We highly recommend you do this in your core track language and framework.
- It will help shake the rust off.
- You'll likely have better-looking and speedier results.
- It will be far easier to demo as part of a portfolio.
- It will take you less time to shake the rust off than it will for you to learn a Python graphics framework.
But if you insist, you might check out:
Out of all those, tkinter with Pillow will be the easiest to do a GUI in, but it's going to not look so hot.