅| ❌|✅| ❌|❌|
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|**Dendrogram Position**| Anywhere | Heatmap only | Anywhere | Heatmap only | Anywhere |
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|**3D Heatmap**|Yes| Yes| No|No|No|
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|**Oncoplot**|Yes| Yes| Yes| No|No|
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|**UpSet plot**|Yes| Yes| Yes| No|No|
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|**Fully Compatible with ggplot2**|Yes| No|No|No| Limited Geometric layers support |
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|**3D Heatmap**|✅| ✅| ❌|❌|❌|
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|**Oncoplot**|✅| ✅| ✅| ❌|❌|
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|**UpSet plot**|✅| ✅| ✅| ❌|❌|
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|**Fully Compatible with ggplot2**|✅| ❌|❌|❌| Limited Geometric layers support |
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|**Ease of Use**| Easy for ggplot2 users | Easy for for grid user | Easy for python user | Easy | Easy for ggplot2 users |
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|**Interactive**|No|Yes| No|No|No|
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|**Interactive**|❌|✅| ❌|❌|❌|
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## Acknowledgements
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I would like to express my sincere gratitude to the contributors of the
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