diff --git a/sentry_sdk/consts.py b/sentry_sdk/consts.py
index ae32294d05..41000d71de 100644
--- a/sentry_sdk/consts.py
+++ b/sentry_sdk/consts.py
@@ -82,6 +82,18 @@ class CompressionAlgo(Enum):
 DEFAULT_MAX_BREADCRUMBS = 100
 MATCH_ALL = r".*"
 
+MAX_STACK_FRAMES = 300  # type: int
+"""The maximum number of stack frames to capture on error events.
+
+Relay enforces a limit of 250 frames on the stack trace. See
+https://github.com/getsentry/relay/blob/aae36669414a1f7c6ef68d5226cb2e96a28f7667/relay-event-normalization/src/trimming.rs#L286.
+We use a slightly higher value here; Relay will trim any frames
+beyond its limit.
+
+This constant is for internal use only, and it may be changed or removed
+at any time.
+"""
+
 FALSE_VALUES = [
     "false",
     "no",
diff --git a/sentry_sdk/utils.py b/sentry_sdk/utils.py
index 4d07974809..b70d924222 100644
--- a/sentry_sdk/utils.py
+++ b/sentry_sdk/utils.py
@@ -1,4 +1,5 @@
 import base64
+import itertools
 import json
 import linecache
 import logging
@@ -26,7 +27,7 @@
 
 import sentry_sdk
 from sentry_sdk._compat import PY37
-from sentry_sdk.consts import DEFAULT_MAX_VALUE_LENGTH, EndpointType
+from sentry_sdk.consts import DEFAULT_MAX_VALUE_LENGTH, MAX_STACK_FRAMES, EndpointType
 
 from typing import TYPE_CHECKING
 
@@ -803,7 +804,7 @@ def single_exception_from_error_tuple(
             max_value_length=max_value_length,
             custom_repr=custom_repr,
         )
-        for tb in iter_stacks(tb)
+        for tb in itertools.islice(iter_stacks(tb), MAX_STACK_FRAMES)
     ]
 
     if frames: