Nair_2016.R

#
# D1_LTP_time_window.R
#
# R vector field functions for: D1_LTP_time_window
#
# This file was generated by the program VFGEN, version: 2.6.0.dev0
# Generated on 24-Feb-2020 at 16:40
#


#
# Nair_2016(t, state, parameters)
#
# The vector field function
#
Nair_2016 <- function(t, state, parameters) {
    AC5        <- state[1]
    AC5_ATP    <- state[2]
    AC5_Ca     <- state[3]
    AC5_Ca_ATP <- state[4]
    AC5_Ca_GaolfGTP <- state[5]
    AC5_Ca_GaolfGTP_ATP <- state[6]
    AC5_GaolfGTP <- state[7]
    AC5_GaolfGTP_ATP <- state[8]
    AMP        <- state[9]
    ATP        <- state[10]
    B56PP2A    <- state[11]
    B56PP2A_D32p75 <- state[12]
    B56PP2A_pARPP21 <- state[13]
    B56PP2Ap   <- state[14]
    B56PP2Ap_D32p75 <- state[15]
    B56PP2Ap_pARPP21 <- state[16]
    B72PP2A    <- state[17]
    B72PP2A_D32p34 <- state[18]
    B72PP2A_D32p75 <- state[19]
    B72PP2A_pARPP21 <- state[20]
    B72PP2A_Ca_D32p34 <- state[21]
    B72PP2A_Ca_D32p75 <- state[22]
    B72PP2A_Ca <- state[23]
    B72PP2A_Ca_pARPP21 <- state[24]
    Ca         <- state[25]
    CaM        <- state[26]
    CaM_Ca2    <- state[27]
    CaM_Ca4    <- state[28]
    CaM_Ca4_pARPP21 <- state[29]
    CaMKII     <- state[30]
    CaMKII_CaM_Ca4 <- state[31]
    CaMKII_CaM <- state[32]
    CaMKII_CaM_Ca2 <- state[33]
    CaMKII_CaM_Ca2_psd <- state[34]
    CaMKII_CaM_psd <- state[35]
    CaMKII_CaM_Ca4_psd <- state[36]
    CaMKII_psd <- state[37]
    cAMP       <- state[38]
    Substrate  <- state[39]
    CDK5       <- state[40]
    CDK5_D32   <- state[41]
    D1R        <- state[42]
    D1R_DA     <- state[43]
    D1R_Golf_DA <- state[44]
    D1R_Golf   <- state[45]
    D32p34     <- state[46]
    D32p75     <- state[47]
    DA         <- state[48]
    D32        <- state[49]
    GaolfGDP   <- state[50]
    GaolfGTP   <- state[51]
    Gbgolf     <- state[52]
    Golf       <- state[53]
    pCaMKII    <- state[54]
    pCaMKII_CaM_Ca4 <- state[55]
    pCaMKII_CaM <- state[56]
    pCaMKII_CaM_Ca2 <- state[57]
    pCaMKII_CaM_Ca2_psd <- state[58]
    pCaMKII_CaM_psd <- state[59]
    pCaMKII_CaM_Ca4_psd <- state[60]
    pCaMKII_psd <- state[61]
    pSubstrate <- state[62]
    PDE4       <- state[63]
    PDE4_cAMP  <- state[64]
    PDE10r     <- state[65]
    PDE10r_cAMP <- state[66]
    PDE10c     <- state[67]
    PDE10c_cAMP <- state[68]
    PKA        <- state[69]
    PKAc       <- state[70]
    PKAc_B56PP2A <- state[71]
    PKAc_D32   <- state[72]
    PKAc_ARPP21 <- state[73]
    PKA_Ca2MP  <- state[74]
    PKA_Ca4MP  <- state[75]
    PKAc_D32p75 <- state[76]
    PKAreg     <- state[77]
    PP1        <- state[78]
    PP1_pCaMKII_psd <- state[79]
    PP1_pSubstrate <- state[80]
    PP1_D32p34 <- state[81]
    CaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd <- state[82]
    pCaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd <- state[83]
    CaMKII_CaM_Ca4_CaMKII_CaM_Ca4 <- state[84]
    pCaMKII_CaM_Ca4_CaMKII_CaM_Ca4 <- state[85]
    PP2B       <- state[86]
    PP2Bc      <- state[87]
    PP2Bc_D32p34 <- state[88]
    PP2B_CaM   <- state[89]
    PP2B_CaM_Ca2 <- state[90]
    pARPP21    <- state[91]
    ARPP21     <- state[92]
    pCaMKII_psd_Substrate <- state[93]
    pCaMKII_CaM_psd_Substrate <- state[94]
    pCaMKII_CaM_Ca2_psd_Substrate <- state[95]
    pCaMKII_CaM_Ca4_psd_Substrate <- state[96]
    CaMKII_CaM_psd_Substrate <- state[97]
    CaMKII_CaM_Ca2_psd_Substrate <- state[98]
    CaMKII_CaM_Ca4_psd_Substrate <- state[99]
    kf_R0      <- parameters[1]
    kf_R1      <- parameters[2]
    kf_R2      <- parameters[3]
    kr_R2      <- parameters[4]
    kf_R3      <- parameters[5]
    kr_R3      <- parameters[6]
    kf_R4      <- parameters[7]
    kr_R4      <- parameters[8]
    kf_R5      <- parameters[9]
    kr_R5      <- parameters[10]
    kf_R6      <- parameters[11]
    kr_R6      <- parameters[12]
    kf_R7      <- parameters[13]
    kr_R7      <- parameters[14]
    kf_R8      <- parameters[15]
    kr_R8      <- parameters[16]
    kf_R9      <- parameters[17]
    kf_R10     <- parameters[18]
    kr_R10     <- parameters[19]
    kf_R11     <- parameters[20]
    kf_R12     <- parameters[21]
    kr_R12     <- parameters[22]
    kf_R13     <- parameters[23]
    kr_R13     <- parameters[24]
    kf_R14     <- parameters[25]
    kf_R15     <- parameters[26]
    kr_R15     <- parameters[27]
    kf_R16     <- parameters[28]
    kr_R16     <- parameters[29]
    kf_R17     <- parameters[30]
    kr_R17     <- parameters[31]
    kf_R18     <- parameters[32]
    kr_R18     <- parameters[33]
    kf_R19     <- parameters[34]
    kr_R19     <- parameters[35]
    kf_R20     <- parameters[36]
    kf_R21     <- parameters[37]
    kf_R22     <- parameters[38]
    kf_R23     <- parameters[39]
    kr_R23     <- parameters[40]
    kf_R24     <- parameters[41]
    kr_R24     <- parameters[42]
    kf_R25     <- parameters[43]
    kr_R25     <- parameters[44]
    kf_R26     <- parameters[45]
    kr_R26     <- parameters[46]
    kf_R27     <- parameters[47]
    kr_R27     <- parameters[48]
    kf_R28     <- parameters[49]
    kr_R28     <- parameters[50]
    kf_R29     <- parameters[51]
    kr_R29     <- parameters[52]
    kf_R30     <- parameters[53]
    kr_R30     <- parameters[54]
    kf_R31     <- parameters[55]
    kf_R32     <- parameters[56]
    kf_R33     <- parameters[57]
    kf_R34     <- parameters[58]
    kr_R34     <- parameters[59]
    kf_R35     <- parameters[60]
    kr_R35     <- parameters[61]
    kf_R36     <- parameters[62]
    kf_R37     <- parameters[63]
    kf_R38     <- parameters[64]
    kr_R38     <- parameters[65]
    kf_R39     <- parameters[66]
    kr_R39     <- parameters[67]
    kf_R40     <- parameters[68]
    kr_R40     <- parameters[69]
    kf_R41     <- parameters[70]
    kr_R41     <- parameters[71]
    kf_R42     <- parameters[72]
    kf_R43     <- parameters[73]
    kr_R43     <- parameters[74]
    kf_R44     <- parameters[75]
    kf_R45     <- parameters[76]
    kr_R45     <- parameters[77]
    kf_R46     <- parameters[78]
    kf_R47     <- parameters[79]
    kf_R48     <- parameters[80]
    kr_R48     <- parameters[81]
    kf_R49     <- parameters[82]
    kr_R49     <- parameters[83]
    kf_R50     <- parameters[84]
    kr_R50     <- parameters[85]
    kf_R51     <- parameters[86]
    kr_R51     <- parameters[87]
    kf_R52     <- parameters[88]
    kr_R52     <- parameters[89]
    kf_R53     <- parameters[90]
    kr_R53     <- parameters[91]
    kf_R54     <- parameters[92]
    kr_R54     <- parameters[93]
    kf_R55     <- parameters[94]
    kf_R56     <- parameters[95]
    kf_R57     <- parameters[96]
    kf_R58     <- parameters[97]
    kf_R59     <- parameters[98]
    kf_R60     <- parameters[99]
    kf_R61     <- parameters[100]
    kf_R62     <- parameters[101]
    kf_R63     <- parameters[102]
    kf_R64     <- parameters[103]
    kf_R65     <- parameters[104]
    kf_R66     <- parameters[105]
    kf_R67     <- parameters[106]
    kr_R67     <- parameters[107]
    kf_R68     <- parameters[108]
    kr_R68     <- parameters[109]
    kf_R69     <- parameters[110]
    kr_R69     <- parameters[111]
    kf_R70     <- parameters[112]
    kr_R70     <- parameters[113]
    kf_R71     <- parameters[114]
    kr_R71     <- parameters[115]
    kf_R72     <- parameters[116]
    kr_R72     <- parameters[117]
    kf_R73     <- parameters[118]
    kr_R73     <- parameters[119]
    kf_R74     <- parameters[120]
    kr_R74     <- parameters[121]
    kf_R75     <- parameters[122]
    kr_R75     <- parameters[123]
    kf_R76     <- parameters[124]
    kr_R76     <- parameters[125]
    kf_R77     <- parameters[126]
    kr_R77     <- parameters[127]
    kf_R78     <- parameters[128]
    kr_R78     <- parameters[129]
    kf_R79     <- parameters[130]
    kr_R79     <- parameters[131]
    kf_R80     <- parameters[132]
    kr_R80     <- parameters[133]
    kf_R81     <- parameters[134]
    kf_R82     <- parameters[135]
    kr_R82     <- parameters[136]
    kf_R83     <- parameters[137]
    kf_R84     <- parameters[138]
    kr_R84     <- parameters[139]
    kf_R85     <- parameters[140]
    kf_R86     <- parameters[141]
    kr_R86     <- parameters[142]
    kf_R87     <- parameters[143]
    kf_R88     <- parameters[144]
    kr_R88     <- parameters[145]
    kf_R89     <- parameters[146]
    kf_R90     <- parameters[147]
    kr_R90     <- parameters[148]
    kf_R91     <- parameters[149]
    kr_R91     <- parameters[150]
    kf_R92     <- parameters[151]
    kf_R93     <- parameters[152]
    kr_R93     <- parameters[153]
    kf_R94     <- parameters[154]
    kf_R95     <- parameters[155]
    kf_R96     <- parameters[156]
    kr_R96     <- parameters[157]
    kf_R97     <- parameters[158]
    kf_R98     <- parameters[159]
    kr_R98     <- parameters[160]
    kf_R99     <- parameters[161]
    kf_R100    <- parameters[162]
    kr_R100    <- parameters[163]
    kf_R101    <- parameters[164]
    kf_R102    <- parameters[165]
    kr_R102    <- parameters[166]
    kf_R103    <- parameters[167]
    kf_R104    <- parameters[168]
    kr_R104    <- parameters[169]
    kf_R105    <- parameters[170]
    kf_R106    <- parameters[171]
    kr_R106    <- parameters[172]
    kf_R107    <- parameters[173]
    kf_R108    <- parameters[174]
    kr_R108    <- parameters[175]
    kf_R109    <- parameters[176]
    kr_R109    <- parameters[177]
    kf_R110    <- parameters[178]
    kr_R110    <- parameters[179]
    kf_R111    <- parameters[180]
    kr_R111    <- parameters[181]
    kf_R112    <- parameters[182]
    kr_R112    <- parameters[183]
    kf_R113    <- parameters[184]
    kr_R113    <- parameters[185]
    kf_R114    <- parameters[186]
    kr_R114    <- parameters[187]
    kf_R115    <- parameters[188]
    kr_R115    <- parameters[189]
    kf_R116    <- parameters[190]
    kr_R116    <- parameters[191]
    kf_R117    <- parameters[192]
    kr_R117    <- parameters[193]
    kf_R118    <- parameters[194]
    kf_R119    <- parameters[195]
    kf_R120    <- parameters[196]
    kr_R120    <- parameters[197]
    kf_R121    <- parameters[198]
    kr_R121    <- parameters[199]
    kf_R122    <- parameters[200]
    kr_R122    <- parameters[201]
    kf_R123    <- parameters[202]
    kr_R123    <- parameters[203]
    kf_R124    <- parameters[204]
    kr_R124    <- parameters[205]
    kf_R125    <- parameters[206]
    kr_R125    <- parameters[207]
    kf_R126    <- parameters[208]
    kr_R126    <- parameters[209]
    kf_R127    <- parameters[210]
    kr_R127    <- parameters[211]
    kf_R128    <- parameters[212]
    kr_R128    <- parameters[213]
    kf_R129    <- parameters[214]
    kr_R129    <- parameters[215]
    kf_R130    <- parameters[216]
    kr_R130    <- parameters[217]
    kf_R131    <- parameters[218]
    kf_R132    <- parameters[219]
    kr_R132    <- parameters[220]
    kf_R133    <- parameters[221]
    kf_R134    <- parameters[222]
    kr_R134    <- parameters[223]
    kf_R135    <- parameters[224]
    kf_R136    <- parameters[225]
    kr_R136    <- parameters[226]
    kf_R137    <- parameters[227]

    ReactionFlux0 <- GaolfGTP*kf_R0;
    ReactionFlux1 <- kf_R1*D1R_Golf_DA;
    ReactionFlux2 <- DA*D1R_Golf*kf_R2-kr_R2*D1R_Golf_DA;
    ReactionFlux3 <- -D1R_DA*kr_R3+DA*D1R*kf_R3;
    ReactionFlux4 <- kf_R4*GaolfGTP*AC5-AC5_GaolfGTP*kr_R4;
    ReactionFlux5 <- -kr_R5*CaM_Ca2+Ca*kf_R5*CaM;
    ReactionFlux6 <- -PP2B_CaM*kr_R6+PP2B*kf_R6*CaM;
    ReactionFlux7 <- -kr_R7*PP2Bc+CaM_Ca4*PP2B*kf_R7;
    ReactionFlux8 <- -PKAc_D32*kr_R8+PKAc*D32*kf_R8;
    ReactionFlux9 <- kf_R9*PKAc_D32;
    ReactionFlux10 <- PKAc*B56PP2A*kf_R10-PKAc_B56PP2A*kr_R10;
    ReactionFlux11 <- kf_R11*PKAc_B56PP2A;
    ReactionFlux12 <- kf_R12*D32p34*PP1-PP1_D32p34*kr_R12;
    ReactionFlux13 <- kf_R13*D32*CDK5-CDK5_D32*kr_R13;
    ReactionFlux14 <- CDK5_D32*kf_R14;
    ReactionFlux15 <- PKAc*D32p75*kf_R15-PKAc_D32p75*kr_R15;
    ReactionFlux16 <- B72PP2A*kf_R16*Ca-B72PP2A_Ca*kr_R16;
    ReactionFlux17 <- -B56PP2Ap_D32p75*kr_R17+kf_R17*B56PP2Ap*D32p75;
    ReactionFlux18 <- kf_R18*B72PP2A*D32p75-kr_R18*B72PP2A_D32p75;
    ReactionFlux19 <- -B72PP2A_Ca_D32p75*kr_R19+B72PP2A_Ca*kf_R19*D32p75;
    ReactionFlux20 <- kf_R20*B56PP2Ap_D32p75;
    ReactionFlux21 <- kf_R21*B72PP2A_D32p75;
    ReactionFlux22 <- B72PP2A_Ca_D32p75*kf_R22;
    ReactionFlux23 <- kf_R23*PP2Bc*D32p34-kr_R23*PP2Bc_D32p34;
    ReactionFlux24 <- Ca*CaM_Ca2*kf_R24-CaM_Ca4*kr_R24;
    ReactionFlux25 <- PP2B_CaM*kf_R25*Ca-PP2B_CaM_Ca2*kr_R25;
    ReactionFlux26 <- -kr_R26*PP2Bc+kf_R26*PP2B_CaM_Ca2*Ca;
    ReactionFlux27 <- -PP2B_CaM_Ca2*kr_R27+PP2B*kf_R27*CaM_Ca2;
    ReactionFlux28 <- AC5*kf_R28*Ca-kr_R28*AC5_Ca;
    ReactionFlux29 <- -kr_R29*AC5_Ca_GaolfGTP+GaolfGTP*AC5_Ca*kf_R29;
    ReactionFlux30 <- -B56PP2A_D32p75*kr_R30+B56PP2A*kf_R30*D32p75;
    ReactionFlux31 <- kf_R31*B56PP2A_D32p75;
    ReactionFlux32 <- B72PP2A_Ca_D32p34*kf_R32;
    ReactionFlux33 <- B72PP2A_D32p34*kf_R33;
    ReactionFlux34 <- B72PP2A_Ca*kf_R34*D32p34-kr_R34*B72PP2A_Ca_D32p34;
    ReactionFlux35 <- -B72PP2A_D32p34*kr_R35+B72PP2A*D32p34*kf_R35;
    ReactionFlux36 <- kf_R36*PP2Bc_D32p34;
    ReactionFlux37 <- B56PP2Ap*kf_R37;
    ReactionFlux38 <- -kr_R38*PKA_Ca2MP+cAMP*kf_R38*PKA;
    ReactionFlux39 <- cAMP*PKA_Ca2MP*kf_R39-kr_R39*PKA_Ca4MP;
    ReactionFlux40 <- kr_R40*PKA_Ca4MP-PKAc*kf_R40*PKAreg;
    ReactionFlux41 <- PDE4*cAMP*kf_R41-kr_R41*PDE4_cAMP;
    ReactionFlux42 <- PDE4_cAMP*kf_R42;
    ReactionFlux43 <- cAMP^2*PDE10r*kf_R43-kr_R43*PDE10c;
    ReactionFlux44 <- kf_R44*PDE10r_cAMP;
    ReactionFlux45 <- -kr_R45*PDE10r_cAMP+cAMP*PDE10r*kf_R45;
    ReactionFlux46 <- kf_R46*PDE10c_cAMP;
    ReactionFlux47 <- Gbgolf*kf_R47*GaolfGDP;
    ReactionFlux48 <- -kr_R48*AC5_GaolfGTP_ATP+ATP*kf_R48*AC5_GaolfGTP;
    ReactionFlux49 <- -kr_R49*AC5_ATP+ATP*AC5*kf_R49;
    ReactionFlux50 <- ATP*kf_R50*AC5_Ca-AC5_Ca_ATP*kr_R50;
    ReactionFlux51 <- ATP*AC5_Ca_GaolfGTP*kf_R51-kr_R51*AC5_Ca_GaolfGTP_ATP;
    ReactionFlux52 <- GaolfGTP*AC5_ATP*kf_R52-AC5_GaolfGTP_ATP*kr_R52;
    ReactionFlux53 <- -kr_R53*AC5_Ca_GaolfGTP_ATP+GaolfGTP*AC5_Ca_ATP*kf_R53;
    ReactionFlux54 <- -kr_R54*AC5_Ca_ATP+AC5_ATP*Ca*kf_R54;
    ReactionFlux55 <- AC5_GaolfGTP_ATP*kf_R55;
    ReactionFlux56 <- AC5_GaolfGTP*cAMP*kf_R56;
    ReactionFlux57 <- kf_R57*AC5_ATP;
    ReactionFlux58 <- cAMP*AC5*kf_R58;
    ReactionFlux59 <- AC5_Ca_ATP*kf_R59;
    ReactionFlux60 <- cAMP*kf_R60*AC5_Ca;
    ReactionFlux61 <- kf_R61*AC5_Ca_GaolfGTP_ATP;
    ReactionFlux62 <- cAMP*AC5_Ca_GaolfGTP*kf_R62;
    ReactionFlux63 <- AC5_GaolfGTP*kf_R63;
    ReactionFlux64 <- kf_R64*AC5_Ca_GaolfGTP;
    ReactionFlux65 <- AC5_GaolfGTP_ATP*kf_R65;
    ReactionFlux66 <- kf_R66*AC5_Ca_GaolfGTP_ATP;
    ReactionFlux67 <- kf_R67*D1R*Golf-D1R_Golf*kr_R67;
    ReactionFlux68 <- D1R_DA*Golf*kf_R68-kr_R68*D1R_Golf_DA;
    ReactionFlux69 <- -PDE10c_cAMP*kr_R69+cAMP*PDE10c*kf_R69;
    ReactionFlux70 <- CaM_Ca4*kf_R70*CaMKII-kr_R70*CaMKII_CaM_Ca4;
    ReactionFlux71 <- -kr_R71*CaMKII_CaM_Ca2+CaMKII*CaM_Ca2*kf_R71;
    ReactionFlux72 <- kf_R72*CaMKII*CaM-CaMKII_CaM*kr_R72;
    ReactionFlux73 <- kf_R73*CaMKII_CaM_Ca2*Ca-kr_R73*CaMKII_CaM_Ca4;
    ReactionFlux74 <- -CaMKII_CaM_Ca2*kr_R74+CaMKII_CaM*Ca*kf_R74;
    ReactionFlux75 <- kf_R75*Ca*pCaMKII_CaM_Ca2-pCaMKII_CaM_Ca4*kr_R75;
    ReactionFlux76 <- Ca*pCaMKII_CaM*kf_R76-kr_R76*pCaMKII_CaM_Ca2;
    ReactionFlux77 <- CaM_Ca4*pCaMKII*kf_R77-kr_R77*pCaMKII_CaM_Ca4;
    ReactionFlux78 <- -kr_R78*pCaMKII_CaM_Ca2+pCaMKII*kf_R78*CaM_Ca2;
    ReactionFlux79 <- pCaMKII*CaM*kf_R79-kr_R79*pCaMKII_CaM;
    ReactionFlux80 <- PKAc*ARPP21*kf_R80-PKAc_ARPP21*kr_R80;
    ReactionFlux81 <- PKAc_ARPP21*kf_R81;
    ReactionFlux82 <- CaM_Ca4*kf_R82*pARPP21-CaM_Ca4_pARPP21*kr_R82;
    ReactionFlux83 <- kf_R83*B72PP2A_Ca_pARPP21;
    ReactionFlux84 <- B72PP2A_Ca*kf_R84*pARPP21-B72PP2A_Ca_pARPP21*kr_R84;
    ReactionFlux85 <- kf_R85*B72PP2A_pARPP21;
    ReactionFlux86 <- -B72PP2A_pARPP21*kr_R86+B72PP2A*kf_R86*pARPP21;
    ReactionFlux87 <- B56PP2Ap_pARPP21*kf_R87;
    ReactionFlux88 <- -kr_R88*B56PP2Ap_pARPP21+B56PP2Ap*kf_R88*pARPP21;
    ReactionFlux89 <- kf_R89*B56PP2A_pARPP21;
    ReactionFlux90 <- kf_R90*B56PP2A*pARPP21-kr_R90*B56PP2A_pARPP21;
    ReactionFlux91 <- -kr_R91*PP1_pSubstrate+PP1*pSubstrate*kf_R91;
    ReactionFlux92 <- PP1_pSubstrate*kf_R92;
    ReactionFlux93 <- Substrate*pCaMKII_psd*kf_R93-kr_R93*pCaMKII_psd_Substrate;
    ReactionFlux94 <- kf_R94*pCaMKII_psd_Substrate;
    ReactionFlux95 <- pCaMKII*kf_R95;
    ReactionFlux96 <- kf_R96*Substrate*pCaMKII_CaM_psd-kr_R96*pCaMKII_CaM_psd_Substrate;
    ReactionFlux97 <- kf_R97*pCaMKII_CaM_psd_Substrate;
    ReactionFlux98 <- -pCaMKII_CaM_Ca2_psd_Substrate*kr_R98+kf_R98*pCaMKII_CaM_Ca2_psd*Substrate;
    ReactionFlux99 <- pCaMKII_CaM_Ca2_psd_Substrate*kf_R99;
    ReactionFlux100 <- -kr_R100*pCaMKII_CaM_Ca4_psd_Substrate+kf_R100*pCaMKII_CaM_Ca4_psd*Substrate;
    ReactionFlux101 <- pCaMKII_CaM_Ca4_psd_Substrate*kf_R101;
    ReactionFlux102 <- kf_R102*CaMKII_CaM_psd*Substrate-kr_R102*CaMKII_CaM_psd_Substrate;
    ReactionFlux103 <- kf_R103*CaMKII_CaM_psd_Substrate;
    ReactionFlux104 <- Substrate*CaMKII_CaM_Ca2_psd*kf_R104-CaMKII_CaM_Ca2_psd_Substrate*kr_R104;
    ReactionFlux105 <- CaMKII_CaM_Ca2_psd_Substrate*kf_R105;
    ReactionFlux106 <- -kr_R106*Substrate*CaMKII_CaM_Ca4_psd+Substrate*CaMKII_CaM_Ca4_psd*kf_R106;
    ReactionFlux107 <- CaMKII_CaM_Ca4_psd_Substrate*kf_R107;
    ReactionFlux108 <- -kr_R108*pCaMKII_CaM_Ca4_psd+pCaMKII_CaM_Ca4*kf_R108;
    ReactionFlux109 <- -pCaMKII_CaM_Ca2_psd*kr_R109+kf_R109*pCaMKII_CaM_Ca2;
    ReactionFlux110 <- kf_R110*pCaMKII_CaM-kr_R110*pCaMKII_CaM_psd;
    ReactionFlux111 <- -pCaMKII_psd*kr_R111+pCaMKII*kf_R111;
    ReactionFlux112 <- -pCaMKII_CaM_Ca4_psd*kr_R112+CaM_Ca4*kf_R112*pCaMKII_psd;
    ReactionFlux113 <- -kr_R113*pCaMKII_CaM_Ca2_psd+pCaMKII_psd*CaM_Ca2*kf_R113;
    ReactionFlux114 <- pCaMKII_psd*kf_R114*CaM-kr_R114*pCaMKII_CaM_psd;
    ReactionFlux115 <- kf_R115*Ca*pCaMKII_CaM_psd-pCaMKII_CaM_Ca2_psd*kr_R115;
    ReactionFlux116 <- -pCaMKII_CaM_Ca4_psd*kr_R116+pCaMKII_CaM_Ca2_psd*Ca*kf_R116;
    ReactionFlux117 <- pCaMKII_psd*kf_R117*PP1-PP1_pCaMKII_psd*kr_R117;
    ReactionFlux118 <- PP1_pCaMKII_psd*kf_R118;
    ReactionFlux119 <- kf_R119*CaMKII_psd;
    ReactionFlux120 <- -kr_R120*CaMKII_CaM_Ca4_psd+CaM_Ca4*CaMKII_psd*kf_R120;
    ReactionFlux121 <- -kr_R121*CaMKII_CaM_Ca2_psd+kf_R121*CaM_Ca2*CaMKII_psd;
    ReactionFlux122 <- -CaMKII_CaM_psd*kr_R122+kf_R122*CaMKII_psd*CaM;
    ReactionFlux123 <- -CaMKII_CaM_Ca4_psd*kr_R123+Ca*kf_R123*CaMKII_CaM_Ca2_psd;
    ReactionFlux124 <- -kr_R124*CaMKII_CaM_Ca2_psd+CaMKII_CaM_psd*kf_R124*Ca;
    ReactionFlux125 <- -CaMKII_CaM_psd*kr_R125+CaMKII_CaM*kf_R125;
    ReactionFlux126 <- kf_R126*CaMKII_CaM_Ca2-kr_R126*CaMKII_CaM_Ca2_psd;
    ReactionFlux127 <- -kr_R127*CaMKII_CaM_Ca4_psd+kf_R127*CaMKII_CaM_Ca4;
    ReactionFlux152 <- -kr_R128*CaMKII_CaM_Ca4_CaMKII_CaM_Ca4+kf_R128*CaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd;
    ReactionFlux153 <- pCaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd*kf_R129-kr_R129*pCaMKII_CaM_Ca4_CaMKII_CaM_Ca4;
    ReactionFlux128 <- -kr_R130*CaMKII_CaM_Ca4_CaMKII_CaM_Ca4+kf_R130*CaMKII_CaM_Ca4^2;
    ReactionFlux129 <- CaMKII_CaM_Ca4_CaMKII_CaM_Ca4*kf_R131;
    ReactionFlux130 <- pCaMKII_CaM_Ca4*kf_R133*CaMKII_CaM_Ca4-kr_R132*pCaMKII_CaM_Ca4_CaMKII_CaM_Ca4;
    ReactionFlux131 <- kf_R133*pCaMKII_CaM_Ca4_CaMKII_CaM_Ca4;
    ReactionFlux140 <- -kr_R134*CaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd+CaMKII_CaM_Ca4_psd^2*kf_R134;
    ReactionFlux141 <- kf_R135*CaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd;
    ReactionFlux142 <- -pCaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd*kr_R136+kf_R136*pCaMKII_CaM_Ca4_psd*CaMKII_CaM_Ca4_psd;
    ReactionFlux143 <- pCaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd*kf_R137;
    vf_ <- vector(len = 99)
    vf_[1] = -ReactionFlux49-ReactionFlux58-ReactionFlux28+ReactionFlux63+ReactionFlux57-ReactionFlux4;
    vf_[2] = -ReactionFlux52+ReactionFlux49+ReactionFlux58+ReactionFlux65-ReactionFlux54-ReactionFlux57;
    vf_[3] = -ReactionFlux50+ReactionFlux59+ReactionFlux28-ReactionFlux60-ReactionFlux29+ReactionFlux64;
    vf_[4] = -ReactionFlux53+ReactionFlux50-ReactionFlux59+ReactionFlux66+ReactionFlux54+ReactionFlux60;
    vf_[5] = ReactionFlux61-ReactionFlux62-ReactionFlux51+ReactionFlux29-ReactionFlux64;
    vf_[6] = -ReactionFlux61+ReactionFlux53+ReactionFlux62-ReactionFlux66+ReactionFlux51;
    vf_[7] = ReactionFlux55-ReactionFlux56-ReactionFlux63-ReactionFlux48+ReactionFlux4;
    vf_[8] = ReactionFlux52-ReactionFlux55-ReactionFlux65+ReactionFlux56+ReactionFlux48;
    vf_[9] = ReactionFlux46+ReactionFlux44+ReactionFlux42;
    vf_[10] = -ReactionFlux49-ReactionFlux50-ReactionFlux51-ReactionFlux48;
    vf_[11] = -ReactionFlux90-ReactionFlux30+ReactionFlux37+ReactionFlux31-ReactionFlux10+ReactionFlux89;
    vf_[12] = ReactionFlux30-ReactionFlux31;
    vf_[13] = ReactionFlux90-ReactionFlux89;
    vf_[14] = ReactionFlux11+ReactionFlux87-ReactionFlux37-ReactionFlux88+ReactionFlux20-ReactionFlux17;
    vf_[15] = -ReactionFlux20+ReactionFlux17;
    vf_[16] = -ReactionFlux87+ReactionFlux88;
    vf_[17] = ReactionFlux33+ReactionFlux21-ReactionFlux18+ReactionFlux85-ReactionFlux16-ReactionFlux86-ReactionFlux35;
    vf_[18] = -ReactionFlux33+ReactionFlux35;
    vf_[19] = -ReactionFlux21+ReactionFlux18;
    vf_[20] = -ReactionFlux85+ReactionFlux86;
    vf_[21] = ReactionFlux34-ReactionFlux32;
    vf_[22] = -ReactionFlux22+ReactionFlux19;
    vf_[23] = -ReactionFlux84-ReactionFlux34+ReactionFlux22-ReactionFlux19+ReactionFlux16+ReactionFlux83+ReactionFlux32;
    vf_[24] = ReactionFlux84-ReactionFlux83;
    vf_[25] = -ReactionFlux74-ReactionFlux116-ReactionFlux5-ReactionFlux75-ReactionFlux24-ReactionFlux28-ReactionFlux123-ReactionFlux54-ReactionFlux76-ReactionFlux16-ReactionFlux25-ReactionFlux73-ReactionFlux115-ReactionFlux124-ReactionFlux26;
    vf_[26] = -ReactionFlux5-ReactionFlux122-ReactionFlux72-ReactionFlux6-ReactionFlux79-ReactionFlux114;
    vf_[27] = -ReactionFlux121-ReactionFlux71+ReactionFlux5-ReactionFlux78-ReactionFlux27-ReactionFlux113-ReactionFlux24;
    vf_[28] = ReactionFlux24-ReactionFlux82-ReactionFlux120-ReactionFlux70-ReactionFlux7-ReactionFlux77-ReactionFlux112;
    vf_[29] = ReactionFlux82;
    vf_[30] = -ReactionFlux71+ReactionFlux119-ReactionFlux72+ReactionFlux95-ReactionFlux70;
    vf_[31] = ReactionFlux129-ReactionFlux130+ReactionFlux73-2*ReactionFlux128+ReactionFlux70-ReactionFlux127;
    vf_[32] = -ReactionFlux74-ReactionFlux125+ReactionFlux72;
    vf_[33] = ReactionFlux74+ReactionFlux71-ReactionFlux126-ReactionFlux73;
    vf_[34] = ReactionFlux121-ReactionFlux104+ReactionFlux126-ReactionFlux123+ReactionFlux105+ReactionFlux124;
    vf_[35] = ReactionFlux103+ReactionFlux125+ReactionFlux122-ReactionFlux102-ReactionFlux124;
    vf_[36] = -2*ReactionFlux140-ReactionFlux106+ReactionFlux141+ReactionFlux107+ReactionFlux123-ReactionFlux142+ReactionFlux120+ReactionFlux127;
    vf_[37] = -ReactionFlux121-ReactionFlux122-ReactionFlux119-ReactionFlux120+ReactionFlux118;
    vf_[38] = ReactionFlux61-ReactionFlux58+ReactionFlux55-2*ReactionFlux43-ReactionFlux62+ReactionFlux59-ReactionFlux56-ReactionFlux69-ReactionFlux41-ReactionFlux38-ReactionFlux60+ReactionFlux57-ReactionFlux45-ReactionFlux39;
    vf_[39] = -ReactionFlux96-ReactionFlux93-ReactionFlux106-ReactionFlux100-ReactionFlux104-ReactionFlux98+ReactionFlux92-ReactionFlux102;
    vf_[40] = ReactionFlux14-ReactionFlux13;
    vf_[41] = -ReactionFlux14+ReactionFlux13;
    vf_[42] = -ReactionFlux3-ReactionFlux67;
    vf_[43] = ReactionFlux1-ReactionFlux68+ReactionFlux3;
    vf_[44] = -ReactionFlux1+ReactionFlux68+ReactionFlux2;
    vf_[45] = -ReactionFlux2+ReactionFlux67;
    vf_[46] = -ReactionFlux23-ReactionFlux12-ReactionFlux34+ReactionFlux9-ReactionFlux35;
    vf_[47] = ReactionFlux14-ReactionFlux30-ReactionFlux18-ReactionFlux15-ReactionFlux19-ReactionFlux17;
    vf_[48] = -ReactionFlux2-ReactionFlux3;
    vf_[49] = ReactionFlux36+ReactionFlux33-ReactionFlux8+ReactionFlux21+ReactionFlux22+ReactionFlux31-ReactionFlux13+ReactionFlux32+ReactionFlux20;
    vf_[50] = ReactionFlux65-ReactionFlux47+ReactionFlux66+ReactionFlux63+ReactionFlux0+ReactionFlux64;
    vf_[51] = -ReactionFlux52+ReactionFlux1-ReactionFlux53-ReactionFlux0-ReactionFlux29-ReactionFlux4;
    vf_[52] = ReactionFlux1-ReactionFlux47;
    vf_[53] = -ReactionFlux68+ReactionFlux47-ReactionFlux67;
    vf_[54] = -ReactionFlux78-ReactionFlux79-ReactionFlux111-ReactionFlux95-ReactionFlux77;
    vf_[55] = ReactionFlux129+ReactionFlux75-ReactionFlux130+2*ReactionFlux131-ReactionFlux108+ReactionFlux77;
    vf_[56] = -ReactionFlux110+ReactionFlux79-ReactionFlux76;
    vf_[57] = -ReactionFlux109+ReactionFlux78-ReactionFlux75+ReactionFlux76;
    vf_[58] = ReactionFlux109-ReactionFlux116+ReactionFlux113-ReactionFlux98+ReactionFlux115+ReactionFlux99;
    vf_[59] = -ReactionFlux96+ReactionFlux97+ReactionFlux110+ReactionFlux114-ReactionFlux115;
    vf_[60] = ReactionFlux116-ReactionFlux100+ReactionFlux141+ReactionFlux101-ReactionFlux142+ReactionFlux108+2*ReactionFlux143+ReactionFlux112;
    vf_[61] = -ReactionFlux93-ReactionFlux113+ReactionFlux94-ReactionFlux117-ReactionFlux114+ReactionFlux111-ReactionFlux112;
    vf_[62] = ReactionFlux103+ReactionFlux97+ReactionFlux94+ReactionFlux107-ReactionFlux91+ReactionFlux101+ReactionFlux105+ReactionFlux99;
    vf_[63] = -ReactionFlux41+ReactionFlux42;
    vf_[64] = ReactionFlux41-ReactionFlux42;
    vf_[65] = -ReactionFlux43+ReactionFlux44-ReactionFlux45;
    vf_[66] = -ReactionFlux44+ReactionFlux45;
    vf_[67] = ReactionFlux46+ReactionFlux43-ReactionFlux69;
    vf_[68] = -ReactionFlux46+ReactionFlux69;
    vf_[69] = -ReactionFlux38;
    vf_[70] = ReactionFlux11-ReactionFlux8+ReactionFlux81+ReactionFlux40-ReactionFlux15+ReactionFlux9-ReactionFlux10-ReactionFlux80;
    vf_[71] = -ReactionFlux11+ReactionFlux10;
    vf_[72] = ReactionFlux8-ReactionFlux9;
    vf_[73] = -ReactionFlux81+ReactionFlux80;
    vf_[74] = ReactionFlux38-ReactionFlux39;
    vf_[75] = -ReactionFlux40+ReactionFlux39;
    vf_[76] = ReactionFlux15;
    vf_[77] = ReactionFlux40;
    vf_[78] = -ReactionFlux12-ReactionFlux91-ReactionFlux117+ReactionFlux92+ReactionFlux118;
    vf_[79] = ReactionFlux117-ReactionFlux118;
    vf_[80] = ReactionFlux91-ReactionFlux92;
    vf_[81] = ReactionFlux12;
    vf_[82] = ReactionFlux140-ReactionFlux152-ReactionFlux141;
    vf_[83] = -ReactionFlux153+ReactionFlux142-ReactionFlux143;
    vf_[84] = -ReactionFlux129+ReactionFlux152+ReactionFlux128;
    vf_[85] = ReactionFlux130+ReactionFlux153-ReactionFlux131;
    vf_[86] = -ReactionFlux27-ReactionFlux6-ReactionFlux7;
    vf_[87] = -ReactionFlux23+ReactionFlux36+ReactionFlux7+ReactionFlux26;
    vf_[88] = ReactionFlux23-ReactionFlux36;
    vf_[89] = ReactionFlux6-ReactionFlux25;
    vf_[90] = ReactionFlux27+ReactionFlux25-ReactionFlux26;
    vf_[91] = -ReactionFlux84+ReactionFlux81-ReactionFlux90-ReactionFlux82-ReactionFlux88-ReactionFlux86;
    vf_[92] = ReactionFlux87+ReactionFlux85+ReactionFlux83-ReactionFlux80+ReactionFlux89;
    vf_[93] = ReactionFlux93-ReactionFlux94;
    vf_[94] = ReactionFlux96-ReactionFlux97;
    vf_[95] = ReactionFlux98-ReactionFlux99;
    vf_[96] = ReactionFlux100-ReactionFlux101;
    vf_[97] = -ReactionFlux103+ReactionFlux102;
    vf_[98] = ReactionFlux104-ReactionFlux105;
    vf_[99] = ReactionFlux106-ReactionFlux107;
    return(list(vf_))
}

#
# Nair_2016_jac(t, state, parameters)
#
# The jacobian function
#
Nair_2016_jac <- function(t, state, parameters) {
    AC5        <- state[1]
    AC5_ATP    <- state[2]
    AC5_Ca     <- state[3]
    AC5_Ca_ATP <- state[4]
    AC5_Ca_GaolfGTP <- state[5]
    AC5_Ca_GaolfGTP_ATP <- state[6]
    AC5_GaolfGTP <- state[7]
    AC5_GaolfGTP_ATP <- state[8]
    AMP        <- state[9]
    ATP        <- state[10]
    B56PP2A    <- state[11]
    B56PP2A_D32p75 <- state[12]
    B56PP2A_pARPP21 <- state[13]
    B56PP2Ap   <- state[14]
    B56PP2Ap_D32p75 <- state[15]
    B56PP2Ap_pARPP21 <- state[16]
    B72PP2A    <- state[17]
    B72PP2A_D32p34 <- state[18]
    B72PP2A_D32p75 <- state[19]
    B72PP2A_pARPP21 <- state[20]
    B72PP2A_Ca_D32p34 <- state[21]
    B72PP2A_Ca_D32p75 <- state[22]
    B72PP2A_Ca <- state[23]
    B72PP2A_Ca_pARPP21 <- state[24]
    Ca         <- state[25]
    CaM        <- state[26]
    CaM_Ca2    <- state[27]
    CaM_Ca4    <- state[28]
    CaM_Ca4_pARPP21 <- state[29]
    CaMKII     <- state[30]
    CaMKII_CaM_Ca4 <- state[31]
    CaMKII_CaM <- state[32]
    CaMKII_CaM_Ca2 <- state[33]
    CaMKII_CaM_Ca2_psd <- state[34]
    CaMKII_CaM_psd <- state[35]
    CaMKII_CaM_Ca4_psd <- state[36]
    CaMKII_psd <- state[37]
    cAMP       <- state[38]
    Substrate  <- state[39]
    CDK5       <- state[40]
    CDK5_D32   <- state[41]
    D1R        <- state[42]
    D1R_DA     <- state[43]
    D1R_Golf_DA <- state[44]
    D1R_Golf   <- state[45]
    D32p34     <- state[46]
    D32p75     <- state[47]
    DA         <- state[48]
    D32        <- state[49]
    GaolfGDP   <- state[50]
    GaolfGTP   <- state[51]
    Gbgolf     <- state[52]
    Golf       <- state[53]
    pCaMKII    <- state[54]
    pCaMKII_CaM_Ca4 <- state[55]
    pCaMKII_CaM <- state[56]
    pCaMKII_CaM_Ca2 <- state[57]
    pCaMKII_CaM_Ca2_psd <- state[58]
    pCaMKII_CaM_psd <- state[59]
    pCaMKII_CaM_Ca4_psd <- state[60]
    pCaMKII_psd <- state[61]
    pSubstrate <- state[62]
    PDE4       <- state[63]
    PDE4_cAMP  <- state[64]
    PDE10r     <- state[65]
    PDE10r_cAMP <- state[66]
    PDE10c     <- state[67]
    PDE10c_cAMP <- state[68]
    PKA        <- state[69]
    PKAc       <- state[70]
    PKAc_B56PP2A <- state[71]
    PKAc_D32   <- state[72]
    PKAc_ARPP21 <- state[73]
    PKA_Ca2MP  <- state[74]
    PKA_Ca4MP  <- state[75]
    PKAc_D32p75 <- state[76]
    PKAreg     <- state[77]
    PP1        <- state[78]
    PP1_pCaMKII_psd <- state[79]
    PP1_pSubstrate <- state[80]
    PP1_D32p34 <- state[81]
    CaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd <- state[82]
    pCaMKII_CaM_Ca4_psd_CaMKII_CaM_Ca4_psd <- state[83]
    CaMKII_CaM_Ca4_CaMKII_CaM_Ca4 <- state[84]
    pCaMKII_CaM_Ca4_CaMKII_CaM_Ca4 <- state[85]
    PP2B       <- state[86]
    PP2Bc      <- state[87]
    PP2Bc_D32p34 <- state[88]
    PP2B_CaM   <- state[89]
    PP2B_CaM_Ca2 <- state[90]
    pARPP21    <- state[91]
    ARPP21     <- state[92]
    pCaMKII_psd_Substrate <- state[93]
    pCaMKII_CaM_psd_Substrate <- state[94]
    pCaMKII_CaM_Ca2_psd_Substrate <- state[95]
    pCaMKII_CaM_Ca4_psd_Substrate <- state[96]
    CaMKII_CaM_psd_Substrate <- state[97]
    CaMKII_CaM_Ca2_psd_Substrate <- state[98]
    CaMKII_CaM_Ca4_psd_Substrate <- state[99]
    kf_R0      <- parameters[1]
    kf_R1      <- parameters[2]
    kf_R2      <- parameters[3]
    kr_R2      <- parameters[4]
    kf_R3      <- parameters[5]
    kr_R3      <- parameters[6]
    kf_R4      <- parameters[7]
    kr_R4      <- parameters[8]
    kf_R5      <- parameters[9]
    kr_R5      <- parameters[10]
    kf_R6      <- parameters[11]
    kr_R6      <- parameters[12]
    kf_R7      <- parameters[13]
    kr_R7      <- parameters[14]
    kf_R8      <- parameters[15]
    kr_R8      <- parameters[16]
    kf_R9      <- parameters[17]
    kf_R10     <- parameters[18]
    kr_R10     <- parameters[19]
    kf_R11     <- parameters[20]
    kf_R12     <- parameters[21]
    kr_R12     <- parameters[22]
    kf_R13     <- parameters[23]
    kr_R13     <- parameters[24]
    kf_R14     <- parameters[25]
    kf_R15     <- parameters[26]
    kr_R15     <- parameters[27]
    kf_R16     <- parameters[28]
    kr_R16     <- parameters[29]
    kf_R17     <- parameters[30]
    kr_R17     <- parameters[31]
    kf_R18     <- parameters[32]
    kr_R18     <- parameters[33]
    kf_R19     <- parameters[34]
    kr_R19     <- parameters[35]
    kf_R20     <- parameters[36]
    kf_R21     <- parameters[37]
    kf_R22     <- parameters[38]
    kf_R23     <- parameters[39]
    kr_R23     <- parameters[40]
    kf_R24     <- parameters[41]
    kr_R24     <- parameters[42]
    kf_R25     <- parameters[43]
    kr_R25     <- parameters[44]
    kf_R26     <- parameters[45]
    kr_R26     <- parameters[46]
    kf_R27     <- parameters[47]
    kr_R27     <- parameters[48]
    kf_R28     <- parameters[49]
    kr_R28     <- parameters[50]
    kf_R29     <- parameters[51]
    kr_R29     <- parameters[52]
    kf_R30     <- parameters[53]
    kr_R30     <- parameters[54]
    kf_R31     <- parameters[55]
    kf_R32     <- parameters[56]
    kf_R33     <- parameters[57]
    kf_R34     <- parameters[58]
    kr_R34     <- parameters[59]
    kf_R35     <- parameters[60]
    kr_R35     <- parameters[61]
    kf_R36     <- parameters[62]
    kf_R37     <- parameters[63]
    kf_R38     <- parameters[64]
    kr_R38     <- parameters[65]
    kf_R39     <- parameters[66]
    kr_R39     <- parameters[67]
    kf_R40     <- parameters[68]
    kr_R40     <- parameters[69]
    kf_R41     <- parameters[70]
    kr_R41     <- parameters[71]
    kf_R42     <- parameters[72]
    kf_R43     <- parameters[73]
    kr_R43     <- parameters[74]
    kf_R44     <- parameters[75]
    kf_R45     <- parameters[76]
    kr_R45     <- parameters[77]
    kf_R46     <- parameters[78]
    kf_R47     <- parameters[79]
    kf_R48     <- parameters[80]
    kr_R48     <- parameters[81]
    kf_R49     <- parameters[82]
    kr_R49     <- parameters[83]
    kf_R50     <- parameters[84]
    kr_R50     <- parameters[85]
    kf_R51     <- parameters[86]
    kr_R51     <- parameters[87]
    kf_R52     <- parameters[88]
    kr_R52     <- parameters[89]
    kf_R53     <- parameters[90]
    kr_R53     <- parameters[91]
    kf_R54     <- parameters[92]
    kr_R54     <- parameters[93]
    kf_R55     <- parameters[94]
    kf_R56     <- parameters[95]
    kf_R57     <- parameters[96]
    kf_R58     <- parameters[97]
    kf_R59     <- parameters[98]
    kf_R60     <- parameters[99]
    kf_R61     <- parameters[100]
    kf_R62     <- parameters[101]
    kf_R63     <- parameters[102]
    kf_R64     <- parameters[103]
    kf_R65     <- parameters[104]
    kf_R66     <- parameters[105]
    kf_R67     <- parameters[106]
    kr_R67     <- parameters[107]
    kf_R68     <- parameters[108]
    kr_R68     <- parameters[109]
    kf_R69     <- parameters[110]
    kr_R69     <- parameters[111]
    kf_R70     <- parameters[112]
    kr_R70     <- parameters[113]
    kf_R71     <- parameters[114]
    kr_R71     <- parameters[115]
    kf_R72     <- parameters[116]
    kr_R72     <- parameters[117]
    kf_R73     <- parameters[118]
    kr_R73     <- parameters[119]
    kf_R74     <- parameters[120]
    kr_R74     <- parameters[121]
    kf_R75     <- parameters[122]
    kr_R75     <- parameters[123]
    kf_R76     <- parameters[124]
    kr_R76     <- parameters[125]
    kf_R77     <- parameters[126]
    kr_R77     <- parameters[127]
    kf_R78     <- parameters[128]
    kr_R78     <- parameters[129]
    kf_R79     <- parameters[130]
    kr_R79     <- parameters[131]
    kf_R80     <- parameters[132]
    kr_R80     <- parameters[133]
    kf_R81     <- parameters[134]
    kf_R82     <- parameters[135]
    kr_R82     <- parameters[136]
    kf_R83     <- parameters[137]
    kf_R84     <- parameters[138]
    kr_R84     <- parameters[139]
    kf_R85     <- parameters[140]
    kf_R86     <- parameters[141]
    kr_R86     <- parameters[142]
    kf_R87     <- parameters[143]
    kf_R88     <- parameters[144]
    kr_R88     <- parameters[145]
    kf_R89     <- parameters[146]
    kf_R90     <- parameters[147]
    kr_R90     <- parameters[148]
    kf_R91     <- parameters[149]
    kr_R91     <- parameters[150]
    kf_R92     <- parameters[151]
    kf_R93     <- parameters[152]
    kr_R93     <- parameters[153]
    kf_R94     <- parameters[154]
    kf_R95     <- parameters[155]
    kf_R96     <- parameters[156]
    kr_R96     <- parameters[157]
    kf_R97     <- parameters[158]
    kf_R98     <- parameters[159]
    kr_R98     <- parameters[160]
    kf_R99     <- parameters[161]
    kf_R100    <- parameters[162]
    kr_R100    <- parameters[163]
    kf_R101    <- parameters[164]
    kf_R102    <- parameters[165]
    kr_R102    <- parameters[166]
    kf_R103    <- parameters[167]
    kf_R104    <- parameters[168]
    kr_R104    <- parameters[169]
    kf_R105    <- parameters[170]
    kf_R106    <- parameters[171]
    kr_R106    <- parameters[172]
    kf_R107    <- parameters[173]
    kf_R108    <- parameters[174]
    kr_R108    <- parameters[175]
    kf_R109    <- parameters[176]
    kr_R109    <- parameters[177]
    kf_R110    <- parameters[178]
    kr_R110    <- parameters[179]
    kf_R111    <- parameters[180]
    kr_R111    <- parameters[181]
    kf_R112    <- parameters[182]
    kr_R112    <- parameters[183]
    kf_R113    <- parameters[184]
    kr_R113    <- parameters[185]
    kf_R114    <- parameters[186]
    kr_R114    <- parameters[187]
    kf_R115    <- parameters[188]
    kr_R115    <- parameters[189]
    kf_R116    <- parameters[190]
    kr_R116    <- parameters[191]
    kf_R117    <- parameters[192]
    kr_R117    <- parameters[193]
    kf_R118    <- parameters[194]
    kf_R119    <- parameters[195]
    kf_R120    <- parameters[196]
    kr_R120    <- parameters[197]
    kf_R121    <- parameters[198]
    kr_R121    <- parameters[199]
    kf_R122    <- parameters[200]
    kr_R122    <- parameters[201]
    kf_R123    <- parameters[202]
    kr_R123    <- parameters[203]
    kf_R124    <- parameters[204]
    kr_R124    <- parameters[205]
    kf_R125    <- parameters[206]
    kr_R125    <- parameters[207]
    kf_R126    <- parameters[208]
    kr_R126    <- parameters[209]
    kf_R127    <- parameters[210]
    kr_R127    <- parameters[211]
    kf_R128    <- parameters[212]
    kr_R128    <- parameters[213]
    kf_R129    <- parameters[214]
    kr_R129    <- parameters[215]
    kf_R130    <- parameters[216]
    kr_R130    <- parameters[217]
    kf_R131    <- parameters[218]
    kf_R132    <- parameters[219]
    kr_R132    <- parameters[220]
    kf_R133    <- parameters[221]
    kf_R134    <- parameters[222]
    kr_R134    <- parameters[223]
    kf_R135    <- parameters[224]
    kf_R136    <- parameters[225]
    kr_R136    <- parameters[226]
    kf_R137    <- parameters[227]
    jac_ = matrix(nrow = 99, ncol = 99)
    jac_[1,1] = -kf_R4*GaolfGTP-kf_R28*Ca-ATP*kf_R49-cAMP*kf_R58
    jac_[1,2] = kr_R49+kf_R57
    jac_[1,3] = kr_R28
    jac_[1,4] = 0
    jac_[1,5] = 0
    jac_[1,6] = 0
    jac_[1,7] = kf_R63+kr_R4
    jac_[1,8] = 0
    jac_[1,9] = 0
    jac_[1,10] = -AC5*kf_R49
    jac_[1,11] = 0
    jac_[1,12] = 0
    jac_[1,13] = 0
    jac_[1,14] = 0
    jac_[1,15] = 0
    jac_[1,16] = 0
    jac_[1,17] = 0
    jac_[1,18] = 0
    jac_[1,19] = 0
    jac_[1,20] = 0
    jac_[1,21] = 0
    jac_[1,22] = 0
    jac_[1,23] = 0
    jac_[1,24] = 0
    jac_[1,25] = -AC5*kf_R28
    jac_[1,26] = 0
    jac_[1,27] = 0
    jac_[1,28] = 0
    jac_[1,29] = 0
    jac_[1,30] = 0
    jac_[1,31] = 0
    jac_[1,32] = 0
    jac_[1,33] = 0
    jac_[1,34] = 0
    jac_[1,35] = 0
    jac_[1,36] = 0
    jac_[1,37] = 0
    jac_[1,38] = -AC5*kf_R58
    jac_[1,39] = 0
    jac_[1,40] = 0
    jac_[1,41] = 0
    jac_[1,42] = 0
    jac_[1,43] = 0
    jac_[1,44] = 0
    jac_[1,45] = 0
    jac_[1,46] = 0
    jac_[1,47] = 0
    jac_[1,48] = 0
    jac_[1,49] = 0
    jac_[1,50] = 0
    jac_[1,51] = -kf_R4*AC5
    jac_[1,52] = 0
    jac_[1,53] = 0
    jac_[1,54] = 0
    jac_[1,55] = 0
    jac_[1,56] = 0
    jac_[1,57] = 0
    jac_[1,58] = 0
    jac_[1,59] = 0
    jac_[1,60] = 0
    jac_[1,61] = 0
    jac_[1,62] = 0
    jac_[1,63] = 0
    jac_[1,64] = 0
    jac_[1,65] = 0
    jac_[1,66] = 0
    jac_[1,67] = 0
    jac_[1,68] = 0
    jac_[1,69] = 0
    jac_[1,70] = 0
    jac_[1,71] = 0
    jac_[1,72] = 0
    jac_[1,73] = 0
    jac_[1,74] = 0
    jac_[1,75] = 0
    jac_[1,76] = 0
    jac_[1,77] = 0
    jac_[1,78] = 0
    jac_[1,79] = 0
    jac_[1,80] = 0
    jac_[1,81] = 0
    jac_[1,82] = 0
    jac_[1,83] = 0
    jac_[1,84] = 0
    jac_[1,85] = 0
    jac_[1,86] = 0
    jac_[1,87] = 0
    jac_[1,88] = 0
    jac_[1,89] = 0
    jac_[1,90] = 0
    jac_[1,91] = 0
    jac_[1,92] = 0
    jac_[1,93] = 0
    jac_[1,94] = 0
    jac_[1,95] = 0
    jac_[1,96] = 0
    jac_[1,97] = 0
    jac_[1,98] = 0
    jac_[1,99] = 0
    jac_[2,1] = ATP*kf_R49+cAMP*kf_R58
    jac_[2,2] = -kr_R49-Ca*kf_R54-kf_R57-GaolfGTP*kf_R52
    jac_[2,3] = 0
    jac_[2,4] = kr_R54
    jac_[2,5] = 0
    jac_[2,6] = 0
    jac_[2,7] = 0
    jac_[2,8] = kf_R65+kr_R52
    jac_[2,9] = 0
    jac_[2,10] = AC5*kf_R49
    jac_[2,11] = 0
    jac_[2,12] = 0
    jac_[2,13] = 0
    jac_[2,14] = 0
    jac_[2,15] = 0
    jac_[2,16] = 0
    jac_[2,17] = 0
    jac_[2,18] = 0
    jac_[2,19] = 0
    jac_[2,20] = 0
    jac_[2,21] = 0
    jac_[2,22] = 0
    jac_[2,23] = 0
    jac_[2,24] = 0
    jac_[2,25] = -AC5_ATP*kf_R54
    jac_[2,26] = 0
    jac_[2,27] = 0
    jac_[2,28] = 0
    jac_[2,29] = 0
    jac_[2,30] = 0
    jac_[2,31] = 0
    jac_[2,32] = 0
    jac_[2,33] = 0
    jac_[2,34] = 0
    jac_[2,35] = 0
    jac_[2,36] = 0
    jac_[2,37] = 0
    jac_[2,38] = AC5*kf_R58
    jac_[2,39] = 0
    jac_[2,40] = 0
    jac_[2,41] = 0
    jac_[2,42] = 0
    jac_[2,43] = 0
    jac_[2,44] = 0
    jac_[2,45] = 0
    jac_[2,46] = 0
    jac_[2,47] = 0
    jac_[2,48] = 0
    jac_[2,49] = 0
    jac_[2,50] = 0
    jac_[2,51] = -AC5_ATP*kf_R52
    jac_[2,52] = 0
    jac_[2,53] = 0
    jac_[2,54] = 0
    jac_[2,55] = 0
    jac_[2,56] = 0
    jac_[2,57] = 0
    jac_[2,58] = 0
    jac_[2,59] = 0
    jac_[2,60] = 0
    jac_[2,61] = 0
    jac_[2,62] = 0
    jac_[2,63] = 0
    jac_[2,64] = 0
    jac_[2,65] = 0
    jac_[2,66] = 0
    jac_[2,67] = 0
    jac_[2,68] = 0
    jac_[2,69] = 0
    jac_[2,70] = 0
    jac_[2,71] = 0
    jac_[2,72] = 0
    jac_[2,73] = 0
    jac_[2,74] = 0
    jac_[2,75] = 0
    jac_[2,76] = 0
    jac_[2,77] = 0
    jac_[2,78] = 0
    jac_[2,79] = 0
    jac_[2,80] = 0
    jac_[2,81] = 0
    jac_[2,82] = 0
    jac_[2,83] = 0
    jac_[2,84] = 0
    jac_[2,85] = 0
    jac_[2,86] = 0
    jac_[2,87] = 0
    jac_[2,88] = 0
    jac_[2,89] = 0
    jac_[2,90] = 0
    jac_[2,91] = 0
    jac_[2,92] = 0
    jac_[2,93] = 0
    jac_[2,94] = 0
    jac_[2,95] = 0
    jac_[2,96] = 0
    jac_[2,97] = 0
    jac_[2,98] = 0
    jac_[2,99] = 0
    jac_[3,1] = kf_R28*Ca
    jac_[3,2] = 0
    jac_[3,3] = -cAMP*kf_R60-GaolfGTP*kf_R29-kr_R28-ATP*kf_R50
    jac_[3,4] = kr_R50+kf_R59
    jac_[3,5] = kr_R29+kf_R64
    jac_[3,6] = 0
    jac_[3,7] = 0
    jac_[3,8] = 0
    jac_[3,9] = 0
    jac_[3,10] = -kf_R50*AC5_Ca
    jac_[3,11] = 0
    jac_[3,12] = 0
    jac_[3,13] = 0
    jac_[3,14] = 0
    jac_[3,15] = 0
    jac_[3,16] = 0
    jac_[3,17] = 0
    jac_[3,18] = 0
    jac_[3,19] = 0
    jac_[3,20] = 0
    jac_[3,21] = 0
    jac_[3,22] = 0
    jac_[3,23] = 0
    jac_[3,24] = 0
    jac_[3,25] = AC5*kf_R28
    jac_[3,26] = 0
    jac_[3,27] = 0
    jac_[3,28] = 0
    jac_[3,29] = 0
    jac_[3,30] = 0
    jac_[3,31] = 0
    jac_[3,32] = 0
    jac_[3,33] = 0
    jac_[3,34] = 0
    jac_[3,35] = 0
    jac_[3,36] = 0
    jac_[3,37] = 0
    jac_[3,38] = -kf_R60*AC5_Ca
    jac_[3,39] = 0
    jac_[3,40] = 0
    jac_[3,41] = 0
    jac_[3,42] = 0
    jac_[3,43] = 0
    jac_[3,44] = 0
    jac_[3,45] = 0
    jac_[3,46] = 0
    jac_[3,47] = 0
    jac_[3,48] = 0
    jac_[3,49] = 0
    jac_[3,50] = 0
    jac_[3,51] = -AC5_Ca*kf_R29
    jac_[3,52] = 0
    jac_[3,53] = 0
    jac_[3,54] = 0
    jac_[3,55] = 0
    jac_[3,56] = 0
    jac_[3,57] = 0
    jac_[3,58] = 0
    jac_[3,59] = 0
    jac_[3,60] = 0
    jac_[3,61] = 0
    jac_[3,62] = 0
    jac_[3,63] = 0
    jac_[3,64] = 0
    jac_[3,65] = 0
    jac_[3,66] = 0
    jac_[3,67] = 0
    jac_[3,68] = 0
    jac_[3,69] = 0
    jac_[3,70] = 0
    jac_[3,71] = 0
    jac_[3,72] = 0
    jac_[3,73] = 0
    jac_[3,74] = 0
    jac_[3,75] = 0
    jac_[3,76] = 0
    jac_[3,77] = 0
    jac_[3,78] = 0
    jac_[3,79] = 0
    jac_[3,80] = 0
    jac_[3,81] = 0
    jac_[3,82] = 0
    jac_[3,83] = 0
    jac_[3,84] = 0
    jac_[3,85] = 0
    jac_[3,86] = 0
    jac_[3,87] = 0
    jac_[3,88] = 0
    jac_[3,89] = 0
    jac_[3,90] = 0
    jac_[3,91] = 0
    jac_[3,92] = 0
    jac_[3,93] = 0
    jac_[3,94] = 0
    jac_[3,95] = 0
    jac_[3,96] = 0
    jac_[3,97] = 0
    jac_[3,98] = 0
    jac_[3,99] = 0
    jac_[4,1] = 0
    jac_[4,2] = Ca*kf_R54
    jac_[4,3] = cAMP*kf_R60+ATP*kf_R50
    jac_[4,4] = -kr_R54-kr_R50-GaolfGTP*kf_R53-kf_R59
    jac_[4,5] = 0
    jac_[4,6] = kf_R66+kr_R53
    jac_[4,7] = 0
    jac_[4,8] = 0
    jac_[4,9] = 0
    jac_[4,10] = kf_R50*AC5_Ca
    jac_[4,11] = 0
    jac_[4,12] = 0
    jac_[4,13] = 0
    jac_[4,14] = 0
    jac_[4,15] = 0
    jac_[4,16] = 0
    jac_[4,17] = 0
    jac_[4,18] = 0
    jac_[4,19] = 0
    jac_[4,20] = 0
    jac_[4,21] = 0
    jac_[4,22] = 0
    jac_[4,23] = 0
    jac_[4,24] = 0
    jac_[4,25] = AC5_ATP*kf_R54
    jac_[4,26] = 0
    jac_[4,27] = 0
    jac_[4,28] = 0
    jac_[4,29] = 0
    jac_[4,30] = 0
    jac_[4,31] = 0
    jac_[4,32] = 0
    jac_[4,33] = 0
    jac_[4,34] = 0
    jac_[4,35] = 0
    jac_[4,36] = 0
    jac_[4,37] = 0
    jac_[4,38] = kf_R60*AC5_Ca
    jac_[4,39] = 0
    jac_[4,40] = 0
    jac_[4,41] = 0
    jac_[4,42] = 0
    jac_[4,43] = 0
    jac_[4,44] = 0
    jac_[4,45] = 0
    jac_[4,46] = 0
    jac_[4,47] = 0
    jac_[4,48] = 0
    jac_[4,49] = 0
    jac_[4,50] = 0
    jac_[4,51] = -AC5_Ca_ATP*kf_R53
    jac_[4,52] = 0
    jac_[4,53] = 0
    jac_[4,54] = 0
    jac_[4,55] = 0
    jac_[4,56] = 0
    jac_[4,57] = 0
    jac_[4,58] = 0
    jac_[4,59] = 0
    jac_[4,60] = 0
    jac_[4,61] = 0
    jac_[4,62] = 0
    jac_[4,63] = 0
    jac_[4,64] = 0
    jac_[4,65] = 0
    jac_[4,66] = 0
    jac_[4,67] = 0
    jac_[4,68] = 0
    jac_[4,69] = 0
    jac_[4,70] = 0
    jac_[4,71] = 0
    jac_[4,72] = 0
    jac_[4,73] = 0
    jac_[4,74] = 0
    jac_[4,75] = 0
    jac_[4,76] = 0
    jac_[4,77] = 0
    jac_[4,78] = 0
    jac_[4,79] = 0
    jac_[4,80] = 0
    jac_[4,81] = 0
    jac_[4,82] = 0
    jac_[4,83] = 0
    jac_[4,84] = 0
    jac_[4,85] = 0
    jac_[4,86] = 0
    jac_[4,87] = 0
    jac_[4,88] = 0
    jac_[4,89] = 0
    jac_[4,90] = 0
    jac_[4,91] = 0
    jac_[4,92] = 0
    jac_[4,93] = 0
    jac_[4,94] = 0
    jac_[4,95] = 0
    jac_[4,96] = 0
    jac_[4,97] = 0
    jac_[4,98] = 0
    jac_[4,99] = 0
    jac_[5,1] = 0
    jac_[5,2] = 0
    jac_[5,3] = GaolfGTP*kf_R29
    jac_[5,4] = 0
    jac_[5,5] = -kr_R29-kf_R64-ATP*kf_R51-cAMP*kf_R62
    jac_[5,6] = kr_R51+kf_R61
    jac_[5,7] = 0
    jac_[5,8] = 0
    jac_[5,9] = 0
    jac_[5,10] = -AC5_Ca_GaolfGTP*kf_R51
    jac_[5,11] = 0
    jac_[5,12] = 0
    jac_[5,13] = 0
    jac_[5,14] = 0
    jac_[5,15] = 0
    jac_[5,16] = 0
    jac_[5,17] = 0
    jac_[5,18] = 0
    jac_[5,19] = 0
    jac_[5,20] = 0
    jac_[5,21] = 0
    jac_[5,22] = 0
    jac_[5,23] = 0
    jac_[5,24] = 0
    jac_[5,25] = 0
    jac_[5,26] = 0
    jac_[5,27] = 0
    jac_[5,28] = 0
    jac_[5,29] = 0
    jac_[5,30] = 0
    jac_[5,31] = 0
    jac_[5,32] = 0
    jac_[5,33] = 0
    jac_[5,34] = 0
    jac_[5,35] = 0
    jac_[5,36] = 0
    jac_[5,37] = 0
    jac_[5,38] = -AC5_Ca_GaolfGTP*kf_R62
    jac_[5,39] = 0
    jac_[5,40] = 0
    jac_[5,41] = 0
    jac_[5,42] = 0
    jac_[5,43] = 0
    jac_[5,44] = 0
    jac_[5,45] = 0
    jac_[5,46] = 0
    jac_[5,47] = 0
    jac_[5,48] = 0
    jac_[5,49] = 0
    jac_[5,50] = 0
    jac_[5,51] = AC5_Ca*kf_R29
    jac_[5,52] = 0
    jac_[5,53] = 0
    jac_[5,54] = 0
    jac_[5,55] = 0
    jac_[5,56] = 0
    jac_[5,57] = 0
    jac_[5,58] = 0
    jac_[5,59] = 0
    jac_[5,60] = 0
    jac_[5,61] = 0
    jac_[5,62] = 0
    jac_[5,63] = 0
    jac_[5,64] = 0
    jac_[5,65] = 0
    jac_[5,66] = 0
    jac_[5,67] = 0
    jac_[5,68] = 0
    jac_[5,69] = 0
    jac_[5,70] = 0
    jac_[5,71] = 0
    jac_[5,72] = 0
    jac_[5,73] = 0
    jac_[5,74] = 0
    jac_[5,75] = 0
    jac_[5,76] = 0
    jac_[5,77] = 0
    jac_[5,78] = 0
    jac_[5,79] = 0
    jac_[5,80] = 0
    jac_[5,81] = 0
    jac_[5,82] = 0
    jac_[5,83] = 0
    jac_[5,84] = 0
    jac_[5,85] = 0
    jac_[5,86] = 0
    jac_[5,87] = 0
    jac_[5,88] = 0
    jac_[5,89] = 0
    jac_[5,90] = 0
    jac_[5,91] = 0
    jac_[5,92] = 0
    jac_[5,93] = 0
    jac_[5,94] = 0
    jac_[5,95] = 0
    jac_[5,96] = 0
    jac_[5,97] = 0
    jac_[5,98] = 0
    jac_[5,99] = 0
    jac_[6,1] = 0
    jac_[6,2] = 0
    jac_[6,3] = 0
    jac_[6,4] = GaolfGTP*kf_R53
    jac_[6,5] = ATP*kf_R51+cAMP*kf_R62
    jac_[6,6] = -kf_R66-kr_R51-kr_R53-kf_R61
    jac_[6,7] = 0
    jac_[6,8] = 0
    jac_[6,9] = 0
    jac_[6,10] = AC5_Ca_GaolfGTP*kf_R51
    jac_[6,11] = 0
    jac_[6,12] = 0
    jac_[6,13] = 0
    jac_[6,14] = 0
    jac_[6,15] = 0
    jac_[6,16] = 0
    jac_[6,17] = 0
    jac_[6,18] = 0
    jac_[6,19] = 0
    jac_[6,20] = 0
    jac_[6,21] = 0
    jac_[6,22] = 0
    jac_[6,23] = 0
    jac_[6,24] = 0
    jac_[6,25] = 0
    jac_[6,26] = 0
    jac_[6,27] = 0
    jac_[6,28] = 0
    jac_[6,29] = 0
    jac_[6,30] = 0
    jac_[6,31] = 0
    jac_[6,32] = 0
    jac_[6,33] = 0
    jac_[6,34] = 0
    jac_[6,35] = 0
    jac_[6,36] = 0
    jac_[6,37] = 0
    jac_[6,38] = AC5_Ca_GaolfGTP*kf_R62
    jac_[6,39] = 0
    jac_[6,40] = 0
    jac_[6,41] = 0
    jac_[6,42] = 0
    jac_[6,43] = 0
    jac_[6,44] = 0
    jac_[6,45] = 0
    jac_[6,46] = 0
    jac_[6,47] = 0
    jac_[6,48] = 0
    jac_[6,49] = 0
    jac_[6,50] = 0
    jac_[6,51] = AC5_Ca_ATP*kf_R53
    jac_[6,52] = 0
    jac_[6,53] = 0
    jac_[6,54] = 0
    jac_[6,55] = 0
    jac_[6,56] = 0
    jac_[6,57] = 0
    jac_[6,58] = 0
    jac_[6,59] = 0
    jac_[6,60] = 0
    jac_[6,61] = 0
    jac_[6,62] = 0
    jac_[6,63] = 0
    jac_[6,64] = 0
    jac_[6,65] = 0
    jac_[6,66] = 0
    jac_[6,67] = 0
    jac_[6,68] = 0
    jac_[6,69] = 0
    jac_[6,70] = 0
    jac_[6,71] = 0
    jac_[6,72] = 0
    jac_[6,73] = 0
    jac_[6,74] = 0
    jac_[6,75] = 0
    jac_[6,76] = 0
    jac_[6,77] = 0
    jac_[6,78] = 0
    jac_[6,79] = 0
    jac_[6,80] = 0
    jac_[6,81] = 0
    jac_[6,82] = 0
    jac_[6,83] = 0
    jac_[6,84] = 0
    jac_[6,85] = 0
    jac_[6,86] = 0
    jac_[6,87] = 0
    jac_[6,88] = 0
    jac_[6,89] = 0
    jac_[6,90] = 0
    jac_[6,91] = 0
    jac_[6,92] = 0
    jac_[6,93] = 0
    jac_[6,94] = 0
    jac_[6,95] = 0
    jac_[6,96] = 0
    jac_[6,97] = 0
    jac_[6,98] = 0
    jac_[6,99] = 0
    jac_[7,1] = kf_R4*GaolfGTP
    jac_[7,2] = 0
    jac_[7,3] = 0
    jac_[7,4] = 0
    jac_[7,5] = 0
    jac_[7,6] = 0
    jac_[7,7] = -kf_R63-ATP*kf_R48-kr_R4-cAMP*kf_R56
    jac_[7,8] = kr_R48+kf_R55
    jac_[7,9] = 0
    jac_[7,10] = -kf_R48*AC5_GaolfGTP
    jac_[7,11] = 0
    jac_[7,12] = 0
    jac_[7,13] = 0
    jac_[7,14] = 0
    jac_[7,15] = 0
    jac_[7,16] = 0
    jac_[7,17] = 0
    jac_[7,18] = 0
    jac_[7,19] = 0
    jac_[7,20] = 0
    jac_[7,21] = 0
    jac_[7,22] = 0
    jac_[7,23] = 0
    jac_[7,24] = 0
    jac_[7,25] = 0
    jac_[7,26] = 0
    jac_[7,27] = 0
    jac_[7,28] = 0
    jac_[7,29] = 0
    jac_[7,30] = 0
    jac_[7,31] = 0
    jac_[7,32] = 0
    jac_[7,33] = 0
    jac_[7,34] = 0
    jac_[7,35] = 0
    jac_[7,36] = 0
    jac_[7,37] = 0
    jac_[7,38] = -AC5_GaolfGTP*kf_R56
    jac_[7,39] = 0
    jac_[7,40] = 0
    jac_[7,41] = 0
    jac_[7,42] = 0
    jac_[7,43] = 0
    jac_[7,44] = 0
    jac_[7,45] = 0
    jac_[7,46] = 0
    jac_[7,47] = 0
    jac_[7,48] = 0
    jac_[7,49] = 0
    jac_[7,50] = 0
    jac_[7,51] = kf_R4*AC5
    jac_[7,52] = 0
    jac_[7,53] = 0
    jac_[7,54] = 0
    jac_[7,55] = 0
    jac_[7,56] = 0
    jac_[7,57] = 0
    jac_[7,58] = 0
    jac_[7,59] = 0
    jac_[7,60] = 0
    jac_[7,61] = 0
    jac_[7,62] = 0
    jac_[7,63] = 0
    jac_[7,64] = 0
    jac_[7,65] = 0
    jac_[7,66] = 0
    jac_[7,67] = 0
    jac_[7,68] = 0
    jac_[7,69] = 0
    jac_[7,70] = 0
    jac_[7,71] = 0
    jac_[7,72] = 0
    jac_[7,73] = 0
    jac_[7,74] = 0
    jac_[7,75] = 0
    jac_[7,76] = 0
    jac_[7,77] = 0
    jac_[7,78] = 0
    jac_[7,79] = 0
    jac_[7,80] = 0
    jac_[7,81] = 0
    jac_[7,82] = 0
    jac_[7,83] = 0
    jac_[7,84] = 0
    jac_[7,85] = 0
    jac_[7,86] = 0
    jac_[7,87] = 0
    jac_[7,88] = 0
    jac_[7,89] = 0
    jac_[7,90] = 0
    jac_[7,91] = 0
    jac_[7,92] = 0
    jac_[7,93] = 0
    jac_[7,94] = 0
    jac_[7,95] = 0
    jac_[7,96] = 0
    jac_[7,97] = 0
    jac_[7,98] = 0
    jac_[7,99] = 0
    jac_[8,1] = 0
    jac_[8,2] = GaolfGTP*kf_R52
    jac_[8,3] = 0
    jac_[8,4] = 0
    jac_[8,5] = 0
    jac_[8,6] = 0
    jac_[8,7] = ATP*kf_R48+cAMP*kf_R56
    jac_[8,8] = -kr_R48-kf_R55-kf_R65-kr_R52
    jac_[8,9] = 0
    jac_[8,10] = kf_R48*AC5_GaolfGTP
    jac_[8,11] = 0
    jac_[8,12] = 0
    jac_[8,13] = 0
    jac_[8,14] = 0
    jac_[8,15] = 0
    jac_[8,16] = 0
    jac_[8,17] = 0
    jac_[8,18] = 0
    jac_[8,19] = 0
    jac_[8,20] = 0
    jac_[8,21] = 0
    jac_[8,22] = 0
    jac_[8,23] = 0
    jac_[8,24] = 0
    jac_[8,25] = 0
    jac_[8,26] = 0
    jac_[8,27] = 0
    jac_[8,28] = 0
    jac_[8,29] = 0
    jac_[8,30] = 0
    jac_[8,31] = 0
    jac_[8,32] = 0
    jac_[8,33] = 0
    jac_[8,34] = 0
    jac_[8,35] = 0
    jac_[8,36] = 0
    jac_[8,37] = 0
    jac_[8,38] = AC5_GaolfGTP*kf_R56
    jac_[8,39] = 0
    jac_[8,40] = 0
    jac_[8,41] = 0
    jac_[8,42] = 0
    jac_[8,43] = 0
    jac_[8,44] = 0
    jac_[8,45] = 0
    jac_[8,46] = 0
    jac_[8,47] = 0
    jac_[8,48] = 0
    jac_[8,49] = 0
    jac_[8,50] = 0
    jac_[8,51] = AC5_ATP*kf_R52
    jac_[8,52] = 0
    jac_[8,53] = 0
    jac_[8,54] = 0
    jac_[8,55] = 0
    jac_[8,56] = 0
    jac_[8,57] = 0
    jac_[8,58] = 0
    jac_[8,59] = 0
    jac_[8,60] = 0
    jac_[8,61] = 0
    jac_[8,62] = 0
    jac_[8,63] = 0
    jac_[8,64] = 0
    jac_[8,65] = 0
    jac_[8,66] = 0
    jac_[8,67] = 0
    jac_[8,68] = 0
    jac_[8,69] = 0
    jac_[8,70] = 0
    jac_[8,71] = 0
    jac_[8,72] = 0
    jac_[8,73] = 0
    jac_[8,74] = 0
    jac_[8,75] = 0
    jac_[8,76] = 0
    jac_[8,77] = 0
    jac_[8,78] = 0
    jac_[8,79] = 0
    jac_[8,80] = 0
    jac_[8,81] = 0
    jac_[8,82] = 0
    jac_[8,83] = 0
    jac_[8,84] = 0
    jac_[8,85] = 0
    jac_[8,86] = 0
    jac_[8,87] = 0
    jac_[8,88] = 0
    jac_[8,89] = 0
    jac_[8,90] = 0
    jac_[8,91] = 0
    jac_[8,92] = 0
    jac_[8,93] = 0
    jac_[8,94] = 0
    jac_[8,95] = 0
    jac_[8,96] = 0
    jac_[8,97] = 0
    jac_[8,98] = 0
    jac_[8,99] = 0
    jac_[9,1] = 0
    jac_[9,2] = 0
    jac_[9,3] = 0
    jac_[9,4] = 0
    jac_[9,5] = 0
    jac_[9,6] = 0
    jac_[9,7] = 0
    jac_[9,8] = 0
    jac_[9,9] = 0
    jac_[9,10] = 0
    jac_[9,11] = 0
    jac_[9,12] = 0
    jac_[9,13] = 0
    jac_[9,14] = 0
    jac_[9,15] = 0
    jac_[9,16] = 0
    jac_[9,17] = 0
    jac_[9,18] = 0
    jac_[9,19] = 0
    jac_[9,20] = 0
    jac_[9,21] = 0
    jac_[9,22] = 0
    jac_[9,23] = 0
    jac_[9,24] = 0
    jac_[9,25] = 0
    jac_[9,26] = 0
    jac_[9,27] = 0
    jac_[9,28] = 0
    jac_[9,29] = 0
    jac_[9,30] = 0
    jac_[9,31] = 0
    jac_[9,32] = 0
    jac_[9,33] = 0
    jac_[9,34] = 0
    jac_[9,35] = 0
    jac_[9,36] = 0
    jac_[9,37] = 0
    jac_[9,38] = 0
    jac_[9,39] = 0
    jac_[9,40] = 0
    jac_[9,41] = 0
    jac_[9,42] = 0
    jac_[9,43] = 0
    jac_[9,44] = 0
    jac_[9,45] = 0
    jac_[9,46] = 0
    jac_[9,47] = 0
    jac_[9,48] = 0
    jac_[9,49] = 0
    jac_[9,50] = 0
    jac_[9,51] = 0
    jac_[9,52] = 0
    jac_[9,53] = 0
    jac_[9,54] = 0
    jac_[9,55] = 0
    jac_[9,56] = 0
    jac_[9,57] = 0
    jac_[9,58] = 0
    jac_[9,59] = 0
    jac_[9,60] = 0
    jac_[9,61] = 0
    jac_[9,62] = 0
    jac_[9,63] = 0
    jac_[9,64] = kf_R42
    jac_[9,65] = 0
    jac_[9,66] = kf_R44
    jac_[9,67] = 0
    jac_[9,68] = kf_R46
    jac_[9,69] = 0
    jac_[9,70] = 0
    jac_[9,71] = 0
    jac_[9,72] = 0
    jac_[9,73] = 0
    jac_[9,74] = 0
    jac_[9,75] = 0
    jac_[9,76] = 0
    jac_[9,77] = 0
    jac_[9,78] = 0
    jac_[9,79] = 0
    jac_[9,80] = 0
    jac_[9,81] = 0
    jac_[9,82] = 0
    jac_[9,83] = 0
    jac_[9,84] = 0
    jac_[9,85] = 0
    jac_[9,86] = 0
    jac_[9,87] = 0
    jac_[9,88] = 0
    jac_[9,89] = 0
    jac_[9,90] = 0
    jac_[9,91] = 0
    jac_[9,92] = 0
    jac_[9,93] = 0
    jac_[9,94] = 0
    jac_[9,95] = 0
    jac_[9,96] = 0
    jac_[9,97] = 0
    jac_[9,98] = 0
    jac_[9,99] = 0
    jac_[10,1] = -ATP*kf_R49
    jac_[10,2] = kr_R49
    jac_[10,3] = -ATP*kf_R50
    jac_[10,4] = kr_R50
    jac_[10,5] = -ATP*kf_R51
    jac_[10,6] = kr_R51
    jac_[10,7] = -ATP*kf_R48
    jac_[10,8] = kr_R48
    jac_[10,9] = 0
    jac_[10,10] = -AC5_Ca_GaolfGTP*kf_R51-kf_R48*AC5_GaolfGTP-AC5*kf_R49-kf_R50*AC5_Ca
    jac_[10,11] = 0
    jac_[10,12] = 0
    jac_[10,13] = 0
    jac_[10,14] = 0
    jac_[10,15] = 0
    jac_[10,16] = 0
    jac_[10,17] = 0
    jac_[10,18] = 0
    jac_[10,19] = 0
    jac_[10,20] = 0
    jac_[10,21] = 0
    jac_[10,22] = 0
    jac_[10,23] = 0
    jac_[10,24] = 0
    jac_[10,25] = 0
    jac_[10,26] = 0
    jac_[10,27] = 0
    jac_[10,28] = 0
    jac_[10,29] = 0
    jac_[10,30] = 0
    jac_[10,31] = 0
    jac_[10,32] = 0
    jac_[10,33] = 0
    jac_[10,34] = 0
    jac_[10,35] = 0
    jac_[10,36] = 0
    jac_[10,37] = 0
    jac_[10,38] = 0
    jac_[10,39] = 0
    jac_[10,40] = 0
    jac_[10,41] = 0
    jac_[10,42] = 0
    jac_[10,43] = 0
    jac_[10,44] = 0
    jac_[10,45] = 0
    jac_[10,46] = 0
    jac_[10,47] = 0
    jac_[10,48] = 0
    jac_[10,49] = 0
    jac_[10,50] = 0
    jac_[10,51] = 0
    jac_[10,52] = 0
    jac_[10,53] = 0
    jac_[10,54] = 0
    jac_[10,55] = 0
    jac_[10,56] = 0
    jac_[10,57] = 0
    jac_[10,58] = 0
    jac_[10,59] = 0
    jac_[10,60] = 0
    jac_[10,61] = 0
    jac_[10,62] = 0
    jac_[10,63] = 0
    jac_[10,64] = 0
    jac_[10,65] = 0
    jac_[10,66] = 0
    jac_[10,67] = 0
    jac_[10,68] = 0
    jac_[10,69] = 0
    jac_[10,70] = 0
    jac_[10,71] = 0
    jac_[10,72] = 0
    jac_[10,73] = 0
    jac_[10,74] = 0
    jac_[10,75] = 0
    jac_[10,76] = 0
    jac_[10,77] = 0
    jac_[10,78] = 0
    jac_[10,79] = 0
    jac_[10,80] = 0
    jac_[10,81] = 0
    jac_[10,82] = 0
    jac_[10,83] = 0
    jac_[10,84] = 0
    jac_[10,85] = 0
    jac_[10,86] = 0
    jac_[10,87] = 0
    jac_[10,88] = 0
    jac_[10,89] = 0
    jac_[10,90] = 0
    jac_[10,91] = 0
    jac_[10,92] = 0
    jac_[10,93] = 0
    jac_[10,94] = 0
    jac_[10,95] = 0
    jac_[10,96] = 0
    jac_[10,97] = 0
    jac_[10,98] = 0
    jac_[10,99] = 0
    jac_[11,1] = 0
    jac_[11,2] = 0
    jac_[11,3] = 0
    jac_[11,4] = 0
    jac_[11,5] = 0
    jac_[11,6] = 0
    jac_[11,7] = 0
    jac_[11,8] = 0
    jac_[11,9] = 0
    jac_[11,10] = 0
    jac_[11,11] = -PKAc*kf_R10-kf_R90*pARPP21-kf_R30*D32p75
    jac_[11,12] = kf_R31+kr_R30
    jac_[11,13] = kr_R90+kf_R89
    jac_[11,14] = kf_R37
    jac_[11,15] = 0
    jac_[11,16] = 0
    jac_[11,17] = 0
    jac_[11,18] = 0
    jac_[11,19] = 0
    jac_[11,20] = 0
    jac_[11,21] = 0
    jac_[11,22] = 0
    jac_[11,23] = 0
    jac_[11,24] = 0
    jac_[11,25] = 0
    jac_[11,26] = 0
    jac_[11,27] = 0
    jac_[11,28] = 0
    jac_[11,29] = 0
    jac_[11,30] = 0
    jac_[11,31] = 0
    jac_[11,32] = 0
    jac_[11,33] = 0
    jac_[11,34] = 0
    jac_[11,35] = 0
    jac_[11,36] = 0
    jac_[11,37] = 0
    jac_[11,38] = 0
    jac_[11,39] = 0
    jac_[11,40] = 0
    jac_[11,41] = 0
    jac_[11,42] = 0
    jac_[11,43] = 0
    jac_[11,44] = 0
    jac_[11,45] = 0
    jac_[11,46] = 0
    jac_[11,47] = -B56PP2A*kf_R30
    jac_[11,48] = 0
    jac_[11,49] = 0
    jac_[11,50] = 0
    jac_[11,51] = 0
    jac_[11,52] = 0
    jac_[11,53] = 0
    jac_[11,54] = 0
    jac_[11,55] = 0
    jac_[11,56] = 0
    jac_[11,57] = 0
    jac_[11,58] = 0
    jac_[11,59] = 0
    jac_[11,60] = 0
    jac_[11,61] = 0
    jac_[11,62] = 0
    jac_[11,63] = 0
    jac_[11,64] = 0
    jac_[11,65] = 0
    jac_[11,66] = 0
    jac_[11,67] = 0
    jac_[11,68] = 0
    jac_[11,69] = 0
    jac_[11,70] = -B56PP2A*kf_R10
    jac_[11,71] = kr_R10
    jac_[11,72] = 0
    jac_[11,73] = 0
    jac_[11,74] = 0
    jac_[11,75] = 0
    jac_[11,76] = 0
    jac_[11,77] = 0
    jac_[11,78] = 0
    jac_[11,79] = 0
    jac_[11,80] = 0
    jac_[11,81] = 0
    jac_[11,82] = 0
    jac_[11,83] = 0
    jac_[11,84] = 0
    jac_[11,85] = 0
    jac_[11,86] = 0
    jac_[11,87] = 0
    jac_[11,88] = 0
    jac_[11,89] = 0
    jac_[11,90] = 0
    jac_[11,91] = -kf_R90*B56PP2A
    jac_[11,92] = 0
    jac_[11,93] = 0
    jac_[11,94] = 0
    jac_[11,95] = 0
    jac_[11,96] = 0
    jac_[11,97] = 0
    jac_[11,98] = 0
    jac_[11,99] = 0
    jac_[12,1] = 0
    jac_[12,2] = 0
    jac_[12,3] = 0
    jac_[12,4] = 0
    jac_[12,5] = 0
    jac_[12,6] = 0
    jac_[12,7] = 0
    jac_[12,8] = 0
    jac_[12,9] = 0
    jac_[12,10] = 0
    jac_[12,11] = kf_R30*D32p75
    jac_[12,12] = -kf_R31-kr_R30
    jac_[12,13] = 0
    jac_[12,14] = 0
    jac_[12,15] = 0
    jac_[12,16] = 0
    jac_[12,17] = 0
    jac_[12,18] = 0
    jac_[12,19] = 0
    jac_[12,20] = 0
    jac_[12,21] = 0
    jac_[12,22] = 0
    jac_[12,23] = 0
    jac_[12,24] = 0
    jac_[12,25] = 0
    jac_[12,26] = 0
    jac_[12,27] = 0
    jac_[12,28] = 0
    jac_[12,29] = 0
    jac_[12,30] = 0
    jac_[12,31] = 0
    jac_[12,32] = 0
    jac_[12,33] = 0
    jac_[12,34] = 0
    jac_[12,35] = 0
    jac_[12,36] = 0
    jac_[12,37] = 0
    jac_[12,38] = 0
    jac_[12,39] = 0
    jac_[12,40] = 0
    jac_[12,41] = 0
    jac_[12,42] = 0
    jac_[12,43] = 0
    jac_[12,44] = 0
    jac_[12,45] = 0
    jac_[12,46] = 0
    jac_[12,47] = B56PP2A*kf_R30
    jac_[12,48] = 0
    jac_[12,49] = 0
    jac_[12,50] = 0
    jac_[12,51] = 0
    jac_[12,52] = 0
    jac_[12,53] = 0
    jac_[12,54] = 0
    jac_[12,55] = 0
    jac_[12,56] = 0
    jac_[12,57] = 0
    jac_[12,58] = 0
    jac_[12,59] = 0
    jac_[12,60] = 0
    jac_[12,61] = 0
    jac_[12,62] = 0
    jac_[12,63] = 0
    jac_[12,64] = 0
    jac_[12,65] = 0
    jac_[12,66] = 0
    jac_[12,67] = 0
    jac_[12,68] = 0
    jac_[12,69] = 0
    jac_[12,70] = 0
    jac_[12,71] = 0
    jac_[12,72] = 0
    jac_[12,73] = 0
    jac_[12,74] = 0
    jac_[12,75] = 0
    jac_[12,76] = 0
    jac_[12,77] = 0
    jac_[12,78] = 0
    jac_[12,79] = 0
    jac_[12,80] = 0
    jac_[12,81] = 0
    jac_[12,82] = 0
    jac_[12,83] = 0
    jac_[12,84] = 0
    jac_[12,85] = 0
    jac_[12,86] = 0
    jac_[12,87] = 0
    jac_[12,88] = 0
    jac_[12,89] = 0
    jac_[12,90] = 0
    jac_[12,91] = 0
    jac_[12,92] = 0
    jac_[12,93] = 0
    jac_[12,94] = 0
    jac_[12,95] = 0
    jac_[12,96] = 0
    jac_[12,97] = 0
    jac_[12,98] = 0
    jac_[12,99] = 0
    jac_[13,1] = 0
    jac_[13,2] = 0
    jac_[13,3] = 0
    jac_[13,4] = 0
    jac_[13,5] = 0
    jac_[13,6] = 0
    jac_[13,7] = 0
    jac_[13,8] = 0
    jac_[13,9] = 0
    jac_[13,10] = 0
    jac_[13,11] = kf_R90*pARPP21
    jac_[13,12] = 0
    jac_[13,13] = -kr_R90-kf_R89
    jac_[13,14] = 0
    jac_[13,15] = 0
    jac_[13,16] = 0
    jac_[13,17] = 0
    jac_[13,18] = 0
    jac_[13,19] = 0
    jac_[13,20] = 0
    jac_[13,21] = 0
    jac_[13,22] = 0
    jac_[13,23] = 0
    jac_[13,24] = 0
    jac_[13,25] = 0
    jac_[13,26] = 0
    jac_[13,27] = 0
    jac_[13,28] = 0
    jac_[13,29] = 0
    jac_[13,30] = 0
    jac_[13,31] = 0
    jac_[13,32] = 0
    jac_[13,33] = 0
    jac_[13,34] = 0
    jac_[13,35] = 0
    jac_[13,36] = 0
    jac_[13,37] = 0
    jac_[13,38] = 0
    jac_[13,39] = 0
    jac_[13,40] = 0
    jac_[13,41] = 0
    jac_[13,42] = 0
    jac_[13,43] = 0
    jac_[13,44] = 0
    jac_[13,45] = 0
    jac_[13,46] = 0
    jac_[13,47] = 0
    jac_[13,48] = 0
    jac_[13,49] = 0
    jac_[13,50] = 0
    jac_[13,51] = 0
    jac_[13,52] = 0
    jac_[13,53] = 0
    jac_[13,54] = 0
    jac_[13,55] = 0
    jac_[13,56] = 0
    jac_[13,57] = 0
    jac_[13,58] = 0
    jac_[13,59] = 0
    jac_[13,60] = 0
    jac_[13,61] = 0
    jac_[13,62] = 0
    jac_[13,63] = 0
    jac_[13,64] = 0
    jac_[13,65] = 0
    jac_[13,66] = 0
    jac_[13,67] = 0
    jac_[13,68] = 0
    jac_[13,69] = 0
    jac_[13,70] = 0
    jac_[13,71] = 0
    jac_[13,72] = 0
    jac_[13,73] = 0
    jac_[13,74] = 0
    jac_[13,75] = 0
    jac_[13,76] = 0
    jac_[13,77] = 0
    jac_[13,78] = 0
    jac_[13,79] = 0
    jac_[13,80] = 0
    jac_[13,81] = 0
    jac_[13,82] = 0
    jac_[13,83] = 0
    jac_[13,84] = 0
    jac_[13,85] = 0
    jac_[13,86] = 0
    jac_[13,87] = 0
    jac_[13,88] = 0
    jac_[13,89] = 0
    jac_[13,90] = 0
    jac_[13,91] = kf_R90*B56PP2A
    jac_[13,92] = 0
    jac_[13,93] = 0
    jac_[13,94] = 0
    jac_[13,95] = 0
    jac_[13,96] = 0
    jac_[13,97] = 0
    jac_[13,98] = 0
    jac_[13,99] = 0
    jac_[14,1] = 0
    jac_[14,2] = 0
    jac_[14,3] = 0
    jac_[14,4] = 0
    jac_[14,5] = 0
    jac_[14,6] = 0
    jac_[14,7] = 0
    jac_[14,8] = 0
    jac_[14,9] = 0
    jac_[14,10] = 0
    jac_[14,11] = 0
    jac_[14,12] = 0
    jac_[14,13] = 0
    jac_[14,14] = -kf_R17*D32p75-kf_R88*pARPP21-kf_R37
    jac_[14,15] = kf_R20+kr_R17
    jac_[14,16] = kr_R88+kf_R87
    jac_[14,17] = 0
    jac_[14,18] = 0
    jac_[14,19] = 0
    jac_[14,20] = 0
    jac_[14,21] = 0
    jac_[14,22] = 0
    jac_[14,23] = 0
    jac_[14,24] = 0
    jac_[14,25] = 0
    jac_[14,26] = 0
    jac_[14,27] = 0
    jac_[14,28] = 0
    jac_[14,29] = 0
    jac_[14,30] = 0
    jac_[14,31] = 0
    jac_[14,32] = 0
    jac_[14,33] = 0
    jac_[14,34] = 0
    jac_[14,35] = 0
    jac_[14,36] = 0
    jac_[14,37] = 0
    jac_[14,38] = 0
    jac_[14,39] = 0
    jac_[14,40] = 0
    jac_[14,41] = 0
    jac_[14,42] = 0
    jac_[14,43] = 0
    jac_[14,44] = 0
    jac_[14,45] = 0
    jac_[14,46] = 0
    jac_[14,47] = -kf_R17*B56PP2Ap
    jac_[14,48] = 0
    jac_[14,49] = 0
    jac_[14,50] = 0
    jac_[14,51] = 0
    jac_[14,52] = 0
    jac_[14,53] = 0
    jac_[14,54] = 0
    jac_[14,55] = 0
    jac_[14,56] = 0
    jac_[14,57] = 0
    jac_[14,58] = 0
    jac_[14,59] = 0
    jac_[14,60] = 0
    jac_[14,61] = 0
    jac_[14,62] = 0
    jac_[14,63] = 0
    jac_[14,64] = 0
    jac_[14,65] = 0
    jac_[14,66] = 0
    jac_[14,67] = 0
    jac_[14,68] = 0
    jac_[14,69] = 0
    jac_[14,70] = 0
    jac_[14,71] = kf_R11
    jac_[14,72] = 0
    jac_[14,73] = 0
    jac_[14,74] = 0
    jac_[14,75] = 0
    jac_[14,76] = 0
    jac_[14,77] = 0
    jac_[14,78] = 0
    jac_[14,79] = 0
    jac_[14,80] = 0
    jac_[14,81] = 0
    jac_[14,82] = 0
    jac_[14,83] = 0
    jac_[14,84] = 0
    jac_[14,85] = 0
    jac_[14,86] = 0
    jac_[14,87] = 0
    jac_[14,88] = 0
    jac_[14,89] = 0
    jac_[14,90] = 0
    jac_[14,91] = -B56PP2Ap*kf_R88
    jac_[14,92] = 0
    jac_[14,93] = 0
    jac_[14,94] = 0
    jac_[14,95] = 0
    jac_[14,96] = 0
    jac_[14,97] = 0
    jac_[14,98] = 0
    jac_[14,99] = 0
    jac_[15,1] = 0
    jac_[15,2] = 0
    jac_[15,3] = 0
    jac_[15,4] = 0
    jac_[15,5] = 0
    jac_[15,6] = 0
    jac_[15,7] = 0
    jac_[15,8] = 0
    jac_[15,9] = 0
    jac_[15,10] = 0
    jac_[15,11] = 0
    jac_[15,12] = 0
    jac_[15,13] = 0
    jac_[15,14] = kf_R17*D32p75
    jac_[15,15] = -kf_R20-kr_R17
    jac_[15,16] = 0
    jac_[15,17] = 0
    jac_[15,18] = 0
    jac_[15,19] = 0
    jac_[15,20] = 0
    jac_[15,21] = 0
    jac_[15,22] = 0
    jac_[15,23] = 0
    jac_[15,24] = 0
    jac_[15,25] = 0
    jac_[15,26] = 0
    jac_[15,27] = 0
    jac_[15,28] = 0
    jac_[15,29] = 0
    jac_[15,30] = 0
    jac_[15,31] = 0
    jac_[15,32] = 0
    jac_[15,33] = 0
    jac_[15,34] = 0
    jac_[15,35] = 0
    jac_[15,36] = 0
    jac_[15,37] = 0
    jac_[15,38] = 0
    jac_[15,39] = 0
    jac_[15,40] = 0
    jac_[15,41] = 0
    jac_[15,42] = 0
    jac_[15,43] = 0
    jac_[15,44] = 0
    jac_[15,45] = 0
    jac_[15,46] = 0
    jac_[15,47] = kf_R17*B56PP2Ap
    jac_[15,48] = 0
    jac_[15,49] = 0
    jac_[15,50] = 0
    jac_[15,51] = 0
    jac_[15,52] = 0
    jac_[15,53] = 0
    jac_[15,54] = 0
    jac_[15,55] = 0
    jac_[15,56] = 0
    jac_[15,57] = 0
    jac_[15,58] = 0
    jac_[15,59] = 0
    jac_[15,60] = 0
    jac_[15,61] = 0
    jac_[15,62] = 0
    jac_[15,63] = 0
    jac_[15,64] = 0
    jac_[15,65] = 0
    jac_[15,66] = 0
    jac_[15,67] = 0
    jac_[15,68] = 0
    jac_[15,69] = 0
    jac_[15,70] = 0
    jac_[15,71] = 0
    jac_[15,72] = 0
    jac_[15,73] = 0
    jac_[15,74] = 0
    jac_[15,75] = 0
    jac_[15,76] = 0
    jac_[15,77] = 0
    jac_[15,78] = 0
    jac_[15,79] = 0
    jac_[15,80] = 0
    jac_[15,81] = 0
    jac_[15,82] = 0
    jac_[15,83] = 0
    jac_[15,84] = 0
    jac_[15,85] = 0
    jac_[15,86] = 0
    jac_[15,87] = 0
    jac_[15,88] = 0
    jac_[15,89] = 0
    jac_[15,90] = 0
    jac_[15,91] = 0
    jac_[15,92] = 0
    jac_[15,93] = 0
    jac_[15,94] = 0
    jac_[15,95] = 0
    jac_[15,96] = 0
    jac_[15,97] = 0
    jac_[15,98] = 0
    jac_[15,99] = 0
    jac_[16,1] = 0
    jac_[16,2] = 0
    jac_[16,3] = 0
    jac_[16,4] = 0
    jac_[16,5] = 0
    jac_[16,6] = 0
    jac_[16,7] = 0
    jac_[16,8] = 0
    jac_[16,9] = 0
    jac_[16,10] = 0
    jac_[16,11] = 0
    jac_[16,12] = 0
    jac_[16,13] = 0
    jac_[16,14] = kf_R88*pARPP21
    jac_[16,15] = 0
    jac_[16,16] = -kr_R88-kf_R87
    jac_[16,17] = 0
    jac_[16,18] = 0
    jac_[16,19] = 0
    jac_[16,20] = 0
    jac_[16,21] = 0
    jac_[16,22] = 0
    jac_[16,23] = 0
    jac_[16,24] = 0
    jac_[16,25] = 0
    jac_[16,26] = 0
    jac_[16,27] = 0
    jac_[16,28] = 0
    jac_[16,29] = 0
    jac_[16,30] = 0
    jac_[16,31] = 0
    jac_[16,32] = 0
    jac_[16,33] = 0
    jac_[16,34] = 0
    jac_[16,35] = 0
    jac_[16,36] = 0
    jac_[16,37] = 0
    jac_[16,38] = 0
    jac_[16,39] = 0
    jac_[16,40] = 0
    jac_[16,41] = 0
    jac_[16,42] = 0
    jac_[16,43] = 0
    jac_[16,44] = 0
    jac_[16,45] = 0
    jac_[16,46] = 0
    jac_[16,47] = 0
    jac_[16,48] = 0
    jac_[16,49] = 0
    jac_[16,50] = 0
    jac_[16,51] = 0
    jac_[16,52] = 0
    jac_[16,53] = 0
    jac_[16,54] = 0
    jac_[16,55] = 0
    jac_[16,56] = 0
    jac_[16,57] = 0
    jac_[16,58] = 0
    jac_[16,59] = 0
    jac_[16,60] = 0
    jac_[16,61] = 0
    jac_[16,62] = 0
    jac_[16,63] = 0
    jac_[16,64] = 0
    jac_[16,65] = 0
    jac_[16,66] = 0
    jac_[16,67] = 0
    jac_[16,68] = 0
    jac_[16,69] = 0
    jac_[16,70] = 0
    jac_[16,71] = 0
    jac_[16,72] = 0
    jac_[16,73] = 0
    jac_[16,74] = 0
    jac_[16,75] = 0
    jac_[16,76] = 0
    jac_[16,77] = 0
    jac_[16,78] = 0
    jac_[16,79] = 0
    jac_[16,80] = 0
    jac_[16,81] = 0
    jac_[16,82] = 0
    jac_[16,83] = 0
    jac_[16,84] = 0
    jac_[16,85] = 0
    jac_[16,86] = 0
    jac_[16,87] = 0
    jac_[16,88] = 0
    jac_[16,89] = 0
    jac_[16,90] = 0
    jac_[16,91] = B56PP2Ap*kf_R88
    jac_[16,92] = 0
    jac_[16,93] = 0
    jac_[16,94] = 0
    jac_[16,95] = 0
    jac_[16,96] = 0
    jac_[16,97] = 0
    jac_[16,98] = 0
    jac_[16,99] = 0
    jac_[17,1] = 0
    jac_[17,2] = 0
    jac_[17,3] = 0
    jac_[17,4] = 0
    jac_[17,5] = 0
    jac_[17,6] = 0
    jac_[17,7] = 0
    jac_[17,8] = 0
    jac_[17,9] = 0
    jac_[17,10] = 0
    jac_[17,11] = 0
    jac_[17,12] = 0
    jac_[17,13] = 0
    jac_[17,14] = 0
    jac_[17,15] = 0
    jac_[17,16] = 0
    jac_[17,17] = -kf_R16*Ca-D32p34*kf_R35-kf_R86*pARPP21-kf_R18*D32p75
    jac_[17,18] = kf_R33+kr_R35
    jac_[17,19] = kr_R18+kf_R21
    jac_[17,20] = kf_R85+kr_R86
    jac_[17,21] = 0
    jac_[17,22] = 0
    jac_[17,23] = kr_R16
    jac_[17,24] = 0
    jac_[17,25] = -B72PP2A*kf_R16
    jac_[17,26] = 0
    jac_[17,27] = 0
    jac_[17,28] = 0
    jac_[17,29] = 0
    jac_[17,30] = 0
    jac_[17,31] = 0
    jac_[17,32] = 0
    jac_[17,33] = 0
    jac_[17,34] = 0
    jac_[17,35] = 0
    jac_[17,36] = 0
    jac_[17,37] = 0
    jac_[17,38] = 0
    jac_[17,39] = 0
    jac_[17,40] = 0
    jac_[17,41] = 0
    jac_[17,42] = 0
    jac_[17,43] = 0
    jac_[17,44] = 0
    jac_[17,45] = 0
    jac_[17,46] = -B72PP2A*kf_R35
    jac_[17,47] = -kf_R18*B72PP2A
    jac_[17,48] = 0
    jac_[17,49] = 0
    jac_[17,50] = 0
    jac_[17,51] = 0
    jac_[17,52] = 0
    jac_[17,53] = 0
    jac_[17,54] = 0
    jac_[17,55] = 0
    jac_[17,56] = 0
    jac_[17,57] = 0
    jac_[17,58] = 0
    jac_[17,59] = 0
    jac_[17,60] = 0
    jac_[17,61] = 0
    jac_[17,62] = 0
    jac_[17,63] = 0
    jac_[17,64] = 0
    jac_[17,65] = 0
    jac_[17,66] = 0
    jac_[17,67] = 0
    jac_[17,68] = 0
    jac_[17,69] = 0
    jac_[17,70] = 0
    jac_[17,71] = 0
    jac_[17,72] = 0
    jac_[17,73] = 0
    jac_[17,74] = 0
    jac_[17,75] = 0
    jac_[17,76] = 0
    jac_[17,77] = 0
    jac_[17,78] = 0
    jac_[17,79] = 0
    jac_[17,80] = 0
    jac_[17,81] = 0
    jac_[17,82] = 0
    jac_[17,83] = 0
    jac_[17,84] = 0
    jac_[17,85] = 0
    jac_[17,86] = 0
    jac_[17,87] = 0
    jac_[17,88] = 0
    jac_[17,89] = 0
    jac_[17,90] = 0
    jac_[17,91] = -B72PP2A*kf_R86
    jac_[17,92] = 0
    jac_[17,93] = 0
    jac_[17,94] = 0
    jac_[17,95] = 0
    jac_[17,96] = 0
    jac_[17,97] = 0
    jac_[17,98] = 0
    jac_[17,99] = 0
    jac_[18,1] = 0
    jac_[18,2] = 0
    jac_[18,3] = 0
    jac_[18,4] = 0
    jac_[18,5] = 0
    jac_[18,6] = 0
    jac_[18,7] = 0
    jac_[18,8] = 0
    jac_[18,9] = 0
    jac_[18,10] = 0
    jac_[18,11] = 0
    jac_[18,12] = 0
    jac_[18,13] = 0
    jac_[18,14] = 0
    jac_[18,15] = 0
    jac_[18,16] = 0
    jac_[18,17] = D32p34*kf_R35
    jac_[18,18] = -kf_R33-kr_R35
    jac_[18,19] = 0
    jac_[18,20] = 0
    jac_[18,21] = 0
    jac_[18,22] = 0
    jac_[18,23] = 0
    jac_[18,24] = 0
    jac_[18,25] = 0
    jac_[18,26] = 0
    jac_[18,27] = 0
    jac_[18,28] = 0
    jac_[18,29] = 0
    jac_[18,30] = 0
    jac_[18,31] = 0
    jac_[18,32] = 0
    jac_[18,33] = 0
    jac_[18,34] = 0
    jac_[18,35] = 0
    jac_[18,36] = 0
    jac_[18,37] = 0
    jac_[18,38] = 0
    jac_[18,39] = 0
    jac_[18,40] = 0
    jac_[18,41] = 0
    jac_[18,42] = 0
    jac_[18,43] = 0
    jac_[18,44] = 0
    jac_[18,45] = 0
    jac_[18,46] = B72PP2A*kf_R35
    jac_[18,47] = 0
    jac_[18,48] = 0
    jac_[18,49] = 0
    jac_[18,50] = 0
    jac_[18,51] = 0
    jac_[18,52] = 0
    jac_[18,53] = 0
    jac_[18,54] = 0
    jac_[18,55] = 0
    jac_[18,56] = 0
    jac_[18,57] = 0
    jac_[18,58] = 0
    jac_[18,59] = 0
    jac_[18,60] = 0
    jac_[18,61] = 0
    jac_[18,62] = 0
    jac_[18,63] = 0
    jac_[18,64] = 0
    jac_[18,65] = 0
    jac_[18,66] = 0
    jac_[18,67] = 0
    jac_[18,68] = 0
    jac_[18,69] = 0
    jac_[18,70] = 0
    jac_[18,71] = 0
    jac_[18,72] = 0
    jac_[18,73] = 0
    jac_[18,74] = 0
    jac_[18,75] = 0
    jac_[18,76] = 0
    jac_[18,77] = 0
    jac_[18,78] = 0
    jac_[18,79] = 0
    jac_[18,80] = 0
    jac_[18,81] = 0
    jac_[18,82] = 0
    jac_[18,83] = 0
    jac_[18,84] = 0
    jac_[18,85] = 0
    jac_[18,86] = 0
    jac_[18,87] = 0
    jac_[18,88] = 0
    jac_[18,89] = 0
    jac_[18,90] = 0
    jac_[18,91] = 0
    jac_[18,92] = 0
    jac_[18,93] = 0
    jac_[18,94] = 0
    jac_[18,95] = 0
    jac_[18,96] = 0
    jac_[18,97] = 0
    jac_[18,98] = 0
    jac_[18,99] = 0
    jac_[19,1] = 0
    jac_[19,2] = 0
    jac_[19,3] = 0
    jac_[19,4] = 0
    jac_[19,5] = 0
    jac_[19,6] = 0
    jac_[19,7] = 0
    jac_[19,8] = 0
    jac_[19,9] = 0
    jac_[19,10] = 0
    jac_[19,11] = 0
    jac_[19,12] = 0
    jac_[19,13] = 0
    jac_[19,14] = 0
    jac_[19,15] = 0
    jac_[19,16] = 0
    jac_[19,17] = kf_R18*D32p75
    jac_[19,18] = 0
    jac_[19,19] = -kr_R18-kf_R21
    jac_[19,20] = 0
    jac_[19,21] = 0
    jac_[19,22] = 0
    jac_[19,23] = 0
    jac_[19,24] = 0
    jac_[19,25] = 0
    jac_[19,26] = 0
    jac_[19,27] = 0
    jac_[19,28] = 0
    jac_[19,29] = 0
    jac_[19,30] = 0
    jac_[19,31] = 0
    jac_[19,32] = 0
    jac_[19,33] = 0
    jac_[19,34] = 0
    jac_[19,35] = 0
    jac_[19,36] = 0
    jac_[19,37] = 0
    jac_[19,38] = 0
    jac_[19,39] = 0
    jac_[19,40] = 0
    jac_[19,41] = 0
    jac_[19,42] = 0
    jac_[19,43] = 0
    jac_[19,44] = 0
    jac_[19,45] = 0
    jac_[19,46] = 0
    jac_[19,47] = kf_R18*B72PP2A
    jac_[19,48] = 0
    jac_[19,49] = 0
    jac_[19,50] = 0
    jac_[19,51] = 0
    jac_[19,52] = 0
    jac_[19,53] = 0
    jac_[19,54] = 0
    jac_[19,55] = 0
    jac_[19,56] = 0
    jac_[19,57] = 0
    jac_[19,58] = 0
    jac_[19,59] = 0
    jac_[19,60] = 0
    jac_[19,61] = 0
    jac_[19,62] = 0
    jac_[19,63] = 0
    jac_[19,64] = 0
    jac_[19,65] = 0
    jac_[19,66] = 0
    jac_[19,67] = 0
    jac_[19,68] = 0
    jac_[19,69] = 0
    jac_[19,70] = 0
    jac_[19,71] = 0
    jac_[19,72] = 0
    jac_[19,73] = 0
    jac_[19,74] = 0
    jac_[19,75] = 0
    jac_[19,76] = 0
    jac_[19,77] = 0
    jac_[19,78] = 0
    jac_[19,79] = 0
    jac_[19,80] = 0
    jac_[19,81] = 0
    jac_[19,82] = 0
    jac_[19,83] = 0
    jac_[19,84] = 0
    jac_[19,85] = 0
    jac_[19,86] = 0
    jac_[19,87] = 0
    jac_[19,88] = 0
    jac_[19,89] = 0
    jac_[19,90] = 0
    jac_[19,91] = 0
    jac_[19,92] = 0
    jac_[19,93] = 0
    jac_[19,94] = 0
    jac_[19,95] = 0
    jac_[19,96] = 0
    jac_[19,97] = 0
    jac_[19,98] = 0
    jac_[19,99] = 0
    jac_[20,1] = 0
    jac_[20,2] = 0
    jac_[20,3] = 0
    jac_[20,4] = 0
    jac_[20,5] = 0
    jac_[20,6] = 0
    jac_[20,7] = 0
    jac_[20,8] = 0
    jac_[20,9] = 0
    jac_[20,10] = 0
    jac_[20,11] = 0
    jac_[20,12] = 0
    jac_[20,13] = 0
    jac_[20,14] = 0
    jac_[20,15] = 0
    jac_[20,16] = 0
    jac_[20,17] = kf_R86*pARPP21
    jac_[20,18] = 0
    jac_[20,19] = 0
    jac_[20,20] = -kf_R85-kr_R86
    jac_[20,21] = 0
    jac_[20,22] = 0
    jac_[20,23] = 0
    jac_[20,24] = 0
    jac_[20,25] = 0
    jac_[20,26] = 0
    jac_[20,27] = 0
    jac_[20,28] = 0
    jac_[20,29] = 0
    jac_[20,30] = 0
    jac_[20,31] = 0
    jac_[20,32] = 0
    jac_[20,33] = 0
    jac_[20,34] = 0
    jac_[20,35] = 0
    jac_[20,36] = 0
    jac_[20,37] = 0
    jac_[20,38] = 0
    jac_[20,39] = 0
    jac_[20,40] = 0
    jac_[20,41] = 0
    jac_[20,42] = 0
    jac_[20,43] = 0
    jac_[20,44] = 0
    jac_[20,45] = 0
    jac_[20,46] = 0
    jac_[20,47] = 0
    jac_[20,48] = 0
    jac_[20,49] = 0
    jac_[20,50] = 0
    jac_[20,51] = 0
    jac_[20,52] = 0
    jac_[20,53] = 0
    jac_[20,54] = 0
    jac_[20,55] = 0
    jac_[20,56] = 0
    jac_[20,57] = 0
    jac_[20,58] = 0
    jac_[20,59] = 0
    jac_[20,60] = 0
    jac_[20,61] = 0
    jac_[20,62] = 0
    jac_[20,63] = 0
    jac_[20,64] = 0
    jac_[20,65] = 0
    jac_[20,66] = 0
    jac_[20,67] = 0
    jac_[20,68] = 0
    jac_[20,69] = 0
    jac_[20,70] = 0
    jac_[20,71] = 0
    jac_[20,72] = 0
    jac_[20,73] = 0
    jac_[20,74] = 0
    jac_[20,75] = 0
    jac_[20,76] = 0
    jac_[20,77] = 0
    jac_[20,78] = 0
    jac_[20,79] = 0
    jac_[20,80] = 0
    jac_[20,81] = 0
    jac_[20,82] = 0
    jac_[20,83] = 0
    jac_[20,84] = 0
    jac_[20,85] = 0
    jac_[20,86] = 0
    jac_[20,87] = 0
    jac_[20,88] = 0
    jac_[20,89] = 0
    jac_[20,90] = 0
    jac_[20,91] = B72PP2A*kf_R86
    jac_[20,92] = 0
    jac_[20,93] = 0
    jac_[20,94] = 0
    jac_[20,95] = 0
    jac_[20,96] = 0
    jac_[20,97] = 0
    jac_[20,98] = 0
    jac_[20,99] = 0
    jac_[21,1] = 0
    jac_[21,2] = 0
    jac_[21,3] = 0
    jac_[21,4] = 0
    jac_[21,5] = 0
    jac_[21,6] = 0
    jac_[21,7] = 0
    jac_[21,8] = 0
    jac_[21,9] = 0
    jac_[21,10] = 0
    jac_[21,11] = 0
    jac_[21,12] = 0
    jac_[21,13] = 0
    jac_[21,14] = 0
    jac_[21,15] = 0
    jac_[21,16] = 0
    jac_[21,17] = 0
    jac_[21,18] = 0
    jac_[21,19] = 0
    jac_[21,20] = 0
    jac_[21,21] = -kr_R34-kf_R32
    jac_[21,22] = 0
    jac_[21,23] = kf_R34*D32p34
    jac_[21,24] = 0
    jac_[21,25] = 0
    jac_[21,26] = 0
    jac_[21,27] = 0
    jac_[21,28] = 0
    jac_[21,29] = 0
    jac_[21,30] = 0
    jac_[21,31] = 0
    jac_[21,32] = 0
    jac_[21,33] = 0
    jac_[21,34] = 0
    jac_[21,35] = 0
    jac_[21,36] = 0
    jac_[21,37] = 0
    jac_[21,38] = 0
    jac_[21,39] = 0
    jac_[21,40] = 0
    jac_[21,41] = 0
    jac_[21,42] = 0
    jac_[21,43] = 0
    jac_[21,44] = 0
    jac_[21,45] = 0
    jac_[21,46] = B72PP2A_Ca*kf_R34
    jac_[21,47] = 0
    jac_[21,48] = 0
    jac_[21,49] = 0
    jac_[21,50] = 0
    jac_[21,51] = 0
    jac_[21,52] = 0
    jac_[21,53] = 0
    jac_[21,54] = 0
    jac_[21,55] = 0
    jac_[21,56] = 0
    jac_[21,57] = 0
    jac_[21,58] = 0
    jac_[21,59] = 0
    jac_[21,60] = 0
    jac_[21,61] = 0
    jac_[21,62] = 0
    jac_[21,63] = 0
    jac_[21,64] = 0
    jac_[21,65] = 0
    jac_[21,66] = 0
    jac_[21,67] = 0
    jac_[21,68] = 0
    jac_[21,69] = 0
    jac_[21,70] = 0
    jac_[21,71] = 0
    jac_[21,72] = 0
    jac_[21,73] = 0
    jac_[21,74] = 0
    jac_[21,75] = 0
    jac_[21,76] = 0
    jac_[21,77] = 0
    jac_[21,78] = 0
    jac_[21,79] = 0
    jac_[21,80] = 0
    jac_[21,81] = 0
    jac_[21,82] = 0
    jac_[21,83] = 0
    jac_[21,84] = 0
    jac_[21,85] = 0
    jac_[21,86] = 0
    jac_[21,87] = 0
    jac_[21,88] = 0
    jac_[21,89] = 0
    jac_[21,90] = 0
    jac_[21,91] = 0
    jac_[21,92] = 0
    jac_[21,93] = 0
    jac_[21,94] = 0
    jac_[21,95] = 0
    jac_[21,96] = 0
    jac_[21,97] = 0
    jac_[21,98] = 0
    jac_[21,99] = 0
    jac_[22,1] = 0
    jac_[22,2] = 0
    jac_[22,3] = 0
    jac_[22,4] = 0
    jac_[22,5] = 0
    jac_[22,6] = 0
    jac_[22,7] = 0
    jac_[22,8] = 0
    jac_[22,9] = 0
    jac_[22,10] = 0
    jac_[22,11] = 0
    jac_[22,12] = 0
    jac_[22,13] = 0
    jac_[22,14] = 0
    jac_[22,15] = 0
    jac_[22,16] = 0
    jac_[22,17] = 0
    jac_[22,18] = 0
    jac_[22,19] = 0
    jac_[22,20] = 0
    jac_[22,21] = 0
    jac_[22,22] = -kf_R22-kr_R19
    jac_[22,23] = kf_R19*D32p75
    jac_[22,24] = 0
    jac_[22,25] = 0
    jac_[22,26] = 0
    jac_[22,27] = 0
    jac_[22,28] = 0
    jac_[22,29] = 0
    jac_[22,30] = 0
    jac_[22,31] = 0
    jac_[22,32] = 0
    jac_[22,33] = 0
    jac_[22,34] = 0
    jac_[22,35] = 0
    jac_[22,36] = 0
    jac_[22,37] = 0
    jac_[22,38] = 0
    jac_[22,39] = 0
    jac_[22,40] = 0
    jac_[22,41] = 0
    jac_[22,42] = 0
    jac_[22,43] = 0
    jac_[22,44] = 0
    jac_[22,45] = 0
    jac_[22,46] = 0
    jac_[22,47] = B72PP2A_Ca*kf_R19
    jac_[22,48] = 0
    jac_[22,49] = 0
    jac_[22,50] = 0
    jac_[22,51] = 0
    jac_[22,52] = 0
    jac_[22,53] = 0
    jac_[22,54] = 0
    jac_[22,55] = 0
    jac_[22,56] = 0
    jac_[22,57] = 0
    jac_[22,58] = 0
    jac_[22,59] = 0
    jac_[22,60] = 0
    jac_[22,61] = 0
    jac_[22,62] = 0
    jac_[22,63] = 0
    jac_[22,64] = 0
    jac_[22,65] = 0
    jac_[22,66] = 0
    jac_[22,67] = 0
    jac_[22,68] = 0
    jac_[22,69] = 0
    jac_[22,70] = 0
    jac_[22,71] = 0
    jac_[22,72] = 0
    jac_[22,73] = 0
    jac_[22,74] = 0
    jac_[22,75] = 0
    jac_[22,76] = 0
    jac_[22,77] = 0
    jac_[22,78] = 0
    jac_[22,79] = 0
    jac_[22,80] = 0
    jac_[22,81] = 0
    jac_[22,82] = 0
    jac_[22,83] = 0
    jac_[22,84] = 0
    jac_[22,85] = 0
    jac_[22,86] = 0
    jac_[22,87] = 0
    jac_[22,88] = 0
    jac_[22,89] = 0
    jac_[22,90] = 0
    jac_[22,91] = 0
    jac_[22,92] = 0
    jac_[22,93] = 0
    jac_[22,94] = 0
    jac_[22,95] = 0
    jac_[22,96] = 0
    jac_[22,97] = 0
    jac_[22,98] = 0
    jac_[22,99] = 0
    jac_[23,1] = 0
    jac_[23,2] = 0
    jac_[23,3] = 0
    jac_[23,4] = 0
    jac_[23,5] = 0
    jac_[23,6] = 0
    jac_[23,7] = 0
    jac_[23,8] = 0
    jac_[23,9] = 0
    jac_[23,10] = 0
    jac_[23,11] = 0
    jac_[23,12] = 0
    jac_[23,13] = 0
    jac_[23,14] = 0
    jac_[23,15] = 0
    jac_[23,16] = 0
    jac_[23,17] = kf_R16*Ca
    jac_[23,18] = 0
    jac_[23,19] = 0
    jac_[23,20] = 0
    jac_[23,21] = kr_R34+kf_R32
    jac_[23,22] = kf_R22+kr_R19
    jac_[23,23] = -kf_R84*pARPP21-kf_R19*D32p75-kf_R34*D32p34-kr_R16
    jac_[23,24] = kf_R83+kr_R84
    jac_[23,25] = B72PP2A*kf_R16
    jac_[23,26] = 0
    jac_[23,27] = 0
    jac_[23,28] = 0
    jac_[23,29] = 0
    jac_[23,30] = 0
    jac_[23,31] = 0
    jac_[23,32] = 0
    jac_[23,33] = 0
    jac_[23,34] = 0
    jac_[23,35] = 0
    jac_[23,36] = 0
    jac_[23,37] = 0
    jac_[23,38] = 0
    jac_[23,39] = 0
    jac_[23,40] = 0
    jac_[23,41] = 0
    jac_[23,42] = 0
    jac_[23,43] = 0
    jac_[23,44] = 0
    jac_[23,45] = 0
    jac_[23,46] = -B72PP2A_Ca*kf_R34
    jac_[23,47] = -B72PP2A_Ca*kf_R19
    jac_[23,48] = 0
    jac_[23,49] = 0
    jac_[23,50] = 0
    jac_[23,51] = 0
    jac_[23,52] = 0
    jac_[23,53] = 0
    jac_[23,54] = 0
    jac_[23,55] = 0
    jac_[23,56] = 0
    jac_[23,57] = 0
    jac_[23,58] = 0
    jac_[23,59] = 0
    jac_[23,60] = 0
    jac_[23,61] = 0
    jac_[23,62] = 0
    jac_[23,63] = 0
    jac_[23,64] = 0
    jac_[23,65] = 0
    jac_[23,66] = 0
    jac_[23,67] = 0
    jac_[23,68] = 0
    jac_[23,69] = 0
    jac_[23,70] = 0
    jac_[23,71] = 0
    jac_[23,72] = 0
    jac_[23,73] = 0
    jac_[23,74] = 0
    jac_[23,75] = 0
    jac_[23,76] = 0
    jac_[23,77] = 0
    jac_[23,78] = 0
    jac_[23,79] = 0
    jac_[23,80] = 0
    jac_[23,81] = 0
    jac_[23,82] = 0
    jac_[23,83] = 0
    jac_[23,84] = 0
    jac_[23,85] = 0
    jac_[23,86] = 0
    jac_[23,87] = 0
    jac_[23,88] = 0
    jac_[23,89] = 0
    jac_[23,90] = 0
    jac_[23,91] = -B72PP2A_Ca*kf_R84
    jac_[23,92] = 0
    jac_[23,93] = 0
    jac_[23,94] = 0
    jac_[23,95] = 0
    jac_[23,96] = 0
    jac_[23,97] = 0
    jac_[23,98] = 0
    jac_[23,99] = 0
    jac_[24,1] = 0
    jac_[24,2] = 0
    jac_[24,3] = 0
    jac_[24,4] = 0
    jac_[24,5] = 0
    jac_[24,6] = 0
    jac_[24,7] = 0
    jac_[24,8] = 0
    jac_[24,9] = 0
    jac_[24,10] = 0
    jac_[24,11] = 0
    jac_[24,12] = 0
    jac_[24,13] = 0
    jac_[24,14] = 0
    jac_[24,15] = 0
    jac_[24,16] = 0
    jac_[24,17] = 0
    jac_[24,18] = 0
    jac_[24,19] = 0
    jac_[24,20] = 0
    jac_[24,21] = 0
    jac_[24,22] = 0
    jac_[24,23] = kf_R84*pARPP21
    jac_[24,24] = -kf_R83-kr_R84
    jac_[24,25] = 0
    jac_[24,26] = 0
    jac_[24,27] = 0
    jac_[24,28] = 0
    jac_[24,29] = 0
    jac_[24,30] = 0
    jac_[24,31] = 0
    jac_[24,32] = 0
    jac_[24,33] = 0
    jac_[24,34] = 0
    jac_[24,35] = 0
    jac_[24,36] = 0
    jac_[24,37] = 0
    jac_[24,38] = 0
    jac_[24,39] = 0
    jac_[24,40] = 0
    jac_[24,41] = 0
    jac_[24,42] = 0
    jac_[24,43] = 0
    jac_[24,44] = 0
    jac_[24,45] = 0
    jac_[24,46] = 0
    jac_[24,47] = 0
    jac_[24,48] = 0
    jac_[24,49] = 0
    jac_[24,50] = 0
    jac_[24,51] = 0
    jac_[24,52] = 0
    jac_[24,53] = 0
    jac_[24,54] = 0
    jac_[24,55] = 0
    jac_[24,56] = 0
    jac_[24,57] = 0
    jac_[24,58] = 0
    jac_[24,59] = 0
    jac_[24,60] = 0
    jac_[24,61] = 0
    jac_[24,62] = 0
    jac_[24,63] = 0
    jac_[24,64] = 0
    jac_[24,65] = 0
    jac_[24,66] = 0
    jac_[24,67] = 0
    jac_[24,68] = 0
    jac_[24,69] = 0
    jac_[24,70] = 0
    jac_[24,71] = 0
    jac_[24,72] = 0
    jac_[24,73] = 0
    jac_[24,74] = 0
    jac_[24,75] = 0
    jac_[24,76] = 0
    jac_[24,77] = 0
    jac_[24,78] = 0
    jac_[24,79] = 0
    jac_[24,80] = 0
    jac_[24,81] = 0
    jac_[24,82] = 0
    jac_[24,83] = 0
    jac_[24,84] = 0
    jac_[24,85] = 0
    jac_[24,86] = 0
    jac_[24,87] = 0
    jac_[24,88] = 0
    jac_[24,89] = 0
    jac_[24,90] = 0
    jac_[24,91] = B72PP2A_Ca*kf_R84
    jac_[24,92] = 0
    jac_[24,93] = 0
    jac_[24,94] = 0
    jac_[24,95] = 0
    jac_[24,96] = 0
    jac_[24,97] = 0
    jac_[24,98] = 0
    jac_[24,99] = 0
    jac_[25,1] = -kf_R28*Ca
    jac_[25,2] = -Ca*kf_R54
    jac_[25,3] = kr_R28
    jac_[25,4] = kr_R54
    jac_[25,5] = 0
    jac_[25,6] = 0
    jac_[25,7] = 0
    jac_[25,8] = 0
    jac_[25,9] = 0
    jac_[25,10] = 0
    jac_[25,11] = 0
    jac_[25,12] = 0
    jac_[25,13] = 0
    jac_[25,14] = 0
    jac_[25,15] = 0
    jac_[25,16] = 0
    jac_[25,17] = -kf_R16*Ca
    jac_[25,18] = 0
    jac_[25,19] = 0
    jac_[25,20] = 0
    jac_[25,21] = 0
    jac_[25,22] = 0
    jac_[25,23] = kr_R16
    jac_[25,24] = 0
    jac_[25,25] = -kf_R73*CaMKII_CaM_Ca2-kf_R5*CaM-kf_R115*pCaMKII_CaM_psd-CaMKII_CaM*kf_R74-CaMKII_CaM_psd*kf_R124-pCaMKII_CaM_Ca2_psd*kf_R116-CaM_Ca2*kf_R24-pCaMKII_CaM*kf_R76-kf_R123*CaMKII_CaM_Ca2_psd-AC5*kf_R28-B72PP2A*kf_R16-PP2B_CaM*kf_R25-AC5_ATP*kf_R54-kf_R75*pCaMKII_CaM_Ca2-kf_R26*PP2B_CaM_Ca2
    jac_[25,26] = -Ca*kf_R5
    jac_[25,27] = kr_R5-Ca*kf_R24
    jac_[25,28] = kr_R24
    jac_[25,29] = 0
    jac_[25,30] = 0
    jac_[25,31] = kr_R73
    jac_[25,32] = -Ca*kf_R74
    jac_[25,33] = -kf_R73*Ca+kr_R74
    jac_[25,34] = kr_R124-Ca*kf_R123
    jac_[25,35] = -kf_R124*Ca
    jac_[25,36] = kr_R123
    jac_[25,37] = 0
    jac_[25,38] = 0
    jac_[25,39] = 0
    jac_[25,40] = 0
    jac_[25,41] = 0
    jac_[25,42] = 0
    jac_[25,43] = 0
    jac_[25,44] = 0
    jac_[25,45] = 0
    jac_[25,46] = 0
    jac_[25,47] = 0
    jac_[25,48] = 0
    jac_[25,49] = 0
    jac_[25,50] = 0
    jac_[25,51] = 0
    jac_[25,52] = 0
    jac_[25,53] = 0
    jac_[25,54] = 0
    jac_[25,55] = kr_R75
    jac_[25,56] = -Ca*kf_R76
    jac_[25,57] = kr_R76-kf_R75*Ca
    jac_[25,58] = kr_R115-Ca*kf_R116
    jac_[25,59] = -kf_R115*Ca
    jac_[25,60] = kr_R116
    jac_[25,61] = 0
    jac_[25,62] = 0
    jac_[25,63] = 0
    jac_[25,64] = 0
    jac_[25,65] = 0
    jac_[25,66] = 0
    jac_[25,67] = 0
    jac_[25,68] = 0
    jac_[25,69] = 0
    jac_[25,70] = 0
    jac_[25,71] = 0
    jac_[25,72] = 0
    jac_[25,73] = 0
    jac_[25,74] = 0
    jac_[25,75] = 0
    jac_[25,76] = 0
    jac_[25,77] = 0
    jac_[25,78] = 0
    jac_[25,79] = 0
    jac_[25,80] = 0
    jac_[25,81] = 0
    jac_[25,82] = 0
    jac_[25,83] = 0
    jac_[25,84] = 0
    jac_[25,85] = 0
    jac_[25,86] = 0
    jac_[25,87] = kr_R26
    jac_[25,88] = 0
    jac_[25,89] = -kf_R25*Ca
    jac_[25,90] = -kf_R26*Ca+kr_R25
    jac_[25,91] = 0
    jac_[25,92] = 0
    jac_[25,93] = 0
    jac_[25,94] = 0
    jac_[25,95] = 0
    jac_[25,96] = 0
    jac_[25,97] = 0
    jac_[25,98] = 0
    jac_[25,99] = 0
    jac_[26,1] = 0
    jac_[26,2] = 0
    jac_[26,3] = 0
    jac_[26,4] = 0
    jac_[26,5] = 0
    jac_[26,6] = 0
    jac_[26,7] = 0
    jac_[26,8] = 0
    jac_[26,9] = 0
    jac_[26,10] = 0
    jac_[26,11] = 0
    jac_[26,12] = 0
    jac_[26,13] = 0
    jac_[26,14] = 0
    jac_[26,15] = 0
    jac_[26,16] = 0
    jac_[26,17] = 0
    jac_[26,18] = 0
    jac_[26,19] = 0
    jac_[26,20] = 0
    jac_[26,21] = 0
    jac_[26,22] = 0
    jac_[26,23] = 0
    jac_[26,24] = 0
    jac_[26,25] = -kf_R5*CaM
    jac_[26,26] = -PP2B*kf_R6-kf_R122*CaMKII_psd-pCaMKII_psd*kf_R114-pCaMKII*kf_R79-Ca*kf_R5-kf_R72*CaMKII
    jac_[26,27] = kr_R5
    jac_[26,28] = 0
    jac_[26,29] = 0
    jac_[26,30] = -kf_R72*CaM
    jac_[26,31] = 0
    jac_[26,32] = kr_R72
    jac_[26,33] = 0
    jac_[26,34] = 0
    jac_[26,35] = kr_R122
    jac_[26,36] = 0
    jac_[26,37] = -kf_R122*CaM
    jac_[26,38] = 0
    jac_[26,39] = 0
    jac_[26,40] = 0
    jac_[26,41] = 0
    jac_[26,42] = 0
    jac_[26,43] = 0
    jac_[26,44] = 0
    jac_[26,45] = 0
    jac_[26,46] = 0
    jac_[26,47] = 0
    jac_[26,48] = 0
    jac_[26,49] = 0
    jac_[26,50] = 0
    jac_[26,51] = 0
    jac_[26,52] = 0
    jac_[26,53] = 0
    jac_[26,54] = -CaM*kf_R79
    jac_[26,55] = 0
    jac_[26,56] = kr_R79
    jac_[26,57] = 0
    jac_[26,58] = 0
    jac_[26,59] = kr_R114
    jac_[26,60] = 0
    jac_[26,61] = -kf_R114*CaM
    jac_[26,62] = 0
    jac_[26,63] = 0
    jac_[26,64] = 0
    jac_[26,65] = 0
    jac_[26,66] = 0
    jac_[26,67] = 0
    jac_[26,68] = 0
    jac_[26,69] = 0
    jac_[26,70] = 0
    jac_[26,71] = 0
    jac_[26,72] = 0
    jac_[26,73] = 0
    jac_[26,74] = 0
    jac_[26,75] = 0
    jac_[26,76] = 0
    jac_[26,77] = 0
    jac_[26,78] = 0
    jac_[26,79] = 0
    jac_[26,80] = 0
    jac_[26,81] = 0
    jac_[26,82] = 0
    jac_[26,83] = 0
    jac_[26,84] = 0
    jac_[26,85] = 0
    jac_[26,86] = -kf_R6*CaM
    jac_[26,87] = 0
    jac_[26,88] = 0
    jac_[26,89] = kr_R6
    jac_[26,90] = 0
    jac_[26,91] = 0
    jac_[26,92] = 0
    jac_[26,93] = 0
    jac_[26,94] = 0
    jac_[26,95] = 0
    jac_[26,96] = 0
    jac_[26,97] = 0
    jac_[26,98] = 0
    jac_[26,99] = 0
    jac_[27,1] = 0
    jac_[27,2] = 0
    jac_[27,3] = 0
    jac_[27,4] = 0
    jac_[27,5] = 0
    jac_[27,6] = 0
    jac_[27,7] = 0
    jac_[27,8] = 0
    jac_[27,9] = 0
    jac_[27,10] = 0
    jac_[27,11] = 0
    jac_[27,12] = 0
    jac_[27,13] = 0
    jac_[27,14] = 0
    jac_[27,15] = 0
    jac_[27,16] = 0
    jac_[27,17] = 0
    jac_[27,18] = 0
    jac_[27,19] = 0
    jac_[27,20] = 0
    jac_[27,21] = 0
    jac_[27,22] = 0
    jac_[27,23] = 0
    jac_[27,24] = 0
    jac_[27,25] = kf_R5*CaM-CaM_Ca2*kf_R24
    jac_[27,26] = Ca*kf_R5
    jac_[27,27] = -kr_R5-pCaMKII_psd*kf_R113-Ca*kf_R24-CaMKII*kf_R71-kf_R121*CaMKII_psd-pCaMKII*kf_R78-PP2B*kf_R27
    jac_[27,28] = kr_R24
    jac_[27,29] = 0
    jac_[27,30] = -CaM_Ca2*kf_R71
    jac_[27,31] = 0
    jac_[27,32] = 0
    jac_[27,33] = kr_R71
    jac_[27,34] = kr_R121
    jac_[27,35] = 0
    jac_[27,36] = 0
    jac_[27,37] = -kf_R121*CaM_Ca2
    jac_[27,38] = 0
    jac_[27,39] = 0
    jac_[27,40] = 0
    jac_[27,41] = 0
    jac_[27,42] = 0
    jac_[27,43] = 0
    jac_[27,44] = 0
    jac_[27,45] = 0
    jac_[27,46] = 0
    jac_[27,47] = 0
    jac_[27,48] = 0
    jac_[27,49] = 0
    jac_[27,50] = 0
    jac_[27,51] = 0
    jac_[27,52] = 0
    jac_[27,53] = 0
    jac_[27,54] = -kf_R78*CaM_Ca2
    jac_[27,55] = 0
    jac_[27,56] = 0
    jac_[27,57] = kr_R78
    jac_[27,58] = kr_R113
    jac_[27,59] = 0
    jac_[27,60] = 0
    jac_[27,61] = -CaM_Ca2*kf_R113
    jac_[27,62] = 0
    jac_[27,63] = 0
    jac_[27,64] = 0
    jac_[27,65] = 0
    jac_[27,66] = 0
    jac_[27,67] = 0
    jac_[27,68] = 0
    jac_[27,69] = 0
    jac_[27,70] = 0
    jac_[27,71] = 0
    jac_[27,72] = 0
    jac_[27,73] = 0
    jac_[27,74] = 0
    jac_[27,75] = 0
    jac_[27,76] = 0
    jac_[27,77] = 0
    jac_[27,78] = 0
    jac_[27,79] = 0
    jac_[27,80] = 0
    jac_[27,81] = 0
    jac_[27,82] = 0
    jac_[27,83] = 0
    jac_[27,84] = 0
    jac_[27,85] = 0
    jac_[27,86] = -kf_R27*CaM_Ca2
    jac_[27,87] = 0
    jac_[27,88] = 0
    jac_[27,89] = 0
    jac_[27,90] = kr_R27
    jac_[27,91] = 0
    jac_[27,92] = 0
    jac_[27,93] = 0
    jac_[27,94] = 0
    jac_[27,95] = 0
    jac_[27,96] = 0
    jac_[27,97] = 0
    jac_[27,98] = 0
    jac_[27,99] = 0
    jac_[28,1] = 0
    jac_[28,2] = 0
    jac_[28,3] = 0
    jac_[28,4] = 0
    jac_[28,5] = 0
    jac_[28,6] = 0
    jac_[28,7] = 0
    jac_[28,8] = 0
    jac_[28,9] = 0
    jac_[28,10] = 0
    jac_[28,11] = 0
    jac_[28,12] = 0
    jac_[28,13] = 0
    jac_[28,14] = 0
    jac_[28,15] = 0
    jac_[28,16] = 0
    jac_[28,17] = 0
    jac_[28,18] = 0
    jac_[28,19] = 0
    jac_[28,20] = 0
    jac_[28,21] = 0
    jac_[28,22] = 0
    jac_[28,23] = 0
    jac_[28,24] = 0
    jac_[28,25] = CaM_Ca2*kf_R24
    jac_[28,26] = 0
    jac_[28,27] = Ca*kf_R24
    jac_[28,28] = -kr_R24-pCaMKII*kf_R77-PP2B*kf_R7-CaMKII_psd*kf_R120-kf_R70*CaMKII-kf_R82*pARPP21-kf_R112*pCaMKII_psd
    jac_[28,29] = kr_R82
    jac_[28,30] = -CaM_Ca4*kf_R70
    jac_[28,31] = kr_R70
    jac_[28,32] = 0
    jac_[28,33] = 0
    jac_[28,34] = 0
    jac_[28,35] = 0
    jac_[28,36] = kr_R120
    jac_[28,37] = -CaM_Ca4*kf_R120
    jac_[28,38] = 0
    jac_[28,39] = 0
    jac_[28,40] = 0
    jac_[28,41] = 0
    jac_[28,42] = 0
    jac_[28,43] = 0
    jac_[28,44] = 0
    jac_[28,45] = 0
    jac_[28,46] = 0
    jac_[28,47] = 0
    jac_[28,48] = 0
    jac_[28,49] = 0
    jac_[28,50] = 0
    jac_[28,51] = 0
    jac_[28,52] = 0
    jac_[28,53] = 0
    jac_[28,54] = -CaM_Ca4*kf_R77
    jac_[28,55] = kr_R77
    jac_[28,56] = 0
    jac_[28,57] = 0
    jac_[28,58] = 0
    jac_[28,59] = 0
    jac_[28,60] = kr_R112
    jac_[28,61] = -CaM_Ca4*kf_R112
    jac_[28,62] = 0
    jac_[28,63] = 0
    jac_[28,64] = 0
    jac_[28,65] = 0
    jac_[28,66] = 0
    jac_[28,67] = 0
    jac_[28,68] = 0
    jac_[28,69] = 0
    jac_[28,70] = 0
    jac_[28,71] = 0
    jac_[28,72] = 0
    jac_[28,73] = 0
    jac_[28,74] = 0
    jac_[28,75] = 0
    jac_[28,76] = 0
    jac_[28,77] = 0
    jac_[28,78] = 0
    jac_[28,79] = 0
    jac_[28,80] = 0
    jac_[28,81] = 0
    jac_[28,82] = 0
    jac_[28,83] = 0
    jac_[28,84] = 0
    jac_[28,85] = 0
    jac_[28,86] = -CaM_Ca4*kf_R7
    jac_[28,87] = kr_R7
    jac_[28,88] = 0
    jac_[28,89] = 0
    jac_[28,90] = 0
    jac_[28,91] = -CaM_Ca4*kf_R82
    jac_[28,92] = 0
    jac_[28,93] = 0
    jac_[28,94] = 0
    jac_[28,95] = 0
    jac_[28,96] = 0
    jac_[28,97] = 0
    jac_[28,98] = 0
    jac_[28,99] = 0
    jac_[29,1] = 0
    jac_[29,2] = 0
    jac_[29,3] = 0
    jac_[29,4] = 0
    jac_[29,5] = 0
    jac_[29,6] = 0
    jac_[29,7] = 0
    jac_[29,8] = 0
    jac_[29,9] = 0
    jac_[29,10] = 0
    jac_[29,11] = 0
    jac_[29,12] = 0
    jac_[29,13] = 0
    jac_[29,14] = 0
    jac_[29,15] = 0
    jac_[29,16] = 0
    jac_[29,17] = 0
    jac_[29,18] = 0
    jac_[29,19] = 0
    jac_[29,20] = 0
    jac_[29,21] = 0
    jac_[29,22] = 0
    jac_[29,23] = 0
    jac_[29,24] = 0
    jac_[29,25] = 0
    jac_[29,26] = 0
    jac_[29,27] = 0
    jac_[29,28] = kf_R82*pARPP21
    jac_[29,29] = -kr_R82
    jac_[29,30] = 0
    jac_[29,31] = 0
    jac_[29,32] = 0
    jac_[29,33] = 0
    jac_[29,34] = 0
    jac_[29,35] = 0
    jac_[29,36] = 0
    jac_[29,37] = 0
    jac_[29,38] = 0
    jac_[29,39] = 0
    jac_[29,40] = 0
    jac_[29,41] = 0
    jac_[29,42] = 0
    jac_[29,43] = 0
    jac_[29,44] = 0
    jac_[29,45] = 0
    jac_[29,46] = 0
    jac_[29,47] = 0
    jac_[29,48] = 0
    jac_[29,49] = 0
    jac_[29,50] = 0
    jac_[29,51] = 0
    jac_[29,52] = 0
    jac_[29,53] = 0
    jac_[29,54] = 0
    jac_[29,55] = 0
    jac_[29,56] = 0
    jac_[29,57] = 0
    jac_[29,58] = 0
    jac_[29,59] = 0
    jac_[29,60] = 0
    jac_[29,61] = 0
    jac_[29,62] = 0
    jac_[29,63] = 0
    jac_[29,64] = 0
    jac_[29,65] = 0
    jac_[29,66] = 0
    jac_[29,67] = 0
    jac_[29,68] = 0
    jac_[29,69] = 0
    jac_[29,70] = 0
    jac_[29,71] = 0
    jac_[29,72] = 0
    jac_[29,73] = 0
    jac_[29,74] = 0
    jac_[29,75] = 0
    jac_[29,76] = 0
    jac_[29,77] = 0
    jac_[29,78] = 0
    jac_[29,79] = 0
    jac_[29,80] = 0
    jac_[29,81] = 0
    jac_[29,82] = 0
    jac_[29,83] = 0
    jac_[29,84] = 0
    jac_[29,85] = 0
    jac_[29,86] = 0
    jac_[29,87] = 0
    jac_[29,88] = 0
    jac_[29,89] = 0
    jac_[29,90] = 0
    jac_[29,91] = CaM_Ca4*kf_R82
    jac_[29,92] = 0
    jac_[29,93] = 0
    jac_[29,94] = 0
    jac_[29,95] = 0
    jac_[29,96] = 0
    jac_[29,97] = 0
    jac_[29,98] = 0
    jac_[29,99] = 0
    jac_[30,1] = 0
    jac_[30,2] = 0
    jac_[30,3] = 0
    jac_[30,4] = 0
    jac_[30,5] = 0
    jac_[30,6] = 0
    jac_[30,7] = 0
    jac_[30,8] = 0
    jac_[30,9] = 0
    jac_[30,10] = 0
    jac_[30,11] = 0
    jac_[30,12] = 0
    jac_[30,13] = 0
    jac_[30,14] = 0
    jac_[30,15] = 0
    jac_[30,16] = 0
    jac_[30,17] = 0
    jac_[30,18] = 0
    jac_[30,19] = 0
    jac_[30,20] = 0
    jac_[30,21] = 0
    jac_[30,22] = 0
    jac_[30,23] = 0
    jac_[30,24] = 0
    jac_[30,25] = 0
    jac_[30,26] = -kf_R72*CaMKII
    jac_[30,27] = -CaMKII*kf_R71
    jac_[30,28] = -kf_R70*CaMKII
    jac_[30,29] = 0
    jac_[30,30] = -kf_R72*CaM-CaM_Ca2*kf_R71-CaM_Ca4*kf_R70
    jac_[30,31] = kr_R70
    jac_[30,32] = kr_R72
    jac_[30,33] = kr_R71
    jac_[30,34] = 0
    jac_[30,35] = 0
    jac_[30,36] = 0
    jac_[30,37] = kf_R119
    jac_[30,38] = 0
    jac_[30,39] = 0
    jac_[30,40] = 0
    jac_[30,41] = 0
    jac_[30,42] = 0
    jac_[30,43] = 0
    jac_[30,44] = 0
    jac_[30,45] = 0
    jac_[30,46] = 0
    jac_[30,47] = 0
    jac_[30,48] = 0
    jac_[30,49] = 0
    jac_[30,50] = 0
    jac_[30,51] = 0
    jac_[30,52] = 0
    jac_[30,53] = 0
    jac_[30,54] = kf_R95
    jac_[30,55] = 0
    jac_[30,56] = 0
    jac_[30,57] = 0
    jac_[30,58] = 0
    jac_[30,59] = 0
    jac_[30,60] = 0
    jac_[30,61] = 0
    jac_[30,62] = 0
    jac_[30,63] = 0
    jac_[30,64] = 0
    jac_[30,65] = 0
    jac_[30,66] = 0
    jac_[30,67] = 0
    jac_[30,68] = 0
    jac_[30,69] = 0
    jac_[30,70] = 0
    jac_[30,71] = 0
    jac_[30,72] = 0
    jac_[30,73] = 0
    jac_[30,74] = 0
    jac_[30,75] = 0
    jac_[30,76] = 0
    jac_[30,77] = 0
    jac_[30,78] = 0
    jac_[30,79] = 0
    jac_[30,80] = 0
    jac_[30,81] = 0
    jac_[30,82] = 0
    jac_[30,83] = 0
    jac_[30,84] = 0
    jac_[30,85] = 0
    jac_[30,86] = 0
    jac_[30,87] = 0
    jac_[30,88] = 0
    jac_[30,89] = 0
    jac_[30,90] = 0
    jac_[30,91] = 0
    jac_[30,92] = 0
    jac_[30,93] = 0
    jac_[30,94] = 0
    jac_[30,95] = 0
    jac_[30,96] = 0
    jac_[30,97] = 0
    jac_[30,98] = 0
    jac_[30,99] = 0
    jac_[31,1] = 0
    jac_[31,2] = 0
    jac_[31,3] = 0
    jac_[31,4] = 0
    jac_[31,5] = 0
    jac_[31,6] = 0
    jac_[31,7] = 0
    jac_[31,8] = 0
    jac_[31,9] = 0
    jac_[31,10] = 0
    jac_[31,11] = 0
    jac_[31,12] = 0
    jac_[31,13] = 0
    jac_[31,14] = 0
    jac_[31,15] = 0
    jac_[31,16] = 0
    jac_[31,17] = 0
    jac_[31,18] = 0
    jac_[31,19] = 0
    jac_[31,20] = 0
    jac_[31,21] = 0
    jac_[31,22] = 0
    jac_[31,23] = 0
    jac_[31,24] = 0
    jac_[31,25] = kf_R73*CaMKII_CaM_Ca2
    jac_[31,26] = 0
    jac_[31,27] = 0
    jac_[31,28] = kf_R70*CaMKII
    jac_[31,29] = 0
    jac_[31,30] = CaM_Ca4*kf_R70
    jac_[31,31] = -kf_R127-kr_R73-pCaMKII_CaM_Ca4*kf_R133-kr_R70-4*kf_R130*CaMKII_CaM_Ca4
    jac_[31,32] = 0
    jac_[31,33] = kf_R73*Ca
    jac_[31,34] = 0
    jac_[31,35] = 0
    jac_[31,36] = kr_R127
    jac_[31,37] = 0
    jac_[31,38] = 0
    jac_[31,39] = 0
    jac_[31,40] = 0
    jac_[31,41] = 0
    jac_[31,42] = 0
    jac_[31,43] = 0
    jac_[31,44] = 0
    jac_[31,45] = 0
    jac_[31,46] = 0
    jac_[31,47] = 0
    jac_[31,48] = 0
    jac_[31,49] = 0
    jac_[31,50] = 0
    jac_[31,51] = 0
    jac_[31,52] = 0
    jac_[31,53] = 0
    jac_[31,54] = 0
    jac_[31,55] = -kf_R133*CaMKII_CaM_Ca4
    jac_[31,56] = 0
    jac_[31,57] = 0
    jac_[31,58] = 0
    jac_[31,59] = 0
    jac_[31,60] = 0
    jac_[31,61] = 0
    jac_[31,62] = 0
    jac_[31,63] = 0
    jac_[31,64] = 0
    jac_[31,65] = 0
    jac_[31,66] = 0
    jac_[31,67] = 0
    jac_[31,68] = 0
    jac_[31,69] = 0
    jac_[31,70] = 0
    jac_[31,71] = 0
    jac_[31,72] = 0
    jac_[31,73] = 0
    jac_[31,74] = 0
    jac_[31,75] = 0
    jac_[31,76] = 0
    jac_[31,77] = 0
    jac_[31,78] = 0
    jac_[31,79] = 0
    jac_[31,80] = 0
    jac_[31,81] = 0
    jac_[31,82] = 0
    jac_[31,83] = 0
    jac_[31,84] = 2*kr_R130+kf_R131
    jac_[31,85] = kr_R132
    jac_[31,86] = 0
    jac_[31,87] = 0
    jac_[31,88] = 0
    jac_[31,89] = 0
    jac_[31,90] = 0
    jac_[31,91] = 0
    jac_[31,92] = 0
    jac_[31,93] = 0
    jac_[31,94] = 0
    jac_[31,95] = 0
    jac_[31,96] = 0
    jac_[31,97] = 0
    jac_[31,98] = 0
    jac_[31,99] = 0
    jac_[32,1] = 0
    jac_[32,2] = 0
    jac_[32,3] = 0
    jac_[32,4] = 0
    jac_[32,5] = 0
    jac_[32,6] = 0
    jac_[32,7] = 0
    jac_[32,8] = 0
    jac_[32,9] = 0
    jac_[32,10] = 0
    jac_[32,11] = 0
    jac_[32,12] = 0
    jac_[32,13] = 0
    jac_[32,14] = 0
    jac_[32,15] = 0
    jac_[32,16] = 0
    jac_[32,17] = 0
    jac_[32,18] = 0
    jac_[32,19] = 0
    jac_[32,20] = 0
    jac_[32,21] = 0
    jac_[32,22] = 0
    jac_[32,23] = 0
    jac_[32,24] = 0
    jac_[32,25] = -CaMKII_CaM*kf_R74
    jac_[32,26] = kf_R72*CaMKII
    jac_[32,27] = 0
    jac_[32,28] = 0
    jac_[32,29] = 0
    jac_[32,30] = kf_R72*CaM
    jac_[32,31] = 0
    jac_[32,32] = -kr_R72-kf_R125-Ca*kf_R74
    jac_[32,33] = kr_R74
    jac_[32,34] = 0
    jac_[32,35] = kr_R125
    jac_[32,36] = 0
    jac_[32,37] = 0
    jac_[32,38] = 0
    jac_[32,39] = 0
    jac_[32,40] = 0
    jac_[32,41] = 0
    jac_[32,42] = 0
    jac_[32,43] = 0
    jac_[32,44] = 0
    jac_[32,45] = 0
    jac_[32,46] = 0
    jac_[32,47] = 0
    jac_[32,48] = 0
    jac_[32,49] = 0
    jac_[32,50] = 0
    jac_[32,51] = 0
    jac_[32,52] = 0
    jac_[32,53] = 0
    jac_[32,54] = 0
    jac_[32,55] = 0
    jac_[32,56] = 0
    jac_[32,57] = 0
    jac_[32,58] = 0
    jac_[32,59] = 0
    jac_[32,60] = 0
    jac_[32,61] = 0
    jac_[32,62] = 0
    jac_[32,63] = 0
    jac_[32,64] = 0
    jac_[32,65] = 0
    jac_[32,66] = 0
    jac_[32,67] = 0
    jac_[32,68] = 0
    jac_[32,69] = 0
    jac_[32,70] = 0
    jac_[32,71] = 0
    jac_[32,72] = 0
    jac_[32,73] = 0
    jac_[32,74] = 0
    jac_[32,75] = 0
    jac_[32,76] = 0
    jac_[32,77] = 0
    jac_[32,78] = 0
    jac_[32,79] = 0
    jac_[32,80] = 0
    jac_[32,81] = 0
    jac_[32,82] = 0
    jac_[32,83] = 0
    jac_[32,84] = 0
    jac_[32,85] = 0
    jac_[32,86] = 0
    jac_[32,87] = 0
    jac_[32,88] = 0
    jac_[32,89] = 0
    jac_[32,90] = 0
    jac_[32,91] = 0
    jac_[32,92] = 0
    jac_[32,93] = 0
    jac_[32,94] = 0
    jac_[32,95] = 0
    jac_[32,96] = 0
    jac_[32,97] = 0
    jac_[32,98] = 0
    jac_[32,99] = 0
    jac_[33,1] = 0
    jac_[33,2] = 0
    jac_[33,3] = 0
    jac_[33,4] = 0
    jac_[33,5] = 0
    jac_[33,6] = 0
    jac_[33,7] = 0
    jac_[33,8] = 0
    jac_[33,9] = 0
    jac_[33,10] = 0
    jac_[33,11] = 0
    jac_[33,12] = 0
    jac_[33,13] = 0
    jac_[33,14] = 0
    jac_[33,15] = 0
    jac_[33,16] = 0
    jac_[33,17] = 0
    jac_[33,18] = 0
    jac_[33,19] = 0
    jac_[33,20] = 0
    jac_[33,21] = 0
    jac_[33,22] = 0
    jac_[33,23] = 0
    jac_[33,24] = 0
    jac_[33,25] = -kf_R73*CaMKII_CaM_Ca2+CaMKII_CaM*kf_R74
    jac_[33,26] = 0
    jac_[33,27] = CaMKII*kf_R71
    jac_[33,28] = 0
    jac_[33,29] = 0
    jac_[33,30] = CaM_Ca2*kf_R71
    jac_[33,31] = kr_R73
    jac_[33,32] = Ca*kf_R74
    jac_[33,33] = -kr_R71-kf_R73*Ca-kf_R126-kr_R74
    jac_[33,34] = kr_R126
    jac_[33,35] = 0
    jac_[33,36] = 0
    jac_[33,37] = 0
    jac_[33,38] = 0
    jac_[33,39] = 0
    jac_[33,40] = 0
    jac_[33,41] = 0
    jac_[33,42] = 0
    jac_[33,43] = 0
    jac_[33,44] = 0
    jac_[33,45] = 0
    jac_[33,46] = 0
    jac_[33,47] = 0
    jac_[33,48] = 0
    jac_[33,49] = 0
    jac_[33,50] = 0
    jac_[33,51] = 0
    jac_[33,52] = 0
    jac_[33,53] = 0
    jac_[33,54] = 0
    jac_[33,55] = 0
    jac_[33,56] = 0
    jac_[33,57] = 0
    jac_[33,58] = 0
    jac_[33,59] = 0
    jac_[33,60] = 0
    jac_[33,61] = 0
    jac_[33,62] = 0
    jac_[33,63] = 0
    jac_[33,64] = 0
    jac_[33,65] = 0
    jac_[33,66] = 0
    jac_[33,67] = 0
    jac_[33,68] = 0
    jac_[33,69] = 0
    jac_[33,70] = 0
    jac_[33,71] = 0
    jac_[33,72] = 0
    jac_[33,73] = 0
    jac_[33,74] = 0
    jac_[33,75] = 0
    jac_[33,76] = 0
    jac_[33,77] = 0
    jac_[33,78] = 0
    jac_[33,79] = 0
    jac_[33,80] = 0
    jac_[33,81] = 0
    jac_[33,82] = 0
    jac_[33,83] = 0
    jac_[33,84] = 0
    jac_[33,85] = 0
    jac_[33,86] = 0
    jac_[33,87] = 0
    jac_[33,88] = 0
    jac_[33,89] = 0
    jac_[33,90] = 0
    jac_[33,91] = 0
    jac_[33,92] = 0
    jac_[33,93] = 0
    jac_[33,94] = 0
    jac_[33,95] = 0
    jac_[33,96] = 0
    jac_[33,97] = 0
    jac_[33,98] = 0
    jac_[33,99] = 0
    jac_[34,1] = 0
    jac_[34,2] = 0
    jac_[34,3] = 0
    jac_[34,4] = 0
    jac_[34,5] = 0
    jac_[34,6] = 0
    jac_[34,7] = 0
    jac_[34,8] = 0
    jac_[34,9] = 0
    jac_[34,10] = 0
    jac_[34,11] = 0
    jac_[34,12] = 0
    jac_[34,13] = 0
    jac_[34,14] = 0
    jac_[34,15] = 0
    jac_[34,16] = 0
    jac_[34,17] = 0
    jac_[34,18] = 0
    jac_[34,19] = 0
    jac_[34,20] = 0
    jac_[34,21] = 0
    jac_[34,22] = 0
    jac_[34,23] = 0
    jac_[34,24] = 0
    jac_[34,25] = CaMKII_CaM_psd*kf_R124-kf_R123*CaMKII_CaM_Ca2_psd
    jac_[34,26] = 0
    jac_[34,27] = kf_R121*CaMKII_psd
    jac_[34,28] = 0
    jac_[34,29] = 0
    jac_[34,30] = 0
    jac_[34,31] = 0
    jac_[34,32] = 0
    jac_[34,33] = kf_R126
    jac_[34,34] = -Substrate*kf_R104-kr_R124-kr_R121-kr_R126-Ca*kf_R123
    jac_[34,35] = kf_R124*Ca
    jac_[34,36] = kr_R123
    jac_[34,37] = kf_R121*CaM_Ca2
    jac_[34,38] = 0
    jac_[34,39] = -CaMKII_CaM_Ca2_psd*kf_R104
    jac_[34,40] = 0
    jac_[34,41] = 0
    jac_[34,42] = 0
    jac_[34,43] = 0
    jac_[34,44] = 0
    jac_[34,45] = 0
    jac_[34,46] = 0
    jac_[34,47] = 0
    jac_[34,48] = 0
    jac_[34,49] = 0
    jac_[34,50] = 0
    jac_[34,51] = 0
    jac_[34,52] = 0
    jac_[34,53] = 0
    jac_[34,54] = 0
    jac_[34,55] = 0
    jac_[34,56] = 0
    jac_[34,57] = 0
    jac_[34,58] = 0
    jac_[34,59] = 0
    jac_[34,60] = 0
    jac_[34,61] = 0
    jac_[34,62] = 0
    jac_[34,63] = 0
    jac_[34,64] = 0
    jac_[34,65] = 0
    jac_[34,66] = 0
    jac_[34,67] = 0
    jac_[34,68] = 0
    jac_[34,69] = 0
    jac_[34,70] = 0
    jac_[34,71] = 0
    jac_[34,72] = 0
    jac_[34,73] = 0
    jac_[34,74] = 0
    jac_[34,75] = 0
    jac_[34,76] = 0
    jac_[34,77] = 0
    jac_[34,78] = 0
    jac_[34,79] = 0
    jac_[34,80] = 0
    jac_[34,81] = 0
    jac_[34,82] = 0
    jac_[34,83] = 0
    jac_[34,84] = 0
    jac_[34,85] = 0
    jac_[34,86] = 0
    jac_[34,87] = 0
    jac_[34,88] = 0
    jac_[34,89] = 0
    jac_[34,90] = 0
    jac_[34,91] = 0
    jac_[34,92] = 0
    jac_[34,93] = 0
    jac_[34,94] = 0
    jac_[34,95] = 0
    jac_[34,96] = 0
    jac_[34,97] = 0
    jac_[34,98] = kr_R104+kf_R105
    jac_[34,99] = 0
    jac_[35,1] = 0
    jac_[35,2] = 0
    jac_[35,3] = 0
    jac_[35,4] = 0
    jac_[35,5] = 0
    jac_[35,6] = 0
    jac_[35,7] = 0
    jac_[35,8] = 0
    jac_[35,9] = 0
    jac_[35,10] = 0
    jac_[35,11] = 0
    jac_[35,12] = 0
    jac_[35,13] = 0
    jac_[35,14] = 0
    jac_[35,15] = 0
    jac_[35,16] = 0
    jac_[35,17] = 0
    jac_[35,18] = 0
    jac_[35,19] = 0
    jac_[35,20] = 0
    jac_[35,21] = 0
    jac_[35,22] = 0
    jac_[35,23] = 0
    jac_[35,24] = 0
    jac_[35,25] = -CaMKII_CaM_psd*kf_R124
    jac_[35,26] = kf_R122*CaMKII_psd
    jac_[35,27] = 0
    jac_[35,28] = 0
    jac_[35,29] = 0
    jac_[35,30] = 0
    jac_[35,31] = 0
    jac_[35,32] = kf_R125
    jac_[35,33] = 0
    jac_[35,34] = kr_R124
    jac_[35,35] = -kr_R125-kr_R122-kf_R124*Ca-kf_R102*Substrate
    jac_[35,36] = 0
    jac_[35,37] = kf_R122*CaM
    jac_[35,38] = 0
    jac_[35,39] = -kf_R102*CaMKII_CaM_psd
    jac_[35,40] = 0
    jac_[35,41] = 0
    jac_[35,42] = 0
    jac_[35,43] = 0
    jac_[35,44] = 0
    jac_[35,45] = 0
    jac_[35,46] = 0
    jac_[35,47] = 0
    jac_[35,48] = 0
    jac_[35,49] = 0
    jac_[35,50] = 0
    jac_[35,51] = 0
    jac_[35,52] = 0
    jac_[35,53] = 0
    jac_[35,54] = 0
    jac_[35,55] = 0
    jac_[35,56] = 0
    jac_[35,57] = 0
    jac_[35,58] = 0
    jac_[35,59] = 0
    jac_[35,60] = 0
    jac_[35,61] = 0
    jac_[35,62] = 0
    jac_[35,63] = 0
    jac_[35,64] = 0
    jac_[35,65] = 0
    jac_[35,66] = 0
    jac_[35,67] = 0
    jac_[35,68] = 0
    jac_[35,69] = 0
    jac_[35,70] = 0
    jac_[35,71] = 0
    jac_[35,72] = 0
    jac_[35,73] = 0
    jac_[35,74] = 0
    jac_[35,75] = 0
    jac_[35,76] = 0
    jac_[35,77] = 0
    jac_[35,78] = 0
    jac_[35,79] = 0
    jac_[35,80] = 0
    jac_[35,81] = 0
    jac_[35,82] = 0
    jac_[35,83] = 0
    jac_[35,84] = 0
    jac_[35,85] = 0
    jac_[35,86] = 0
    jac_[35,87] = 0
    jac_[35,88] = 0
    jac_[35,89] = 0
    jac_[35,90] = 0
    jac_[35,91] = 0
    jac_[35,92] = 0
    jac_[35,93] = 0
    jac_[35,94] = 0
    jac_[35,95] = 0
    jac_[35,96] = 0
    jac_[35,97] = kr_R102+kf_R103
    jac_[35,98] = 0
    jac_[35,99] = 0
    jac_[36,1] = 0
    jac_[36,2] = 0
    jac_[36,3] = 0
    jac_[36,4] = 0
    jac_[36,5] = 0
    jac_[36,6] = 0
    jac_[36,7] = 0
    jac_[36,8] = 0
    jac_[36,9] = 0
    jac_[36,10] = 0
    jac_[36,11] = 0
    jac_[36,12] = 0
    jac_[36,13] = 0
    jac_[36,14] = 0
    jac_[36,15] = 0
    jac_[36,16] = 0
    jac_[36,17] = 0
    jac_[36,18] = 0
    jac_[36,19] = 0
    jac_[36,20] = 0
    jac_[36,21] = 0
    jac_[36,22] = 0
    jac_[36,23] = 0
    jac_[36,24] = 0
    jac_[36,25] = kf_R123*CaMKII_CaM_Ca2_psd
    jac_[36,26] = 0
    jac_[36,27] = 0
    jac_[36,28] = CaMKII_psd*kf_R120
    jac_[36,29] = 0
    jac_[36,30] = 0
    jac_[36,31] = kf_R127
    jac_[36,32] = 0
    jac_[36,33] = 0
    jac_[36,34] = Ca*kf_R123
    jac_[36,35] = 0
    jac_[36,36] = -Substrate*kf_R106-kr_R120-4*CaMKII_CaM_Ca4_psd*kf_R134-kf_R136*pCaMKII_CaM_Ca4_psd-kr_R127+kr_R106*Substrate-kr_R123
    jac_[36,37] = CaM_Ca4*kf_R120
    jac_[36,38] = 0
    jac_[36,39] = kr_R106*CaMKII_CaM_Ca4_psd-CaMKII_CaM_Ca4_psd*kf_R106
    jac_[36,40] = 0
    jac_[36,41] = 0
    jac_[36,42] = 0
    jac_[36,43] = 0
    jac_[36,44] = 0
    jac_[36,45] = 0
    jac_[36,46] = 0
    jac_[36,47] = 0
    jac_[36,48] = 0
    jac_[36,49] = 0
    jac_[36,50] = 0
    jac_[36,51] = 0
    jac_[36,52] = 0
    jac_[36,53] = 0
    jac_[36,54] = 0
    jac_[36,55] = 0
    jac_[36,56] = 0
    jac_[36,57] = 0
    jac_[36,58] = 0
    jac_[36,59] = 0
    jac_[36,60] = -kf_R136*CaMKII_CaM_Ca4_psd
    jac_[36,61] = 0
    jac_[36,62] = 0
    jac_[36,63] = 0
    jac_[36,64] = 0
    jac_[36,65] = 0
    jac_[36,66] = 0
    jac_[36,67] = 0
    jac_[36,68] = 0
    jac_[36,69] = 0
    jac_[36,70] = 0
    jac_[36,71] = 0
    jac_[36,72] = 0
    jac_[36,73] = 0
    jac_[36,74] = 0
    jac_[36,75] = 0
    jac_[36,76] = 0
    jac_[36,77] = 0
    jac_[36,78] = 0
    jac_[36,79] = 0
    jac_[36,80] = 0
    jac_[36,81] = 0
    jac_[36,82] = 2*kr_R134+kf_R135
    jac_[36,83] = kr_R136
    jac_[36,84] = 0
    jac_[36,85] = 0
    jac_[36,86] = 0
    jac_[36,87] = 0
    jac_[36,88] = 0
    jac_[36,89] = 0
    jac_[36,90] = 0
    jac_[36,91] = 0
    jac_[36,92] = 0
    jac_[36,93] = 0
    jac_[36,94] = 0
    jac_[36,95] = 0
    jac_[36,96] = 0
    jac_[36,97] = 0
    jac_[36,98] = 0
    jac_[36,99] = kf_R107
    jac_[37,1] = 0
    jac_[37,2] = 0
    jac_[37,3] = 0
    jac_[37,4] = 0
    jac_[37,5] = 0
    jac_[37,6] = 0
    jac_[37,7] = 0
    jac_[37,8] = 0
    jac_[37,9] = 0
    jac_[37,10] = 0
    jac_[37,11] = 0
    jac_[37,12] = 0
    jac_[37,13] = 0
    jac_[37,14] = 0
    jac_[37,15] = 0
    jac_[37,16] = 0
    jac_[37,17] = 0
    jac_[37,18] = 0
    jac_[37,19] = 0
    jac_[37,20] = 0
    jac_[37,21] = 0
    jac_[37,22] = 0
    jac_[37,23] = 0
    jac_[37,24] = 0
    jac_[37,25] = 0
    jac_[37,26] = -kf_R122*CaMKII_psd
    jac_[37,27] = -kf_R121*CaMKII_psd
    jac_[37,28] = -CaMKII_psd*kf_R120
    jac_[37,29] = 0
    jac_[37,30] = 0
    jac_[37,31] = 0
    jac_[37,32] = 0
    jac_[37,33] = 0
    jac_[37,34] = kr_R121
    jac_[37,35] = kr_R122
    jac_[37,36] = kr_R120
    jac_[37,37] = -kf_R119-CaM_Ca4*kf_R120-kf_R121*CaM_Ca2-kf_R122*CaM
    jac_[37,38] = 0
    jac_[37,39] = 0
    jac_[37,40] = 0
    jac_[37,41] = 0
    jac_[37,42] = 0
    jac_[37,43] = 0
    jac_[37,44] = 0
    jac_[37,45] = 0
    jac_[37,46] = 0
    jac_[37,47] = 0
    jac_[37,48] = 0
    jac_[37,49] = 0
    jac_[37,50] = 0
    jac_[37,51] = 0
    jac_[37,52] = 0
    jac_[37,53] = 0
    jac_[37,54] = 0
    jac_[37,55] = 0
    jac_[37,56] = 0
    jac_[37,57] = 0
    jac_[37,58] = 0
    jac_[37,59] = 0
    jac_[37,60] = 0
    jac_[37,61] = 0
    jac_[37,62] = 0
    jac_[37,63] = 0
    jac_[37,64] = 0
    jac_[37,65] = 0
    jac_[37,66] = 0
    jac_[37,67] = 0
    jac_[37,68] = 0
    jac_[37,69] = 0
    jac_[37,70] = 0
    jac_[37,71] = 0
    jac_[37,72] = 0
    jac_[37,73] = 0
    jac_[37,74] = 0
    jac_[37,75] = 0
    jac_[37,76] = 0
    jac_[37,77] = 0
    jac_[37,78] = 0
    jac_[37,79] = kf_R118
    jac_[37,80] = 0
    jac_[37,81] = 0
    jac_[37,82] = 0
    jac_[37,83] = 0
    jac_[37,84] = 0
    jac_[37,85] = 0
    jac_[37,86] = 0
    jac_[37,87] = 0
    jac_[37,88] = 0
    jac_[37,89] = 0
    jac_[37,90] = 0
    jac_[37,91] = 0
    jac_[37,92] = 0
    jac_[37,93] = 0
    jac_[37,94] = 0
    jac_[37,95] = 0
    jac_[37,96] = 0
    jac_[37,97] = 0
    jac_[37,98] = 0
    jac_[37,99] = 0
    jac_[38,1] = -cAMP*kf_R58
    jac_[38,2] = kf_R57
    jac_[38,3] = -cAMP*kf_R60
    jac_[38,4] = kf_R59
    jac_[38,5] = -cAMP*kf_R62
    jac_[38,6] = kf_R61
    jac_[38,7] = -cAMP*kf_R56
    jac_[38,8] = kf_R55
    jac_[38,9] = 0
    jac_[38,10] = 0
    jac_[38,11] = 0
    jac_[38,12] = 0
    jac_[38,13] = 0
    jac_[38,14] = 0
    jac_[38,15] = 0
    jac_[38,16] = 0
    jac_[38,17] = 0
    jac_[38,18] = 0
    jac_[38,19] = 0
    jac_[38,20] = 0
    jac_[38,21] = 0
    jac_[38,22] = 0
    jac_[38,23] = 0
    jac_[38,24] = 0
    jac_[38,25] = 0
    jac_[38,26] = 0
    jac_[38,27] = 0
    jac_[38,28] = 0
    jac_[38,29] = 0
    jac_[38,30] = 0
    jac_[38,31] = 0
    jac_[38,32] = 0
    jac_[38,33] = 0
    jac_[38,34] = 0
    jac_[38,35] = 0
    jac_[38,36] = 0
    jac_[38,37] = 0
    jac_[38,38] = -PDE10c*kf_R69-kf_R60*AC5_Ca-PDE10r*kf_R45-PKA_Ca2MP*kf_R39-kf_R38*PKA-AC5_Ca_GaolfGTP*kf_R62-4*cAMP*PDE10r*kf_R43-AC5_GaolfGTP*kf_R56-PDE4*kf_R41-AC5*kf_R58
    jac_[38,39] = 0
    jac_[38,40] = 0
    jac_[38,41] = 0
    jac_[38,42] = 0
    jac_[38,43] = 0
    jac_[38,44] = 0
    jac_[38,45] = 0
    jac_[38,46] = 0
    jac_[38,47] = 0
    jac_[38,48] = 0
    jac_[38,49] = 0
    jac_[38,50] = 0
    jac_[38,51] = 0
    jac_[38,52] = 0
    jac_[38,53] = 0
    jac_[38,54] = 0
    jac_[38,55] = 0
    jac_[38,56] = 0
    jac_[38,57] = 0
    jac_[38,58] = 0
    jac_[38,59] = 0
    jac_[38,60] = 0
    jac_[38,61] = 0
    jac_[38,62] = 0
    jac_[38,63] = -cAMP*kf_R41
    jac_[38,64] = kr_R41
    jac_[38,65] = -2*cAMP^2*kf_R43-cAMP*kf_R45
    jac_[38,66] = kr_R45
    jac_[38,67] = 2*kr_R43-cAMP*kf_R69
    jac_[38,68] = kr_R69
    jac_[38,69] = -cAMP*kf_R38
    jac_[38,70] = 0
    jac_[38,71] = 0
    jac_[38,72] = 0
    jac_[38,73] = 0
    jac_[38,74] = kr_R38-cAMP*kf_R39
    jac_[38,75] = kr_R39
    jac_[38,76] = 0
    jac_[38,77] = 0
    jac_[38,78] = 0
    jac_[38,79] = 0
    jac_[38,80] = 0
    jac_[38,81] = 0
    jac_[38,82] = 0
    jac_[38,83] = 0
    jac_[38,84] = 0
    jac_[38,85] = 0
    jac_[38,86] = 0
    jac_[38,87] = 0
    jac_[38,88] = 0
    jac_[38,89] = 0
    jac_[38,90] = 0
    jac_[38,91] = 0
    jac_[38,92] = 0
    jac_[38,93] = 0
    jac_[38,94] = 0
    jac_[38,95] = 0
    jac_[38,96] = 0
    jac_[38,97] = 0
    jac_[38,98] = 0
    jac_[38,99] = 0
    jac_[39,1] = 0
    jac_[39,2] = 0
    jac_[39,3] = 0
    jac_[39,4] = 0
    jac_[39,5] = 0
    jac_[39,6] = 0
    jac_[39,7] = 0
    jac_[39,8] = 0
    jac_[39,9] = 0
    jac_[39,10] = 0
    jac_[39,11] = 0
    jac_[39,12] = 0
    jac_[39,13] = 0
    jac_[39,14] = 0
    jac_[39,15] = 0
    jac_[39,16] = 0
    jac_[39,17] = 0
    jac_[39,18] = 0
    jac_[39,19] = 0
    jac_[39,20] = 0
    jac_[39,21] = 0
    jac_[39,22] = 0
    jac_[39,23] = 0
    jac_[39,24] = 0
    jac_[39,25] = 0
    jac_[39,26] = 0
    jac_[39,27] = 0
    jac_[39,28] = 0
    jac_[39,29] = 0
    jac_[39,30] = 0
    jac_[39,31] = 0
    jac_[39,32] = 0
    jac_[39,33] = 0
    jac_[39,34] = -Substrate*kf_R104
    jac_[39,35] = -kf_R102*Substrate
    jac_[39,36] = -Substrate*kf_R106+kr_R106*Substrate
    jac_[39,37] = 0
    jac_[39,38] = 0
    jac_[39,39] = -kf_R100*pCaMKII_CaM_Ca4_psd-kf_R98*pCaMKII_CaM_Ca2_psd+kr_R106*CaMKII_CaM_Ca4_psd-pCaMKII_psd*kf_R93-CaMKII_CaM_Ca4_psd*kf_R106-kf_R102*CaMKII_CaM_psd-CaMKII_CaM_Ca2_psd*kf_R104-kf_R96*pCaMKII_CaM_psd
    jac_[39,40] = 0
    jac_[39,41] = 0
    jac_[39,42] = 0
    jac_[39,43] = 0
    jac_[39,44] = 0
    jac_[39,45] = 0
    jac_[39,46] = 0
    jac_[39,47] = 0
    jac_[39,48] = 0
    jac_[39,49] = 0
    jac_[39,50] = 0
    jac_[39,51] = 0
    jac_[39,52] = 0
    jac_[39,53] = 0
    jac_[39,54] = 0
    jac_[39,55] = 0
    jac_[39,56] = 0
    jac_[39,57] = 0
    jac_[39,58] = -kf_R98*Substrate
    jac_[39,59] = -kf_R96*Substrate
    jac_[39,60] = -kf_R100*Substrate
    jac_[39,61] = -Substrate*kf_R93
    jac_[39,62] = 0
    jac_[39,63] = 0
    jac_[39,64] = 0
    jac_[39,65] = 0
    jac_[39,66] = 0
    jac_[39,67] = 0
    jac_[39,68] = 0
    jac_[39,69] = 0
    jac_[39,70] = 0
    jac_[39,71] = 0
    jac_[39,72] = 0
    jac_[39,73] = 0
    jac_[39,74] = 0
    jac_[39,75] = 0
    jac_[39,76] = 0
    jac_[39,77] = 0
    jac_[39,78] = 0
    jac_[39,79] = 0
    jac_[39,80] = kf_R92
    jac_[39,81] = 0
    jac_[39,82] = 0
    jac_[39,83] = 0
    jac_[39,84] = 0
    jac_[39,85] = 0
    jac_[39,86] = 0
    jac_[39,87] = 0
    jac_[39,88] = 0
    jac_[39,89] = 0
    jac_[39,90] = 0
    jac_[39,91] = 0
    jac_[39,92] = 0
    jac_[39,93] = kr_R93
    jac_[39,94] = kr_R96
    jac_[39,95] = kr_R98
    jac_[39,96] = kr_R100
    jac_[39,97] = kr_R102
    jac_[39,98] = kr_R104
    jac_[39,99] = 0
    jac_[40,1] = 0
    jac_[40,2] = 0
    jac_[40,3] = 0
    jac_[40,4] = 0
    jac_[40,5] = 0
    jac_[40,6] = 0
    jac_[40,7] = 0
    jac_[40,8] = 0
    jac_[40,9] = 0
    jac_[40,10] = 0
    jac_[40,11] = 0
    jac_[40,12] = 0
    jac_[40,13] = 0
    jac_[40,14] = 0
    jac_[40,15] = 0
    jac_[40,16] = 0
    jac_[40,17] = 0
    jac_[40,18] = 0
    jac_[40,19] = 0
    jac_[40,20] = 0
    jac_[40,21] = 0
    jac_[40,22] = 0
    jac_[40,23] = 0
    jac_[40,24] = 0
    jac_[40,25] = 0
    jac_[40,26] = 0
    jac_[40,27] = 0
    jac_[40,28] = 0
    jac_[40,29] = 0
    jac_[40,30] = 0
    jac_[40,31] = 0
    jac_[40,32] = 0
    jac_[40,33] = 0
    jac_[40,34] = 0
    jac_[40,35] = 0
    jac_[40,36] = 0
    jac_[40,37] = 0
    jac_[40,38] = 0
    jac_[40,39] = 0
    jac_[40,40] = -kf_R13*D32
    jac_[40,41] = kr_R13+kf_R14
    jac_[40,42] = 0
    jac_[40,43] = 0
    jac_[40,44] = 0
    jac_[40,45] = 0
    jac_[40,46] = 0
    jac_[40,47] = 0
    jac_[40,48] = 0
    jac_[40,49] = -kf_R13*CDK5
    jac_[40,50] = 0
    jac_[40,51] = 0
    jac_[40,52] = 0
    jac_[40,53] = 0
    jac_[40,54] = 0
    jac_[40,55] = 0
    jac_[40,56] = 0
    jac_[40,57] = 0
    jac_[40,58] = 0
    jac_[40,59] = 0
    jac_[40,60] = 0
    jac_[40,61] = 0
    jac_[40,62] = 0
    jac_[40,63] = 0
    jac_[40,64] = 0
    jac_[40,65] = 0
    jac_[40,66] = 0
    jac_[40,67] = 0
    jac_[40,68] = 0
    jac_[40,69] = 0
    jac_[40,70] = 0
    jac_[40,71] = 0
    jac_[40,72] = 0
    jac_[40,73] = 0
    jac_[40,74] = 0
    jac_[40,75] = 0
    jac_[40,76] = 0
    jac_[40,77] = 0
    jac_[40,78] = 0
    jac_[40,79] = 0
    jac_[40,80] = 0
    jac_[40,81] = 0
    jac_[40,82] = 0
    jac_[40,83] = 0
    jac_[40,84] = 0
    jac_[40,85] = 0
    jac_[40,86] = 0
    jac_[40,87] = 0
    jac_[40,88] = 0
    jac_[40,89] = 0
    jac_[40,90] = 0
    jac_[40,91] = 0
    jac_[40,92] = 0
    jac_[40,93] = 0
    jac_[40,94] = 0
    jac_[40,95] = 0
    jac_[40,96] = 0
    jac_[40,97] = 0
    jac_[40,98] = 0
    jac_[40,99] = 0
    jac_[41,1] = 0
    jac_[41,2] = 0
    jac_[41,3] = 0
    jac_[41,4] = 0
    jac_[41,5] = 0
    jac_[41,6] = 0
    jac_[41,7] = 0
    jac_[41,8] = 0
    jac_[41,9] = 0
    jac_[41,10] = 0
    jac_[41,11] = 0
    jac_[41,12] = 0
    jac_[41,13] = 0
    jac_[41,14] = 0
    jac_[41,15] = 0
    jac_[41,16] = 0
    jac_[41,17] = 0
    jac_[41,18] = 0
    jac_[41,19] = 0
    jac_[41,20] = 0
    jac_[41,21] = 0
    jac_[41,22] = 0
    jac_[41,23] = 0
    jac_[41,24] = 0
    jac_[41,25] = 0
    jac_[41,26] = 0
    jac_[41,27] = 0
    jac_[41,28] = 0
    jac_[41,29] = 0
    jac_[41,30] = 0
    jac_[41,31] = 0
    jac_[41,32] = 0
    jac_[41,33] = 0
    jac_[41,34] = 0
    jac_[41,35] = 0
    jac_[41,36] = 0
    jac_[41,37] = 0
    jac_[41,38] = 0
    jac_[41,39] = 0
    jac_[41,40] = kf_R13*D32
    jac_[41,41] = -kr_R13-kf_R14
    jac_[41,42] = 0
    jac_[41,43] = 0
    jac_[41,44] = 0
    jac_[41,45] = 0
    jac_[41,46] = 0
    jac_[41,47] = 0
    jac_[41,48] = 0
    jac_[41,49] = kf_R13*CDK5
    jac_[41,50] = 0
    jac_[41,51] = 0
    jac_[41,52] = 0
    jac_[41,53] = 0
    jac_[41,54] = 0
    jac_[41,55] = 0
    jac_[41,56] = 0
    jac_[41,57] = 0
    jac_[41,58] = 0
    jac_[41,59] = 0
    jac_[41,60] = 0
    jac_[41,61] = 0
    jac_[41,62] = 0
    jac_[41,63] = 0
    jac_[41,64] = 0
    jac_[41,65] = 0
    jac_[41,66] = 0
    jac_[41,67] = 0
    jac_[41,68] = 0
    jac_[41,69] = 0
    jac_[41,70] = 0
    jac_[41,71] = 0
    jac_[41,72] = 0
    jac_[41,73] = 0
    jac_[41,74] = 0
    jac_[41,75] = 0
    jac_[41,76] = 0
    jac_[41,77] = 0
    jac_[41,78] = 0
    jac_[41,79] = 0
    jac_[41,80] = 0
    jac_[41,81] = 0
    jac_[41,82] = 0
    jac_[41,83] = 0
    jac_[41,84] = 0
    jac_[41,85] = 0
    jac_[41,86] = 0
    jac_[41,87] = 0
    jac_[41,88] = 0
    jac_[41,89] = 0
    jac_[41,90] = 0
    jac_[41,91] = 0
    jac_[41,92] = 0
    jac_[41,93] = 0
    jac_[41,94] = 0
    jac_[41,95] = 0
    jac_[41,96] = 0
    jac_[41,97] = 0
    jac_[41,98] = 0
    jac_[41,99] = 0
    jac_[42,1] = 0
    jac_[42,2] = 0
    jac_[42,3] = 0
    jac_[42,4] = 0
    jac_[42,5] = 0
    jac_[42,6] = 0
    jac_[42,7] = 0
    jac_[42,8] = 0
    jac_[42,9] = 0
    jac_[42,10] = 0
    jac_[42,11] = 0
    jac_[42,12] = 0
    jac_[42,13] = 0
    jac_[42,14] = 0
    jac_[42,15] = 0
    jac_[42,16] = 0
    jac_[42,17] = 0
    jac_[42,18] = 0
    jac_[42,19] = 0
    jac_[42,20] = 0
    jac_[42,21] = 0
    jac_[42,22] = 0
    jac_[42,23] = 0
    jac_[42,24] = 0
    jac_[42,25] = 0
    jac_[42,26] = 0
    jac_[42,27] = 0
    jac_[42,28] = 0
    jac_[42,29] = 0
    jac_[42,30] = 0
    jac_[42,31] = 0
    jac_[42,32] = 0
    jac_[42,33] = 0
    jac_[42,34] = 0
    jac_[42,35] = 0
    jac_[42,36] = 0
    jac_[42,37] = 0
    jac_[42,38] = 0
    jac_[42,39] = 0
    jac_[42,40] = 0
    jac_[42,41] = 0
    jac_[42,42] = -DA*kf_R3-kf_R67*Golf
    jac_[42,43] = kr_R3
    jac_[42,44] = 0
    jac_[42,45] = kr_R67
    jac_[42,46] = 0
    jac_[42,47] = 0
    jac_[42,48] = -D1R*kf_R3
    jac_[42,49] = 0
    jac_[42,50] = 0
    jac_[42,51] = 0
    jac_[42,52] = 0
    jac_[42,53] = -kf_R67*D1R
    jac_[42,54] = 0
    jac_[42,55] = 0
    jac_[42,56] = 0
    jac_[42,57] = 0
    jac_[42,58] = 0
    jac_[42,59] = 0
    jac_[42,60] = 0
    jac_[42,61] = 0
    jac_[42,62] = 0
    jac_[42,63] = 0
    jac_[42,64] = 0
    jac_[42,65] = 0
    jac_[42,66] = 0
    jac_[42,67] = 0
    jac_[42,68] = 0
    jac_[42,69] = 0
    jac_[42,70] = 0
    jac_[42,71] = 0
    jac_[42,72] = 0
    jac_[42,73] = 0
    jac_[42,74] = 0
    jac_[42,75] = 0
    jac_[42,76] = 0
    jac_[42,77] = 0
    jac_[42,78] = 0
    jac_[42,79] = 0
    jac_[42,80] = 0
    jac_[42,81] = 0
    jac_[42,82] = 0
    jac_[42,83] = 0
    jac_[42,84] = 0
    jac_[42,85] = 0
    jac_[42,86] = 0
    jac_[42,87] = 0
    jac_[42,88] = 0
    jac_[42,89] = 0
    jac_[42,90] = 0
    jac_[42,91] = 0
    jac_[42,92] = 0
    jac_[42,93] = 0
    jac_[42,94] = 0
    jac_[42,95] = 0
    jac_[42,96] = 0
    jac_[42,97] = 0
    jac_[42,98] = 0
    jac_[42,99] = 0
    jac_[43,1] = 0
    jac_[43,2] = 0
    jac_[43,3] = 0
    jac_[43,4] = 0
    jac_[43,5] = 0
    jac_[43,6] = 0
    jac_[43,7] = 0
    jac_[43,8] = 0
    jac_[43,9] = 0
    jac_[43,10] = 0
    jac_[43,11] = 0
    jac_[43,12] = 0
    jac_[43,13] = 0
    jac_[43,14] = 0
    jac_[43,15] = 0
    jac_[43,16] = 0
    jac_[43,17] = 0
    jac_[43,18] = 0
    jac_[43,19] = 0
    jac_[43,20] = 0
    jac_[43,21] = 0
    jac_[43,22] = 0
    jac_[43,23] = 0
    jac_[43,24] = 0
    jac_[43,25] = 0
    jac_[43,26] = 0
    jac_[43,27] = 0
    jac_[43,28] = 0
    jac_[43,29] = 0
    jac_[43,30] = 0
    jac_[43,31] = 0
    jac_[43,32] = 0
    jac_[43,33] = 0
    jac_[43,34] = 0
    jac_[43,35] = 0
    jac_[43,36] = 0
    jac_[43,37] = 0
    jac_[43,38] = 0
    jac_[43,39] = 0
    jac_[43,40] = 0
    jac_[43,41] = 0
    jac_[43,42] = DA*kf_R3
    jac_[43,43] = -kr_R3-Golf*kf_R68
    jac_[43,44] = kr_R68+kf_R1
    jac_[43,45] = 0
    jac_[43,46] = 0
    jac_[43,47] = 0
    jac_[43,48] = D1R*kf_R3
    jac_[43,49] = 0
    jac_[43,50] = 0
    jac_[43,51] = 0
    jac_[43,52] = 0
    jac_[43,53] = -D1R_DA*kf_R68
    jac_[43,54] = 0
    jac_[43,55] = 0
    jac_[43,56] = 0
    jac_[43,57] = 0
    jac_[43,58] = 0
    jac_[43,59] = 0
    jac_[43,60] = 0
    jac_[43,61] = 0
    jac_[43,62] = 0
    jac_[43,63] = 0
    jac_[43,64] = 0
    jac_[43,65] = 0
    jac_[43,66] = 0
    jac_[43,67] = 0
    jac_[43,68] = 0
    jac_[43,69] = 0
    jac_[43,70] = 0
    jac_[43,71] = 0
    jac_[43,72] = 0
    jac_[43,73] = 0
    jac_[43,74] = 0
    jac_[43,75] = 0
    jac_[43,76] = 0
    jac_[43,77] = 0
    jac_[43,78] = 0
    jac_[43,79] = 0
    jac_[43,80] = 0
    jac_[43,81] = 0
    jac_[43,82] = 0
    jac_[43,83] = 0
    jac_[43,84] = 0
    jac_[43,85] = 0
    jac_[43,86] = 0
    jac_[43,87] = 0
    jac_[43,88] = 0
    jac_[43,89] = 0
    jac_[43,90] = 0
    jac_[43,91] = 0
    jac_[43,92] = 0
    jac_[43,93] = 0
    jac_[43,94] = 0
    jac_[43,95] = 0
    jac_[43,96] = 0
    jac_[43,97] = 0
    jac_[43,98] = 0
    jac_[43,99] = 0
    jac_[44,1] = 0
    jac_[44,2] = 0
    jac_[44,3] = 0
    jac_[44,4] = 0
    jac_[44,5] = 0
    jac_[44,6] = 0
    jac_[44,7] = 0
    jac_[44,8] = 0
    jac_[44,9] = 0
    jac_[44,10] = 0
    jac_[44,11] = 0
    jac_[44,12] = 0
    jac_[44,13] = 0
    jac_[44,14] = 0
    jac_[44,15] = 0
    jac_[44,16] = 0
    jac_[44,17] = 0
    jac_[44,18] = 0
    jac_[44,19] = 0
    jac_[44,20] = 0
    jac_[44,21] = 0
    jac_[44,22] = 0
    jac_[44,23] = 0
    jac_[44,24] = 0
    jac_[44,25] = 0
    jac_[44,26] = 0
    jac_[44,27] = 0
    jac_[44,28] = 0
    jac_[44,29] = 0
    jac_[44,30] = 0
    jac_[44,31] = 0
    jac_[44,32] = 0
    jac_[44,33] = 0
    jac_[44,34] = 0
    jac_[44,35] = 0
    jac_[44,36] = 0
    jac_[44,37] = 0
    jac_[44,38] = 0
    jac_[44,39] = 0
    jac_[44,40] = 0
    jac_[44,41] = 0
    jac_[44,42] = 0
    jac_[44,43] = Golf*kf_R68
    jac_[44,44] = -kr_R2-kr_R68-kf_R1
    jac_[44,45] = DA*kf_R2
    jac_[44,46] = 0
    jac_[44,47] = 0
    jac_[44,48] = D1R_Golf*kf_R2
    jac_[44,49] = 0
    jac_[44,50] = 0
    jac_[44,51] = 0
    jac_[44,52] = 0
    jac_[44,53] = D1R_DA*kf_R68
    jac_[44,54] = 0
    jac_[44,55] = 0
    jac_[44,56] = 0
    jac_[44,57] = 0
    jac_[44,58] = 0
    jac_[44,59] = 0
    jac_[44,60] = 0
    jac_[44,61] = 0
    jac_[44,62] = 0
    jac_[44,63] = 0
    jac_[44,64] = 0
    jac_[44,65] = 0
    jac_[44,66] = 0
    jac_[44,67] = 0
    jac_[44,68] = 0
    jac_[44,69] = 0
    jac_[44,70] = 0
    jac_[44,71] = 0
    jac_[44,72] = 0
    jac_[44,73] = 0
    jac_[44,74] = 0
    jac_[44,75] = 0
    jac_[44,76] = 0
    jac_[44,77] = 0
    jac_[44,78] = 0
    jac_[44,79] = 0
    jac_[44,80] = 0
    jac_[44,81] = 0
    jac_[44,82] = 0
    jac_[44,83] = 0
    jac_[44,84] = 0
    jac_[44,85] = 0
    jac_[44,86] = 0
    jac_[44,87] = 0
    jac_[44,88] = 0
    jac_[44,89] = 0
    jac_[44,90] = 0
    jac_[44,91] = 0
    jac_[44,92] = 0
    jac_[44,93] = 0
    jac_[44,94] = 0
    jac_[44,95] = 0
    jac_[44,96] = 0
    jac_[44,97] = 0
    jac_[44,98] = 0
    jac_[44,99] = 0
    jac_[45,1] = 0
    jac_[45,2] = 0
    jac_[45,3] = 0
    jac_[45,4] = 0
    jac_[45,5] = 0
    jac_[45,6] = 0
    jac_[45,7] = 0
    jac_[45,8] = 0
    jac_[45,9] = 0
    jac_[45,10] = 0
    jac_[45,11] = 0
    jac_[45,12] = 0
    jac_[45,13] = 0
    jac_[45,14] = 0
    jac_[45,15] = 0
    jac_[45,16] = 0
    jac_[45,17] = 0
    jac_[45,18] = 0
    jac_[45,19] = 0
    jac_[45,20] = 0
    jac_[45,21] = 0
    jac_[45,22] = 0
    jac_[45,23] = 0
    jac_[45,24] = 0
    jac_[45,25] = 0
    jac_[45,26] = 0
    jac_[45,27] = 0
    jac_[45,28] = 0
    jac_[45,29] = 0
    jac_[45,30] = 0
    jac_[45,31] = 0
    jac_[45,32] = 0
    jac_[45,33] = 0
    jac_[45,34] = 0
    jac_[45,35] = 0
    jac_[45,36] = 0
    jac_[45,37] = 0
    jac_[45,38] = 0
    jac_[45,39] = 0
    jac_[45,40] = 0
    jac_[45,41] = 0
    jac_[45,42] = kf_R67*Golf
    jac_[45,43] = 0
    jac_[45,44] = kr_R2
    jac_[45,45] = -DA*kf_R2-kr_R67
    jac_[45,46] = 0
    jac_[45,47] = 0
    jac_[45,48] = -D1R_Golf*kf_R2
    jac_[45,49] = 0
    jac_[45,50] = 0
    jac_[45,51] = 0
    jac_[45,52] = 0
    jac_[45,53] = kf_R67*D1R
    jac_[45,54] = 0
    jac_[45,55] = 0
    jac_[45,56] = 0
    jac_[45,57] = 0
    jac_[45,58] = 0
    jac_[45,59] = 0
    jac_[45,60] = 0
    jac_[45,61] = 0
    jac_[45,62] = 0
    jac_[45,63] = 0
    jac_[45,64] = 0
    jac_[45,65] = 0
    jac_[45,66] = 0
    jac_[45,67] = 0
    jac_[45,68] = 0
    jac_[45,69] = 0
    jac_[45,70] = 0
    jac_[45,71] = 0
    jac_[45,72] = 0
    jac_[45,73] = 0
    jac_[45,74] = 0
    jac_[45,75] = 0
    jac_[45,76] = 0
    jac_[45,77] = 0
    jac_[45,78] = 0
    jac_[45,79] = 0
    jac_[45,80] = 0
    jac_[45,81] = 0
    jac_[45,82] = 0
    jac_[45,83] = 0
    jac_[45,84] = 0
    jac_[45,85] = 0
    jac_[45,86] = 0
    jac_[45,87] = 0
    jac_[45,88] = 0
    jac_[45,89] = 0
    jac_[45,90] = 0
    jac_[45,91] = 0
    jac_[45,92] = 0
    jac_[45,93] = 0
    jac_[45,94] = 0
    jac_[45,95] = 0
    jac_[45,96] = 0
    jac_[45,97] = 0
    jac_[45,98] = 0
    jac_[45,99] = 0
    jac_[46,1] = 0
    jac_[46,2] = 0
    jac_[46,3] = 0
    jac_[46,4] = 0
    jac_[46,5] = 0
    jac_[46,6] = 0
    jac_[46,7] = 0
    jac_[46,8] = 0
    jac_[46,9] = 0
    jac_[46,10] = 0
    jac_[46,11] = 0
    jac_[46,12] = 0
    jac_[46,13] = 0
    jac_[46,14] = 0
    jac_[46,15] = 0
    jac_[46,16] = 0
    jac_[46,17] = -D32p34*kf_R35
    jac_[46,18] = kr_R35
    jac_[46,19] = 0
    jac_[46,20] = 0
    jac_[46,21] = kr_R34
    jac_[46,22] = 0
    jac_[46,23] = -kf_R34*D32p34
    jac_[46,24] = 0
    jac_[46,25] = 0
    jac_[46,26] = 0
    jac_[46,27] = 0
    jac_[46,28] = 0
    jac_[46,29] = 0
    jac_[46,30] = 0
    jac_[46,31] = 0
    jac_[46,32] = 0
    jac_[46,33] = 0
    jac_[46,34] = 0
    jac_[46,35] = 0
    jac_[46,36] = 0
    jac_[46,37] = 0
    jac_[46,38] = 0
    jac_[46,39] = 0
    jac_[46,40] = 0
    jac_[46,41] = 0
    jac_[46,42] = 0
    jac_[46,43] = 0
    jac_[46,44] = 0
    jac_[46,45] = 0
    jac_[46,46] = -B72PP2A_Ca*kf_R34-kf_R23*PP2Bc-kf_R12*PP1-B72PP2A*kf_R35
    jac_[46,47] = 0
    jac_[46,48] = 0
    jac_[46,49] = 0
    jac_[46,50] = 0
    jac_[46,51] = 0
    jac_[46,52] = 0
    jac_[46,53] = 0
    jac_[46,54] = 0
    jac_[46,55] = 0
    jac_[46,56] = 0
    jac_[46,57] = 0
    jac_[46,58] = 0
    jac_[46,59] = 0
    jac_[46,60] = 0
    jac_[46,61] = 0
    jac_[46,62] = 0
    jac_[46,63] = 0
    jac_[46,64] = 0
    jac_[46,65] = 0
    jac_[46,66] = 0
    jac_[46,67] = 0
    jac_[46,68] = 0
    jac_[46,69] = 0
    jac_[46,70] = 0
    jac_[46,71] = 0
    jac_[46,72] = kf_R9
    jac_[46,73] = 0
    jac_[46,74] = 0
    jac_[46,75] = 0
    jac_[46,76] = 0
    jac_[46,77] = 0
    jac_[46,78] = -kf_R12*D32p34
    jac_[46,79] = 0
    jac_[46,80] = 0
    jac_[46,81] = kr_R12
    jac_[46,82] = 0
    jac_[46,83] = 0
    jac_[46,84] = 0
    jac_[46,85] = 0
    jac_[46,86] = 0
    jac_[46,87] = -kf_R23*D32p34
    jac_[46,88] = kr_R23
    jac_[46,89] = 0
    jac_[46,90] = 0
    jac_[46,91] = 0
    jac_[46,92] = 0
    jac_[46,93] = 0
    jac_[46,94] = 0
    jac_[46,95] = 0
    jac_[46,96] = 0
    jac_[46,97] = 0
    jac_[46,98] = 0
    jac_[46,99] = 0
    jac_[47,1] = 0
    jac_[47,2] = 0
    jac_[47,3] = 0
    jac_[47,4] = 0
    jac_[47,5] = 0
    jac_[47,6] = 0
    jac_[47,7] = 0
    jac_[47,8] = 0
    jac_[47,9] = 0
    jac_[47,10] = 0
    jac_[47,11] = -kf_R30*D32p75
    jac_[47,12] = kr_R30
    jac_[47,13] = 0
    jac_[47,14] = -kf_R17*D32p75
    jac_[47,15] = kr_R17
    jac_[47,16] = 0
    jac_[47,17] = -kf_R18*D32p75
    jac_[47,18] = 0
    jac_[47,19] = kr_R18
    jac_[47,20] = 0
    jac_[47,21] = 0
    jac_[47,22] = kr_R19
    jac_[47,23] = -kf_R19*D32p75
    jac_[47,24] = 0
    jac_[47,25] = 0
    jac_[47,26] = 0
    jac_[47,27] = 0
    jac_[47,28] = 0
    jac_[47,29] = 0
    jac_[47,30] = 0
    jac_[47,31] = 0
    jac_[47,32] = 0
    jac_[47,33] = 0
    jac_[47,34] = 0
    jac_[47,35] = 0
    jac_[47,36] = 0
    jac_[47,37] = 0
    jac_[47,38] = 0
    jac_[47,39] = 0
    jac_[47,40] = 0
    jac_[47,41] = kf_R14
    jac_[47,42] = 0
    jac_[47,43] = 0
    jac_[47,44] = 0
    jac_[47,45] = 0
    jac_[47,46] = 0
    jac_[47,47] = -PKAc*kf_R15-kf_R17*B56PP2Ap-B56PP2A*kf_R30-kf_R18*B72PP2A-B72PP2A_Ca*kf_R19
    jac_[47,48] = 0
    jac_[47,49] = 0
    jac_[47,50] = 0
    jac_[47,51] = 0
    jac_[47,52] = 0
    jac_[47,53] = 0
    jac_[47,54] = 0
    jac_[47,55] = 0
    jac_[47,56] = 0
    jac_[47,57] = 0
    jac_[47,58] = 0
    jac_[47,59] = 0
    jac_[47,60] = 0
    jac_[47,61] = 0
    jac_[47,62] = 0
    jac_[47,63] = 0
    jac_[47,64] = 0
    jac_[47,65] = 0
    jac_[47,66] = 0
    jac_[47,67] = 0
    jac_[47,68] = 0
    jac_[47,69] = 0
    jac_[47,70] = -D32p75*kf_R15
    jac_[47,71] = 0
    jac_[47,72] = 0
    jac_[47,73] = 0
    jac_[47,74] = 0
    jac_[47,75] = 0
    jac_[47,76] = kr_R15
    jac_[47,77] = 0
    jac_[47,78] = 0
    jac_[47,79] = 0
    jac_[47,80] = 0
    jac_[47,81] = 0
    jac_[47,82] = 0
    jac_[47,83] = 0
    jac_[47,84] = 0
    jac_[47,85] = 0
    jac_[47,86] = 0
    jac_[47,87] = 0
    jac_[47,88] = 0
    jac_[47,89] = 0
    jac_[47,90] = 0
    jac_[47,91] = 0
    jac_[47,92] = 0
    jac_[47,93] = 0
    jac_[47,94] = 0
    jac_[47,95] = 0
    jac_[47,96] = 0
    jac_[47,97] = 0
    jac_[47,98] = 0
    jac_[47,99] = 0
    jac_[48,1] = 0
    jac_[48,2] = 0
    jac_[48,3] = 0
    jac_[48,4] = 0
    jac_[48,5] = 0
    jac_[48,6] = 0
    jac_[48,7] = 0
    jac_[48,8] = 0
    jac_[48,9] = 0
    jac_[48,10] = 0
    jac_[48,11] = 0
    jac_[48,12] = 0
    jac_[48,13] = 0
    jac_[48,14] = 0
    jac_[48,15] = 0
    jac_[48,16] = 0
    jac_[48,17] = 0
    jac_[48,18] = 0
    jac_[48,19] = 0
    jac_[48,20] = 0
    jac_[48,21] = 0
    jac_[48,22] = 0
    jac_[48,23] = 0
    jac_[48,24] = 0
    jac_[48,25] = 0
    jac_[48,26] = 0
    jac_[48,27] = 0
    jac_[48,28] = 0
    jac_[48,29] = 0
    jac_[48,30] = 0
    jac_[48,31] = 0
    jac_[48,32] = 0
    jac_[48,33] = 0
    jac_[48,34] = 0
    jac_[48,35] = 0
    jac_[48,36] = 0
    jac_[48,37] = 0
    jac_[48,38] = 0
    jac_[48,39] = 0
    jac_[48,40] = 0
    jac_[48,41] = 0
    jac_[48,42] = -DA*kf_R3
    jac_[48,43] = kr_R3
    jac_[48,44] = kr_R2
    jac_[48,45] = -DA*kf_R2
    jac_[48,46] = 0
    jac_[48,47] = 0
    jac_[48,48] = -D1R*kf_R3-D1R_Golf*kf_R2
    jac_[48,49] = 0
    jac_[48,50] = 0
    jac_[48,51] = 0
    jac_[48,52] = 0
    jac_[48,53] = 0
    jac_[48,54] = 0
    jac_[48,55] = 0
    jac_[48,56] = 0
    jac_[48,57] = 0
    jac_[48,58] = 0
    jac_[48,59] = 0
    jac_[48,60] = 0
    jac_[48,61] = 0
    jac_[48,62] = 0
    jac_[48,63] = 0
    jac_[48,64] = 0
    jac_[48,65] = 0
    jac_[48,66] = 0
    jac_[48,67] = 0
    jac_[48,68] = 0
    jac_[48,69] = 0
    jac_[48,70] = 0
    jac_[48,71] = 0
    jac_[48,72] = 0
    jac_[48,73] = 0
    jac_[48,74] = 0
    jac_[48,75] = 0
    jac_[48,76] = 0
    jac_[48,77] = 0
    jac_[48,78] = 0
    jac_[48,79] = 0
    jac_[48,80] = 0
    jac_[48,81] = 0
    jac_[48,82] = 0
    jac_[48,83] = 0
    jac_[48,84] = 0
    jac_[48,85] = 0
    jac_[48,86] = 0
    jac_[48,87] = 0
    jac_[48,88] = 0
    jac_[48,89] = 0
    jac_[48,90] = 0
    jac_[48,91] = 0
    jac_[48,92] = 0
    jac_[48,93] = 0
    jac_[48,94] = 0
    jac_[48,95] = 0
    jac_[48,96] = 0
    jac_[48,97] = 0
    jac_[48,98] = 0
    jac_[48,99] = 0
    jac_[49,1] = 0
    jac_[49,2] = 0
    jac_[49,3] = 0
    jac_[49,4] = 0
    jac_[49,5] = 0
    jac_[49,6] = 0
    jac_[49,7] = 0
    jac_[49,8] = 0
    jac_[49,9] = 0
    jac_[49,10] = 0
    jac_[49,11] = 0
    jac_[49,12] = kf_R31
    jac_[49,13] = 0
    jac_[49,14] = 0
    jac_[49,15] = kf_R20
    jac_[49,16] = 0
    jac_[49,17] = 0
    jac_[49,18] = kf_R33
    jac_[49,19] = kf_R21
    jac_[49,20] = 0
    jac_[49,21] = kf_R32
    jac_[49,22] = kf_R22
    jac_[49,23] = 0
    jac_[49,24] = 0
    jac_[49,25] = 0
    jac_[49,26] = 0
    jac_[49,27] = 0
    jac_[49,28] = 0
    jac_[49,29] = 0
    jac_[49,30] = 0
    jac_[49,31] = 0
    jac_[49,32] = 0
    jac_[49,33] = 0
    jac_[49,34] = 0
    jac_[49,35] = 0
    jac_[49,36] = 0
    jac_[49,37] = 0
    jac_[49,38] = 0
    jac_[49,39] = 0
    jac_[49,40] = -kf_R13*D32
    jac_[49,41] = kr_R13
    jac_[49,42] = 0
    jac_[49,43] = 0
    jac_[49,44] = 0
    jac_[49,45] = 0
    jac_[49,46] = 0
    jac_[49,47] = 0
    jac_[49,48] = 0
    jac_[49,49] = -kf_R13*CDK5-PKAc*kf_R8
    jac_[49,50] = 0
    jac_[49,51] = 0
    jac_[49,52] = 0
    jac_[49,53] = 0
    jac_[49,54] = 0
    jac_[49,55] = 0
    jac_[49,56] = 0
    jac_[49,57] = 0
    jac_[49,58] = 0
    jac_[49,59] = 0
    jac_[49,60] = 0
    jac_[49,61] = 0
    jac_[49,62] = 0
    jac_[49,63] = 0
    jac_[49,64] = 0
    jac_[49,65] = 0
    jac_[49,66] = 0
    jac_[49,67] = 0
    jac_[49,68] = 0
    jac_[49,69] = 0
    jac_[49,70] = -D32*kf_R8
    jac_[49,71] = 0
    jac_[49,72] = kr_R8
    jac_[49,73] = 0
    jac_[49,74] = 0
    jac_[49,75] = 0
    jac_[49,76] = 0
    jac_[49,77] = 0
    jac_[49,78] = 0
    jac_[49,79] = 0
    jac_[49,80] = 0
    jac_[49,81] = 0
    jac_[49,82] = 0
    jac_[49,83] = 0
    jac_[49,84] = 0
    jac_[49,85] = 0
    jac_[49,86] = 0
    jac_[49,87] = 0
    jac_[49,88] = kf_R36
    jac_[49,89] = 0
    jac_[49,90] = 0
    jac_[49,91] = 0
    jac_[49,92] = 0
    jac_[49,93] = 0
    jac_[49,94] = 0
    jac_[49,95] = 0
    jac_[49,96] = 0
    jac_[49,97] = 0
    jac_[49,98] = 0
    jac_[49,99] = 0
    jac_[50,1] = 0
    jac_[50,2] = 0
    jac_[50,3] = 0
    jac_[50,4] = 0
    jac_[50,5] = kf_R64
    jac_[50,6] = kf_R66
    jac_[50,7] = kf_R63
    jac_[50,8] = kf_R65
    jac_[50,9] = 0
    jac_[50,10] = 0
    jac_[50,11] = 0
    jac_[50,12] = 0
    jac_[50,13] = 0
    jac_[50,14] = 0
    jac_[50,15] = 0
    jac_[50,16] = 0
    jac_[50,17] = 0
    jac_[50,18] = 0
    jac_[50,19] = 0
    jac_[50,20] = 0
    jac_[50,21] = 0
    jac_[50,22] = 0
    jac_[50,23] = 0
    jac_[50,24] = 0
    jac_[50,25] = 0
    jac_[50,26] = 0
    jac_[50,27] = 0
    jac_[50,28] = 0
    jac_[50,29] = 0
    jac_[50,30] = 0
    jac_[50,31] = 0
    jac_[50,32] = 0
    jac_[50,33] = 0
    jac_[50,34] = 0
    jac_[50,35] = 0
    jac_[50,36] = 0
    jac_[50,37] = 0
    jac_[50,38] = 0
    jac_[50,39] = 0
    jac_[50,40] = 0
    jac_[50,41] = 0
    jac_[50,42] = 0
    jac_[50,43] = 0
    jac_[50,44] = 0
    jac_[50,45] = 0
    jac_[50,46] = 0
    jac_[50,47] = 0
    jac_[50,48] = 0
    jac_[50,49] = 0
    jac_[50,50] = -Gbgolf*kf_R47
    jac_[50,51] = kf_R0
    jac_[50,52] = -kf_R47*GaolfGDP
    jac_[50,53] = 0
    jac_[50,54] = 0
    jac_[50,55] = 0
    jac_[50,56] = 0
    jac_[50,57] = 0
    jac_[50,58] = 0
    jac_[50,59] = 0
    jac_[50,60] = 0
    jac_[50,61] = 0
    jac_[50,62] = 0
    jac_[50,63] = 0
    jac_[50,64] = 0
    jac_[50,65] = 0
    jac_[50,66] = 0
    jac_[50,67] = 0
    jac_[50,68] = 0
    jac_[50,69] = 0
    jac_[50,70] = 0
    jac_[50,71] = 0
    jac_[50,72] = 0
    jac_[50,73] = 0
    jac_[50,74] = 0
    jac_[50,75] = 0
    jac_[50,76] = 0
    jac_[50,77] = 0
    jac_[50,78] = 0
    jac_[50,79] = 0
    jac_[50,80] = 0
    jac_[50,81] = 0
    jac_[50,82] = 0
    jac_[50,83] = 0
    jac_[50,84] = 0
    jac_[50,85] = 0
    jac_[50,86] = 0
    jac_[50,87] = 0
    jac_[50,88] = 0
    jac_[50,89] = 0
    jac_[50,90] = 0
    jac_[50,91] = 0
    jac_[50,92] = 0
    jac_[50,93] = 0
    jac_[50,94] = 0
    jac_[50,95] = 0
    jac_[50,96] = 0
    jac_[50,97] = 0
    jac_[50,98] = 0
    jac_[50,99] = 0
    jac_[51,1] = -kf_R4*GaolfGTP
    jac_[51,2] = -GaolfGTP*kf_R52
    jac_[51,3] = -GaolfGTP*kf_R29
    jac_[51,4] = -GaolfGTP*kf_R53
    jac_[51,5] = kr_R29
    jac_[51,6] = kr_R53
    jac_[51,7] = kr_R4
    jac_[51,8] = kr_R52
    jac_[51,9] = 0
    jac_[51,10] = 0
    jac_[51,11] = 0
    jac_[51,12] = 0
    jac_[51,13] = 0
    jac_[51,14] = 0
    jac_[51,15] = 0
    jac_[51,16] = 0
    jac_[51,17] = 0
    jac_[51,18] = 0
    jac_[51,19] = 0
    jac_[51,20] = 0
    jac_[51,21] = 0
    jac_[51,22] = 0
    jac_[51,23] = 0
    jac_[51,24] = 0
    jac_[51,25] = 0
    jac_[51,26] = 0
    jac_[51,27] = 0
    jac_[51,28] = 0
    jac_[51,29] = 0
    jac_[51,30] = 0
    jac_[51,31] = 0
    jac_[51,32] = 0
    jac_[51,33] = 0
    jac_[51,34] = 0
    jac_[51,35] = 0
    jac_[51,36] = 0
    jac_[51,37] = 0
    jac_[51,38] = 0
    jac_[51,39] = 0
    jac_[51,40] = 0
    jac_[51,41] = 0
    jac_[51,42] = 0
    jac_[51,43] = 0
    jac_[51,44] = kf_R1
    jac_[51,45] = 0
    jac_[51,46] = 0
    jac_[51,47] = 0
    jac_[51,48] = 0
    jac_[51,49] = 0
    jac_[51,50] = 0
    jac_[51,51] = -kf_R4*AC5-AC5_ATP*kf_R52-kf_R0-AC5_Ca*kf_R29-AC5_Ca_ATP*kf_R53
    jac_[51,52] = 0
    jac_[51,53] = 0
    jac_[51,54] = 0
    jac_[51,55] = 0
    jac_[51,56] = 0
    jac_[51,57] = 0
    jac_[51,58] = 0
    jac_[51,59] = 0
    jac_[51,60] = 0
    jac_[51,61] = 0
    jac_[51,62] = 0
    jac_[51,63] = 0
    jac_[51,64] = 0
    jac_[51,65] = 0
    jac_[51,66] = 0
    jac_[51,67] = 0
    jac_[51,68] = 0
    jac_[51,69] = 0
    jac_[51,70] = 0
    jac_[51,71] = 0
    jac_[51,72] = 0
    jac_[51,73] = 0
    jac_[51,74] = 0
    jac_[51,75] = 0
    jac_[51,76] = 0
    jac_[51,77] = 0
    jac_[51,78] = 0
    jac_[51,79] = 0
    jac_[51,80] = 0
    jac_[51,81] = 0
    jac_[51,82] = 0
    jac_[51,83] = 0
    jac_[51,84] = 0
    jac_[51,85] = 0
    jac_[51,86] = 0
    jac_[51,87] = 0
    jac_[51,88] = 0
    jac_[51,89] = 0
    jac_[51,90] = 0
    jac_[51,91] = 0
    jac_[51,92] = 0
    jac_[51,93] = 0
    jac_[51,94] = 0
    jac_[51,95] = 0
    jac_[51,96] = 0
    jac_[51,97] = 0
    jac_[51,98] = 0
    jac_[51,99] = 0
    jac_[52,1] = 0
    jac_[52,2] = 0
    jac_[52,3] = 0
    jac_[52,4] = 0
    jac_[52,5] = 0
    jac_[52,6] = 0
    jac_[52,7] = 0
    jac_[52,8] = 0
    jac_[52,9] = 0
    jac_[52,10] = 0
    jac_[52,11] = 0
    jac_[52,12] = 0
    jac_[52,13] = 0
    jac_[52,14] = 0
    jac_[52,15] = 0
    jac_[52,16] = 0
    jac_[52,17] = 0
    jac_[52,18] = 0
    jac_[52,19] = 0
    jac_[52,20] = 0
    jac_[52,21] = 0
    jac_[52,22] = 0
    jac_[52,23] = 0
    jac_[52,24] = 0
    jac_[52,25] = 0
    jac_[52,26] = 0
    jac_[52,27] = 0
    jac_[52,28] = 0
    jac_[52,29] = 0
    jac_[52,30] = 0
    jac_[52,31] = 0
    jac_[52,32] = 0
    jac_[52,33] = 0
    jac_[52,34] = 0
    jac_[52,35] = 0
    jac_[52,36] = 0
    jac_[52,37] = 0
    jac_[52,38] = 0
    jac_[52,39] = 0
    jac_[52,40] = 0
    jac_[52,41] = 0
    jac_[52,42] = 0
    jac_[52,43] = 0
    jac_[52,44] = kf_R1
    jac_[52,45] = 0
    jac_[52,46] = 0
    jac_[52,47] = 0
    jac_[52,48] = 0
    jac_[52,49] = 0
    jac_[52,50] = -Gbgolf*kf_R47
    jac_[52,51] = 0
    jac_[52,52] = -kf_R47*GaolfGDP
    jac_[52,53] = 0
    jac_[52,54] = 0
    jac_[52,55] = 0
    jac_[52,56] = 0
    jac_[52,57] = 0
    jac_[52,58] = 0
    jac_[52,59] = 0
    jac_[52,60] = 0
    jac_[52,61] = 0
    jac_[52,62] = 0
    jac_[52,63] = 0
    jac_[52,64] = 0
    jac_[52,65] = 0
    jac_[52,66] = 0
    jac_[52,67] = 0
    jac_[52,68] = 0
    jac_[52,69] = 0
    jac_[52,70] = 0
    jac_[52,71] = 0
    jac_[52,72] = 0
    jac_[52,73] = 0
    jac_[52,74] = 0
    jac_[52,75] = 0
    jac_[52,76] = 0
    jac_[52,77] = 0
    jac_[52,78] = 0
    jac_[52,79] = 0
    jac_[52,80] = 0
    jac_[52,81] = 0
    jac_[52,82] = 0
    jac_[52,83] = 0
    jac_[52,84] = 0
    jac_[52,85] = 0
    jac_[52,86] = 0
    jac_[52,87] = 0
    jac_[52,88] = 0
    jac_[52,89] = 0
    jac_[52,90] = 0
    jac_[52,91] = 0
    jac_[52,92] = 0
    jac_[52,93] = 0
    jac_[52,94] = 0
    jac_[52,95] = 0
    jac_[52,96] = 0
    jac_[52,97] = 0
    jac_[52,98] = 0
    jac_[52,99] = 0
    jac_[53,1] = 0
    jac_[53,2] = 0
    jac_[53,3] = 0
    jac_[53,4] = 0
    jac_[53,5] = 0
    jac_[53,6] = 0
    jac_[53,7] = 0
    jac_[53,8] = 0
    jac_[53,9] = 0
    jac_[53,10] = 0
    jac_[53,11] = 0
    jac_[53,12] = 0
    jac_[53,13] = 0
    jac_[53,14] = 0
    jac_[53,15] = 0
    jac_[53,16] = 0
    jac_[53,17] = 0
    jac_[53,18] = 0
    jac_[53,19] = 0
    jac_[53,20] = 0
    jac_[53,21] = 0
    jac_[53,22] = 0
    jac_[53,23] = 0
    jac_[53,24] = 0
    jac_[53,25] = 0
    jac_[53,26] = 0
    jac_[53,27] = 0
    jac_[53,28] = 0
    jac_[53,29] = 0
    jac_[53,30] = 0
    jac_[53,31] = 0
    jac_[53,32] = 0
    jac_[53,33] = 0
    jac_[53,34] = 0
    jac_[53,35] = 0
    jac_[53,36] = 0
    jac_[53,37] = 0
    jac_[53,38] = 0
    jac_[53,39] = 0
    jac_[53,40] = 0
    jac_[53,41] = 0
    jac_[53,42] = -kf_R67*Golf
    jac_[53,43] = -Golf*kf_R68
    jac_[53,44] = kr_R68
    jac_[53,45] = kr_R67
    jac_[53,46] = 0
    jac_[53,47] = 0
    jac_[53,48] = 0
    jac_[53,49] = 0
    jac_[53,50] = Gbgolf*kf_R47
    jac_[53,51] = 0
    jac_[53,52] = kf_R47*GaolfGDP
    jac_[53,53] = -D1R_DA*kf_R68-kf_R67*D1R
    jac_[53,54] = 0
    jac_[53,55] = 0
    jac_[53,56] = 0
    jac_[53,57] = 0
    jac_[53,58] = 0
    jac_[53,59] = 0
    jac_[53,60] = 0
    jac_[53,61] = 0
    jac_[53,62] = 0
    jac_[53,63] = 0
    jac_[53,64] = 0
    jac_[53,65] = 0
    jac_[53,66] = 0
    jac_[53,67] = 0
    jac_[53,68] = 0
    jac_[53,69] = 0
    jac_[53,70] = 0
    jac_[53,71] = 0
    jac_[53,72] = 0
    jac_[53,73] = 0
    jac_[53,74] = 0
    jac_[53,75] = 0
    jac_[53,76] = 0
    jac_[53,77] = 0
    jac_[53,78] = 0
    jac_[53,79] = 0
    jac_[53,80] = 0
    jac_[53,81] = 0
    jac_[53,82] = 0
    jac_[53,83] = 0
    jac_[53,84] = 0
    jac_[53,85] = 0
    jac_[53,86] = 0
    jac_[53,87] = 0
    jac_[53,88] = 0
    jac_[53,89] = 0
    jac_[53,90] = 0
    jac_[53,91] = 0
    jac_[53,92] = 0
    jac_[53,93] = 0
    jac_[53,94] = 0
    jac_[53,95] = 0
    jac_[53,96] = 0
    jac_[53,97] = 0
    jac_[53,98] = 0
    jac_[53,99] = 0
    jac_[54,1] = 0
    jac_[54,2] = 0
    jac_[54,3] = 0
    jac_[54,4] = 0
    jac_[54,5] = 0
    jac_[54,6] = 0
    jac_[54,7] = 0
    jac_[54,8] = 0
    jac_[54,9] = 0
    jac_[54,10] = 0
    jac_[54,11] = 0
    jac_[54,12] = 0
    jac_[54,13] = 0
    jac_[54,14] = 0
    jac_[54,15] = 0
    jac_[54,16] = 0
    jac_[54,17] = 0
    jac_[54,18] = 0
    jac_[54,19] = 0
    jac_[54,20] = 0
    jac_[54,21] = 0
    jac_[54,22] = 0
    jac_[54,23] = 0
    jac_[54,24] = 0
    jac_[54,25] = 0
    jac_[54,26] = -pCaMKII*kf_R79
    jac_[54,27] = -pCaMKII*kf_R78
    jac_[54,28] = -pCaMKII*kf_R77
    jac_[54,29] = 0
    jac_[54,30] = 0
    jac_[54,31] = 0
    jac_[54,32] = 0
    jac_[54,33] = 0
    jac_[54,34] = 0
    jac_[54,35] = 0
    jac_[54,36] = 0
    jac_[54,37] = 0
    jac_[54,38] = 0
    jac_[54,39] = 0
    jac_[54,40] = 0
    jac_[54,41] = 0
    jac_[54,42] = 0
    jac_[54,43] = 0
    jac_[54,44] = 0
    jac_[54,45] = 0
    jac_[54,46] = 0
    jac_[54,47] = 0
    jac_[54,48] = 0
    jac_[54,49] = 0
    jac_[54,50] = 0
    jac_[54,51] = 0
    jac_[54,52] = 0
    jac_[54,53] = 0
    jac_[54,54] = -kf_R78*CaM_Ca2-CaM_Ca4*kf_R77-CaM*kf_R79-kf_R111-kf_R95
    jac_[54,55] = kr_R77
    jac_[54,56] = kr_R79
    jac_[54,57] = kr_R78
    jac_[54,58] = 0
    jac_[54,59] = 0
    jac_[54,60] = 0
    jac_[54,61] = kr_R111
    jac_[54,62] = 0
    jac_[54,63] = 0
    jac_[54,64] = 0
    jac_[54,65] = 0
    jac_[54,66] = 0
    jac_[54,67] = 0
    jac_[54,68] = 0
    jac_[54,69] = 0
    jac_[54,70] = 0
    jac_[54,71] = 0
    jac_[54,72] = 0
    jac_[54,73] = 0
    jac_[54,74] = 0
    jac_[54,75] = 0
    jac_[54,76] = 0
    jac_[54,77] = 0
    jac_[54,78] = 0
    jac_[54,79] = 0
    jac_[54,80] = 0
    jac_[54,81] = 0
    jac_[54,82] = 0
    jac_[54,83] = 0
    jac_[54,84] = 0
    jac_[54,85] = 0
    jac_[54,86] = 0
    jac_[54,87] = 0
    jac_[54,88] = 0
    jac_[54,89] = 0
    jac_[54,90] = 0
    jac_[54,91] = 0
    jac_[54,92] = 0
    jac_[54,93] = 0
    jac_[54,94] = 0
    jac_[54,95] = 0
    jac_[54,96] = 0
    jac_[54,97] = 0
    jac_[54,98] = 0
    jac_[54,99] = 0
    jac_[55,1] = 0
    jac_[55,2] = 0
    jac_[55,3] = 0
    jac_[55,4] = 0
    jac_[55,5] = 0
    jac_[55,6] = 0
    jac_[55,7] = 0
    jac_[55,8] = 0
    jac_[55,9] = 0
    jac_[55,10] = 0
    jac_[55,11] = 0
    jac_[55,12] = 0
    jac_[55,13] = 0
    jac_[55,14] = 0
    jac_[55,15] = 0
    jac_[55,16] = 0
    jac_[55,17] = 0
    jac_[55,18] = 0
    jac_[55,19] = 0
    jac_[55,20] = 0
    jac_[55,21] = 0
    jac_[55,22] = 0
    jac_[55,23] = 0
    jac_[55,24] = 0
    jac_[55,25] = kf_R75*pCaMKII_CaM_Ca2
    jac_[55,26] = 0
    jac_[55,27] = 0
    jac_[55,28] = pCaMKII*kf_R77
    jac_[55,29] = 0
    jac_[55,30] = 0
    jac_[55,31] = -pCaMKII_CaM_Ca4*kf_R133
    jac_[55,32] = 0
    jac_[55,33] = 0
    jac_[55,34] = 0
    jac_[55,35] = 0
    jac_[55,36] = 0
    jac_[55,37] = 0
    jac_[55,38] = 0
    jac_[55,39] = 0
    jac_[55,40] = 0
    jac_[55,41] = 0
    jac_[55,42] = 0
    jac_[55,43] = 0
    jac_[55,44] = 0
    jac_[55,45] = 0
    jac_[55,46] = 0
    jac_[55,47] = 0
    jac_[55,48] = 0
    jac_[55,49] = 0
    jac_[55,50] = 0
    jac_[55,51] = 0
    jac_[55,52] = 0
    jac_[55,53] = 0
    jac_[55,54] = CaM_Ca4*kf_R77
    jac_[55,55] = -kr_R77-kr_R75-kf_R133*CaMKII_CaM_Ca4-kf_R108
    jac_[55,56] = 0
    jac_[55,57] = kf_R75*Ca
    jac_[55,58] = 0
    jac_[55,59] = 0
    jac_[55,60] = kr_R108
    jac_[55,61] = 0
    jac_[55,62] = 0
    jac_[55,63] = 0
    jac_[55,64] = 0
    jac_[55,65] = 0
    jac_[55,66] = 0
    jac_[55,67] = 0
    jac_[55,68] = 0
    jac_[55,69] = 0
    jac_[55,70] = 0
    jac_[55,71] = 0
    jac_[55,72] = 0
    jac_[55,73] = 0
    jac_[55,74] = 0
    jac_[55,75] = 0
    jac_[55,76] = 0
    jac_[55,77] = 0
    jac_[55,78] = 0
    jac_[55,79] = 0
    jac_[55,80] = 0
    jac_[55,81] = 0
    jac_[55,82] = 0
    jac_[55,83] = 0
    jac_[55,84] = kf_R131
    jac_[55,85] = kr_R132+2*kf_R133
    jac_[55,86] = 0
    jac_[55,87] = 0
    jac_[55,88] = 0
    jac_[55,89] = 0
    jac_[55,90] = 0
    jac_[55,91] = 0
    jac_[55,92] = 0
    jac_[55,93] = 0
    jac_[55,94] = 0
    jac_[55,95] = 0
    jac_[55,96] = 0
    jac_[55,97] = 0
    jac_[55,98] = 0
    jac_[55,99] = 0
    jac_[56,1] = 0
    jac_[56,2] = 0
    jac_[56,3] = 0
    jac_[56,4] = 0
    jac_[56,5] = 0
    jac_[56,6] = 0
    jac_[56,7] = 0
    jac_[56,8] = 0
    jac_[56,9] = 0
    jac_[56,10] = 0
    jac_[56,11] = 0
    jac_[56,12] = 0
    jac_[56,13] = 0
    jac_[56,14] = 0
    jac_[56,15] = 0
    jac_[56,16] = 0
    jac_[56,17] = 0
    jac_[56,18] = 0
    jac_[56,19] = 0
    jac_[56,20] = 0
    jac_[56,21] = 0
    jac_[56,22] = 0
    jac_[56,23] = 0
    jac_[56,24] = 0
    jac_[56,25] = -pCaMKII_CaM*kf_R76
    jac_[56,26] = pCaMKII*kf_R79
    jac_[56,27] = 0
    jac_[56,28] = 0
    jac_[56,29] = 0
    jac_[56,30] = 0
    jac_[56,31] = 0
    jac_[56,32] = 0
    jac_[56,33] = 0
    jac_[56,34] = 0
    jac_[56,35] = 0
    jac_[56,36] = 0
    jac_[56,37] = 0
    jac_[56,38] = 0
    jac_[56,39] = 0
    jac_[56,40] = 0
    jac_[56,41] = 0
    jac_[56,42] = 0
    jac_[56,43] = 0
    jac_[56,44] = 0
    jac_[56,45] = 0
    jac_[56,46] = 0
    jac_[56,47] = 0
    jac_[56,48] = 0
    jac_[56,49] = 0
    jac_[56,50] = 0
    jac_[56,51] = 0
    jac_[56,52] = 0
    jac_[56,53] = 0
    jac_[56,54] = CaM*kf_R79
    jac_[56,55] = 0
    jac_[56,56] = -kf_R110-kr_R79-Ca*kf_R76
    jac_[56,57] = kr_R76
    jac_[56,58] = 0
    jac_[56,59] = kr_R110
    jac_[56,60] = 0
    jac_[56,61] = 0
    jac_[56,62] = 0
    jac_[56,63] = 0
    jac_[56,64] = 0
    jac_[56,65] = 0
    jac_[56,66] = 0
    jac_[56,67] = 0
    jac_[56,68] = 0
    jac_[56,69] = 0
    jac_[56,70] = 0
    jac_[56,71] = 0
    jac_[56,72] = 0
    jac_[56,73] = 0
    jac_[56,74] = 0
    jac_[56,75] = 0
    jac_[56,76] = 0
    jac_[56,77] = 0
    jac_[56,78] = 0
    jac_[56,79] = 0
    jac_[56,80] = 0
    jac_[56,81] = 0
    jac_[56,82] = 0
    jac_[56,83] = 0
    jac_[56,84] = 0
    jac_[56,85] = 0
    jac_[56,86] = 0
    jac_[56,87] = 0
    jac_[56,88] = 0
    jac_[56,89] = 0
    jac_[56,90] = 0
    jac_[56,91] = 0
    jac_[56,92] = 0
    jac_[56,93] = 0
    jac_[56,94] = 0
    jac_[56,95] = 0
    jac_[56,96] = 0
    jac_[56,97] = 0
    jac_[56,98] = 0
    jac_[56,99] = 0
    jac_[57,1] = 0
    jac_[57,2] = 0
    jac_[57,3] = 0
    jac_[57,4] = 0
    jac_[57,5] = 0
    jac_[57,6] = 0
    jac_[57,7] = 0
    jac_[57,8] = 0
    jac_[57,9] = 0
    jac_[57,10] = 0
    jac_[57,11] = 0
    jac_[57,12] = 0
    jac_[57,13] = 0
    jac_[57,14] = 0
    jac_[57,15] = 0
    jac_[57,16] = 0
    jac_[57,17] = 0
    jac_[57,18] = 0
    jac_[57,19] = 0
    jac_[57,20] = 0
    jac_[57,21] = 0
    jac_[57,22] = 0
    jac_[57,23] = 0
    jac_[57,24] = 0
    jac_[57,25] = pCaMKII_CaM*kf_R76-kf_R75*pCaMKII_CaM_Ca2
    jac_[57,26] = 0
    jac_[57,27] = pCaMKII*kf_R78
    jac_[57,28] = 0
    jac_[57,29] = 0
    jac_[57,30] = 0
    jac_[57,31] = 0
    jac_[57,32] = 0
    jac_[57,33] = 0
    jac_[57,34] = 0
    jac_[57,35] = 0
    jac_[57,36] = 0
    jac_[57,37] = 0
    jac_[57,38] = 0
    jac_[57,39] = 0
    jac_[57,40] = 0
    jac_[57,41] = 0
    jac_[57,42] = 0
    jac_[57,43] = 0
    jac_[57,44] = 0
    jac_[57,45] = 0
    jac_[57,46] = 0
    jac_[57,47] = 0
    jac_[57,48] = 0
    jac_[57,49] = 0
    jac_[57,50] = 0
    jac_[57,51] = 0
    jac_[57,52] = 0
    jac_[57,53] = 0
    jac_[57,54] = kf_R78*CaM_Ca2
    jac_[57,55] = kr_R75
    jac_[57,56] = Ca*kf_R76
    jac_[57,57] = -kr_R76-kf_R75*Ca-kf_R109-kr_R78
    jac_[57,58] = kr_R109
    jac_[57,59] = 0
    jac_[57,60] = 0
    jac_[57,61] = 0
    jac_[57,62] = 0
    jac_[57,63] = 0
    jac_[57,64] = 0
    jac_[57,65] = 0
    jac_[57,66] = 0
    jac_[57,67] = 0
    jac_[57,68] = 0
    jac_[57,69] = 0
    jac_[57,70] = 0
    jac_[57,71] = 0
    jac_[57,72] = 0
    jac_[57,73] = 0
    jac_[57,74] = 0
    jac_[57,75] = 0
    jac_[57,76] = 0
    jac_[57,77] = 0
    jac_[57,78] = 0
    jac_[57,79] = 0
    jac_[57,80] = 0
    jac_[57,81] = 0
    jac_[57,82] = 0
    jac_[57,83] = 0
    jac_[57,84] = 0
    jac_[57,85] = 0
    jac_[57,86] = 0
    jac_[57,87] = 0
    jac_[57,88] = 0
    jac_[57,89] = 0
    jac_[57,90] = 0
    jac_[57,91] = 0
    jac_[57,92] = 0
    jac_[57,93] = 0
    jac_[57,94] = 0
    jac_[57,95] = 0
    jac_[57,96] = 0
    jac_[57,97] = 0
    jac_[57,98] = 0
    jac_[57,99] = 0
    jac_[58,1] = 0
    jac_[58,2] = 0
    jac_[58,3] = 0
    jac_[58,4] = 0
    jac_[58,5] = 0
    jac_[58,6] = 0
    jac_[58,7] = 0
    jac_[58,8] = 0
    jac_[58,9] = 0
    jac_[58,10] = 0
    jac_[58,11] = 0
    jac_[58,12] = 0
    jac_[58,13] = 0
    jac_[58,14] = 0
    jac_[58,15] = 0
    jac_[58,16] = 0
    jac_[58,17] = 0
    jac_[58,18] = 0
    jac_[58,19] = 0
    jac_[58,20] = 0
    jac_[58,21] = 0
    jac_[58,22] = 0
    jac_[58,23] = 0
    jac_[58,24] = 0
    jac_[58,25] = kf_R115*pCaMKII_CaM_psd-pCaMKII_CaM_Ca2_psd*kf_R116
    jac_[58,26] = 0
    jac_[58,27] = pCaMKII_psd*kf_R113
    jac_[58,28] = 0
    jac_[58,29] = 0
    jac_[58,30] = 0
    jac_[58,31] = 0
    jac_[58,32] = 0
    jac_[58,33] = 0
    jac_[58,34] = 0
    jac_[58,35] = 0
    jac_[58,36] = 0
    jac_[58,37] = 0
    jac_[58,38] = 0
    jac_[58,39] = -kf_R98*pCaMKII_CaM_Ca2_psd
    jac_[58,40] = 0
    jac_[58,41] = 0
    jac_[58,42] = 0
    jac_[58,43] = 0
    jac_[58,44] = 0
    jac_[58,45] = 0
    jac_[58,46] = 0
    jac_[58,47] = 0
    jac_[58,48] = 0
    jac_[58,49] = 0
    jac_[58,50] = 0
    jac_[58,51] = 0
    jac_[58,52] = 0
    jac_[58,53] = 0
    jac_[58,54] = 0
    jac_[58,55] = 0
    jac_[58,56] = 0
    jac_[58,57] = kf_R109
    jac_[58,58] = -kr_R113-kf_R98*Substrate-kr_R115-kr_R109-Ca*kf_R116
    jac_[58,59] = kf_R115*Ca
    jac_[58,60] = kr_R116
    jac_[58,61] = CaM_Ca2*kf_R113
    jac_[58,62] = 0
    jac_[58,63] = 0
    jac_[58,64] = 0
    jac_[58,65] = 0
    jac_[58,66] = 0
    jac_[58,67] = 0
    jac_[58,68] = 0
    jac_[58,69] = 0
    jac_[58,70] = 0
    jac_[58,71] = 0
    jac_[58,72] = 0
    jac_[58,73] = 0
    jac_[58,74] = 0
    jac_[58,75] = 0
    jac_[58,76] = 0
    jac_[58,77] = 0
    jac_[58,78] = 0
    jac_[58,79] = 0
    jac_[58,80] = 0
    jac_[58,81] = 0
    jac_[58,82] = 0
    jac_[58,83] = 0
    jac_[58,84] = 0
    jac_[58,85] = 0
    jac_[58,86] = 0
    jac_[58,87] = 0
    jac_[58,88] = 0
    jac_[58,89] = 0
    jac_[58,90] = 0
    jac_[58,91] = 0
    jac_[58,92] = 0
    jac_[58,93] = 0
    jac_[58,94] = 0
    jac_[58,95] = kr_R98+kf_R99
    jac_[58,96] = 0
    jac_[58,97] = 0
    jac_[58,98] = 0
    jac_[58,99] = 0
    jac_[59,1] = 0
    jac_[59,2] = 0
    jac_[59,3] = 0
    jac_[59,4] = 0
    jac_[59,5] = 0
    jac_[59,6] = 0
    jac_[59,7] = 0
    jac_[59,8] = 0
    jac_[59,9] = 0
    jac_[59,10] = 0
    jac_[59,11] = 0
    jac_[59,12] = 0
    jac_[59,13] = 0
    jac_[59,14] = 0
    jac_[59,15] = 0
    jac_[59,16] = 0
    jac_[59,17] = 0
    jac_[59,18] = 0
    jac_[59,19] = 0
    jac_[59,20] = 0
    jac_[59,21] = 0
    jac_[59,22] = 0
    jac_[59,23] = 0
    jac_[59,24] = 0
    jac_[59,25] = -kf_R115*pCaMKII_CaM_psd
    jac_[59,26] = pCaMKII_psd*kf_R114
    jac_[59,27] = 0
    jac_[59,28] = 0
    jac_[59,29] = 0
    jac_[59,30] = 0
    jac_[59,31] = 0
    jac_[59,32] = 0
    jac_[59,33] = 0
    jac_[59,34] = 0
    jac_[59,35] = 0
    jac_[59,36] = 0
    jac_[59,37] = 0
    jac_[59,38] = 0
    jac_[59,39] = -kf_R96*pCaMKII_CaM_psd
    jac_[59,40] = 0
    jac_[59,41] = 0
    jac_[59,42] = 0
    jac_[59,43] = 0
    jac_[59,44] = 0
    jac_[59,45] = 0
    jac_[59,46] = 0
    jac_[59,47] = 0
    jac_[59,48] = 0
    jac_[59,49] = 0
    jac_[59,50] = 0
    jac_[59,51] = 0
    jac_[59,52] = 0
    jac_[59,53] = 0
    jac_[59,54] = 0
    jac_[59,55] = 0
    jac_[59,56] = kf_R110
    jac_[59,57] = 0
    jac_[59,58] = kr_R115
    jac_[59,59] = -kr_R110-kf_R96*Substrate-kf_R115*Ca-kr_R114
    jac_[59,60] = 0
    jac_[59,61] = kf_R114*CaM
    jac_[59,62] = 0
    jac_[59,63] = 0
    jac_[59,64] = 0
    jac_[59,65] = 0
    jac_[59,66] = 0
    jac_[59,67] = 0
    jac_[59,68] = 0
    jac_[59,69] = 0
    jac_[59,70] = 0
    jac_[59,71] = 0
    jac_[59,72] = 0
    jac_[59,73] = 0
    jac_[59,74] = 0
    jac_[59,75] = 0
    jac_[59,76] = 0
    jac_[59,77] = 0
    jac_[59,78] = 0
    jac_[59,79] = 0
    jac_[59,80] = 0
    jac_[59,81] = 0
    jac_[59,82] = 0
    jac_[59,83] = 0
    jac_[59,84] = 0
    jac_[59,85] = 0
    jac_[59,86] = 0
    jac_[59,87] = 0
    jac_[59,88] = 0
    jac_[59,89] = 0
    jac_[59,90] = 0
    jac_[59,91] = 0
    jac_[59,92] = 0
    jac_[59,93] = 0
    jac_[59,94] = kr_R96+kf_R97
    jac_[59,95] = 0
    jac_[59,96] = 0
    jac_[59,97] = 0
    jac_[59,98] = 0
    jac_[59,99] = 0
    jac_[60,1] = 0
    jac_[60,2] = 0
    jac_[60,3] = 0
    jac_[60,4] = 0
    jac_[60,5] = 0
    jac_[60,6] = 0
    jac_[60,7] = 0
    jac_[60,8] = 0
    jac_[60,9] = 0
    jac_[60,10] = 0
    jac_[60,11] = 0
    jac_[60,12] = 0
    jac_[60,13] = 0
    jac_[60,14] = 0
    jac_[60,15] = 0
    jac_[60,16] = 0
    jac_[60,17] = 0
    jac_[60,18] = 0
    jac_[60,19] = 0
    jac_[60,20] = 0
    jac_[60,21] = 0
    jac_[60,22] = 0
    jac_[60,23] = 0
    jac_[60,24] = 0
    jac_[60,25] = pCaMKII_CaM_Ca2_psd*kf_R116
    jac_[60,26] = 0
    jac_[60,27] = 0
    jac_[60,28] = kf_R112*pCaMKII_psd
    jac_[60,29] = 0
    jac_[60,30] = 0
    jac_[60,31] = 0
    jac_[60,32] = 0
    jac_[60,33] = 0
    jac_[60,34] = 0
    jac_[60,35] = 0
    jac_[60,36] = -kf_R136*pCaMKII_CaM_Ca4_psd
    jac_[60,37] = 0
    jac_[60,38] = 0
    jac_[60,39] = -kf_R100*pCaMKII_CaM_Ca4_psd
    jac_[60,40] = 0
    jac_[60,41] = 0
    jac_[60,42] = 0
    jac_[60,43] = 0
    jac_[60,44] = 0
    jac_[60,45] = 0
    jac_[60,46] = 0
    jac_[60,47] = 0
    jac_[60,48] = 0
    jac_[60,49] = 0
    jac_[60,50] = 0
    jac_[60,51] = 0
    jac_[60,52] = 0
    jac_[60,53] = 0
    jac_[60,54] = 0
    jac_[60,55] = kf_R108
    jac_[60,56] = 0
    jac_[60,57] = 0
    jac_[60,58] = Ca*kf_R116
    jac_[60,59] = 0
    jac_[60,60] = -kr_R108-kr_R116-kr_R112-kf_R100*Substrate-kf_R136*CaMKII_CaM_Ca4_psd
    jac_[60,61] = CaM_Ca4*kf_R112
    jac_[60,62] = 0
    jac_[60,63] = 0
    jac_[60,64] = 0
    jac_[60,65] = 0
    jac_[60,66] = 0
    jac_[60,67] = 0
    jac_[60,68] = 0
    jac_[60,69] = 0
    jac_[60,70] = 0
    jac_[60,71] = 0
    jac_[60,72] = 0
    jac_[60,73] = 0
    jac_[60,74] = 0
    jac_[60,75] = 0
    jac_[60,76] = 0
    jac_[60,77] = 0
    jac_[60,78] = 0
    jac_[60,79] = 0
    jac_[60,80] = 0
    jac_[60,81] = 0
    jac_[60,82] = kf_R135
    jac_[60,83] = kr_R136+2*kf_R137
    jac_[60,84] = 0
    jac_[60,85] = 0
    jac_[60,86] = 0
    jac_[60,87] = 0
    jac_[60,88] = 0
    jac_[60,89] = 0
    jac_[60,90] = 0
    jac_[60,91] = 0
    jac_[60,92] = 0
    jac_[60,93] = 0
    jac_[60,94] = 0
    jac_[60,95] = 0
    jac_[60,96] = kr_R100+kf_R101
    jac_[60,97] = 0
    jac_[60,98] = 0
    jac_[60,99] = 0
    jac_[61,1] = 0
    jac_[61,2] = 0
    jac_[61,3] = 0
    jac_[61,4] = 0
    jac_[61,5] = 0
    jac_[61,6] = 0
    jac_[61,7] = 0
    jac_[61,8] = 0
    jac_[61,9] = 0
    jac_[61,10] = 0
    jac_[61,11] = 0
    jac_[61,12] = 0
    jac_[61,13] = 0
    jac_[61,14] = 0
    jac_[61,15] = 0
    jac_[61,16] = 0
    jac_[61,17] = 0
    jac_[61,18] = 0
    jac_[61,19] = 0
    jac_[61,20] = 0
    jac_[61,21] = 0
    jac_[61,22] = 0
    jac_[61,23] = 0
    jac_[61,24] = 0
    jac_[61,25] = 0
    jac_[61,26] = -pCaMKII_psd*kf_R114
    jac_[61,27] = -pCaMKII_psd*kf_R113
    jac_[61,28] = -kf_R112*pCaMKII_psd
    jac_[61,29] = 0
    jac_[61,30] = 0
    jac_[61,31] = 0
    jac_[61,32] = 0
    jac_[61,33] = 0
    jac_[61,34] = 0
    jac_[61,35] = 0
    jac_[61,36] = 0
    jac_[61,37] = 0
    jac_[61,38] = 0
    jac_[61,39] = -pCaMKII_psd*kf_R93
    jac_[61,40] = 0
    jac_[61,41] = 0
    jac_[61,42] = 0
    jac_[61,43] = 0
    jac_[61,44] = 0
    jac_[61,45] = 0
    jac_[61,46] = 0
    jac_[61,47] = 0
    jac_[61,48] = 0
    jac_[61,49] = 0
    jac_[61,50] = 0
    jac_[61,51] = 0
    jac_[61,52] = 0
    jac_[61,53] = 0
    jac_[61,54] = kf_R111
    jac_[61,55] = 0
    jac_[61,56] = 0
    jac_[61,57] = 0
    jac_[61,58] = kr_R113
    jac_[61,59] = kr_R114
    jac_[61,60] = kr_R112
    jac_[61,61] = -CaM_Ca2*kf_R113-Substrate*kf_R93-kf_R117*PP1-CaM_Ca4*kf_R112-kr_R111-kf_R114*CaM
    jac_[61,62] = 0
    jac_[61,63] = 0
    jac_[61,64] = 0
    jac_[61,65] = 0
    jac_[61,66] = 0
    jac_[61,67] = 0
    jac_[61,68] = 0
    jac_[61,69] = 0
    jac_[61,70] = 0
    jac_[61,71] = 0
    jac_[61,72] = 0
    jac_[61,73] = 0
    jac_[61,74] = 0
    jac_[61,75] = 0
    jac_[61,76] = 0
    jac_[61,77] = 0
    jac_[61,78] = -pCaMKII_psd*kf_R117
    jac_[61,79] = kr_R117
    jac_[61,80] = 0
    jac_[61,81] = 0
    jac_[61,82] = 0
    jac_[61,83] = 0
    jac_[61,84] = 0
    jac_[61,85] = 0
    jac_[61,86] = 0
    jac_[61,87] = 0
    jac_[61,88] = 0
    jac_[61,89] = 0
    jac_[61,90] = 0
    jac_[61,91] = 0
    jac_[61,92] = 0
    jac_[61,93] = kr_R93+kf_R94
    jac_[61,94] = 0
    jac_[61,95] = 0
    jac_[61,96] = 0
    jac_[61,97] = 0
    jac_[61,98] = 0
    jac_[61,99] = 0
    jac_[62,1] = 0
    jac_[62,2] = 0
    jac_[62,3] = 0
    jac_[62,4] = 0
    jac_[62,5] = 0
    jac_[62,6] = 0
    jac_[62,7] = 0
    jac_[62,8] = 0
    jac_[62,9] = 0
    jac_[62,10] = 0
    jac_[62,11] = 0
    jac_[62,12] = 0
    jac_[62,13] = 0
    jac_[62,14] = 0
    jac_[62,15] = 0
    jac_[62,16] = 0
    jac_[62,17] = 0
    jac_[62,18] = 0
    jac_[62,19] = 0
    jac_[62,20] = 0
    jac_[62,21] = 0
    jac_[62,22] = 0
    jac_[62,23] = 0
    jac_[62,24] = 0
    jac_[62,25] = 0
    jac_[62,26] = 0
    jac_[62,27] = 0
    jac_[62,28] = 0
    jac_[62,29] = 0
    jac_[62,30] = 0
    jac_[62,31] = 0
    jac_[62,32] = 0
    jac_[62,33] = 0
    jac_[62,34] = 0
    jac_[62,35] = 0
    jac_[62,36] = 0
    jac_[62,37] = 0
    jac_[62,38] = 0
    jac_[62,39] = 0
    jac_[62,40] = 0
    jac_[62,41] = 0
    jac_[62,42] = 0
    jac_[62,43] = 0
    jac_[62,44] = 0
    jac_[62,45] = 0
    jac_[62,46] = 0
    jac_[62,47] = 0
    jac_[62,48] = 0
    jac_[62,49] = 0
    jac_[62,50] = 0
    jac_[62,51] = 0
    jac_[62,52] = 0
    jac_[62,53] = 0
    jac_[62,54] = 0
    jac_[62,55] = 0
    jac_[62,56] = 0
    jac_[62,57] = 0
    jac_[62,58] = 0
    jac_[62,59] = 0
    jac_[62,60] = 0
    jac_[62,61] = 0
    jac_[62,62] = -PP1*kf_R91
    jac_[62,63] = 0
    jac_[62,64] = 0
    jac_[62,65] = 0
    jac_[62,66] = 0
    jac_[62,67] = 0
    jac_[62,68] = 0
    jac_[62,69] = 0
    jac_[62,70] = 0
    jac_[62,71] = 0
    jac_[62,72] = 0
    jac_[62,73] = 0
    jac_[62,74] = 0
    jac_[62,75] = 0
    jac_[62,76] = 0
    jac_[62,77] = 0
    jac_[62,78] = -pSubstrate*kf_R91
    jac_[62,79] = 0
    jac_[62,80] = kr_R91
    jac_[62,81] = 0
    jac_[62,82] = 0
    jac_[62,83] = 0
    jac_[62,84] = 0
    jac_[62,85] = 0
    jac_[62,86] = 0
    jac_[62,87] = 0
    jac_[62,88] = 0
    jac_[62,89] = 0
    jac_[62,90] = 0
    jac_[62,91] = 0
    jac_[62,92] = 0
    jac_[62,93] = kf_R94
    jac_[62,94] = kf_R97
    jac_[62,95] = kf_R99
    jac_[62,96] = kf_R101
    jac_[62,97] = kf_R103
    jac_[62,98] = kf_R105
    jac_[62,99] = kf_R107
    jac_[63,1] = 0
    jac_[63,2] = 0
    jac_[63,3] = 0
    jac_[63,4] = 0
    jac_[63,5] = 0
    jac_[63,6] = 0
    jac_[63,7] = 0
    jac_[63,8] = 0
    jac_[63,9] = 0
    jac_[63,10] = 0
    jac_[63,11] = 0
    jac_[63,12] = 0
    jac_[63,13] = 0
    jac_[63,14] = 0
    jac_[63,15] = 0
    jac_[63,16] = 0
    jac_[63,17] = 0
    jac_[63,18] = 0
    jac_[63,19] = 0
    jac_[63,20] = 0
    jac_[63,21] = 0
    jac_[63,22] = 0
    jac_[63,23] = 0
    jac_[63,24] = 0
    jac_[63,25] = 0
    jac_[63,26] = 0
    jac_[63,27] = 0
    jac_[63,28] = 0
    jac_[63,29] = 0
    jac_[63,30] = 0
    jac_[63,31] = 0
    jac_[63,32] = 0
    jac_[63,33] = 0
    jac_[63,34] = 0
    jac_[63,35] = 0
    jac_[63,36] = 0
    jac_[63,37] = 0
    jac_[63,38] = -PDE4*kf_R41
    jac_[63,39] = 0
    jac_[63,40] = 0
    jac_[63,41] = 0
    jac_[63,42] = 0
    jac_[63,43] = 0
    jac_[63,44] = 0
    jac_[63,45] = 0
    jac_[63,46] = 0
    jac_[63,47] = 0
    jac_[63,48] = 0
    jac_[63,49] = 0
    jac_[63,50] = 0
    jac_[63,51] = 0
    jac_[63,52] = 0
    jac_[63,53] = 0
    jac_[63,54] = 0
    jac_[63,55] = 0
    jac_[63,56] = 0
    jac_[63,57] = 0
    jac_[63,58] = 0
    jac_[63,59] = 0
    jac_[63,60] = 0
    jac_[63,61] = 0
    jac_[63,62] = 0
    jac_[63,63] = -cAMP*kf_R41
    jac_[63,64] = kr_R41+kf_R42
    jac_[63,65] = 0
    jac_[63,66] = 0
    jac_[63,67] = 0
    jac_[63,68] = 0
    jac_[63,69] = 0
    jac_[63,70] = 0
    jac_[63,71] = 0
    jac_[63,72] = 0
    jac_[63,73] = 0
    jac_[63,74] = 0
    jac_[63,75] = 0
    jac_[63,76] = 0
    jac_[63,77] = 0
    jac_[63,78] = 0
    jac_[63,79] = 0
    jac_[63,80] = 0
    jac_[63,81] = 0
    jac_[63,82] = 0
    jac_[63,83] = 0
    jac_[63,84] = 0
    jac_[63,85] = 0
    jac_[63,86] = 0
    jac_[63,87] = 0
    jac_[63,88] = 0
    jac_[63,89] = 0
    jac_[63,90] = 0
    jac_[63,91] = 0
    jac_[63,92] = 0
    jac_[63,93] = 0
    jac_[63,94] = 0
    jac_[63,95] = 0
    jac_[63,96] = 0
    jac_[63,97] = 0
    jac_[63,98] = 0
    jac_[63,99] = 0
    jac_[64,1] = 0
    jac_[64,2] = 0
    jac_[64,3] = 0
    jac_[64,4] = 0
    jac_[64,5] = 0
    jac_[64,6] = 0
    jac_[64,7] = 0
    jac_[64,8] = 0
    jac_[64,9] = 0
    jac_[64,10] = 0
    jac_[64,11] = 0
    jac_[64,12] = 0
    jac_[64,13] = 0
    jac_[64,14] = 0
    jac_[64,15] = 0
    jac_[64,16] = 0
    jac_[64,17] = 0
    jac_[64,18] = 0
    jac_[64,19] = 0
    jac_[64,20] = 0
    jac_[64,21] = 0
    jac_[64,22] = 0
    jac_[64,23] = 0
    jac_[64,24] = 0
    jac_[64,25] = 0
    jac_[64,26] = 0
    jac_[64,27] = 0
    jac_[64,28] = 0
    jac_[64,29] = 0
    jac_[64,30] = 0
    jac_[64,31] = 0
    jac_[64,32] = 0
    jac_[64,33] = 0
    jac_[64,34] = 0
    jac_[64,35] = 0
    jac_[64,36] = 0
    jac_[64,37] = 0
    jac_[64,38] = PDE4*kf_R41
    jac_[64,39] = 0
    jac_[64,40] = 0
    jac_[64,41] = 0
    jac_[64,42] = 0
    jac_[64,43] = 0
    jac_[64,44] = 0
    jac_[64,45] = 0
    jac_[64,46] = 0
    jac_[64,47] = 0
    jac_[64,48] = 0
    jac_[64,49] = 0
    jac_[64,50] = 0
    jac_[64,51] = 0
    jac_[64,52] = 0
    jac_[64,53] = 0
    jac_[64,54] = 0
    jac_[64,55] = 0
    jac_[64,56] = 0
    jac_[64,57] = 0
    jac_[64,58] = 0
    jac_[64,59] = 0
    jac_[64,60] = 0
    jac_[64,61] = 0
    jac_[64,62] = 0
    jac_[64,63] = cAMP*kf_R41
    jac_[64,64] = -kr_R41-kf_R42
    jac_[64,65] = 0
    jac_[64,66] = 0
    jac_[64,67] = 0
    jac_[64,68] = 0
    jac_[64,69] = 0
    jac_[64,70] = 0
    jac_[64,71] = 0
    jac_[64,72] = 0
    jac_[64,73] = 0
    jac_[64,74] = 0
    jac_[64,75] = 0
    jac_[64,76] = 0
    jac_[64,77] = 0
    jac_[64,78] = 0
    jac_[64,79] = 0
    jac_[64,80] = 0
    jac_[64,81] = 0
    jac_[64,82] = 0
    jac_[64,83] = 0
    jac_[64,84] = 0
    jac_[64,85] = 0
    jac_[64,86] = 0
    jac_[64,87] = 0
    jac_[64,88] = 0
    jac_[64,89] = 0
    jac_[64,90] = 0
    jac_[64,91] = 0
    jac_[64,92] = 0
    jac_[64,93] = 0
    jac_[64,94] = 0
    jac_[64,95] = 0
    jac_[64,96] = 0
    jac_[64,97] = 0
    jac_[64,98] = 0
    jac_[64,99] = 0
    jac_[65,1] = 0
    jac_[65,2] = 0
    jac_[65,3] = 0
    jac_[65,4] = 0
    jac_[65,5] = 0
    jac_[65,6] = 0
    jac_[65,7] = 0
    jac_[65,8] = 0
    jac_[65,9] = 0
    jac_[65,10] = 0
    jac_[65,11] = 0
    jac_[65,12] = 0
    jac_[65,13] = 0
    jac_[65,14] = 0
    jac_[65,15] = 0
    jac_[65,16] = 0
    jac_[65,17] = 0
    jac_[65,18] = 0
    jac_[65,19] = 0
    jac_[65,20] = 0
    jac_[65,21] = 0
    jac_[65,22] = 0
    jac_[65,23] = 0
    jac_[65,24] = 0
    jac_[65,25] = 0
    jac_[65,26] = 0
    jac_[65,27] = 0
    jac_[65,28] = 0
    jac_[65,29] = 0
    jac_[65,30] = 0
    jac_[65,31] = 0
    jac_[65,32] = 0
    jac_[65,33] = 0
    jac_[65,34] = 0
    jac_[65,35] = 0
    jac_[65,36] = 0
    jac_[65,37] = 0
    jac_[65,38] = -PDE10r*kf_R45-2*cAMP*PDE10r*kf_R43
    jac_[65,39] = 0
    jac_[65,40] = 0
    jac_[65,41] = 0
    jac_[65,42] = 0
    jac_[65,43] = 0
    jac_[65,44] = 0
    jac_[65,45] = 0
    jac_[65,46] = 0
    jac_[65,47] = 0
    jac_[65,48] = 0
    jac_[65,49] = 0
    jac_[65,50] = 0
    jac_[65,51] = 0
    jac_[65,52] = 0
    jac_[65,53] = 0
    jac_[65,54] = 0
    jac_[65,55] = 0
    jac_[65,56] = 0
    jac_[65,57] = 0
    jac_[65,58] = 0
    jac_[65,59] = 0
    jac_[65,60] = 0
    jac_[65,61] = 0
    jac_[65,62] = 0
    jac_[65,63] = 0
    jac_[65,64] = 0
    jac_[65,65] = -cAMP^2*kf_R43-cAMP*kf_R45
    jac_[65,66] = kr_R45+kf_R44
    jac_[65,67] = kr_R43
    jac_[65,68] = 0
    jac_[65,69] = 0
    jac_[65,70] = 0
    jac_[65,71] = 0
    jac_[65,72] = 0
    jac_[65,73] = 0
    jac_[65,74] = 0
    jac_[65,75] = 0
    jac_[65,76] = 0
    jac_[65,77] = 0
    jac_[65,78] = 0
    jac_[65,79] = 0
    jac_[65,80] = 0
    jac_[65,81] = 0
    jac_[65,82] = 0
    jac_[65,83] = 0
    jac_[65,84] = 0
    jac_[65,85] = 0
    jac_[65,86] = 0
    jac_[65,87] = 0
    jac_[65,88] = 0
    jac_[65,89] = 0
    jac_[65,90] = 0
    jac_[65,91] = 0
    jac_[65,92] = 0
    jac_[65,93] = 0
    jac_[65,94] = 0
    jac_[65,95] = 0
    jac_[65,96] = 0
    jac_[65,97] = 0
    jac_[65,98] = 0
    jac_[65,99] = 0
    jac_[66,1] = 0
    jac_[66,2] = 0
    jac_[66,3] = 0
    jac_[66,4] = 0
    jac_[66,5] = 0
    jac_[66,6] = 0
    jac_[66,7] = 0
    jac_[66,8] = 0
    jac_[66,9] = 0
    jac_[66,10] = 0
    jac_[66,11] = 0
    jac_[66,12] = 0
    jac_[66,13] = 0
    jac_[66,14] = 0
    jac_[66,15] = 0
    jac_[66,16] = 0
    jac_[66,17] = 0
    jac_[66,18] = 0
    jac_[66,19] = 0
    jac_[66,20] = 0
    jac_[66,21] = 0
    jac_[66,22] = 0
    jac_[66,23] = 0
    jac_[66,24] = 0
    jac_[66,25] = 0
    jac_[66,26] = 0
    jac_[66,27] = 0
    jac_[66,28] = 0
    jac_[66,29] = 0
    jac_[66,30] = 0
    jac_[66,31] = 0
    jac_[66,32] = 0
    jac_[66,33] = 0
    jac_[66,34] = 0
    jac_[66,35] = 0
    jac_[66,36] = 0
    jac_[66,37] = 0
    jac_[66,38] = PDE10r*kf_R45
    jac_[66,39] = 0
    jac_[66,40] = 0
    jac_[66,41] = 0
    jac_[66,42] = 0
    jac_[66,43] = 0
    jac_[66,44] = 0
    jac_[66,45] = 0
    jac_[66,46] = 0
    jac_[66,47] = 0
    jac_[66,48] = 0
    jac_[66,49] = 0
    jac_[66,50] = 0
    jac_[66,51] = 0
    jac_[66,52] = 0
    jac_[66,53] = 0
    jac_[66,54] = 0
    jac_[66,55] = 0
    jac_[66,56] = 0
    jac_[66,57] = 0
    jac_[66,58] = 0
    jac_[66,59] = 0
    jac_[66,60] = 0
    jac_[66,61] = 0
    jac_[66,62] = 0
    jac_[66,63] = 0
    jac_[66,64] = 0
    jac_[66,65] = cAMP*kf_R45
    jac_[66,66] = -kr_R45-kf_R44
    jac_[66,67] = 0
    jac_[66,68] = 0
    jac_[66,69] = 0
    jac_[66,70] = 0
    jac_[66,71] = 0
    jac_[66,72] = 0
    jac_[66,73] = 0
    jac_[66,74] = 0
    jac_[66,75] = 0
    jac_[66,76] = 0
    jac_[66,77] = 0
    jac_[66,78] = 0
    jac_[66,79] = 0
    jac_[66,80] = 0
    jac_[66,81] = 0
    jac_[66,82] = 0
    jac_[66,83] = 0
    jac_[66,84] = 0
    jac_[66,85] = 0
    jac_[66,86] = 0
    jac_[66,87] = 0
    jac_[66,88] = 0
    jac_[66,89] = 0
    jac_[66,90] = 0
    jac_[66,91] = 0
    jac_[66,92] = 0
    jac_[66,93] = 0
    jac_[66,94] = 0
    jac_[66,95] = 0
    jac_[66,96] = 0
    jac_[66,97] = 0
    jac_[66,98] = 0
    jac_[66,99] = 0
    jac_[67,1] = 0
    jac_[67,2] = 0
    jac_[67,3] = 0
    jac_[67,4] = 0
    jac_[67,5] = 0
    jac_[67,6] = 0
    jac_[67,7] = 0
    jac_[67,8] = 0
    jac_[67,9] = 0
    jac_[67,10] = 0
    jac_[67,11] = 0
    jac_[67,12] = 0
    jac_[67,13] = 0
    jac_[67,14] = 0
    jac_[67,15] = 0
    jac_[67,16] = 0
    jac_[67,17] = 0
    jac_[67,18] = 0
    jac_[67,19] = 0
    jac_[67,20] = 0
    jac_[67,21] = 0
    jac_[67,22] = 0
    jac_[67,23] = 0
    jac_[67,24] = 0
    jac_[67,25] = 0
    jac_[67,26] = 0
    jac_[67,27] = 0
    jac_[67,28] = 0
    jac_[67,29] = 0
    jac_[67,30] = 0
    jac_[67,31] = 0
    jac_[67,32] = 0
    jac_[67,33] = 0
    jac_[67,34] = 0
    jac_[67,35] = 0
    jac_[67,36] = 0
    jac_[67,37] = 0
    jac_[67,38] = -PDE10c*kf_R69+2*cAMP*PDE10r*kf_R43
    jac_[67,39] = 0
    jac_[67,40] = 0
    jac_[67,41] = 0
    jac_[67,42] = 0
    jac_[67,43] = 0
    jac_[67,44] = 0
    jac_[67,45] = 0
    jac_[67,46] = 0
    jac_[67,47] = 0
    jac_[67,48] = 0
    jac_[67,49] = 0
    jac_[67,50] = 0
    jac_[67,51] = 0
    jac_[67,52] = 0
    jac_[67,53] = 0
    jac_[67,54] = 0
    jac_[67,55] = 0
    jac_[67,56] = 0
    jac_[67,57] = 0
    jac_[67,58] = 0
    jac_[67,59] = 0
    jac_[67,60] = 0
    jac_[67,61] = 0
    jac_[67,62] = 0
    jac_[67,63] = 0
    jac_[67,64] = 0
    jac_[67,65] = cAMP^2*kf_R43
    jac_[67,66] = 0
    jac_[67,67] = -kr_R43-cAMP*kf_R69
    jac_[67,68] = kf_R46+kr_R69
    jac_[67,69] = 0
    jac_[67,70] = 0
    jac_[67,71] = 0
    jac_[67,72] = 0
    jac_[67,73] = 0
    jac_[67,74] = 0
    jac_[67,75] = 0
    jac_[67,76] = 0
    jac_[67,77] = 0
    jac_[67,78] = 0
    jac_[67,79] = 0
    jac_[67,80] = 0
    jac_[67,81] = 0
    jac_[67,82] = 0
    jac_[67,83] = 0
    jac_[67,84] = 0
    jac_[67,85] = 0
    jac_[67,86] = 0
    jac_[67,87] = 0
    jac_[67,88] = 0
    jac_[67,89] = 0
    jac_[67,90] = 0
    jac_[67,91] = 0
    jac_[67,92] = 0
    jac_[67,93] = 0
    jac_[67,94] = 0
    jac_[67,95] = 0
    jac_[67,96] = 0
    jac_[67,97] = 0
    jac_[67,98] = 0
    jac_[67,99] = 0
    jac_[68,1] = 0
    jac_[68,2] = 0
    jac_[68,3] = 0
    jac_[68,4] = 0
    jac_[68,5] = 0
    jac_[68,6] = 0
    jac_[68,7] = 0
    jac_[68,8] = 0
    jac_[68,9] = 0
    jac_[68,10] = 0
    jac_[68,11] = 0
    jac_[68,12] = 0
    jac_[68,13] = 0
    jac_[68,14] = 0
    jac_[68,15] = 0
    jac_[68,16] = 0
    jac_[68,17] = 0
    jac_[68,18] = 0
    jac_[68,19] = 0
    jac_[68,20] = 0
    jac_[68,21] = 0
    jac_[68,22] = 0
    jac_[68,23] = 0
    jac_[68,24] = 0
    jac_[68,25] = 0
    jac_[68,26] = 0
    jac_[68,27] = 0
    jac_[68,28] = 0
    jac_[68,29] = 0
    jac_[68,30] = 0
    jac_[68,31] = 0
    jac_[68,32] = 0
    jac_[68,33] = 0
    jac_[68,34] = 0
    jac_[68,35] = 0
    jac_[68,36] = 0
    jac_[68,37] = 0
    jac_[68,38] = PDE10c*kf_R69
    jac_[68,39] = 0
    jac_[68,40] = 0
    jac_[68,41] = 0
    jac_[68,42] = 0
    jac_[68,43] = 0
    jac_[68,44] = 0
    jac_[68,45] = 0
    jac_[68,46] = 0
    jac_[68,47] = 0
    jac_[68,48] = 0
    jac_[68,49] = 0
    jac_[68,50] = 0
    jac_[68,51] = 0
    jac_[68,52] = 0
    jac_[68,53] = 0
    jac_[68,54] = 0
    jac_[68,55] = 0
    jac_[68,56] = 0
    jac_[68,57] = 0
    jac_[68,58] = 0
    jac_[68,59] = 0
    jac_[68,60] = 0
    jac_[68,61] = 0
    jac_[68,62] = 0
    jac_[68,63] = 0
    jac_[68,64] = 0
    jac_[68,65] = 0
    jac_[68,66] = 0
    jac_[68,67] = cAMP*kf_R69
    jac_[68,68] = -kf_R46-kr_R69
    jac_[68,69] = 0
    jac_[68,70] = 0
    jac_[68,71] = 0
    jac_[68,72] = 0
    jac_[68,73] = 0
    jac_[68,74] = 0
    jac_[68,75] = 0
    jac_[68,76] = 0
    jac_[68,77] = 0
    jac_[68,78] = 0
    jac_[68,79] = 0
    jac_[68,80] = 0
    jac_[68,81] = 0
    jac_[68,82] = 0
    jac_[68,83] = 0
    jac_[68,84] = 0
    jac_[68,85] = 0
    jac_[68,86] = 0
    jac_[68,87] = 0
    jac_[68,88] = 0
    jac_[68,89] = 0
    jac_[68,90] = 0
    jac_[68,91] = 0
    jac_[68,92] = 0
    jac_[68,93] = 0
    jac_[68,94] = 0
    jac_[68,95] = 0
    jac_[68,96] = 0
    jac_[68,97] = 0
    jac_[68,98] = 0
    jac_[68,99] = 0
    jac_[69,1] = 0
    jac_[69,2] = 0
    jac_[69,3] = 0
    jac_[69,4] = 0
    jac_[69,5] = 0
    jac_[69,6] = 0
    jac_[69,7] = 0
    jac_[69,8] = 0
    jac_[69,9] = 0
    jac_[69,10] = 0
    jac_[69,11] = 0
    jac_[69,12] = 0
    jac_[69,13] = 0
    jac_[69,14] = 0
    jac_[69,15] = 0
    jac_[69,16] = 0
    jac_[69,17] = 0
    jac_[69,18] = 0
    jac_[69,19] = 0
    jac_[69,20] = 0
    jac_[69,21] = 0
    jac_[69,22] = 0
    jac_[69,23] = 0
    jac_[69,24] = 0
    jac_[69,25] = 0
    jac_[69,26] = 0
    jac_[69,27] = 0
    jac_[69,28] = 0
    jac_[69,29] = 0
    jac_[69,30] = 0
    jac_[69,31] = 0
    jac_[69,32] = 0
    jac_[69,33] = 0
    jac_[69,34] = 0
    jac_[69,35] = 0
    jac_[69,36] = 0
    jac_[69,37] = 0
    jac_[69,38] = -kf_R38*PKA
    jac_[69,39] = 0
    jac_[69,40] = 0
    jac_[69,41] = 0
    jac_[69,42] = 0
    jac_[69,43] = 0
    jac_[69,44] = 0
    jac_[69,45] = 0
    jac_[69,46] = 0
    jac_[69,47] = 0
    jac_[69,48] = 0
    jac_[69,49] = 0
    jac_[69,50] = 0
    jac_[69,51] = 0
    jac_[69,52] = 0
    jac_[69,53] = 0
    jac_[69,54] = 0
    jac_[69,55] = 0
    jac_[69,56] = 0
    jac_[69,57] = 0
    jac_[69,58] = 0
    jac_[69,59] = 0
    jac_[69,60] = 0
    jac_[69,61] = 0
    jac_[69,62] = 0
    jac_[69,63] = 0
    jac_[69,64] = 0
    jac_[69,65] = 0
    jac_[69,66] = 0
    jac_[69,67] = 0
    jac_[69,68] = 0
    jac_[69,69] = -cAMP*kf_R38
    jac_[69,70] = 0
    jac_[69,71] = 0
    jac_[69,72] = 0
    jac_[69,73] = 0
    jac_[69,74] = kr_R38
    jac_[69,75] = 0
    jac_[69,76] = 0
    jac_[69,77] = 0
    jac_[69,78] = 0
    jac_[69,79] = 0
    jac_[69,80] = 0
    jac_[69,81] = 0
    jac_[69,82] = 0
    jac_[69,83] = 0
    jac_[69,84] = 0
    jac_[69,85] = 0
    jac_[69,86] = 0
    jac_[69,87] = 0
    jac_[69,88] = 0
    jac_[69,89] = 0
    jac_[69,90] = 0
    jac_[69,91] = 0
    jac_[69,92] = 0
    jac_[69,93] = 0
    jac_[69,94] = 0
    jac_[69,95] = 0
    jac_[69,96] = 0
    jac_[69,97] = 0
    jac_[69,98] = 0
    jac_[69,99] = 0
    jac_[70,1] = 0
    jac_[70,2] = 0
    jac_[70,3] = 0
    jac_[70,4] = 0
    jac_[70,5] = 0
    jac_[70,6] = 0
    jac_[70,7] = 0
    jac_[70,8] = 0
    jac_[70,9] = 0
    jac_[70,10] = 0
    jac_[70,11] = -PKAc*kf_R10
    jac_[70,12] = 0
    jac_[70,13] = 0
    jac_[70,14] = 0
    jac_[70,15] = 0
    jac_[70,16] = 0
    jac_[70,17] = 0
    jac_[70,18] = 0
    jac_[70,19] = 0
    jac_[70,20] = 0
    jac_[70,21] = 0
    jac_[70,22] = 0
    jac_[70,23] = 0
    jac_[70,24] = 0
    jac_[70,25] = 0
    jac_[70,26] = 0
    jac_[70,27] = 0
    jac_[70,28] = 0
    jac_[70,29] = 0
    jac_[70,30] = 0
    jac_[70,31] = 0
    jac_[70,32] = 0
    jac_[70,33] = 0
    jac_[70,34] = 0
    jac_[70,35] = 0
    jac_[70,36] = 0
    jac_[70,37] = 0
    jac_[70,38] = 0
    jac_[70,39] = 0
    jac_[70,40] = 0
    jac_[70,41] = 0
    jac_[70,42] = 0
    jac_[70,43] = 0
    jac_[70,44] = 0
    jac_[70,45] = 0
    jac_[70,46] = 0
    jac_[70,47] = -PKAc*kf_R15
    jac_[70,48] = 0
    jac_[70,49] = -PKAc*kf_R8
    jac_[70,50] = 0
    jac_[70,51] = 0
    jac_[70,52] = 0
    jac_[70,53] = 0
    jac_[70,54] = 0
    jac_[70,55] = 0
    jac_[70,56] = 0
    jac_[70,57] = 0
    jac_[70,58] = 0
    jac_[70,59] = 0
    jac_[70,60] = 0
    jac_[70,61] = 0
    jac_[70,62] = 0
    jac_[70,63] = 0
    jac_[70,64] = 0
    jac_[70,65] = 0
    jac_[70,66] = 0
    jac_[70,67] = 0
    jac_[70,68] = 0
    jac_[70,69] = 0
    jac_[70,70] = -D32*kf_R8-kf_R40*PKAreg-D32p75*kf_R15-B56PP2A*kf_R10-ARPP21*kf_R80
    jac_[70,71] = kf_R11+kr_R10
    jac_[70,72] = kf_R9+kr_R8
    jac_[70,73] = kf_R81+kr_R80
    jac_[70,74] = 0
    jac_[70,75] = kr_R40
    jac_[70,76] = kr_R15
    jac_[70,77] = -PKAc*kf_R40
    jac_[70,78] = 0
    jac_[70,79] = 0
    jac_[70,80] = 0
    jac_[70,81] = 0
    jac_[70,82] = 0
    jac_[70,83] = 0
    jac_[70,84] = 0
    jac_[70,85] = 0
    jac_[70,86] = 0
    jac_[70,87] = 0
    jac_[70,88] = 0
    jac_[70,89] = 0
    jac_[70,90] = 0
    jac_[70,91] = 0
    jac_[70,92] = -PKAc*kf_R80
    jac_[70,93] = 0
    jac_[70,94] = 0
    jac_[70,95] = 0
    jac_[70,96] = 0
    jac_[70,97] = 0
    jac_[70,98] = 0
    jac_[70,99] = 0
    jac_[71,1] = 0
    jac_[71,2] = 0
    jac_[71,3] = 0
    jac_[71,4] = 0
    jac_[71,5] = 0
    jac_[71,6] = 0
    jac_[71,7] = 0
    jac_[71,8] = 0
    jac_[71,9] = 0
    jac_[71,10] = 0
    jac_[71,11] = PKAc*kf_R10
    jac_[71,12] = 0
    jac_[71,13] = 0
    jac_[71,14] = 0
    jac_[71,15] = 0
    jac_[71,16] = 0
    jac_[71,17] = 0
    jac_[71,18] = 0
    jac_[71,19] = 0
    jac_[71,20] = 0
    jac_[71,21] = 0
    jac_[71,22] = 0
    jac_[71,23] = 0
    jac_[71,24] = 0
    jac_[71,25] = 0
    jac_[71,26] = 0
    jac_[71,27] = 0
    jac_[71,28] = 0
    jac_[71,29] = 0
    jac_[71,30] = 0
    jac_[71,31] = 0
    jac_[71,32] = 0
    jac_[71,33] = 0
    jac_[71,34] = 0
    jac_[71,35] = 0
    jac_[71,36] = 0
    jac_[71,37] = 0
    jac_[71,38] = 0
    jac_[71,39] = 0
    jac_[71,40] = 0
    jac_[71,41] = 0
    jac_[71,42] = 0
    jac_[71,43] = 0
    jac_[71,44] = 0
    jac_[71,45] = 0
    jac_[71,46] = 0
    jac_[71,47] = 0
    jac_[71,48] = 0
    jac_[71,49] = 0
    jac_[71,50] = 0
    jac_[71,51] = 0
    jac_[71,52] = 0
    jac_[71,53] = 0
    jac_[71,54] = 0
    jac_[71,55] = 0
    jac_[71,56] = 0
    jac_[71,57] = 0
    jac_[71,58] = 0
    jac_[71,59] = 0
    jac_[71,60] = 0
    jac_[71,61] = 0
    jac_[71,62] = 0
    jac_[71,63] = 0
    jac_[71,64] = 0
    jac_[71,65] = 0
    jac_[71,66] = 0
    jac_[71,67] = 0
    jac_[71,68] = 0
    jac_[71,69] = 0
    jac_[71,70] = B56PP2A*kf_R10
    jac_[71,71] = -kf_R11-kr_R10
    jac_[71,72] = 0
    jac_[71,73] = 0
    jac_[71,74] = 0
    jac_[71,75] = 0
    jac_[71,76] = 0
    jac_[71,77] = 0
    jac_[71,78] = 0
    jac_[71,79] = 0
    jac_[71,80] = 0
    jac_[71,81] = 0
    jac_[71,82] = 0
    jac_[71,83] = 0
    jac_[71,84] = 0
    jac_[71,85] = 0
    jac_[71,86] = 0
    jac_[71,87] = 0
    jac_[71,88] = 0
    jac_[71,89] = 0
    jac_[71,90] = 0
    jac_[71,91] = 0
    jac_[71,92] = 0
    jac_[71,93] = 0
    jac_[71,94] = 0
    jac_[71,95] = 0
    jac_[71,96] = 0
    jac_[71,97] = 0
    jac_[71,98] = 0
    jac_[71,99] = 0
    jac_[72,1] = 0
    jac_[72,2] = 0
    jac_[72,3] = 0
    jac_[72,4] = 0
    jac_[72,5] = 0
    jac_[72,6] = 0
    jac_[72,7] = 0
    jac_[72,8] = 0
    jac_[72,9] = 0
    jac_[72,10] = 0
    jac_[72,11] = 0
    jac_[72,12] = 0
    jac_[72,13] = 0
    jac_[72,14] = 0
    jac_[72,15] = 0
    jac_[72,16] = 0
    jac_[72,17] = 0
    jac_[72,18] = 0
    jac_[72,19] = 0
    jac_[72,20] = 0
    jac_[72,21] = 0
    jac_[72,22] = 0
    jac_[72,23] = 0
    jac_[72,24] = 0
    jac_[72,25] = 0
    jac_[72,26] = 0
    jac_[72,27] = 0
    jac_[72,28] = 0
    jac_[72,29] = 0
    jac_[72,30] = 0
    jac_[72,31] = 0
    jac_[72,32] = 0
    jac_[72,33] = 0
    jac_[72,34] = 0
    jac_[72,35] = 0
    jac_[72,36] = 0
    jac_[72,37] = 0
    jac_[72,38] = 0
    jac_[72,39] = 0
    jac_[72,40] = 0
    jac_[72,41] = 0
    jac_[72,42] = 0
    jac_[72,43] = 0
    jac_[72,44] = 0
    jac_[72,45] = 0
    jac_[72,46] = 0
    jac_[72,47] = 0
    jac_[72,48] = 0
    jac_[72,49] = PKAc*kf_R8
    jac_[72,50] = 0
    jac_[72,51] = 0
    jac_[72,52] = 0
    jac_[72,53] = 0
    jac_[72,54] = 0
    jac_[72,55] = 0
    jac_[72,56] = 0
    jac_[72,57] = 0
    jac_[72,58] = 0
    jac_[72,59] = 0
    jac_[72,60] = 0
    jac_[72,61] = 0
    jac_[72,62] = 0
    jac_[72,63] = 0
    jac_[72,64] = 0
    jac_[72,65] = 0
    jac_[72,66] = 0
    jac_[72,67] = 0
    jac_[72,68] = 0
    jac_[72,69] = 0
    jac_[72,70] = D32*kf_R8
    jac_[72,71] = 0
    jac_[72,72] = -kf_R9-kr_R8
    jac_[72,73] = 0
    jac_[72,74] = 0
    jac_[72,75] = 0
    jac_[72,76] = 0
    jac_[72,77] = 0
    jac_[72,78] = 0
    jac_[72,79] = 0
    jac_[72,80] = 0
    jac_[72,81] = 0
    jac_[72,82] = 0
    jac_[72,83] = 0
    jac_[72,84] = 0
    jac_[72,85] = 0
    jac_[72,86] = 0
    jac_[72,87] = 0
    jac_[72,88] = 0
    jac_[72,89] = 0
    jac_[72,90] = 0
    jac_[72,91] = 0
    jac_[72,92] = 0
    jac_[72,93] = 0
    jac_[72,94] = 0
    jac_[72,95] = 0
    jac_[72,96] = 0
    jac_[72,97] = 0
    jac_[72,98] = 0
    jac_[72,99] = 0
    jac_[73,1] = 0
    jac_[73,2] = 0
    jac_[73,3] = 0
    jac_[73,4] = 0
    jac_[73,5] = 0
    jac_[73,6] = 0
    jac_[73,7] = 0
    jac_[73,8] = 0
    jac_[73,9] = 0
    jac_[73,10] = 0
    jac_[73,11] = 0
    jac_[73,12] = 0
    jac_[73,13] = 0
    jac_[73,14] = 0
    jac_[73,15] = 0
    jac_[73,16] = 0
    jac_[73,17] = 0
    jac_[73,18] = 0
    jac_[73,19] = 0
    jac_[73,20] = 0
    jac_[73,21] = 0
    jac_[73,22] = 0
    jac_[73,23] = 0
    jac_[73,24] = 0
    jac_[73,25] = 0
    jac_[73,26] = 0
    jac_[73,27] = 0
    jac_[73,28] = 0
    jac_[73,29] = 0
    jac_[73,30] = 0
    jac_[73,31] = 0
    jac_[73,32] = 0
    jac_[73,33] = 0
    jac_[73,34] = 0
    jac_[73,35] = 0
    jac_[73,36] = 0
    jac_[73,37] = 0
    jac_[73,38] = 0
    jac_[73,39] = 0
    jac_[73,40] = 0
    jac_[73,41] = 0
    jac_[73,42] = 0
    jac_[73,43] = 0
    jac_[73,44] = 0
    jac_[73,45] = 0
    jac_[73,46] = 0
    jac_[73,47] = 0
    jac_[73,48] = 0
    jac_[73,49] = 0
    jac_[73,50] = 0
    jac_[73,51] = 0
    jac_[73,52] = 0
    jac_[73,53] = 0
    jac_[73,54] = 0
    jac_[73,55] = 0
    jac_[73,56] = 0
    jac_[73,57] = 0
    jac_[73,58] = 0
    jac_[73,59] = 0
    jac_[73,60] = 0
    jac_[73,61] = 0
    jac_[73,62] = 0
    jac_[73,63] = 0
    jac_[73,64] = 0
    jac_[73,65] = 0
    jac_[73,66] = 0
    jac_[73,67] = 0
    jac_[73,68] = 0
    jac_[73,69] = 0
    jac_[73,70] = ARPP21*kf_R80
    jac_[73,71] = 0
    jac_[73,72] = 0
    jac_[73,73] = -kf_R81-kr_R80
    jac_[73,74] = 0
    jac_[73,75] = 0
    jac_[73,76] = 0
    jac_[73,77] = 0
    jac_[73,78] = 0
    jac_[73,79] = 0
    jac_[73,80] = 0
    jac_[73,81] = 0
    jac_[73,82] = 0
    jac_[73,83] = 0
    jac_[73,84] = 0
    jac_[73,85] = 0
    jac_[73,86] = 0
    jac_[73,87] = 0
    jac_[73,88] = 0
    jac_[73,89] = 0
    jac_[73,90] = 0
    jac_[73,91] = 0
    jac_[73,92] = PKAc*kf_R80
    jac_[73,93] = 0
    jac_[73,94] = 0
    jac_[73,95] = 0
    jac_[73,96] = 0
    jac_[73,97] = 0
    jac_[73,98] = 0
    jac_[73,99] = 0
    jac_[74,1] = 0
    jac_[74,2] = 0
    jac_[74,3] = 0
    jac_[74,4] = 0
    jac_[74,5] = 0
    jac_[74,6] = 0
    jac_[74,7] = 0
    jac_[74,8] = 0
    jac_[74,9] = 0
    jac_[74,10] = 0
    jac_[74,11] = 0
    jac_[74,12] = 0
    jac_[74,13] = 0
    jac_[74,14] = 0
    jac_[74,15] = 0
    jac_[74,16] = 0
    jac_[74,17] = 0
    jac_[74,18] = 0
    jac_[74,19] = 0
    jac_[74,20] = 0
    jac_[74,21] = 0
    jac_[74,22] = 0
    jac_[74,23] = 0
    jac_[74,24] = 0
    jac_[74,25] = 0
    jac_[74,26] = 0
    jac_[74,27] = 0
    jac_[74,28] = 0
    jac_[74,29] = 0
    jac_[74,30] = 0
    jac_[74,31] = 0
    jac_[74,32] = 0
    jac_[74,33] = 0
    jac_[74,34] = 0
    jac_[74,35] = 0
    jac_[74,36] = 0
    jac_[74,37] = 0
    jac_[74,38] = -PKA_Ca2MP*kf_R39+kf_R38*PKA
    jac_[74,39] = 0
    jac_[74,40] = 0
    jac_[74,41] = 0
    jac_[74,42] = 0
    jac_[74,43] = 0
    jac_[74,44] = 0
    jac_[74,45] = 0
    jac_[74,46] = 0
    jac_[74,47] = 0
    jac_[74,48] = 0
    jac_[74,49] = 0
    jac_[74,50] = 0
    jac_[74,51] = 0
    jac_[74,52] = 0
    jac_[74,53] = 0
    jac_[74,54] = 0
    jac_[74,55] = 0
    jac_[74,56] = 0
    jac_[74,57] = 0
    jac_[74,58] = 0
    jac_[74,59] = 0
    jac_[74,60] = 0
    jac_[74,61] = 0
    jac_[74,62] = 0
    jac_[74,63] = 0
    jac_[74,64] = 0
    jac_[74,65] = 0
    jac_[74,66] = 0
    jac_[74,67] = 0
    jac_[74,68] = 0
    jac_[74,69] = cAMP*kf_R38
    jac_[74,70] = 0
    jac_[74,71] = 0
    jac_[74,72] = 0
    jac_[74,73] = 0
    jac_[74,74] = -kr_R38-cAMP*kf_R39
    jac_[74,75] = kr_R39
    jac_[74,76] = 0
    jac_[74,77] = 0
    jac_[74,78] = 0
    jac_[74,79] = 0
    jac_[74,80] = 0
    jac_[74,81] = 0
    jac_[74,82] = 0
    jac_[74,83] = 0
    jac_[74,84] = 0
    jac_[74,85] = 0
    jac_[74,86] = 0
    jac_[74,87] = 0
    jac_[74,88] = 0
    jac_[74,89] = 0
    jac_[74,90] = 0
    jac_[74,91] = 0
    jac_[74,92] = 0
    jac_[74,93] = 0
    jac_[74,94] = 0
    jac_[74,95] = 0
    jac_[74,96] = 0
    jac_[74,97] = 0
    jac_[74,98] = 0
    jac_[74,99] = 0
    jac_[75,1] = 0
    jac_[75,2] = 0
    jac_[75,3] = 0
    jac_[75,4] = 0
    jac_[75,5] = 0
    jac_[75,6] = 0
    jac_[75,7] = 0
    jac_[75,8] = 0
    jac_[75,9] = 0
    jac_[75,10] = 0
    jac_[75,11] = 0
    jac_[75,12] = 0
    jac_[75,13] = 0
    jac_[75,14] = 0
    jac_[75,15] = 0
    jac_[75,16] = 0
    jac_[75,17] = 0
    jac_[75,18] = 0
    jac_[75,19] = 0
    jac_[75,20] = 0
    jac_[75,21] = 0
    jac_[75,22] = 0
    jac_[75,23] = 0
    jac_[75,24] = 0
    jac_[75,25] = 0
    jac_[75,26] = 0
    jac_[75,27] = 0
    jac_[75,28] = 0
    jac_[75,29] = 0
    jac_[75,30] = 0
    jac_[75,31] = 0
    jac_[75,32] = 0
    jac_[75,33] = 0
    jac_[75,34] = 0
    jac_[75,35] = 0
    jac_[75,36] = 0
    jac_[75,37] = 0
    jac_[75,38] = PKA_Ca2MP*kf_R39
    jac_[75,39] = 0
    jac_[75,40] = 0
    jac_[75,41] = 0
    jac_[75,42] = 0
    jac_[75,43] = 0
    jac_[75,44] = 0
    jac_[75,45] = 0
    jac_[75,46] = 0
    jac_[75,47] = 0
    jac_[75,48] = 0
    jac_[75,49] = 0
    jac_[75,50] = 0
    jac_[75,51] = 0
    jac_[75,52] = 0
    jac_[75,53] = 0
    jac_[75,54] = 0
    jac_[75,55] = 0
    jac_[75,56] = 0
    jac_[75,57] = 0
    jac_[75,58] = 0
    jac_[75,59] = 0
    jac_[75,60] = 0
    jac_[75,61] = 0
    jac_[75,62] = 0
    jac_[75,63] = 0
    jac_[75,64] = 0
    jac_[75,65] = 0
    jac_[75,66] = 0
    jac_[75,67] = 0
    jac_[75,68] = 0
    jac_[75,69] = 0
    jac_[75,70] = kf_R40*PKAreg
    jac_[75,71] = 0
    jac_[75,72] = 0
    jac_[75,73] = 0
    jac_[75,74] = cAMP*kf_R39
    jac_[75,75] = -kr_R39-kr_R40
    jac_[75,76] = 0
    jac_[75,77] = PKAc*kf_R40
    jac_[75,78] = 0
    jac_[75,79] = 0
    jac_[75,80] = 0
    jac_[75,81] = 0
    jac_[75,82] = 0
    jac_[75,83] = 0
    jac_[75,84] = 0
    jac_[75,85] = 0
    jac_[75,86] = 0
    jac_[75,87] = 0
    jac_[75,88] = 0
    jac_[75,89] = 0
    jac_[75,90] = 0
    jac_[75,91] = 0
    jac_[75,92] = 0
    jac_[75,93] = 0
    jac_[75,94] = 0
    jac_[75,95] = 0
    jac_[75,96] = 0
    jac_[75,97] = 0
    jac_[75,98] = 0
    jac_[75,99] = 0
    jac_[76,1] = 0
    jac_[76,2] = 0
    jac_[76,3] = 0
    jac_[76,4] = 0
    jac_[76,5] = 0
    jac_[76,6] = 0
    jac_[76,7] = 0
    jac_[76,8] = 0
    jac_[76,9] = 0
    jac_[76,10] = 0
    jac_[76,11] = 0
    jac_[76,12] = 0
    jac_[76,13] = 0
    jac_[76,14] = 0
    jac_[76,15] = 0
    jac_[76,16] = 0
    jac_[76,17] = 0
    jac_[76,18] = 0
    jac_[76,19] = 0
    jac_[76,20] = 0
    jac_[76,21] = 0
    jac_[76,22] = 0
    jac_[76,23] = 0
    jac_[76,24] = 0
    jac_[76,25] = 0
    jac_[76,26] = 0
    jac_[76,27] = 0
    jac_[76,28] = 0
    jac_[76,29] = 0
    jac_[76,30] = 0
    jac_[76,31] = 0
    jac_[76,32] = 0
    jac_[76,33] = 0
    jac_[76,34] = 0
    jac_[76,35] = 0
    jac_[76,36] = 0
    jac_[76,37] = 0
    jac_[76,38] = 0
    jac_[76,39] = 0
    jac_[76,40] = 0
    jac_[76,41] = 0
    jac_[76,42] = 0
    jac_[76,43] = 0
    jac_[76,44] = 0
    jac_[76,45] = 0
    jac_[76,46] = 0
    jac_[76,47] = PKAc*kf_R15
    jac_[76,48] = 0
    jac_[76,49] = 0
    jac_[76,50] = 0
    jac_[76,51] = 0
    jac_[76,52] = 0
    jac_[76,53] = 0
    jac_[76,54] = 0
    jac_[76,55] = 0
    jac_[76,56] = 0
    jac_[76,57] = 0
    jac_[76,58] = 0
    jac_[76,59] = 0
    jac_[76,60] = 0
    jac_[76,61] = 0
    jac_[76,62] = 0
    jac_[76,63] = 0
    jac_[76,64] = 0
    jac_[76,65] = 0
    jac_[76,66] = 0
    jac_[76,67] = 0
    jac_[76,68] = 0
    jac_[76,69] = 0
    jac_[76,70] = D32p75*kf_R15
    jac_[76,71] = 0
    jac_[76,72] = 0
    jac_[76,73] = 0
    jac_[76,74] = 0
    jac_[76,75] = 0
    jac_[76,76] = -kr_R15
    jac_[76,77] = 0
    jac_[76,78] = 0
    jac_[76,79] = 0
    jac_[76,80] = 0
    jac_[76,81] = 0
    jac_[76,82] = 0
    jac_[76,83] = 0
    jac_[76,84] = 0
    jac_[76,85] = 0
    jac_[76,86] = 0
    jac_[76,87] = 0
    jac_[76,88] = 0
    jac_[76,89] = 0
    jac_[76,90] = 0
    jac_[76,91] = 0
    jac_[76,92] = 0
    jac_[76,93] = 0
    jac_[76,94] = 0
    jac_[76,95] = 0
    jac_[76,96] = 0
    jac_[76,97] = 0
    jac_[76,98] = 0
    jac_[76,99] = 0
    jac_[77,1] = 0
    jac_[77,2] = 0
    jac_[77,3] = 0
    jac_[77,4] = 0
    jac_[77,5] = 0
    jac_[77,6] = 0
    jac_[77,7] = 0
    jac_[77,8] = 0
    jac_[77,9] = 0
    jac_[77,10] = 0
    jac_[77,11] = 0
    jac_[77,12] = 0
    jac_[77,13] = 0
    jac_[77,14] = 0
    jac_[77,15] = 0
    jac_[77,16] = 0
    jac_[77,17] = 0
    jac_[77,18] = 0
    jac_[77,19] = 0
    jac_[77,20] = 0
    jac_[77,21] = 0
    jac_[77,22] = 0
    jac_[77,23] = 0
    jac_[77,24] = 0
    jac_[77,25] = 0
    jac_[77,26] = 0
    jac_[77,27] = 0
    jac_[77,28] = 0
    jac_[77,29] = 0
    jac_[77,30] = 0
    jac_[77,31] = 0
    jac_[77,32] = 0
    jac_[77,33] = 0
    jac_[77,34] = 0
    jac_[77,35] = 0
    jac_[77,36] = 0
    jac_[77,37] = 0
    jac_[77,38] = 0
    jac_[77,39] = 0
    jac_[77,40] = 0
    jac_[77,41] = 0
    jac_[77,42] = 0
    jac_[77,43] = 0
    jac_[77,44] = 0
    jac_[77,45] = 0
    jac_[77,46] = 0
    jac_[77,47] = 0
    jac_[77,48] = 0
    jac_[77,49] = 0
    jac_[77,50] = 0
    jac_[77,51] = 0
    jac_[77,52] = 0
    jac_[77,53] = 0
    jac_[77,54] = 0
    jac_[77,55] = 0
    jac_[77,56] = 0
    jac_[77,57] = 0
    jac_[77,58] = 0
    jac_[77,59] = 0
    jac_[77,60] = 0
    jac_[77,61] = 0
    jac_[77,62] = 0
    jac_[77,63] = 0
    jac_[77,64] = 0
    jac_[77,65] = 0
    jac_[77,66] = 0
    jac_[77,67] = 0
    jac_[77,68] = 0
    jac_[77,69] = 0
    jac_[77,70] = -kf_R40*PKAreg
    jac_[77,71] = 0
    jac_[77,72] = 0
    jac_[77,73] = 0
    jac_[77,74] = 0
    jac_[77,75] = kr_R40
    jac_[77,76] = 0
    jac_[77,77] = -PKAc*kf_R40
    jac_[77,78] = 0
    jac_[77,79] = 0
    jac_[77,80] = 0
    jac_[77,81] = 0
    jac_[77,82] = 0
    jac_[77,83] = 0
    jac_[77,84] = 0
    jac_[77,85] = 0
    jac_[77,86] = 0
    jac_[77,87] = 0
    jac_[77,88] = 0
    jac_[77,89] = 0
    jac_[77,90] = 0
    jac_[77,91] = 0
    jac_[77,92] = 0
    jac_[77,93] = 0
    jac_[77,94] = 0
    jac_[77,95] = 0
    jac_[77,96] = 0
    jac_[77,97] = 0
    jac_[77,98] = 0
    jac_[77,99] = 0
    jac_[78,1] = 0
    jac_[78,2] = 0
    jac_[78,3] = 0
    jac_[78,4] = 0
    jac_[78,5] = 0
    jac_[78,6] = 0
    jac_[78,7] = 0
    jac_[78,8] = 0
    jac_[78,9] = 0
    jac_[78,10] = 0
    jac_[78,11] = 0
    jac_[78,12] = 0
    jac_[78,13] = 0
    jac_[78,14] = 0
    jac_[78,15] = 0
    jac_[78,16] = 0
    jac_[78,17] = 0
    jac_[78,18] = 0
    jac_[78,19] = 0
    jac_[78,20] = 0
    jac_[78,21] = 0
    jac_[78,22] = 0
    jac_[78,23] = 0
    jac_[78,24] = 0
    jac_[78,25] = 0
    jac_[78,26] = 0
    jac_[78,27] = 0
    jac_[78,28] = 0
    jac_[78,29] = 0
    jac_[78,30] = 0
    jac_[78,31] = 0
    jac_[78,32] = 0
    jac_[78,33] = 0
    jac_[78,34] = 0
    jac_[78,35] = 0
    jac_[78,36] = 0
    jac_[78,37] = 0
    jac_[78,38] = 0
    jac_[78,39] = 0
    jac_[78,40] = 0
    jac_[78,41] = 0
    jac_[78,42] = 0
    jac_[78,43] = 0
    jac_[78,44] = 0
    jac_[78,45] = 0
    jac_[78,46] = -kf_R12*PP1
    jac_[78,47] = 0
    jac_[78,48] = 0
    jac_[78,49] = 0
    jac_[78,50] = 0
    jac_[78,51] = 0
    jac_[78,52] = 0
    jac_[78,53] = 0
    jac_[78,54] = 0
    jac_[78,55] = 0
    jac_[78,56] = 0
    jac_[78,57] = 0
    jac_[78,58] = 0
    jac_[78,59] = 0
    jac_[78,60] = 0
    jac_[78,61] = -kf_R117*PP1
    jac_[78,62] = -PP1*kf_R91
    jac_[78,63] = 0
    jac_[78,64] = 0
    jac_[78,65] = 0
    jac_[78,66] = 0
    jac_[78,67] = 0
    jac_[78,68] = 0
    jac_[78,69] = 0
    jac_[78,70] = 0
    jac_[78,71] = 0
    jac_[78,72] = 0
    jac_[78,73] = 0
    jac_[78,74] = 0
    jac_[78,75] = 0
    jac_[78,76] = 0
    jac_[78,77] = 0
    jac_[78,78] = -kf_R12*D32p34-pSubstrate*kf_R91-pCaMKII_psd*kf_R117
    jac_[78,79] = kf_R118+kr_R117
    jac_[78,80] = kr_R91+kf_R92
    jac_[78,81] = kr_R12
    jac_[78,82] = 0
    jac_[78,83] = 0
    jac_[78,84] = 0
    jac_[78,85] = 0
    jac_[78,86] = 0
    jac_[78,87] = 0
    jac_[78,88] = 0
    jac_[78,89] = 0
    jac_[78,90] = 0
    jac_[78,91] = 0
    jac_[78,92] = 0
    jac_[78,93] = 0
    jac_[78,94] = 0
    jac_[78,95] = 0
    jac_[78,96] = 0
    jac_[78,97] = 0
    jac_[78,98] = 0
    jac_[78,99] = 0
    jac_[79,1] = 0
    jac_[79,2] = 0
    jac_[79,3] = 0
    jac_[79,4] = 0
    jac_[79,5] = 0
    jac_[79,6] = 0
    jac_[79,7] = 0
    jac_[79,8] = 0
    jac_[79,9] = 0
    jac_[79,10] = 0
    jac_[79,11] = 0
    jac_[79,12] = 0
    jac_[79,13] = 0
    jac_[79,14] = 0
    jac_[79,15] = 0
    jac_[79,16] = 0
    jac_[79,17] = 0
    jac_[79,18] = 0
    jac_[79,19] = 0
    jac_[79,20] = 0
    jac_[79,21] = 0
    jac_[79,22] = 0
    jac_[79,23] = 0
    jac_[79,24] = 0
    jac_[79,25] = 0
    jac_[79,26] = 0
    jac_[79,27] = 0
    jac_[79,28] = 0
    jac_[79,29] = 0
    jac_[79,30] = 0
    jac_[79,31] = 0
    jac_[79,32] = 0
    jac_[79,33] = 0
    jac_[79,34] = 0
    jac_[79,35] = 0
    jac_[79,36] = 0
    jac_[79,37] = 0
    jac_[79,38] = 0
    jac_[79,39] = 0
    jac_[79,40] = 0
    jac_[79,41] = 0
    jac_[79,42] = 0
    jac_[79,43] = 0
    jac_[79,44] = 0
    jac_[79,45] = 0
    jac_[79,46] = 0
    jac_[79,47] = 0
    jac_[79,48] = 0
    jac_[79,49] = 0
    jac_[79,50] = 0
    jac_[79,51] = 0
    jac_[79,52] = 0
    jac_[79,53] = 0
    jac_[79,54] = 0
    jac_[79,55] = 0
    jac_[79,56] = 0
    jac_[79,57] = 0
    jac_[79,58] = 0
    jac_[79,59] = 0
    jac_[79,60] = 0
    jac_[79,61] = kf_R117*PP1
    jac_[79,62] = 0
    jac_[79,63] = 0
    jac_[79,64] = 0
    jac_[79,65] = 0
    jac_[79,66] = 0
    jac_[79,67] = 0
    jac_[79,68] = 0
    jac_[79,69] = 0
    jac_[79,70] = 0
    jac_[79,71] = 0
    jac_[79,72] = 0
    jac_[79,73] = 0
    jac_[79,74] = 0
    jac_[79,75] = 0
    jac_[79,76] = 0
    jac_[79,77] = 0
    jac_[79,78] = pCaMKII_psd*kf_R117
    jac_[79,79] = -kf_R118-kr_R117
    jac_[79,80] = 0
    jac_[79,81] = 0
    jac_[79,82] = 0
    jac_[79,83] = 0
    jac_[79,84] = 0
    jac_[79,85] = 0
    jac_[79,86] = 0
    jac_[79,87] = 0
    jac_[79,88] = 0
    jac_[79,89] = 0
    jac_[79,90] = 0
    jac_[79,91] = 0
    jac_[79,92] = 0
    jac_[79,93] = 0
    jac_[79,94] = 0
    jac_[79,95] = 0
    jac_[79,96] = 0
    jac_[79,97] = 0
    jac_[79,98] = 0
    jac_[79,99] = 0
    jac_[80,1] = 0
    jac_[80,2] = 0
    jac_[80,3] = 0
    jac_[80,4] = 0
    jac_[80,5] = 0
    jac_[80,6] = 0
    jac_[80,7] = 0
    jac_[80,8] = 0
    jac_[80,9] = 0
    jac_[80,10] = 0
    jac_[80,11] = 0
    jac_[80,12] = 0
    jac_[80,13] = 0
    jac_[80,14] = 0
    jac_[80,15] = 0
    jac_[80,16] = 0
    jac_[80,17] = 0
    jac_[80,18] = 0
    jac_[80,19] = 0
    jac_[80,20] = 0
    jac_[80,21] = 0
    jac_[80,22] = 0
    jac_[80,23] = 0
    jac_[80,24] = 0
    jac_[80,25] = 0
    jac_[80,26] = 0
    jac_[80,27] = 0
    jac_[80,28] = 0
    jac_[80,29] = 0
    jac_[80,30] = 0
    jac_[80,31] = 0
    jac_[80,32] = 0
    jac_[80,33] = 0
    jac_[80,34] = 0
    jac_[80,35] = 0
    jac_[80,36] = 0
    jac_[80,37] = 0
    jac_[80,38] = 0
    jac_[80,39] = 0
    jac_[80,40] = 0
    jac_[80,41] = 0
    jac_[80,42] = 0
    jac_[80,43] = 0
    jac_[80,44] = 0
    jac_[80,45] = 0
    jac_[80,46] = 0
    jac_[80,47] = 0
    jac_[80,48] = 0
    jac_[80,49] = 0
    jac_[80,50] = 0
    jac_[80,51] = 0
    jac_[80,52] = 0
    jac_[80,53] = 0
    jac_[80,54] = 0
    jac_[80,55] = 0
    jac_[80,56] = 0
    jac_[80,57] = 0
    jac_[80,58] = 0
    jac_[80,59] = 0
    jac_[80,60] = 0
    jac_[80,61] = 0
    jac_[80,62] = PP1*kf_R91
    jac_[80,63] = 0
    jac_[80,64] = 0
    jac_[80,65] = 0
    jac_[80,66] = 0
    jac_[80,67] = 0
    jac_[80,68] = 0
    jac_[80,69] = 0
    jac_[80,70] = 0
    jac_[80,71] = 0
    jac_[80,72] = 0
    jac_[80,73] = 0
    jac_[80,74] = 0
    jac_[80,75] = 0
    jac_[80,76] = 0
    jac_[80,77] = 0
    jac_[80,78] = pSubstrate*kf_R91
    jac_[80,79] = 0
    jac_[80,80] = -kr_R91-kf_R92
    jac_[80,81] = 0
    jac_[80,82] = 0
    jac_[80,83] = 0
    jac_[80,84] = 0
    jac_[80,85] = 0
    jac_[80,86] = 0
    jac_[80,87] = 0
    jac_[80,88] = 0
    jac_[80,89] = 0
    jac_[80,90] = 0
    jac_[80,91] = 0
    jac_[80,92] = 0
    jac_[80,93] = 0
    jac_[80,94] = 0
    jac_[80,95] = 0
    jac_[80,96] = 0
    jac_[80,97] = 0
    jac_[80,98] = 0
    jac_[80,99] = 0
    jac_[81,1] = 0
    jac_[81,2] = 0
    jac_[81,3] = 0
    jac_[81,4] = 0
    jac_[81,5] = 0
    jac_[81,6] = 0
    jac_[81,7] = 0
    jac_[81,8] = 0
    jac_[81,9] = 0
    jac_[81,10] = 0
    jac_[81,11] = 0
    jac_[81,12] = 0
    jac_[81,13] = 0
    jac_[81,14] = 0
    jac_[81,15] = 0
    jac_[81,16] = 0
    jac_[81,17] = 0
    jac_[81,18] = 0
    jac_[81,19] = 0
    jac_[81,20] = 0
    jac_[81,21] = 0
    jac_[81,22] = 0
    jac_[81,23] = 0
    jac_[81,24] = 0
    jac_[81,25] = 0
    jac_[81,26] = 0
    jac_[81,27] = 0
    jac_[81,28] = 0
    jac_[81,29] = 0
    jac_[81,30] = 0
    jac_[81,31] = 0
    jac_[81,32] = 0
    jac_[81,33] = 0
    jac_[81,34] = 0
    jac_[81,35] = 0
    jac_[81,36] = 0
    jac_[81,37] = 0
    jac_[81,38] = 0
    jac_[81,39] = 0
    jac_[81,40] = 0
    jac_[81,41] = 0
    jac_[81,42] = 0
    jac_[81,43] = 0
    jac_[81,44] = 0
    jac_[81,45] = 0
    jac_[81,46] = kf_R12*PP1
    jac_[81,47] = 0
    jac_[81,48] = 0
    jac_[81,49] = 0
    jac_[81,50] = 0
    jac_[81,51] = 0
    jac_[81,52] = 0
    jac_[81,53] = 0
    jac_[81,54] = 0
    jac_[81,55] = 0
    jac_[81,56] = 0
    jac_[81,57] = 0
    jac_[81,58] = 0
    jac_[81,59] = 0
    jac_[81,60] = 0
    jac_[81,61] = 0
    jac_[81,62] = 0
    jac_[81,63] = 0
    jac_[81,64] = 0
    jac_[81,65] = 0
    jac_[81,66] = 0
    jac_[81,67] = 0
    jac_[81,68] = 0
    jac_[81,69] = 0
    jac_[81,70] = 0
    jac_[81,71] = 0
    jac_[81,72] = 0
    jac_[81,73] = 0
    jac_[81,74] = 0
    jac_[81,75] = 0
    jac_[81,76] = 0
    jac_[81,77] = 0
    jac_[81,78] = kf_R12*D32p34
    jac_[81,79] = 0
    jac_[81,80] = 0
    jac_[81,81] = -kr_R12
    jac_[81,82] = 0
    jac_[81,83] = 0
    jac_[81,84] = 0
    jac_[81,85] = 0
    jac_[81,86] = 0
    jac_[81,87] = 0
    jac_[81,88] = 0
    jac_[81,89] = 0
    jac_[81,90] = 0
    jac_[81,91] = 0
    jac_[81,92] = 0
    jac_[81,93] = 0
    jac_[81,94] = 0
    jac_[81,95] = 0
    jac_[81,96] = 0
    jac_[81,97] = 0
    jac_[81,98] = 0
    jac_[81,99] = 0
    jac_[82,1] = 0
    jac_[82,2] = 0
    jac_[82,3] = 0
    jac_[82,4] = 0
    jac_[82,5] = 0
    jac_[82,6] = 0
    jac_[82,7] = 0
    jac_[82,8] = 0
    jac_[82,9] = 0
    jac_[82,10] = 0
    jac_[82,11] = 0
    jac_[82,12] = 0
    jac_[82,13] = 0
    jac_[82,14] = 0
    jac_[82,15] = 0
    jac_[82,16] = 0
    jac_[82,17] = 0
    jac_[82,18] = 0
    jac_[82,19] = 0
    jac_[82,20] = 0
    jac_[82,21] = 0
    jac_[82,22] = 0
    jac_[82,23] = 0
    jac_[82,24] = 0
    jac_[82,25] = 0
    jac_[82,26] = 0
    jac_[82,27] = 0
    jac_[82,28] = 0
    jac_[82,29] = 0
    jac_[82,30] = 0
    jac_[82,31] = 0
    jac_[82,32] = 0
    jac_[82,33] = 0
    jac_[82,34] = 0
    jac_[82,35] = 0
    jac_[82,36] = 2*CaMKII_CaM_Ca4_psd*kf_R134
    jac_[82,37] = 0
    jac_[82,38] = 0
    jac_[82,39] = 0
    jac_[82,40] = 0
    jac_[82,41] = 0
    jac_[82,42] = 0
    jac_[82,43] = 0
    jac_[82,44] = 0
    jac_[82,45] = 0
    jac_[82,46] = 0
    jac_[82,47] = 0
    jac_[82,48] = 0
    jac_[82,49] = 0
    jac_[82,50] = 0
    jac_[82,51] = 0
    jac_[82,52] = 0
    jac_[82,53] = 0
    jac_[82,54] = 0
    jac_[82,55] = 0
    jac_[82,56] = 0
    jac_[82,57] = 0
    jac_[82,58] = 0
    jac_[82,59] = 0
    jac_[82,60] = 0
    jac_[82,61] = 0
    jac_[82,62] = 0
    jac_[82,63] = 0
    jac_[82,64] = 0
    jac_[82,65] = 0
    jac_[82,66] = 0
    jac_[82,67] = 0
    jac_[82,68] = 0
    jac_[82,69] = 0
    jac_[82,70] = 0
    jac_[82,71] = 0
    jac_[82,72] = 0
    jac_[82,73] = 0
    jac_[82,74] = 0
    jac_[82,75] = 0
    jac_[82,76] = 0
    jac_[82,77] = 0
    jac_[82,78] = 0
    jac_[82,79] = 0
    jac_[82,80] = 0
    jac_[82,81] = 0
    jac_[82,82] = -kr_R134-kf_R135-kf_R128
    jac_[82,83] = 0
    jac_[82,84] = kr_R128
    jac_[82,85] = 0
    jac_[82,86] = 0
    jac_[82,87] = 0
    jac_[82,88] = 0
    jac_[82,89] = 0
    jac_[82,90] = 0
    jac_[82,91] = 0
    jac_[82,92] = 0
    jac_[82,93] = 0
    jac_[82,94] = 0
    jac_[82,95] = 0
    jac_[82,96] = 0
    jac_[82,97] = 0
    jac_[82,98] = 0
    jac_[82,99] = 0
    jac_[83,1] = 0
    jac_[83,2] = 0
    jac_[83,3] = 0
    jac_[83,4] = 0
    jac_[83,5] = 0
    jac_[83,6] = 0
    jac_[83,7] = 0
    jac_[83,8] = 0
    jac_[83,9] = 0
    jac_[83,10] = 0
    jac_[83,11] = 0
    jac_[83,12] = 0
    jac_[83,13] = 0
    jac_[83,14] = 0
    jac_[83,15] = 0
    jac_[83,16] = 0
    jac_[83,17] = 0
    jac_[83,18] = 0
    jac_[83,19] = 0
    jac_[83,20] = 0
    jac_[83,21] = 0
    jac_[83,22] = 0
    jac_[83,23] = 0
    jac_[83,24] = 0
    jac_[83,25] = 0
    jac_[83,26] = 0
    jac_[83,27] = 0
    jac_[83,28] = 0
    jac_[83,29] = 0
    jac_[83,30] = 0
    jac_[83,31] = 0
    jac_[83,32] = 0
    jac_[83,33] = 0
    jac_[83,34] = 0
    jac_[83,35] = 0
    jac_[83,36] = kf_R136*pCaMKII_CaM_Ca4_psd
    jac_[83,37] = 0
    jac_[83,38] = 0
    jac_[83,39] = 0
    jac_[83,40] = 0
    jac_[83,41] = 0
    jac_[83,42] = 0
    jac_[83,43] = 0
    jac_[83,44] = 0
    jac_[83,45] = 0
    jac_[83,46] = 0
    jac_[83,47] = 0
    jac_[83,48] = 0
    jac_[83,49] = 0
    jac_[83,50] = 0
    jac_[83,51] = 0
    jac_[83,52] = 0
    jac_[83,53] = 0
    jac_[83,54] = 0
    jac_[83,55] = 0
    jac_[83,56] = 0
    jac_[83,57] = 0
    jac_[83,58] = 0
    jac_[83,59] = 0
    jac_[83,60] = kf_R136*CaMKII_CaM_Ca4_psd
    jac_[83,61] = 0
    jac_[83,62] = 0
    jac_[83,63] = 0
    jac_[83,64] = 0
    jac_[83,65] = 0
    jac_[83,66] = 0
    jac_[83,67] = 0
    jac_[83,68] = 0
    jac_[83,69] = 0
    jac_[83,70] = 0
    jac_[83,71] = 0
    jac_[83,72] = 0
    jac_[83,73] = 0
    jac_[83,74] = 0
    jac_[83,75] = 0
    jac_[83,76] = 0
    jac_[83,77] = 0
    jac_[83,78] = 0
    jac_[83,79] = 0
    jac_[83,80] = 0
    jac_[83,81] = 0
    jac_[83,82] = 0
    jac_[83,83] = -kr_R136-kf_R129-kf_R137
    jac_[83,84] = 0
    jac_[83,85] = kr_R129
    jac_[83,86] = 0
    jac_[83,87] = 0
    jac_[83,88] = 0
    jac_[83,89] = 0
    jac_[83,90] = 0
    jac_[83,91] = 0
    jac_[83,92] = 0
    jac_[83,93] = 0
    jac_[83,94] = 0
    jac_[83,95] = 0
    jac_[83,96] = 0
    jac_[83,97] = 0
    jac_[83,98] = 0
    jac_[83,99] = 0
    jac_[84,1] = 0
    jac_[84,2] = 0
    jac_[84,3] = 0
    jac_[84,4] = 0
    jac_[84,5] = 0
    jac_[84,6] = 0
    jac_[84,7] = 0
    jac_[84,8] = 0
    jac_[84,9] = 0
    jac_[84,10] = 0
    jac_[84,11] = 0
    jac_[84,12] = 0
    jac_[84,13] = 0
    jac_[84,14] = 0
    jac_[84,15] = 0
    jac_[84,16] = 0
    jac_[84,17] = 0
    jac_[84,18] = 0
    jac_[84,19] = 0
    jac_[84,20] = 0
    jac_[84,21] = 0
    jac_[84,22] = 0
    jac_[84,23] = 0
    jac_[84,24] = 0
    jac_[84,25] = 0
    jac_[84,26] = 0
    jac_[84,27] = 0
    jac_[84,28] = 0
    jac_[84,29] = 0
    jac_[84,30] = 0
    jac_[84,31] = 2*kf_R130*CaMKII_CaM_Ca4
    jac_[84,32] = 0
    jac_[84,33] = 0
    jac_[84,34] = 0
    jac_[84,35] = 0
    jac_[84,36] = 0
    jac_[84,37] = 0
    jac_[84,38] = 0
    jac_[84,39] = 0
    jac_[84,40] = 0
    jac_[84,41] = 0
    jac_[84,42] = 0
    jac_[84,43] = 0
    jac_[84,44] = 0
    jac_[84,45] = 0
    jac_[84,46] = 0
    jac_[84,47] = 0
    jac_[84,48] = 0
    jac_[84,49] = 0
    jac_[84,50] = 0
    jac_[84,51] = 0
    jac_[84,52] = 0
    jac_[84,53] = 0
    jac_[84,54] = 0
    jac_[84,55] = 0
    jac_[84,56] = 0
    jac_[84,57] = 0
    jac_[84,58] = 0
    jac_[84,59] = 0
    jac_[84,60] = 0
    jac_[84,61] = 0
    jac_[84,62] = 0
    jac_[84,63] = 0
    jac_[84,64] = 0
    jac_[84,65] = 0
    jac_[84,66] = 0
    jac_[84,67] = 0
    jac_[84,68] = 0
    jac_[84,69] = 0
    jac_[84,70] = 0
    jac_[84,71] = 0
    jac_[84,72] = 0
    jac_[84,73] = 0
    jac_[84,74] = 0
    jac_[84,75] = 0
    jac_[84,76] = 0
    jac_[84,77] = 0
    jac_[84,78] = 0
    jac_[84,79] = 0
    jac_[84,80] = 0
    jac_[84,81] = 0
    jac_[84,82] = kf_R128
    jac_[84,83] = 0
    jac_[84,84] = -kr_R128-kr_R130-kf_R131
    jac_[84,85] = 0
    jac_[84,86] = 0
    jac_[84,87] = 0
    jac_[84,88] = 0
    jac_[84,89] = 0
    jac_[84,90] = 0
    jac_[84,91] = 0
    jac_[84,92] = 0
    jac_[84,93] = 0
    jac_[84,94] = 0
    jac_[84,95] = 0
    jac_[84,96] = 0
    jac_[84,97] = 0
    jac_[84,98] = 0
    jac_[84,99] = 0
    jac_[85,1] = 0
    jac_[85,2] = 0
    jac_[85,3] = 0
    jac_[85,4] = 0
    jac_[85,5] = 0
    jac_[85,6] = 0
    jac_[85,7] = 0
    jac_[85,8] = 0
    jac_[85,9] = 0
    jac_[85,10] = 0
    jac_[85,11] = 0
    jac_[85,12] = 0
    jac_[85,13] = 0
    jac_[85,14] = 0
    jac_[85,15] = 0
    jac_[85,16] = 0
    jac_[85,17] = 0
    jac_[85,18] = 0
    jac_[85,19] = 0
    jac_[85,20] = 0
    jac_[85,21] = 0
    jac_[85,22] = 0
    jac_[85,23] = 0
    jac_[85,24] = 0
    jac_[85,25] = 0
    jac_[85,26] = 0
    jac_[85,27] = 0
    jac_[85,28] = 0
    jac_[85,29] = 0
    jac_[85,30] = 0
    jac_[85,31] = pCaMKII_CaM_Ca4*kf_R133
    jac_[85,32] = 0
    jac_[85,33] = 0
    jac_[85,34] = 0
    jac_[85,35] = 0
    jac_[85,36] = 0
    jac_[85,37] = 0
    jac_[85,38] = 0
    jac_[85,39] = 0
    jac_[85,40] = 0
    jac_[85,41] = 0
    jac_[85,42] = 0
    jac_[85,43] = 0
    jac_[85,44] = 0
    jac_[85,45] = 0
    jac_[85,46] = 0
    jac_[85,47] = 0
    jac_[85,48] = 0
    jac_[85,49] = 0
    jac_[85,50] = 0
    jac_[85,51] = 0
    jac_[85,52] = 0
    jac_[85,53] = 0
    jac_[85,54] = 0
    jac_[85,55] = kf_R133*CaMKII_CaM_Ca4
    jac_[85,56] = 0
    jac_[85,57] = 0
    jac_[85,58] = 0
    jac_[85,59] = 0
    jac_[85,60] = 0
    jac_[85,61] = 0
    jac_[85,62] = 0
    jac_[85,63] = 0
    jac_[85,64] = 0
    jac_[85,65] = 0
    jac_[85,66] = 0
    jac_[85,67] = 0
    jac_[85,68] = 0
    jac_[85,69] = 0
    jac_[85,70] = 0
    jac_[85,71] = 0
    jac_[85,72] = 0
    jac_[85,73] = 0
    jac_[85,74] = 0
    jac_[85,75] = 0
    jac_[85,76] = 0
    jac_[85,77] = 0
    jac_[85,78] = 0
    jac_[85,79] = 0
    jac_[85,80] = 0
    jac_[85,81] = 0
    jac_[85,82] = 0
    jac_[85,83] = kf_R129
    jac_[85,84] = 0
    jac_[85,85] = -kr_R132-kf_R133-kr_R129
    jac_[85,86] = 0
    jac_[85,87] = 0
    jac_[85,88] = 0
    jac_[85,89] = 0
    jac_[85,90] = 0
    jac_[85,91] = 0
    jac_[85,92] = 0
    jac_[85,93] = 0
    jac_[85,94] = 0
    jac_[85,95] = 0
    jac_[85,96] = 0
    jac_[85,97] = 0
    jac_[85,98] = 0
    jac_[85,99] = 0
    jac_[86,1] = 0
    jac_[86,2] = 0
    jac_[86,3] = 0
    jac_[86,4] = 0
    jac_[86,5] = 0
    jac_[86,6] = 0
    jac_[86,7] = 0
    jac_[86,8] = 0
    jac_[86,9] = 0
    jac_[86,10] = 0
    jac_[86,11] = 0
    jac_[86,12] = 0
    jac_[86,13] = 0
    jac_[86,14] = 0
    jac_[86,15] = 0
    jac_[86,16] = 0
    jac_[86,17] = 0
    jac_[86,18] = 0
    jac_[86,19] = 0
    jac_[86,20] = 0
    jac_[86,21] = 0
    jac_[86,22] = 0
    jac_[86,23] = 0
    jac_[86,24] = 0
    jac_[86,25] = 0
    jac_[86,26] = -PP2B*kf_R6
    jac_[86,27] = -PP2B*kf_R27
    jac_[86,28] = -PP2B*kf_R7
    jac_[86,29] = 0
    jac_[86,30] = 0
    jac_[86,31] = 0
    jac_[86,32] = 0
    jac_[86,33] = 0
    jac_[86,34] = 0
    jac_[86,35] = 0
    jac_[86,36] = 0
    jac_[86,37] = 0
    jac_[86,38] = 0
    jac_[86,39] = 0
    jac_[86,40] = 0
    jac_[86,41] = 0
    jac_[86,42] = 0
    jac_[86,43] = 0
    jac_[86,44] = 0
    jac_[86,45] = 0
    jac_[86,46] = 0
    jac_[86,47] = 0
    jac_[86,48] = 0
    jac_[86,49] = 0
    jac_[86,50] = 0
    jac_[86,51] = 0
    jac_[86,52] = 0
    jac_[86,53] = 0
    jac_[86,54] = 0
    jac_[86,55] = 0
    jac_[86,56] = 0
    jac_[86,57] = 0
    jac_[86,58] = 0
    jac_[86,59] = 0
    jac_[86,60] = 0
    jac_[86,61] = 0
    jac_[86,62] = 0
    jac_[86,63] = 0
    jac_[86,64] = 0
    jac_[86,65] = 0
    jac_[86,66] = 0
    jac_[86,67] = 0
    jac_[86,68] = 0
    jac_[86,69] = 0
    jac_[86,70] = 0
    jac_[86,71] = 0
    jac_[86,72] = 0
    jac_[86,73] = 0
    jac_[86,74] = 0
    jac_[86,75] = 0
    jac_[86,76] = 0
    jac_[86,77] = 0
    jac_[86,78] = 0
    jac_[86,79] = 0
    jac_[86,80] = 0
    jac_[86,81] = 0
    jac_[86,82] = 0
    jac_[86,83] = 0
    jac_[86,84] = 0
    jac_[86,85] = 0
    jac_[86,86] = -kf_R6*CaM-kf_R27*CaM_Ca2-CaM_Ca4*kf_R7
    jac_[86,87] = kr_R7
    jac_[86,88] = 0
    jac_[86,89] = kr_R6
    jac_[86,90] = kr_R27
    jac_[86,91] = 0
    jac_[86,92] = 0
    jac_[86,93] = 0
    jac_[86,94] = 0
    jac_[86,95] = 0
    jac_[86,96] = 0
    jac_[86,97] = 0
    jac_[86,98] = 0
    jac_[86,99] = 0
    jac_[87,1] = 0
    jac_[87,2] = 0
    jac_[87,3] = 0
    jac_[87,4] = 0
    jac_[87,5] = 0
    jac_[87,6] = 0
    jac_[87,7] = 0
    jac_[87,8] = 0
    jac_[87,9] = 0
    jac_[87,10] = 0
    jac_[87,11] = 0
    jac_[87,12] = 0
    jac_[87,13] = 0
    jac_[87,14] = 0
    jac_[87,15] = 0
    jac_[87,16] = 0
    jac_[87,17] = 0
    jac_[87,18] = 0
    jac_[87,19] = 0
    jac_[87,20] = 0
    jac_[87,21] = 0
    jac_[87,22] = 0
    jac_[87,23] = 0
    jac_[87,24] = 0
    jac_[87,25] = kf_R26*PP2B_CaM_Ca2
    jac_[87,26] = 0
    jac_[87,27] = 0
    jac_[87,28] = PP2B*kf_R7
    jac_[87,29] = 0
    jac_[87,30] = 0
    jac_[87,31] = 0
    jac_[87,32] = 0
    jac_[87,33] = 0
    jac_[87,34] = 0
    jac_[87,35] = 0
    jac_[87,36] = 0
    jac_[87,37] = 0
    jac_[87,38] = 0
    jac_[87,39] = 0
    jac_[87,40] = 0
    jac_[87,41] = 0
    jac_[87,42] = 0
    jac_[87,43] = 0
    jac_[87,44] = 0
    jac_[87,45] = 0
    jac_[87,46] = -kf_R23*PP2Bc
    jac_[87,47] = 0
    jac_[87,48] = 0
    jac_[87,49] = 0
    jac_[87,50] = 0
    jac_[87,51] = 0
    jac_[87,52] = 0
    jac_[87,53] = 0
    jac_[87,54] = 0
    jac_[87,55] = 0
    jac_[87,56] = 0
    jac_[87,57] = 0
    jac_[87,58] = 0
    jac_[87,59] = 0
    jac_[87,60] = 0
    jac_[87,61] = 0
    jac_[87,62] = 0
    jac_[87,63] = 0
    jac_[87,64] = 0
    jac_[87,65] = 0
    jac_[87,66] = 0
    jac_[87,67] = 0
    jac_[87,68] = 0
    jac_[87,69] = 0
    jac_[87,70] = 0
    jac_[87,71] = 0
    jac_[87,72] = 0
    jac_[87,73] = 0
    jac_[87,74] = 0
    jac_[87,75] = 0
    jac_[87,76] = 0
    jac_[87,77] = 0
    jac_[87,78] = 0
    jac_[87,79] = 0
    jac_[87,80] = 0
    jac_[87,81] = 0
    jac_[87,82] = 0
    jac_[87,83] = 0
    jac_[87,84] = 0
    jac_[87,85] = 0
    jac_[87,86] = CaM_Ca4*kf_R7
    jac_[87,87] = -kr_R7-kr_R26-kf_R23*D32p34
    jac_[87,88] = kf_R36+kr_R23
    jac_[87,89] = 0
    jac_[87,90] = kf_R26*Ca
    jac_[87,91] = 0
    jac_[87,92] = 0
    jac_[87,93] = 0
    jac_[87,94] = 0
    jac_[87,95] = 0
    jac_[87,96] = 0
    jac_[87,97] = 0
    jac_[87,98] = 0
    jac_[87,99] = 0
    jac_[88,1] = 0
    jac_[88,2] = 0
    jac_[88,3] = 0
    jac_[88,4] = 0
    jac_[88,5] = 0
    jac_[88,6] = 0
    jac_[88,7] = 0
    jac_[88,8] = 0
    jac_[88,9] = 0
    jac_[88,10] = 0
    jac_[88,11] = 0
    jac_[88,12] = 0
    jac_[88,13] = 0
    jac_[88,14] = 0
    jac_[88,15] = 0
    jac_[88,16] = 0
    jac_[88,17] = 0
    jac_[88,18] = 0
    jac_[88,19] = 0
    jac_[88,20] = 0
    jac_[88,21] = 0
    jac_[88,22] = 0
    jac_[88,23] = 0
    jac_[88,24] = 0
    jac_[88,25] = 0
    jac_[88,26] = 0
    jac_[88,27] = 0
    jac_[88,28] = 0
    jac_[88,29] = 0
    jac_[88,30] = 0
    jac_[88,31] = 0
    jac_[88,32] = 0
    jac_[88,33] = 0
    jac_[88,34] = 0
    jac_[88,35] = 0
    jac_[88,36] = 0
    jac_[88,37] = 0
    jac_[88,38] = 0
    jac_[88,39] = 0
    jac_[88,40] = 0
    jac_[88,41] = 0
    jac_[88,42] = 0
    jac_[88,43] = 0
    jac_[88,44] = 0
    jac_[88,45] = 0
    jac_[88,46] = kf_R23*PP2Bc
    jac_[88,47] = 0
    jac_[88,48] = 0
    jac_[88,49] = 0
    jac_[88,50] = 0
    jac_[88,51] = 0
    jac_[88,52] = 0
    jac_[88,53] = 0
    jac_[88,54] = 0
    jac_[88,55] = 0
    jac_[88,56] = 0
    jac_[88,57] = 0
    jac_[88,58] = 0
    jac_[88,59] = 0
    jac_[88,60] = 0
    jac_[88,61] = 0
    jac_[88,62] = 0
    jac_[88,63] = 0
    jac_[88,64] = 0
    jac_[88,65] = 0
    jac_[88,66] = 0
    jac_[88,67] = 0
    jac_[88,68] = 0
    jac_[88,69] = 0
    jac_[88,70] = 0
    jac_[88,71] = 0
    jac_[88,72] = 0
    jac_[88,73] = 0
    jac_[88,74] = 0
    jac_[88,75] = 0
    jac_[88,76] = 0
    jac_[88,77] = 0
    jac_[88,78] = 0
    jac_[88,79] = 0
    jac_[88,80] = 0
    jac_[88,81] = 0
    jac_[88,82] = 0
    jac_[88,83] = 0
    jac_[88,84] = 0
    jac_[88,85] = 0
    jac_[88,86] = 0
    jac_[88,87] = kf_R23*D32p34
    jac_[88,88] = -kf_R36-kr_R23
    jac_[88,89] = 0
    jac_[88,90] = 0
    jac_[88,91] = 0
    jac_[88,92] = 0
    jac_[88,93] = 0
    jac_[88,94] = 0
    jac_[88,95] = 0
    jac_[88,96] = 0
    jac_[88,97] = 0
    jac_[88,98] = 0
    jac_[88,99] = 0
    jac_[89,1] = 0
    jac_[89,2] = 0
    jac_[89,3] = 0
    jac_[89,4] = 0
    jac_[89,5] = 0
    jac_[89,6] = 0
    jac_[89,7] = 0
    jac_[89,8] = 0
    jac_[89,9] = 0
    jac_[89,10] = 0
    jac_[89,11] = 0
    jac_[89,12] = 0
    jac_[89,13] = 0
    jac_[89,14] = 0
    jac_[89,15] = 0
    jac_[89,16] = 0
    jac_[89,17] = 0
    jac_[89,18] = 0
    jac_[89,19] = 0
    jac_[89,20] = 0
    jac_[89,21] = 0
    jac_[89,22] = 0
    jac_[89,23] = 0
    jac_[89,24] = 0
    jac_[89,25] = -PP2B_CaM*kf_R25
    jac_[89,26] = PP2B*kf_R6
    jac_[89,27] = 0
    jac_[89,28] = 0
    jac_[89,29] = 0
    jac_[89,30] = 0
    jac_[89,31] = 0
    jac_[89,32] = 0
    jac_[89,33] = 0
    jac_[89,34] = 0
    jac_[89,35] = 0
    jac_[89,36] = 0
    jac_[89,37] = 0
    jac_[89,38] = 0
    jac_[89,39] = 0
    jac_[89,40] = 0
    jac_[89,41] = 0
    jac_[89,42] = 0
    jac_[89,43] = 0
    jac_[89,44] = 0
    jac_[89,45] = 0
    jac_[89,46] = 0
    jac_[89,47] = 0
    jac_[89,48] = 0
    jac_[89,49] = 0
    jac_[89,50] = 0
    jac_[89,51] = 0
    jac_[89,52] = 0
    jac_[89,53] = 0
    jac_[89,54] = 0
    jac_[89,55] = 0
    jac_[89,56] = 0
    jac_[89,57] = 0
    jac_[89,58] = 0
    jac_[89,59] = 0
    jac_[89,60] = 0
    jac_[89,61] = 0
    jac_[89,62] = 0
    jac_[89,63] = 0
    jac_[89,64] = 0
    jac_[89,65] = 0
    jac_[89,66] = 0
    jac_[89,67] = 0
    jac_[89,68] = 0
    jac_[89,69] = 0
    jac_[89,70] = 0
    jac_[89,71] = 0
    jac_[89,72] = 0
    jac_[89,73] = 0
    jac_[89,74] = 0
    jac_[89,75] = 0
    jac_[89,76] = 0
    jac_[89,77] = 0
    jac_[89,78] = 0
    jac_[89,79] = 0
    jac_[89,80] = 0
    jac_[89,81] = 0
    jac_[89,82] = 0
    jac_[89,83] = 0
    jac_[89,84] = 0
    jac_[89,85] = 0
    jac_[89,86] = kf_R6*CaM
    jac_[89,87] = 0
    jac_[89,88] = 0
    jac_[89,89] = -kr_R6-kf_R25*Ca
    jac_[89,90] = kr_R25
    jac_[89,91] = 0
    jac_[89,92] = 0
    jac_[89,93] = 0
    jac_[89,94] = 0
    jac_[89,95] = 0
    jac_[89,96] = 0
    jac_[89,97] = 0
    jac_[89,98] = 0
    jac_[89,99] = 0
    jac_[90,1] = 0
    jac_[90,2] = 0
    jac_[90,3] = 0
    jac_[90,4] = 0
    jac_[90,5] = 0
    jac_[90,6] = 0
    jac_[90,7] = 0
    jac_[90,8] = 0
    jac_[90,9] = 0
    jac_[90,10] = 0
    jac_[90,11] = 0
    jac_[90,12] = 0
    jac_[90,13] = 0
    jac_[90,14] = 0
    jac_[90,15] = 0
    jac_[90,16] = 0
    jac_[90,17] = 0
    jac_[90,18] = 0
    jac_[90,19] = 0
    jac_[90,20] = 0
    jac_[90,21] = 0
    jac_[90,22] = 0
    jac_[90,23] = 0
    jac_[90,24] = 0
    jac_[90,25] = PP2B_CaM*kf_R25-kf_R26*PP2B_CaM_Ca2
    jac_[90,26] = 0
    jac_[90,27] = PP2B*kf_R27
    jac_[90,28] = 0
    jac_[90,29] = 0
    jac_[90,30] = 0
    jac_[90,31] = 0
    jac_[90,32] = 0
    jac_[90,33] = 0
    jac_[90,34] = 0
    jac_[90,35] = 0
    jac_[90,36] = 0
    jac_[90,37] = 0
    jac_[90,38] = 0
    jac_[90,39] = 0
    jac_[90,40] = 0
    jac_[90,41] = 0
    jac_[90,42] = 0
    jac_[90,43] = 0
    jac_[90,44] = 0
    jac_[90,45] = 0
    jac_[90,46] = 0
    jac_[90,47] = 0
    jac_[90,48] = 0
    jac_[90,49] = 0
    jac_[90,50] = 0
    jac_[90,51] = 0
    jac_[90,52] = 0
    jac_[90,53] = 0
    jac_[90,54] = 0
    jac_[90,55] = 0
    jac_[90,56] = 0
    jac_[90,57] = 0
    jac_[90,58] = 0
    jac_[90,59] = 0
    jac_[90,60] = 0
    jac_[90,61] = 0
    jac_[90,62] = 0
    jac_[90,63] = 0
    jac_[90,64] = 0
    jac_[90,65] = 0
    jac_[90,66] = 0
    jac_[90,67] = 0
    jac_[90,68] = 0
    jac_[90,69] = 0
    jac_[90,70] = 0
    jac_[90,71] = 0
    jac_[90,72] = 0
    jac_[90,73] = 0
    jac_[90,74] = 0
    jac_[90,75] = 0
    jac_[90,76] = 0
    jac_[90,77] = 0
    jac_[90,78] = 0
    jac_[90,79] = 0
    jac_[90,80] = 0
    jac_[90,81] = 0
    jac_[90,82] = 0
    jac_[90,83] = 0
    jac_[90,84] = 0
    jac_[90,85] = 0
    jac_[90,86] = kf_R27*CaM_Ca2
    jac_[90,87] = kr_R26
    jac_[90,88] = 0
    jac_[90,89] = kf_R25*Ca
    jac_[90,90] = -kf_R26*Ca-kr_R25-kr_R27
    jac_[90,91] = 0
    jac_[90,92] = 0
    jac_[90,93] = 0
    jac_[90,94] = 0
    jac_[90,95] = 0
    jac_[90,96] = 0
    jac_[90,97] = 0
    jac_[90,98] = 0
    jac_[90,99] = 0
    jac_[91,1] = 0
    jac_[91,2] = 0
    jac_[91,3] = 0
    jac_[91,4] = 0
    jac_[91,5] = 0
    jac_[91,6] = 0
    jac_[91,7] = 0
    jac_[91,8] = 0
    jac_[91,9] = 0
    jac_[91,10] = 0
    jac_[91,11] = -kf_R90*pARPP21
    jac_[91,12] = 0
    jac_[91,13] = kr_R90
    jac_[91,14] = -kf_R88*pARPP21
    jac_[91,15] = 0
    jac_[91,16] = kr_R88
    jac_[91,17] = -kf_R86*pARPP21
    jac_[91,18] = 0
    jac_[91,19] = 0
    jac_[91,20] = kr_R86
    jac_[91,21] = 0
    jac_[91,22] = 0
    jac_[91,23] = -kf_R84*pARPP21
    jac_[91,24] = kr_R84
    jac_[91,25] = 0
    jac_[91,26] = 0
    jac_[91,27] = 0
    jac_[91,28] = -kf_R82*pARPP21
    jac_[91,29] = kr_R82
    jac_[91,30] = 0
    jac_[91,31] = 0
    jac_[91,32] = 0
    jac_[91,33] = 0
    jac_[91,34] = 0
    jac_[91,35] = 0
    jac_[91,36] = 0
    jac_[91,37] = 0
    jac_[91,38] = 0
    jac_[91,39] = 0
    jac_[91,40] = 0
    jac_[91,41] = 0
    jac_[91,42] = 0
    jac_[91,43] = 0
    jac_[91,44] = 0
    jac_[91,45] = 0
    jac_[91,46] = 0
    jac_[91,47] = 0
    jac_[91,48] = 0
    jac_[91,49] = 0
    jac_[91,50] = 0
    jac_[91,51] = 0
    jac_[91,52] = 0
    jac_[91,53] = 0
    jac_[91,54] = 0
    jac_[91,55] = 0
    jac_[91,56] = 0
    jac_[91,57] = 0
    jac_[91,58] = 0
    jac_[91,59] = 0
    jac_[91,60] = 0
    jac_[91,61] = 0
    jac_[91,62] = 0
    jac_[91,63] = 0
    jac_[91,64] = 0
    jac_[91,65] = 0
    jac_[91,66] = 0
    jac_[91,67] = 0
    jac_[91,68] = 0
    jac_[91,69] = 0
    jac_[91,70] = 0
    jac_[91,71] = 0
    jac_[91,72] = 0
    jac_[91,73] = kf_R81
    jac_[91,74] = 0
    jac_[91,75] = 0
    jac_[91,76] = 0
    jac_[91,77] = 0
    jac_[91,78] = 0
    jac_[91,79] = 0
    jac_[91,80] = 0
    jac_[91,81] = 0
    jac_[91,82] = 0
    jac_[91,83] = 0
    jac_[91,84] = 0
    jac_[91,85] = 0
    jac_[91,86] = 0
    jac_[91,87] = 0
    jac_[91,88] = 0
    jac_[91,89] = 0
    jac_[91,90] = 0
    jac_[91,91] = -CaM_Ca4*kf_R82-kf_R90*B56PP2A-B72PP2A*kf_R86-B56PP2Ap*kf_R88-B72PP2A_Ca*kf_R84
    jac_[91,92] = 0
    jac_[91,93] = 0
    jac_[91,94] = 0
    jac_[91,95] = 0
    jac_[91,96] = 0
    jac_[91,97] = 0
    jac_[91,98] = 0
    jac_[91,99] = 0
    jac_[92,1] = 0
    jac_[92,2] = 0
    jac_[92,3] = 0
    jac_[92,4] = 0
    jac_[92,5] = 0
    jac_[92,6] = 0
    jac_[92,7] = 0
    jac_[92,8] = 0
    jac_[92,9] = 0
    jac_[92,10] = 0
    jac_[92,11] = 0
    jac_[92,12] = 0
    jac_[92,13] = kf_R89
    jac_[92,14] = 0
    jac_[92,15] = 0
    jac_[92,16] = kf_R87
    jac_[92,17] = 0
    jac_[92,18] = 0
    jac_[92,19] = 0
    jac_[92,20] = kf_R85
    jac_[92,21] = 0
    jac_[92,22] = 0
    jac_[92,23] = 0
    jac_[92,24] = kf_R83
    jac_[92,25] = 0
    jac_[92,26] = 0
    jac_[92,27] = 0
    jac_[92,28] = 0
    jac_[92,29] = 0
    jac_[92,30] = 0
    jac_[92,31] = 0
    jac_[92,32] = 0
    jac_[92,33] = 0
    jac_[92,34] = 0
    jac_[92,35] = 0
    jac_[92,36] = 0
    jac_[92,37] = 0
    jac_[92,38] = 0
    jac_[92,39] = 0
    jac_[92,40] = 0
    jac_[92,41] = 0
    jac_[92,42] = 0
    jac_[92,43] = 0
    jac_[92,44] = 0
    jac_[92,45] = 0
    jac_[92,46] = 0
    jac_[92,47] = 0
    jac_[92,48] = 0
    jac_[92,49] = 0
    jac_[92,50] = 0
    jac_[92,51] = 0
    jac_[92,52] = 0
    jac_[92,53] = 0
    jac_[92,54] = 0
    jac_[92,55] = 0
    jac_[92,56] = 0
    jac_[92,57] = 0
    jac_[92,58] = 0
    jac_[92,59] = 0
    jac_[92,60] = 0
    jac_[92,61] = 0
    jac_[92,62] = 0
    jac_[92,63] = 0
    jac_[92,64] = 0
    jac_[92,65] = 0
    jac_[92,66] = 0
    jac_[92,67] = 0
    jac_[92,68] = 0
    jac_[92,69] = 0
    jac_[92,70] = -ARPP21*kf_R80
    jac_[92,71] = 0
    jac_[92,72] = 0
    jac_[92,73] = kr_R80
    jac_[92,74] = 0
    jac_[92,75] = 0
    jac_[92,76] = 0
    jac_[92,77] = 0
    jac_[92,78] = 0
    jac_[92,79] = 0
    jac_[92,80] = 0
    jac_[92,81] = 0
    jac_[92,82] = 0
    jac_[92,83] = 0
    jac_[92,84] = 0
    jac_[92,85] = 0
    jac_[92,86] = 0
    jac_[92,87] = 0
    jac_[92,88] = 0
    jac_[92,89] = 0
    jac_[92,90] = 0
    jac_[92,91] = 0
    jac_[92,92] = -PKAc*kf_R80
    jac_[92,93] = 0
    jac_[92,94] = 0
    jac_[92,95] = 0
    jac_[92,96] = 0
    jac_[92,97] = 0
    jac_[92,98] = 0
    jac_[92,99] = 0
    jac_[93,1] = 0
    jac_[93,2] = 0
    jac_[93,3] = 0
    jac_[93,4] = 0
    jac_[93,5] = 0
    jac_[93,6] = 0
    jac_[93,7] = 0
    jac_[93,8] = 0
    jac_[93,9] = 0
    jac_[93,10] = 0
    jac_[93,11] = 0
    jac_[93,12] = 0
    jac_[93,13] = 0
    jac_[93,14] = 0
    jac_[93,15] = 0
    jac_[93,16] = 0
    jac_[93,17] = 0
    jac_[93,18] = 0
    jac_[93,19] = 0
    jac_[93,20] = 0
    jac_[93,21] = 0
    jac_[93,22] = 0
    jac_[93,23] = 0
    jac_[93,24] = 0
    jac_[93,25] = 0
    jac_[93,26] = 0
    jac_[93,27] = 0
    jac_[93,28] = 0
    jac_[93,29] = 0
    jac_[93,30] = 0
    jac_[93,31] = 0
    jac_[93,32] = 0
    jac_[93,33] = 0
    jac_[93,34] = 0
    jac_[93,35] = 0
    jac_[93,36] = 0
    jac_[93,37] = 0
    jac_[93,38] = 0
    jac_[93,39] = pCaMKII_psd*kf_R93
    jac_[93,40] = 0
    jac_[93,41] = 0
    jac_[93,42] = 0
    jac_[93,43] = 0
    jac_[93,44] = 0
    jac_[93,45] = 0
    jac_[93,46] = 0
    jac_[93,47] = 0
    jac_[93,48] = 0
    jac_[93,49] = 0
    jac_[93,50] = 0
    jac_[93,51] = 0
    jac_[93,52] = 0
    jac_[93,53] = 0
    jac_[93,54] = 0
    jac_[93,55] = 0
    jac_[93,56] = 0
    jac_[93,57] = 0
    jac_[93,58] = 0
    jac_[93,59] = 0
    jac_[93,60] = 0
    jac_[93,61] = Substrate*kf_R93
    jac_[93,62] = 0
    jac_[93,63] = 0
    jac_[93,64] = 0
    jac_[93,65] = 0
    jac_[93,66] = 0
    jac_[93,67] = 0
    jac_[93,68] = 0
    jac_[93,69] = 0
    jac_[93,70] = 0
    jac_[93,71] = 0
    jac_[93,72] = 0
    jac_[93,73] = 0
    jac_[93,74] = 0
    jac_[93,75] = 0
    jac_[93,76] = 0
    jac_[93,77] = 0
    jac_[93,78] = 0
    jac_[93,79] = 0
    jac_[93,80] = 0
    jac_[93,81] = 0
    jac_[93,82] = 0
    jac_[93,83] = 0
    jac_[93,84] = 0
    jac_[93,85] = 0
    jac_[93,86] = 0
    jac_[93,87] = 0
    jac_[93,88] = 0
    jac_[93,89] = 0
    jac_[93,90] = 0
    jac_[93,91] = 0
    jac_[93,92] = 0
    jac_[93,93] = -kr_R93-kf_R94
    jac_[93,94] = 0
    jac_[93,95] = 0
    jac_[93,96] = 0
    jac_[93,97] = 0
    jac_[93,98] = 0
    jac_[93,99] = 0
    jac_[94,1] = 0
    jac_[94,2] = 0
    jac_[94,3] = 0
    jac_[94,4] = 0
    jac_[94,5] = 0
    jac_[94,6] = 0
    jac_[94,7] = 0
    jac_[94,8] = 0
    jac_[94,9] = 0
    jac_[94,10] = 0
    jac_[94,11] = 0
    jac_[94,12] = 0
    jac_[94,13] = 0
    jac_[94,14] = 0
    jac_[94,15] = 0
    jac_[94,16] = 0
    jac_[94,17] = 0
    jac_[94,18] = 0
    jac_[94,19] = 0
    jac_[94,20] = 0
    jac_[94,21] = 0
    jac_[94,22] = 0
    jac_[94,23] = 0
    jac_[94,24] = 0
    jac_[94,25] = 0
    jac_[94,26] = 0
    jac_[94,27] = 0
    jac_[94,28] = 0
    jac_[94,29] = 0
    jac_[94,30] = 0
    jac_[94,31] = 0
    jac_[94,32] = 0
    jac_[94,33] = 0
    jac_[94,34] = 0
    jac_[94,35] = 0
    jac_[94,36] = 0
    jac_[94,37] = 0
    jac_[94,38] = 0
    jac_[94,39] = kf_R96*pCaMKII_CaM_psd
    jac_[94,40] = 0
    jac_[94,41] = 0
    jac_[94,42] = 0
    jac_[94,43] = 0
    jac_[94,44] = 0
    jac_[94,45] = 0
    jac_[94,46] = 0
    jac_[94,47] = 0
    jac_[94,48] = 0
    jac_[94,49] = 0
    jac_[94,50] = 0
    jac_[94,51] = 0
    jac_[94,52] = 0
    jac_[94,53] = 0
    jac_[94,54] = 0
    jac_[94,55] = 0
    jac_[94,56] = 0
    jac_[94,57] = 0
    jac_[94,58] = 0
    jac_[94,59] = kf_R96*Substrate
    jac_[94,60] = 0
    jac_[94,61] = 0
    jac_[94,62] = 0
    jac_[94,63] = 0
    jac_[94,64] = 0
    jac_[94,65] = 0
    jac_[94,66] = 0
    jac_[94,67] = 0
    jac_[94,68] = 0
    jac_[94,69] = 0
    jac_[94,70] = 0
    jac_[94,71] = 0
    jac_[94,72] = 0
    jac_[94,73] = 0
    jac_[94,74] = 0
    jac_[94,75] = 0
    jac_[94,76] = 0
    jac_[94,77] = 0
    jac_[94,78] = 0
    jac_[94,79] = 0
    jac_[94,80] = 0
    jac_[94,81] = 0
    jac_[94,82] = 0
    jac_[94,83] = 0
    jac_[94,84] = 0
    jac_[94,85] = 0
    jac_[94,86] = 0
    jac_[94,87] = 0
    jac_[94,88] = 0
    jac_[94,89] = 0
    jac_[94,90] = 0
    jac_[94,91] = 0
    jac_[94,92] = 0
    jac_[94,93] = 0
    jac_[94,94] = -kr_R96-kf_R97
    jac_[94,95] = 0
    jac_[94,96] = 0
    jac_[94,97] = 0
    jac_[94,98] = 0
    jac_[94,99] = 0
    jac_[95,1] = 0
    jac_[95,2] = 0
    jac_[95,3] = 0
    jac_[95,4] = 0
    jac_[95,5] = 0
    jac_[95,6] = 0
    jac_[95,7] = 0
    jac_[95,8] = 0
    jac_[95,9] = 0
    jac_[95,10] = 0
    jac_[95,11] = 0
    jac_[95,12] = 0
    jac_[95,13] = 0
    jac_[95,14] = 0
    jac_[95,15] = 0
    jac_[95,16] = 0
    jac_[95,17] = 0
    jac_[95,18] = 0
    jac_[95,19] = 0
    jac_[95,20] = 0
    jac_[95,21] = 0
    jac_[95,22] = 0
    jac_[95,23] = 0
    jac_[95,24] = 0
    jac_[95,25] = 0
    jac_[95,26] = 0
    jac_[95,27] = 0
    jac_[95,28] = 0
    jac_[95,29] = 0
    jac_[95,30] = 0
    jac_[95,31] = 0
    jac_[95,32] = 0
    jac_[95,33] = 0
    jac_[95,34] = 0
    jac_[95,35] = 0
    jac_[95,36] = 0
    jac_[95,37] = 0
    jac_[95,38] = 0
    jac_[95,39] = kf_R98*pCaMKII_CaM_Ca2_psd
    jac_[95,40] = 0
    jac_[95,41] = 0
    jac_[95,42] = 0
    jac_[95,43] = 0
    jac_[95,44] = 0
    jac_[95,45] = 0
    jac_[95,46] = 0
    jac_[95,47] = 0
    jac_[95,48] = 0
    jac_[95,49] = 0
    jac_[95,50] = 0
    jac_[95,51] = 0
    jac_[95,52] = 0
    jac_[95,53] = 0
    jac_[95,54] = 0
    jac_[95,55] = 0
    jac_[95,56] = 0
    jac_[95,57] = 0
    jac_[95,58] = kf_R98*Substrate
    jac_[95,59] = 0
    jac_[95,60] = 0
    jac_[95,61] = 0
    jac_[95,62] = 0
    jac_[95,63] = 0
    jac_[95,64] = 0
    jac_[95,65] = 0
    jac_[95,66] = 0
    jac_[95,67] = 0
    jac_[95,68] = 0
    jac_[95,69] = 0
    jac_[95,70] = 0
    jac_[95,71] = 0
    jac_[95,72] = 0
    jac_[95,73] = 0
    jac_[95,74] = 0
    jac_[95,75] = 0
    jac_[95,76] = 0
    jac_[95,77] = 0
    jac_[95,78] = 0
    jac_[95,79] = 0
    jac_[95,80] = 0
    jac_[95,81] = 0
    jac_[95,82] = 0
    jac_[95,83] = 0
    jac_[95,84] = 0
    jac_[95,85] = 0
    jac_[95,86] = 0
    jac_[95,87] = 0
    jac_[95,88] = 0
    jac_[95,89] = 0
    jac_[95,90] = 0
    jac_[95,91] = 0
    jac_[95,92] = 0
    jac_[95,93] = 0
    jac_[95,94] = 0
    jac_[95,95] = -kr_R98-kf_R99
    jac_[95,96] = 0
    jac_[95,97] = 0
    jac_[95,98] = 0
    jac_[95,99] = 0
    jac_[96,1] = 0
    jac_[96,2] = 0
    jac_[96,3] = 0
    jac_[96,4] = 0
    jac_[96,5] = 0
    jac_[96,6] = 0
    jac_[96,7] = 0
    jac_[96,8] = 0
    jac_[96,9] = 0
    jac_[96,10] = 0
    jac_[96,11] = 0
    jac_[96,12] = 0
    jac_[96,13] = 0
    jac_[96,14] = 0
    jac_[96,15] = 0
    jac_[96,16] = 0
    jac_[96,17] = 0
    jac_[96,18] = 0
    jac_[96,19] = 0
    jac_[96,20] = 0
    jac_[96,21] = 0
    jac_[96,22] = 0
    jac_[96,23] = 0
    jac_[96,24] = 0
    jac_[96,25] = 0
    jac_[96,26] = 0
    jac_[96,27] = 0
    jac_[96,28] = 0
    jac_[96,29] = 0
    jac_[96,30] = 0
    jac_[96,31] = 0
    jac_[96,32] = 0
    jac_[96,33] = 0
    jac_[96,34] = 0
    jac_[96,35] = 0
    jac_[96,36] = 0
    jac_[96,37] = 0
    jac_[96,38] = 0
    jac_[96,39] = kf_R100*pCaMKII_CaM_Ca4_psd
    jac_[96,40] = 0
    jac_[96,41] = 0
    jac_[96,42] = 0
    jac_[96,43] = 0
    jac_[96,44] = 0
    jac_[96,45] = 0
    jac_[96,46] = 0
    jac_[96,47] = 0
    jac_[96,48] = 0
    jac_[96,49] = 0
    jac_[96,50] = 0
    jac_[96,51] = 0
    jac_[96,52] = 0
    jac_[96,53] = 0
    jac_[96,54] = 0
    jac_[96,55] = 0
    jac_[96,56] = 0
    jac_[96,57] = 0
    jac_[96,58] = 0
    jac_[96,59] = 0
    jac_[96,60] = kf_R100*Substrate
    jac_[96,61] = 0
    jac_[96,62] = 0
    jac_[96,63] = 0
    jac_[96,64] = 0
    jac_[96,65] = 0
    jac_[96,66] = 0
    jac_[96,67] = 0
    jac_[96,68] = 0
    jac_[96,69] = 0
    jac_[96,70] = 0
    jac_[96,71] = 0
    jac_[96,72] = 0
    jac_[96,73] = 0
    jac_[96,74] = 0
    jac_[96,75] = 0
    jac_[96,76] = 0
    jac_[96,77] = 0
    jac_[96,78] = 0
    jac_[96,79] = 0
    jac_[96,80] = 0
    jac_[96,81] = 0
    jac_[96,82] = 0
    jac_[96,83] = 0
    jac_[96,84] = 0
    jac_[96,85] = 0
    jac_[96,86] = 0
    jac_[96,87] = 0
    jac_[96,88] = 0
    jac_[96,89] = 0
    jac_[96,90] = 0
    jac_[96,91] = 0
    jac_[96,92] = 0
    jac_[96,93] = 0
    jac_[96,94] = 0
    jac_[96,95] = 0
    jac_[96,96] = -kr_R100-kf_R101
    jac_[96,97] = 0
    jac_[96,98] = 0
    jac_[96,99] = 0
    jac_[97,1] = 0
    jac_[97,2] = 0
    jac_[97,3] = 0
    jac_[97,4] = 0
    jac_[97,5] = 0
    jac_[97,6] = 0
    jac_[97,7] = 0
    jac_[97,8] = 0
    jac_[97,9] = 0
    jac_[97,10] = 0
    jac_[97,11] = 0
    jac_[97,12] = 0
    jac_[97,13] = 0
    jac_[97,14] = 0
    jac_[97,15] = 0
    jac_[97,16] = 0
    jac_[97,17] = 0
    jac_[97,18] = 0
    jac_[97,19] = 0
    jac_[97,20] = 0
    jac_[97,21] = 0
    jac_[97,22] = 0
    jac_[97,23] = 0
    jac_[97,24] = 0
    jac_[97,25] = 0
    jac_[97,26] = 0
    jac_[97,27] = 0
    jac_[97,28] = 0
    jac_[97,29] = 0
    jac_[97,30] = 0
    jac_[97,31] = 0
    jac_[97,32] = 0
    jac_[97,33] = 0
    jac_[97,34] = 0
    jac_[97,35] = kf_R102*Substrate
    jac_[97,36] = 0
    jac_[97,37] = 0
    jac_[97,38] = 0
    jac_[97,39] = kf_R102*CaMKII_CaM_psd
    jac_[97,40] = 0
    jac_[97,41] = 0
    jac_[97,42] = 0
    jac_[97,43] = 0
    jac_[97,44] = 0
    jac_[97,45] = 0
    jac_[97,46] = 0
    jac_[97,47] = 0
    jac_[97,48] = 0
    jac_[97,49] = 0
    jac_[97,50] = 0
    jac_[97,51] = 0
    jac_[97,52] = 0
    jac_[97,53] = 0
    jac_[97,54] = 0
    jac_[97,55] = 0
    jac_[97,56] = 0
    jac_[97,57] = 0
    jac_[97,58] = 0
    jac_[97,59] = 0
    jac_[97,60] = 0
    jac_[97,61] = 0
    jac_[97,62] = 0
    jac_[97,63] = 0
    jac_[97,64] = 0
    jac_[97,65] = 0
    jac_[97,66] = 0
    jac_[97,67] = 0
    jac_[97,68] = 0
    jac_[97,69] = 0
    jac_[97,70] = 0
    jac_[97,71] = 0
    jac_[97,72] = 0
    jac_[97,73] = 0
    jac_[97,74] = 0
    jac_[97,75] = 0
    jac_[97,76] = 0
    jac_[97,77] = 0
    jac_[97,78] = 0
    jac_[97,79] = 0
    jac_[97,80] = 0
    jac_[97,81] = 0
    jac_[97,82] = 0
    jac_[97,83] = 0
    jac_[97,84] = 0
    jac_[97,85] = 0
    jac_[97,86] = 0
    jac_[97,87] = 0
    jac_[97,88] = 0
    jac_[97,89] = 0
    jac_[97,90] = 0
    jac_[97,91] = 0
    jac_[97,92] = 0
    jac_[97,93] = 0
    jac_[97,94] = 0
    jac_[97,95] = 0
    jac_[97,96] = 0
    jac_[97,97] = -kr_R102-kf_R103
    jac_[97,98] = 0
    jac_[97,99] = 0
    jac_[98,1] = 0
    jac_[98,2] = 0
    jac_[98,3] = 0
    jac_[98,4] = 0
    jac_[98,5] = 0
    jac_[98,6] = 0
    jac_[98,7] = 0
    jac_[98,8] = 0
    jac_[98,9] = 0
    jac_[98,10] = 0
    jac_[98,11] = 0
    jac_[98,12] = 0
    jac_[98,13] = 0
    jac_[98,14] = 0
    jac_[98,15] = 0
    jac_[98,16] = 0
    jac_[98,17] = 0
    jac_[98,18] = 0
    jac_[98,19] = 0
    jac_[98,20] = 0
    jac_[98,21] = 0
    jac_[98,22] = 0
    jac_[98,23] = 0
    jac_[98,24] = 0
    jac_[98,25] = 0
    jac_[98,26] = 0
    jac_[98,27] = 0
    jac_[98,28] = 0
    jac_[98,29] = 0
    jac_[98,30] = 0
    jac_[98,31] = 0
    jac_[98,32] = 0
    jac_[98,33] = 0
    jac_[98,34] = Substrate*kf_R104
    jac_[98,35] = 0
    jac_[98,36] = 0
    jac_[98,37] = 0
    jac_[98,38] = 0
    jac_[98,39] = CaMKII_CaM_Ca2_psd*kf_R104
    jac_[98,40] = 0
    jac_[98,41] = 0
    jac_[98,42] = 0
    jac_[98,43] = 0
    jac_[98,44] = 0
    jac_[98,45] = 0
    jac_[98,46] = 0
    jac_[98,47] = 0
    jac_[98,48] = 0
    jac_[98,49] = 0
    jac_[98,50] = 0
    jac_[98,51] = 0
    jac_[98,52] = 0
    jac_[98,53] = 0
    jac_[98,54] = 0
    jac_[98,55] = 0
    jac_[98,56] = 0
    jac_[98,57] = 0
    jac_[98,58] = 0
    jac_[98,59] = 0
    jac_[98,60] = 0
    jac_[98,61] = 0
    jac_[98,62] = 0
    jac_[98,63] = 0
    jac_[98,64] = 0
    jac_[98,65] = 0
    jac_[98,66] = 0
    jac_[98,67] = 0
    jac_[98,68] = 0
    jac_[98,69] = 0
    jac_[98,70] = 0
    jac_[98,71] = 0
    jac_[98,72] = 0
    jac_[98,73] = 0
    jac_[98,74] = 0
    jac_[98,75] = 0
    jac_[98,76] = 0
    jac_[98,77] = 0
    jac_[98,78] = 0
    jac_[98,79] = 0
    jac_[98,80] = 0
    jac_[98,81] = 0
    jac_[98,82] = 0
    jac_[98,83] = 0
    jac_[98,84] = 0
    jac_[98,85] = 0
    jac_[98,86] = 0
    jac_[98,87] = 0
    jac_[98,88] = 0
    jac_[98,89] = 0
    jac_[98,90] = 0
    jac_[98,91] = 0
    jac_[98,92] = 0
    jac_[98,93] = 0
    jac_[98,94] = 0
    jac_[98,95] = 0
    jac_[98,96] = 0
    jac_[98,97] = 0
    jac_[98,98] = -kr_R104-kf_R105
    jac_[98,99] = 0
    jac_[99,1] = 0
    jac_[99,2] = 0
    jac_[99,3] = 0
    jac_[99,4] = 0
    jac_[99,5] = 0
    jac_[99,6] = 0
    jac_[99,7] = 0
    jac_[99,8] = 0
    jac_[99,9] = 0
    jac_[99,10] = 0
    jac_[99,11] = 0
    jac_[99,12] = 0
    jac_[99,13] = 0
    jac_[99,14] = 0
    jac_[99,15] = 0
    jac_[99,16] = 0
    jac_[99,17] = 0
    jac_[99,18] = 0
    jac_[99,19] = 0
    jac_[99,20] = 0
    jac_[99,21] = 0
    jac_[99,22] = 0
    jac_[99,23] = 0
    jac_[99,24] = 0
    jac_[99,25] = 0
    jac_[99,26] = 0
    jac_[99,27] = 0
    jac_[99,28] = 0
    jac_[99,29] = 0
    jac_[99,30] = 0
    jac_[99,31] = 0
    jac_[99,32] = 0
    jac_[99,33] = 0
    jac_[99,34] = 0
    jac_[99,35] = 0
    jac_[99,36] = Substrate*kf_R106-kr_R106*Substrate
    jac_[99,37] = 0
    jac_[99,38] = 0
    jac_[99,39] = -kr_R106*CaMKII_CaM_Ca4_psd+CaMKII_CaM_Ca4_psd*kf_R106
    jac_[99,40] = 0
    jac_[99,41] = 0
    jac_[99,42] = 0
    jac_[99,43] = 0
    jac_[99,44] = 0
    jac_[99,45] = 0
    jac_[99,46] = 0
    jac_[99,47] = 0
    jac_[99,48] = 0
    jac_[99,49] = 0
    jac_[99,50] = 0
    jac_[99,51] = 0
    jac_[99,52] = 0
    jac_[99,53] = 0
    jac_[99,54] = 0
    jac_[99,55] = 0
    jac_[99,56] = 0
    jac_[99,57] = 0
    jac_[99,58] = 0
    jac_[99,59] = 0
    jac_[99,60] = 0
    jac_[99,61] = 0
    jac_[99,62] = 0
    jac_[99,63] = 0
    jac_[99,64] = 0
    jac_[99,65] = 0
    jac_[99,66] = 0
    jac_[99,67] = 0
    jac_[99,68] = 0
    jac_[99,69] = 0
    jac_[99,70] = 0
    jac_[99,71] = 0
    jac_[99,72] = 0
    jac_[99,73] = 0
    jac_[99,74] = 0
    jac_[99,75] = 0
    jac_[99,76] = 0
    jac_[99,77] = 0
    jac_[99,78] = 0
    jac_[99,79] = 0
    jac_[99,80] = 0
    jac_[99,81] = 0
    jac_[99,82] = 0
    jac_[99,83] = 0
    jac_[99,84] = 0
    jac_[99,85] = 0
    jac_[99,86] = 0
    jac_[99,87] = 0
    jac_[99,88] = 0
    jac_[99,89] = 0
    jac_[99,90] = 0
    jac_[99,91] = 0
    jac_[99,92] = 0
    jac_[99,93] = 0
    jac_[99,94] = 0
    jac_[99,95] = 0
    jac_[99,96] = 0
    jac_[99,97] = 0
    jac_[99,98] = 0
    jac_[99,99] = -kf_R107
    return(jac_)
}