diff --git a/setup.py b/setup.py
index ea931a6..6c322f3 100644
--- a/setup.py
+++ b/setup.py
@@ -7,8 +7,10 @@
 """
 
 import glob
+import os
 import sys
 from ctypes.util import find_library
+from pathlib import Path
 
 import numpy
 from setuptools import Extension, setup
@@ -26,11 +28,33 @@ def get_boost_libraries():
     raise RuntimeError("Cannot find a suitable Boost.Python library.")
 
 
+def get_boost_config():
+    boost_path = os.environ.get("BOOST_PATH", "")
+    if boost_path:
+        inc = Path(boost_path) / "include"
+        lib = Path(boost_path) / "lib"
+    else:
+        conda_prefix = os.environ.get("CONDA_PREFIX")
+        if not conda_prefix:
+            raise EnvironmentError(
+                "Neither BOOST_PATH nor CONDA_PREFIX are set. " "Please install Boost or set BOOST_PATH."
+            )
+        if os.name == "nt":
+            inc = Path(conda_prefix) / "Library" / "include"
+            lib = Path(conda_prefix) / "Library" / "lib"
+        else:
+            inc = Path(conda_prefix) / "include"
+            lib = Path(conda_prefix) / "lib"
+    return {"include_dirs": [str(inc)], "library_dirs": [str(lib)]}
+
+
+boost_cfg = get_boost_config()
 ext_kws = {
     "libraries": ["diffpy"] + get_boost_libraries(),
     "extra_compile_args": ["-std=c++11"],
     "extra_link_args": [],
-    "include_dirs": [numpy.get_include()],
+    "include_dirs": [numpy.get_include()] + boost_cfg["include_dirs"],
+    "library_dirs": boost_cfg["library_dirs"],
 }