notebooks/cortes-ciriano-refresh.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "id": "44eaec04",
   "metadata": {},
   "source": [
    "# Refreshing the Cortés-Ciriano Datasets\n",
    "\n",
    "A lot of cheminformaticians use the datasets from [*Deep Confidence: A Computationally Efficient Framework for Calculating Reliable Prediction Errors for Deep Neural Networks*](https://pubs.acs.org/doi/10.1021/acs.jcim.8b00542) by Cortés-Ciriano (https://twitter.com/isidrolauscher) and Bender (https://twitter.com/AndreasBenderUK). Here's Table 1 from the manuscript, describing 24 datasets corresponding to 24 protein targets:\n",
    "\n",
    "![](cortes-ciriano-table-1.png)\n",
    "\n",
    "Unfortunately, these were published in 2018 using ChEMBL 23 (2017-05-18) and the paper does not include code to regenerate these 24 datasets. Here's what the manuscript says about how it was made:\n",
    "\n",
    "> We gathered IC50 data for 24 diverse protein targets and receptors from the ChEMBL database version 23 using the [chembl_webresource_client](https://github.com/chembl/chembl_webresource_client) python module. Only IC<sub>50</sub> values for small molecules that satisfied the following filtering criteria were retained: (i) an activity unit equal to `nM`, (ii) activity relationship equal to `=`, (iii) target type equal to `SINGLE PROTEIN`, and (iv) organism equal to Homo sapiens. IC<sub>50</sub> values were modeled in a logarithmic scale (pIC<sub>50</sub> = −log<sub>10</sub> IC<sub>50</sub>). The average pIC<sub>50</sub> value was calculated when multiple pIC<sub>50</sub> values were available for the same compound.\n",
    "\n",
    "Note that pChEMBL values are the same as pIC<sub>50</sub> when the measurement is for inhibitory concentrations. Additionally, there are some methodological issues going on here, since the arithmetic mean isn't appropriate for log values. Instead, the geometric mean should be used:\n",
    "\n",
    "<blockquote class=\"twitter-tweet\"><p lang=\"en\" dir=\"ltr\">pIC50&#39;s should be aggregated using geometric mean<br><br>But it&#39;s generally not reasonable to aggregate across across an arbitrary set of assays</p>&mdash; Rajarshi Guha (@rguha@nerdculture.de) (@rguha) <a href=\"https://twitter.com/rguha/status/1586677163775893504?ref_src=twsrc%5Etfw\">October 30, 2022</a></blockquote> <script async src=\"https://platform.twitter.com/widgets.js\" charset=\"utf-8\"></script> \n",
    "\n",
    "Further, these aging datasets are missing the benefit of many new assays added to ChEMBL. Therefore, this notebook has two goals:\n",
    "\n",
    "1. See if we can automate rebuilding these datasets using a modern version of ChEMBL (facilitated by [`chembl-downloader`](https://github.com/cthoyt/chembl-downloader))\n",
    "2. Assess how much variability has been introduced since the 2018 publication for each target based on new data"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "id": "1d14fba6",
   "metadata": {},
   "outputs": [],
   "source": [
    "import sys\n",
    "import time\n",
    "import zipfile\n",
    "\n",
    "import matplotlib.pyplot as plt\n",
    "import matplotlib_inline\n",
    "import pandas as pd\n",
    "import pystow\n",
    "import seaborn as sns\n",
    "from matplotlib_venn import venn2, venn3\n",
    "from rdkit import Chem\n",
    "from tqdm.auto import tqdm\n",
    "\n",
    "import chembl_downloader\n",
    "from chembl_downloader.contrib import get_target_smi_df"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "id": "426fe188",
   "metadata": {},
   "outputs": [],
   "source": [
    "matplotlib_inline.backend_inline.set_matplotlib_formats(\"svg\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "id": "ace3edc0",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "3.10.8 (main, Oct 13 2022, 10:17:43) [Clang 14.0.0 (clang-1400.0.29.102)]\n"
     ]
    }
   ],
   "source": [
    "print(sys.version)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "id": "2d7a2f09",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Sat Nov 19 22:11:26 2022\n"
     ]
    }
   ],
   "source": [
    "print(time.asctime())"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "id": "2d3b3eb4",
   "metadata": {},
   "outputs": [],
   "source": [
    "mappings = [\n",
    "    (\"A2a\", \"CHEMBL1867\", 203),\n",
    "    (\"ABL1\", \"CHEMBL1862\", 773),\n",
    "    (\"Acetylcholinesterase\", \"CHEMBL220\", 3159),\n",
    "    (\"Aurora-A\", \"CHEMBL4722\", 2125),\n",
    "    (\"B-raf\", \"CHEMBL5145\", 1730),\n",
    "    (\"Cannabinoid\", \"CHEMBL218\", 1116),\n",
    "    (\"Carbonic\", \"CHEMBL205\", 603),\n",
    "    (\"Caspase\", \"CHEMBL2334\", 1606),\n",
    "    (\"Coagulation\", \"CHEMBL204\", 1700),\n",
    "    (\"COX-1\", \"CHEMBL221\", 1343),\n",
    "    (\"COX-2\", \"CHEMBL230\", 2855),\n",
    "    (\"Dihydrofolate\", \"CHEMBL202\", 584),\n",
    "    (\"Dopamine\", \"CHEMBL217\", 479),\n",
    "    (\"Ephrin\", \"CHEMBL222\", 1740),\n",
    "    (\"erbB1\", \"CHEMBL203\", 4868),\n",
    "    (\"Estrogen\", \"CHEMBL206\", 1705),\n",
    "    (\"Glucocorticoid\", \"CHEMBL2034\", 1447),\n",
    "    (\"Glycogen\", \"CHEMBL262\", 1757),\n",
    "    (\"HERG\", \"CHEMBL240\", 5207),\n",
    "    (\"JAK2\", \"CHEMBL2971\", 2655),\n",
    "    (\"LCK\", \"CHEMBL258\", 1352),\n",
    "    (\"Monoamine\", \"CHEMBL1951\", 1379),\n",
    "    (\"opioid\", \"CHEMBL233\", 840),\n",
    "    (\"Vanilloid\", \"CHEMBL4794\", 1923),\n",
    "]"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "1b708868",
   "metadata": {},
   "source": [
    "## Load Old Data\n",
    "\n",
    "While the ACS publication links to the supplementary material at https://pubs.acs.org/doi/suppl/10.1021/acs.jcim.8b00542/suppl_file/ci8b00542_si_001.zip, it's obfuscated in a way such that automatic download isn't possible. I found the corresponding dataset on FigShare and will use that link with `pystow` to get it."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "id": "b01be7f8",
   "metadata": {},
   "outputs": [],
   "source": [
    "url = \"https://figshare.com/ndownloader/files/13426988\"\n",
    "path = pystow.ensure(\"cheminf\", url=url)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "f9ff0309",
   "metadata": {},
   "source": [
    "Inside the zip file are SDF files corresponding to the 24 targets. Each have the structures, ChEMBL identifiers, and pIC<sub>50</sub>'s for hundreds or thousands of molecules."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "id": "b037b7bd",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "application/vnd.jupyter.widget-view+json": {
       "model_id": "374a47ace71c4ba49e5bae1b3441fbd0",
       "version_major": 2,
       "version_minor": 0
      },
      "text/plain": [
       "  0%|          | 0/24 [00:00<?, ?file/s]"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "reference_dfs = {}\n",
    "with zipfile.ZipFile(path) as zip_file:\n",
    "    for stem, target_chembl_id, _ in tqdm(mappings, unit=\"file\"):\n",
    "        with zip_file.open(f\"Datasets/{stem}.sdf\") as file:\n",
    "            rows = [\n",
    "                (\n",
    "                    Chem.MolToSmiles(molecule),\n",
    "                    molecule.GetProp(\"ChEMBL_ID\"),\n",
    "                    float(molecule.GetProp(\"pIC50\")),\n",
    "                )\n",
    "                for molecule in Chem.ForwardSDMolSupplier(file)\n",
    "            ]\n",
    "        reference_dfs[target_chembl_id] = pd.DataFrame(\n",
    "            rows,\n",
    "            columns=[\n",
    "                \"canonical_smiles\",\n",
    "                \"molecule_chembl_id\",\n",
    "                \"pchembl_value\",\n",
    "            ],\n",
    "        )"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "70678ff3",
   "metadata": {},
   "source": [
    "## Refresh Data\n",
    "\n",
    "The following function best implements what was described in the manuscript. A future version of the dataset could switch out `aggregate=\"mean\"` for `aggregate=\"gmean\"` to be more theoretically correct, though, both aggregations disregard the potential inter-assay variability which could also be important.\n",
    "\n",
    "Note the importance of filters for standard type, standard relation, target type, and taxa."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "id": "7653825d",
   "metadata": {},
   "outputs": [],
   "source": [
    "def _get_target_dfs(version: str, *, aggregate):\n",
    "    return {\n",
    "        target_chembl_id: get_target_smi_df(\n",
    "            target_chembl_id,\n",
    "            version=version,\n",
    "            aggregate=\"mean\",\n",
    "            target_type=\"SINGLE PROTEIN\",\n",
    "            standard_relation=\"=\",\n",
    "            standard_type=\"IC50\",\n",
    "            tax_id=\"9606\",\n",
    "        )\n",
    "        for _, target_chembl_id, _ in tqdm(mappings)\n",
    "    }"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "b97d306f",
   "metadata": {},
   "source": [
    "Get the data from the reported version, ChEMBL 23, from the paper to see if we can reproduce their datasets."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "id": "701673ed",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "application/vnd.jupyter.widget-view+json": {
       "model_id": "943125a658a943c3bf4b95c5a37c6637",
       "version_major": 2,
       "version_minor": 0
      },
      "text/plain": [
       "  0%|          | 0/24 [00:00<?, ?it/s]"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "refresh_dfs = _get_target_dfs(\"23\", aggregate=\"mean\")"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "9a13a1bc",
   "metadata": {},
   "source": [
    "Get the latest data to see what the changes are."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "id": "d4ca9e39",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "application/vnd.jupyter.widget-view+json": {
       "model_id": "6b437b9fe2da4b3caabac30957e730de",
       "version_major": 2,
       "version_minor": 0
      },
      "text/plain": [
       "  0%|          | 0/24 [00:00<?, ?it/s]"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "version = chembl_downloader.latest()\n",
    "latest_dfs = _get_target_dfs(version, aggregate=\"mean\")"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "49f30d0b",
   "metadata": {},
   "source": [
    "### Tabular Summary\n",
    "\n",
    "From the following counts of which molecules are available for each protein, it shows that there are discrepancies between the reference datasets and what's in ChEMBL 23. This means that there were probably manual interventions that were not explicitly documented, decreasing the trust in the original dataset. There are major discrepancies between the reference/refreshed datasets and the latest version in ChEMBL for many targets."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "id": "50e54b96",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>name</th>\n",
       "      <th>target_chembl_id</th>\n",
       "      <th>reference_count</th>\n",
       "      <th>refresh_count</th>\n",
       "      <th>latest_count</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>A2a</td>\n",
       "      <td>CHEMBL1867</td>\n",
       "      <td>203</td>\n",
       "      <td>206</td>\n",
       "      <td>210</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>ABL1</td>\n",
       "      <td>CHEMBL1862</td>\n",
       "      <td>773</td>\n",
       "      <td>773</td>\n",
       "      <td>1463</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>Acetylcholinesterase</td>\n",
       "      <td>CHEMBL220</td>\n",
       "      <td>3159</td>\n",
       "      <td>3191</td>\n",
       "      <td>4788</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>Aurora-A</td>\n",
       "      <td>CHEMBL4722</td>\n",
       "      <td>2125</td>\n",
       "      <td>2125</td>\n",
       "      <td>2529</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>B-raf</td>\n",
       "      <td>CHEMBL5145</td>\n",
       "      <td>1730</td>\n",
       "      <td>1730</td>\n",
       "      <td>3886</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>Cannabinoid</td>\n",
       "      <td>CHEMBL218</td>\n",
       "      <td>1116</td>\n",
       "      <td>1116</td>\n",
       "      <td>1364</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>Carbonic</td>\n",
       "      <td>CHEMBL205</td>\n",
       "      <td>603</td>\n",
       "      <td>606</td>\n",
       "      <td>754</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>Caspase</td>\n",
       "      <td>CHEMBL2334</td>\n",
       "      <td>1606</td>\n",
       "      <td>1609</td>\n",
       "      <td>1671</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>Coagulation</td>\n",
       "      <td>CHEMBL204</td>\n",
       "      <td>1700</td>\n",
       "      <td>1705</td>\n",
       "      <td>1888</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>COX-1</td>\n",
       "      <td>CHEMBL221</td>\n",
       "      <td>1343</td>\n",
       "      <td>1344</td>\n",
       "      <td>1544</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>COX-2</td>\n",
       "      <td>CHEMBL230</td>\n",
       "      <td>2855</td>\n",
       "      <td>2859</td>\n",
       "      <td>3618</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>Dihydrofolate</td>\n",
       "      <td>CHEMBL202</td>\n",
       "      <td>584</td>\n",
       "      <td>587</td>\n",
       "      <td>774</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>Dopamine</td>\n",
       "      <td>CHEMBL217</td>\n",
       "      <td>479</td>\n",
       "      <td>480</td>\n",
       "      <td>705</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>Ephrin</td>\n",
       "      <td>CHEMBL222</td>\n",
       "      <td>1740</td>\n",
       "      <td>1747</td>\n",
       "      <td>1941</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>erbB1</td>\n",
       "      <td>CHEMBL203</td>\n",
       "      <td>4868</td>\n",
       "      <td>4892</td>\n",
       "      <td>6865</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>Estrogen</td>\n",
       "      <td>CHEMBL206</td>\n",
       "      <td>1705</td>\n",
       "      <td>1708</td>\n",
       "      <td>2435</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>Glucocorticoid</td>\n",
       "      <td>CHEMBL2034</td>\n",
       "      <td>1447</td>\n",
       "      <td>1447</td>\n",
       "      <td>1656</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>Glycogen</td>\n",
       "      <td>CHEMBL262</td>\n",
       "      <td>1757</td>\n",
       "      <td>1759</td>\n",
       "      <td>2521</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>HERG</td>\n",
       "      <td>CHEMBL240</td>\n",
       "      <td>5207</td>\n",
       "      <td>5209</td>\n",
       "      <td>7412</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>JAK2</td>\n",
       "      <td>CHEMBL2971</td>\n",
       "      <td>2655</td>\n",
       "      <td>2656</td>\n",
       "      <td>5163</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>LCK</td>\n",
       "      <td>CHEMBL258</td>\n",
       "      <td>1352</td>\n",
       "      <td>1352</td>\n",
       "      <td>1530</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>Monoamine</td>\n",
       "      <td>CHEMBL1951</td>\n",
       "      <td>1379</td>\n",
       "      <td>1379</td>\n",
       "      <td>2202</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>opioid</td>\n",
       "      <td>CHEMBL233</td>\n",
       "      <td>840</td>\n",
       "      <td>841</td>\n",
       "      <td>965</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>Vanilloid</td>\n",
       "      <td>CHEMBL4794</td>\n",
       "      <td>1923</td>\n",
       "      <td>1943</td>\n",
       "      <td>2577</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "                    name target_chembl_id  reference_count  refresh_count  \\\n",
       "0                    A2a       CHEMBL1867              203            206   \n",
       "1                   ABL1       CHEMBL1862              773            773   \n",
       "2   Acetylcholinesterase        CHEMBL220             3159           3191   \n",
       "3               Aurora-A       CHEMBL4722             2125           2125   \n",
       "4                  B-raf       CHEMBL5145             1730           1730   \n",
       "5            Cannabinoid        CHEMBL218             1116           1116   \n",
       "6               Carbonic        CHEMBL205              603            606   \n",
       "7                Caspase       CHEMBL2334             1606           1609   \n",
       "8            Coagulation        CHEMBL204             1700           1705   \n",
       "9                  COX-1        CHEMBL221             1343           1344   \n",
       "10                 COX-2        CHEMBL230             2855           2859   \n",
       "11         Dihydrofolate        CHEMBL202              584            587   \n",
       "12              Dopamine        CHEMBL217              479            480   \n",
       "13                Ephrin        CHEMBL222             1740           1747   \n",
       "14                 erbB1        CHEMBL203             4868           4892   \n",
       "15              Estrogen        CHEMBL206             1705           1708   \n",
       "16        Glucocorticoid       CHEMBL2034             1447           1447   \n",
       "17              Glycogen        CHEMBL262             1757           1759   \n",
       "18                  HERG        CHEMBL240             5207           5209   \n",
       "19                  JAK2       CHEMBL2971             2655           2656   \n",
       "20                   LCK        CHEMBL258             1352           1352   \n",
       "21             Monoamine       CHEMBL1951             1379           1379   \n",
       "22                opioid        CHEMBL233              840            841   \n",
       "23             Vanilloid       CHEMBL4794             1923           1943   \n",
       "\n",
       "    latest_count  \n",
       "0            210  \n",
       "1           1463  \n",
       "2           4788  \n",
       "3           2529  \n",
       "4           3886  \n",
       "5           1364  \n",
       "6            754  \n",
       "7           1671  \n",
       "8           1888  \n",
       "9           1544  \n",
       "10          3618  \n",
       "11           774  \n",
       "12           705  \n",
       "13          1941  \n",
       "14          6865  \n",
       "15          2435  \n",
       "16          1656  \n",
       "17          2521  \n",
       "18          7412  \n",
       "19          5163  \n",
       "20          1530  \n",
       "21          2202  \n",
       "22           965  \n",
       "23          2577  "
      ]
     },
     "execution_count": 11,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "summary_rows = []\n",
    "for name, target_chembl_id, _ in mappings:\n",
    "    reference_df = reference_dfs[target_chembl_id]\n",
    "    refresh_df = refresh_dfs[target_chembl_id]\n",
    "    latest_df = latest_dfs[target_chembl_id]\n",
    "    summary_rows.append(\n",
    "        (\n",
    "            name,\n",
    "            target_chembl_id,\n",
    "            len(reference_df.index),\n",
    "            len(refresh_df.index),\n",
    "            len(latest_df.index),\n",
    "        )\n",
    "    )\n",
    "\n",
    "summary_df = pd.DataFrame(\n",
    "    summary_rows,\n",
    "    columns=[\n",
    "        \"name\",\n",
    "        \"target_chembl_id\",\n",
    "        \"reference_count\",\n",
    "        \"refresh_count\",\n",
    "        \"latest_count\",\n",
    "    ],\n",
    ")\n",
    "summary_df"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "31112557",
   "metadata": {},
   "source": [
    "### Graphical Summary\n",
    "\n",
    "Venn diagrams show that there are a minimal number of molecules that were available in the reference datasets but are either not queriable from ChEMBL 23 or the latest ChEMBL."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "id": "2eafda84",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/Users/cthoyt/.virtualenvs/cheminf310/lib/python3.10/site-packages/matplotlib_venn/_venn3.py:117: UserWarning: Bad circle positioning\n",
      "  warnings.warn(\"Bad circle positioning\")\n"
     ]
    },
    {
     "data": {
      "image/svg+xml": [
       "<?xml version=\"1.0\" encoding=\"utf-8\" standalone=\"no\"?>\n",
       "<!DOCTYPE svg PUBLIC \"-//W3C//DTD SVG 1.1//EN\"\n",
       "  \"http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd\">\n",
       "<svg xmlns:xlink=\"http://www.w3.org/1999/xlink\" width=\"603.14539pt\" height=\"1124.347307pt\" viewBox=\"0 0 603.14539 1124.347307\" xmlns=\"http://www.w3.org/2000/svg\" version=\"1.1\">\n",
       " <metadata>\n",
       "  <rdf:RDF xmlns:dc=\"http://purl.org/dc/elements/1.1/\" xmlns:cc=\"http://creativecommons.org/ns#\" xmlns:rdf=\"http://www.w3.org/1999/02/22-rdf-syntax-ns#\">\n",
       "   <cc:Work>\n",
       "    <dc:type rdf:resource=\"http://purl.org/dc/dcmitype/StillImage\"/>\n",
       "    <dc:date>2022-11-19T22:11:41.101592</dc:date>\n",
       "    <dc:format>image/svg+xml</dc:format>\n",
       "    <dc:creator>\n",
       "     <cc:Agent>\n",
       "      <dc:title>Matplotlib v3.6.0, https://matplotlib.org/</dc:title>\n",
       "     </cc:Agent>\n",
       "    </dc:creator>\n",
       "   </cc:Work>\n",
       "  </rdf:RDF>\n",
       " </metadata>\n",
       " <defs>\n",
       "  <style type=\"text/css\">*{stroke-linejoin: round; stroke-linecap: butt}</style>\n",
       " </defs>\n",
       " <g id=\"figure_1\">\n",
       "  <g id=\"patch_1\">\n",
       "   <path d=\"M 0 1124.347307 \n",
       "L 603.14539 1124.347307 \n",
       "L 603.14539 0 \n",
       "L 0 0 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "  </g>\n",
       "  <g id=\"axes_1\">\n",
       "   <g id=\"patch_2\">\n",
       "    <path d=\"M 36.34663 76.851781 \n",
       "C 39.649102 69.394422 44.705524 62.844534 51.083889 57.761722 \n",
       "C 57.462255 52.67891 64.975588 49.212173 72.981968 47.657698 \n",
       "C 80.988348 46.103223 89.253077 46.50658 97.070038 48.833306 \n",
       "C 104.886998 51.160031 112.027043 55.341921 117.880145 61.021684 \n",
       "C 121.25226 64.142118 124.191552 67.699948 126.619636 71.600292 \n",
       "C 129.04772 75.500635 130.942817 79.708508 132.254389 84.111694 \n",
       "C 129.494703 73.844888 123.592081 64.693736 115.376984 57.945746 \n",
       "C 107.161888 51.197756 97.038545 47.184968 86.431246 46.471954 \n",
       "C 75.823947 45.75894 65.25463 48.380786 56.21033 53.968614 \n",
       "C 47.166031 59.556442 40.091778 67.8353 35.982875 77.640406 \n",
       "C 36.042391 77.50846 36.102463 77.376765 36.16309 77.245326 \n",
       "C 36.223716 77.113887 36.284897 76.982704 36.34663 76.851781 \n",
       "\" clip-path=\"url(#pf705a46604)\" style=\"fill: #008000; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_3\">\n",
       "    <path d=\"M 117.880145 61.021684 \n",
       "C 112.027043 55.341921 104.886998 51.160031 97.070038 48.833306 \n",
       "C 89.253077 46.50658 80.988348 46.103223 72.981968 47.657698 \n",
       "C 64.975588 49.212173 57.462255 52.67891 51.083889 57.761722 \n",
       "C 44.705524 62.844534 39.649102 69.394422 36.34663 76.851781 \n",
       "C 39.796476 69.53536 44.922556 63.133935 51.30792 58.168193 \n",
       "C 57.693283 53.202452 65.159977 49.810783 73.100667 48.269062 \n",
       "C 81.041357 46.727342 89.234745 47.078536 97.014386 49.294078 \n",
       "C 104.794028 51.50962 111.943115 55.527766 117.880145 61.021684 \n",
       "\" clip-path=\"url(#pf705a46604)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_4\">\n",
       "    <path d=\"M 33.235848 108.414597 \n",
       "C 32.421977 104.782011 32.011313 101.070703 32.011313 97.348061 \n",
       "C 32.011313 93.625418 32.421977 89.91411 33.235848 86.281524 \n",
       "C 33.564313 84.80414 33.95839 83.342112 34.416909 81.899784 \n",
       "C 34.875428 80.457455 35.397934 79.036255 35.982875 77.640406 \n",
       "C 32.566476 85.214528 31.033908 93.504331 31.516528 101.79928 \n",
       "C 31.999149 110.09423 34.482765 118.150362 38.754501 125.277169 \n",
       "C 43.026236 132.403976 48.960455 138.391852 56.048523 142.727563 \n",
       "C 63.136591 147.063275 71.170042 149.619304 79.460311 150.176569 \n",
       "C 87.75058 150.733834 96.053842 149.275944 103.658409 145.927859 \n",
       "C 111.262975 142.579774 117.945188 137.439964 123.1323 130.948972 \n",
       "C 128.319412 124.457981 131.858866 116.806714 133.447288 108.650979 \n",
       "C 135.035709 100.495243 134.626382 92.074907 132.254389 84.111694 \n",
       "C 134.016975 90.669007 134.452155 97.512816 133.534332 104.240569 \n",
       "C 132.61651 110.968322 130.364039 117.445473 126.909411 123.291036 \n",
       "C 123.454784 129.136599 118.867087 134.233671 113.416168 138.282441 \n",
       "C 107.965249 142.331212 101.76012 145.250712 95.165767 146.869217 \n",
       "C 88.571413 148.487721 81.719712 148.772862 75.013682 147.707867 \n",
       "C 68.307651 146.642872 61.881402 144.249041 56.112927 140.667177 \n",
       "C 50.344451 137.085313 45.349111 132.38705 41.420731 126.848738 \n",
       "C 37.492351 121.310427 34.709494 115.042827 33.235848 108.414597 \n",
       "\" clip-path=\"url(#pf705a46604)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_5\">\n",
       "    <path d=\"M 33.235848 86.281524 \n",
       "C 33.598317 84.6637 34.040052 83.06466 34.559455 81.490189 \n",
       "C 35.078858 79.915718 35.675302 78.367715 36.34663 76.851781 \n",
       "C 36.284897 76.982704 36.223716 77.113887 36.16309 77.245326 \n",
       "C 36.102463 77.376765 36.042391 77.50846 35.982875 77.640406 \n",
       "C 35.397934 79.036255 34.875428 80.457455 34.416909 81.899784 \n",
       "C 33.95839 83.342112 33.564313 84.80414 33.235848 86.281524 \n",
       "M 33.235848 108.414597 \n",
       "C 34.709494 115.042827 37.492351 121.310427 41.420731 126.848738 \n",
       "C 45.349111 132.38705 50.344451 137.085313 56.112927 140.667177 \n",
       "C 61.881402 144.249041 68.307651 146.642872 75.013682 147.707867 \n",
       "C 81.719712 148.772862 88.571413 148.487721 95.165767 146.869217 \n",
       "C 101.76012 145.250712 107.965249 142.331212 113.416168 138.282441 \n",
       "C 118.867087 134.233671 123.454784 129.136599 126.909411 123.291036 \n",
       "C 130.364039 117.445473 132.61651 110.968322 133.534332 104.240569 \n",
       "C 134.452155 97.512816 134.016975 90.669007 132.254389 84.111694 \n",
       "C 130.942817 79.708508 129.04772 75.500635 126.619636 71.600292 \n",
       "C 124.191552 67.699948 121.25226 64.142118 117.880145 61.021684 \n",
       "C 123.538448 66.512415 127.836385 73.249985 130.430228 80.695554 \n",
       "C 133.02407 88.141122 133.842777 96.090766 132.820872 103.908708 \n",
       "C 131.798966 111.726651 128.964437 119.198769 124.543976 125.727479 \n",
       "C 120.123515 132.256188 114.238194 137.662675 107.358692 141.514554 \n",
       "C 100.479191 145.366433 92.79393 147.558207 84.91754 147.914587 \n",
       "C 77.041151 148.270968 69.189357 146.782194 61.99011 143.567331 \n",
       "C 54.790862 140.352468 48.441337 135.499566 43.449342 129.396739 \n",
       "C 38.457346 123.293912 34.959604 116.108308 33.235848 108.414597 \n",
       "\" clip-path=\"url(#pf705a46604)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_6\">\n",
       "    <path d=\"M 33.235848 108.414597 \n",
       "C 34.959604 116.108308 38.457346 123.293912 43.449342 129.396739 \n",
       "C 48.441337 135.499566 54.790862 140.352468 61.99011 143.567331 \n",
       "C 69.189357 146.782194 77.041151 148.270968 84.91754 147.914587 \n",
       "C 92.79393 147.558207 100.479191 145.366433 107.358692 141.514554 \n",
       "C 114.238194 137.662675 120.123515 132.256188 124.543976 125.727479 \n",
       "C 128.964437 119.198769 131.798966 111.726651 132.820872 103.908708 \n",
       "C 133.842777 96.090766 133.02407 88.141122 130.430228 80.695554 \n",
       "C 127.836385 73.249985 123.538448 66.512415 117.880145 61.021684 \n",
       "C 111.943115 55.527766 104.794028 51.50962 97.014386 49.294078 \n",
       "C 89.234745 47.078536 81.041357 46.727342 73.100667 48.269062 \n",
       "C 65.159977 49.810783 57.693283 53.202452 51.30792 58.168193 \n",
       "C 44.922556 63.133935 39.796476 69.53536 36.34663 76.851781 \n",
       "C 35.675302 78.367715 35.078858 79.915718 34.559455 81.490189 \n",
       "C 34.040052 83.06466 33.598317 84.6637 33.235848 86.281524 \n",
       "C 32.428034 89.914946 32.020481 93.625921 32.020481 97.348061 \n",
       "C 32.020481 101.0702 32.428034 104.781175 33.235848 108.414597 \n",
       "\" clip-path=\"url(#pf705a46604)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_1\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(82.192774 52.50596) scale(0.1 -0.1)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-31\" d=\"M 794 531 \n",
       "L 1825 531 \n",
       "L 1825 4091 \n",
       "L 703 3866 \n",
       "L 703 4441 \n",
       "L 1819 4666 \n",
       "L 2450 4666 \n",
       "L 2450 531 \n",
       "L 3481 531 \n",
       "L 3481 0 \n",
       "L 794 0 \n",
       "L 794 531 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_2\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(69.860068 50.722755) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_3\">\n",
       "    <!-- 6 -->\n",
       "    <g transform=\"translate(79.032887 146.93264) scale(0.1 -0.1)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-36\" d=\"M 2113 2584 \n",
       "Q 1688 2584 1439 2293 \n",
       "Q 1191 2003 1191 1497 \n",
       "Q 1191 994 1439 701 \n",
       "Q 1688 409 2113 409 \n",
       "Q 2538 409 2786 701 \n",
       "Q 3034 994 3034 1497 \n",
       "Q 3034 2003 2786 2293 \n",
       "Q 2538 2584 2113 2584 \n",
       "z\n",
       "M 3366 4563 \n",
       "L 3366 3988 \n",
       "Q 3128 4100 2886 4159 \n",
       "Q 2644 4219 2406 4219 \n",
       "Q 1781 4219 1451 3797 \n",
       "Q 1122 3375 1075 2522 \n",
       "Q 1259 2794 1537 2939 \n",
       "Q 1816 3084 2150 3084 \n",
       "Q 2853 3084 3261 2657 \n",
       "Q 3669 2231 3669 1497 \n",
       "Q 3669 778 3244 343 \n",
       "Q 2819 -91 2113 -91 \n",
       "Q 1303 -91 875 529 \n",
       "Q 447 1150 447 2328 \n",
       "Q 447 3434 972 4092 \n",
       "Q 1497 4750 2381 4750 \n",
       "Q 2619 4750 2861 4703 \n",
       "Q 3103 4656 3366 4563 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_4\">\n",
       "    <!-- 2 -->\n",
       "    <g transform=\"translate(100.342042 141.543044) scale(0.1 -0.1)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-32\" d=\"M 1228 531 \n",
       "L 3431 531 \n",
       "L 3431 0 \n",
       "L 469 0 \n",
       "L 469 531 \n",
       "Q 828 903 1448 1529 \n",
       "Q 2069 2156 2228 2338 \n",
       "Q 2531 2678 2651 2914 \n",
       "Q 2772 3150 2772 3378 \n",
       "Q 2772 3750 2511 3984 \n",
       "Q 2250 4219 1831 4219 \n",
       "Q 1534 4219 1204 4116 \n",
       "Q 875 4013 500 3803 \n",
       "L 500 4441 \n",
       "Q 881 4594 1212 4672 \n",
       "Q 1544 4750 1819 4750 \n",
       "Q 2544 4750 2975 4387 \n",
       "Q 3406 4025 3406 3419 \n",
       "Q 3406 3131 3298 2873 \n",
       "Q 3191 2616 2906 2266 \n",
       "Q 2828 2175 2409 1742 \n",
       "Q 1991 1309 1228 531 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_5\">\n",
       "    <!-- 202 -->\n",
       "    <g transform=\"translate(79.914478 111.201121) scale(0.1 -0.1)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-30\" d=\"M 2034 4250 \n",
       "Q 1547 4250 1301 3770 \n",
       "Q 1056 3291 1056 2328 \n",
       "Q 1056 1369 1301 889 \n",
       "Q 1547 409 2034 409 \n",
       "Q 2525 409 2770 889 \n",
       "Q 3016 1369 3016 2328 \n",
       "Q 3016 3291 2770 3770 \n",
       "Q 2525 4250 2034 4250 \n",
       "z\n",
       "M 2034 4750 \n",
       "Q 2819 4750 3233 4129 \n",
       "Q 3647 3509 3647 2328 \n",
       "Q 3647 1150 3233 529 \n",
       "Q 2819 -91 2034 -91 \n",
       "Q 1250 -91 836 529 \n",
       "Q 422 1150 422 2328 \n",
       "Q 422 3509 836 4129 \n",
       "Q 1250 4750 2034 4750 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_6\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(10.362943 46.729799) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-4f\" d=\"M 2522 4238 \n",
       "Q 1834 4238 1429 3725 \n",
       "Q 1025 3213 1025 2328 \n",
       "Q 1025 1447 1429 934 \n",
       "Q 1834 422 2522 422 \n",
       "Q 3209 422 3611 934 \n",
       "Q 4013 1447 4013 2328 \n",
       "Q 4013 3213 3611 3725 \n",
       "Q 3209 4238 2522 4238 \n",
       "z\n",
       "M 2522 4750 \n",
       "Q 3503 4750 4090 4092 \n",
       "Q 4678 3434 4678 2328 \n",
       "Q 4678 1225 4090 567 \n",
       "Q 3503 -91 2522 -91 \n",
       "Q 1538 -91 948 565 \n",
       "Q 359 1222 359 2328 \n",
       "Q 359 3434 948 4092 \n",
       "Q 1538 4750 2522 4750 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-72\" d=\"M 2631 2963 \n",
       "Q 2534 3019 2420 3045 \n",
       "Q 2306 3072 2169 3072 \n",
       "Q 1681 3072 1420 2755 \n",
       "Q 1159 2438 1159 1844 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 3500 \n",
       "L 1159 3500 \n",
       "L 1159 2956 \n",
       "Q 1341 3275 1631 3429 \n",
       "Q 1922 3584 2338 3584 \n",
       "Q 2397 3584 2469 3576 \n",
       "Q 2541 3569 2628 3553 \n",
       "L 2631 2963 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-69\" d=\"M 603 3500 \n",
       "L 1178 3500 \n",
       "L 1178 0 \n",
       "L 603 0 \n",
       "L 603 3500 \n",
       "z\n",
       "M 603 4863 \n",
       "L 1178 4863 \n",
       "L 1178 4134 \n",
       "L 603 4134 \n",
       "L 603 4863 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-67\" d=\"M 2906 1791 \n",
       "Q 2906 2416 2648 2759 \n",
       "Q 2391 3103 1925 3103 \n",
       "Q 1463 3103 1205 2759 \n",
       "Q 947 2416 947 1791 \n",
       "Q 947 1169 1205 825 \n",
       "Q 1463 481 1925 481 \n",
       "Q 2391 481 2648 825 \n",
       "Q 2906 1169 2906 1791 \n",
       "z\n",
       "M 3481 434 \n",
       "Q 3481 -459 3084 -895 \n",
       "Q 2688 -1331 1869 -1331 \n",
       "Q 1566 -1331 1297 -1286 \n",
       "Q 1028 -1241 775 -1147 \n",
       "L 775 -588 \n",
       "Q 1028 -725 1275 -790 \n",
       "Q 1522 -856 1778 -856 \n",
       "Q 2344 -856 2625 -561 \n",
       "Q 2906 -266 2906 331 \n",
       "L 2906 616 \n",
       "Q 2728 306 2450 153 \n",
       "Q 2172 0 1784 0 \n",
       "Q 1141 0 747 490 \n",
       "Q 353 981 353 1791 \n",
       "Q 353 2603 747 3093 \n",
       "Q 1141 3584 1784 3584 \n",
       "Q 2172 3584 2450 3431 \n",
       "Q 2728 3278 2906 2969 \n",
       "L 2906 3500 \n",
       "L 3481 3500 \n",
       "L 3481 434 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-6e\" d=\"M 3513 2113 \n",
       "L 3513 0 \n",
       "L 2938 0 \n",
       "L 2938 2094 \n",
       "Q 2938 2591 2744 2837 \n",
       "Q 2550 3084 2163 3084 \n",
       "Q 1697 3084 1428 2787 \n",
       "Q 1159 2491 1159 1978 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 3500 \n",
       "L 1159 3500 \n",
       "L 1159 2956 \n",
       "Q 1366 3272 1645 3428 \n",
       "Q 1925 3584 2291 3584 \n",
       "Q 2894 3584 3203 3211 \n",
       "Q 3513 2838 3513 2113 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-61\" d=\"M 2194 1759 \n",
       "Q 1497 1759 1228 1600 \n",
       "Q 959 1441 959 1056 \n",
       "Q 959 750 1161 570 \n",
       "Q 1363 391 1709 391 \n",
       "Q 2188 391 2477 730 \n",
       "Q 2766 1069 2766 1631 \n",
       "L 2766 1759 \n",
       "L 2194 1759 \n",
       "z\n",
       "M 3341 1997 \n",
       "L 3341 0 \n",
       "L 2766 0 \n",
       "L 2766 531 \n",
       "Q 2569 213 2275 61 \n",
       "Q 1981 -91 1556 -91 \n",
       "Q 1019 -91 701 211 \n",
       "Q 384 513 384 1019 \n",
       "Q 384 1609 779 1909 \n",
       "Q 1175 2209 1959 2209 \n",
       "L 2766 2209 \n",
       "L 2766 2266 \n",
       "Q 2766 2663 2505 2880 \n",
       "Q 2244 3097 1772 3097 \n",
       "Q 1472 3097 1187 3025 \n",
       "Q 903 2953 641 2809 \n",
       "L 641 3341 \n",
       "Q 956 3463 1253 3523 \n",
       "Q 1550 3584 1831 3584 \n",
       "Q 2591 3584 2966 3190 \n",
       "Q 3341 2797 3341 1997 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-6c\" d=\"M 603 4863 \n",
       "L 1178 4863 \n",
       "L 1178 0 \n",
       "L 603 0 \n",
       "L 603 4863 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_7\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(108.506856 46.357144) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-52\" d=\"M 2841 2188 \n",
       "Q 3044 2119 3236 1894 \n",
       "Q 3428 1669 3622 1275 \n",
       "L 4263 0 \n",
       "L 3584 0 \n",
       "L 2988 1197 \n",
       "Q 2756 1666 2539 1819 \n",
       "Q 2322 1972 1947 1972 \n",
       "L 1259 1972 \n",
       "L 1259 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "L 2053 4666 \n",
       "Q 2853 4666 3247 4331 \n",
       "Q 3641 3997 3641 3322 \n",
       "Q 3641 2881 3436 2590 \n",
       "Q 3231 2300 2841 2188 \n",
       "z\n",
       "M 1259 4147 \n",
       "L 1259 2491 \n",
       "L 2053 2491 \n",
       "Q 2509 2491 2742 2702 \n",
       "Q 2975 2913 2975 3322 \n",
       "Q 2975 3731 2742 3939 \n",
       "Q 2509 4147 2053 4147 \n",
       "L 1259 4147 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-65\" d=\"M 3597 1894 \n",
       "L 3597 1613 \n",
       "L 953 1613 \n",
       "Q 991 1019 1311 708 \n",
       "Q 1631 397 2203 397 \n",
       "Q 2534 397 2845 478 \n",
       "Q 3156 559 3463 722 \n",
       "L 3463 178 \n",
       "Q 3153 47 2828 -22 \n",
       "Q 2503 -91 2169 -91 \n",
       "Q 1331 -91 842 396 \n",
       "Q 353 884 353 1716 \n",
       "Q 353 2575 817 3079 \n",
       "Q 1281 3584 2069 3584 \n",
       "Q 2775 3584 3186 3129 \n",
       "Q 3597 2675 3597 1894 \n",
       "z\n",
       "M 3022 2063 \n",
       "Q 3016 2534 2758 2815 \n",
       "Q 2500 3097 2075 3097 \n",
       "Q 1594 3097 1305 2825 \n",
       "Q 1016 2553 972 2059 \n",
       "L 3022 2063 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-66\" d=\"M 2375 4863 \n",
       "L 2375 4384 \n",
       "L 1825 4384 \n",
       "Q 1516 4384 1395 4259 \n",
       "Q 1275 4134 1275 3809 \n",
       "L 1275 3500 \n",
       "L 2222 3500 \n",
       "L 2222 3053 \n",
       "L 1275 3053 \n",
       "L 1275 0 \n",
       "L 697 0 \n",
       "L 697 3053 \n",
       "L 147 3053 \n",
       "L 147 3500 \n",
       "L 697 3500 \n",
       "L 697 3744 \n",
       "Q 697 4328 969 4595 \n",
       "Q 1241 4863 1831 4863 \n",
       "L 2375 4863 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-73\" d=\"M 2834 3397 \n",
       "L 2834 2853 \n",
       "Q 2591 2978 2328 3040 \n",
       "Q 2066 3103 1784 3103 \n",
       "Q 1356 3103 1142 2972 \n",
       "Q 928 2841 928 2578 \n",
       "Q 928 2378 1081 2264 \n",
       "Q 1234 2150 1697 2047 \n",
       "L 1894 2003 \n",
       "Q 2506 1872 2764 1633 \n",
       "Q 3022 1394 3022 966 \n",
       "Q 3022 478 2636 193 \n",
       "Q 2250 -91 1575 -91 \n",
       "Q 1294 -91 989 -36 \n",
       "Q 684 19 347 128 \n",
       "L 347 722 \n",
       "Q 666 556 975 473 \n",
       "Q 1284 391 1588 391 \n",
       "Q 1994 391 2212 530 \n",
       "Q 2431 669 2431 922 \n",
       "Q 2431 1156 2273 1281 \n",
       "Q 2116 1406 1581 1522 \n",
       "L 1381 1569 \n",
       "Q 847 1681 609 1914 \n",
       "Q 372 2147 372 2553 \n",
       "Q 372 3047 722 3315 \n",
       "Q 1072 3584 1716 3584 \n",
       "Q 2034 3584 2315 3537 \n",
       "Q 2597 3491 2834 3397 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-68\" d=\"M 3513 2113 \n",
       "L 3513 0 \n",
       "L 2938 0 \n",
       "L 2938 2094 \n",
       "Q 2938 2591 2744 2837 \n",
       "Q 2550 3084 2163 3084 \n",
       "Q 1697 3084 1428 2787 \n",
       "Q 1159 2491 1159 1978 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 4863 \n",
       "L 1159 4863 \n",
       "L 1159 2956 \n",
       "Q 1366 3272 1645 3428 \n",
       "Q 1925 3584 2291 3584 \n",
       "Q 2894 3584 3203 3211 \n",
       "Q 3513 2838 3513 2113 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_8\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(46.596327 164.558973) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-4c\" d=\"M 628 4666 \n",
       "L 1259 4666 \n",
       "L 1259 531 \n",
       "L 3531 531 \n",
       "L 3531 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-74\" d=\"M 1172 4494 \n",
       "L 1172 3500 \n",
       "L 2356 3500 \n",
       "L 2356 3053 \n",
       "L 1172 3053 \n",
       "L 1172 1153 \n",
       "Q 1172 725 1289 603 \n",
       "Q 1406 481 1766 481 \n",
       "L 2356 481 \n",
       "L 2356 0 \n",
       "L 1766 0 \n",
       "Q 1100 0 847 248 \n",
       "Q 594 497 594 1153 \n",
       "L 594 3053 \n",
       "L 172 3053 \n",
       "L 172 3500 \n",
       "L 594 3500 \n",
       "L 594 4494 \n",
       "L 1172 4494 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-20\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-28\" d=\"M 1984 4856 \n",
       "Q 1566 4138 1362 3434 \n",
       "Q 1159 2731 1159 2009 \n",
       "Q 1159 1288 1364 580 \n",
       "Q 1569 -128 1984 -844 \n",
       "L 1484 -844 \n",
       "Q 1016 -109 783 600 \n",
       "Q 550 1309 550 2009 \n",
       "Q 550 2706 781 3412 \n",
       "Q 1013 4119 1484 4856 \n",
       "L 1984 4856 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-76\" d=\"M 191 3500 \n",
       "L 800 3500 \n",
       "L 1894 563 \n",
       "L 2988 3500 \n",
       "L 3597 3500 \n",
       "L 2284 0 \n",
       "L 1503 0 \n",
       "L 191 3500 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-33\" d=\"M 2597 2516 \n",
       "Q 3050 2419 3304 2112 \n",
       "Q 3559 1806 3559 1356 \n",
       "Q 3559 666 3084 287 \n",
       "Q 2609 -91 1734 -91 \n",
       "Q 1441 -91 1130 -33 \n",
       "Q 819 25 488 141 \n",
       "L 488 750 \n",
       "Q 750 597 1062 519 \n",
       "Q 1375 441 1716 441 \n",
       "Q 2309 441 2620 675 \n",
       "Q 2931 909 2931 1356 \n",
       "Q 2931 1769 2642 2001 \n",
       "Q 2353 2234 1838 2234 \n",
       "L 1294 2234 \n",
       "L 1294 2753 \n",
       "L 1863 2753 \n",
       "Q 2328 2753 2575 2939 \n",
       "Q 2822 3125 2822 3475 \n",
       "Q 2822 3834 2567 4026 \n",
       "Q 2313 4219 1838 4219 \n",
       "Q 1578 4219 1281 4162 \n",
       "Q 984 4106 628 3988 \n",
       "L 628 4550 \n",
       "Q 988 4650 1302 4700 \n",
       "Q 1616 4750 1894 4750 \n",
       "Q 2613 4750 3031 4423 \n",
       "Q 3450 4097 3450 3541 \n",
       "Q 3450 3153 3228 2886 \n",
       "Q 3006 2619 2597 2516 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-29\" d=\"M 513 4856 \n",
       "L 1013 4856 \n",
       "Q 1481 4119 1714 3412 \n",
       "Q 1947 2706 1947 2009 \n",
       "Q 1947 1309 1714 600 \n",
       "Q 1481 -109 1013 -844 \n",
       "L 513 -844 \n",
       "Q 928 -128 1133 580 \n",
       "Q 1338 1288 1338 2009 \n",
       "Q 1338 2731 1133 3434 \n",
       "Q 928 4138 513 4856 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_9\">\n",
       "    <!-- CHEMBL1867 -->\n",
       "    <g transform=\"translate(42.513514 17.751189) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-43\" d=\"M 4122 4306 \n",
       "L 4122 3641 \n",
       "Q 3803 3938 3442 4084 \n",
       "Q 3081 4231 2675 4231 \n",
       "Q 1875 4231 1450 3742 \n",
       "Q 1025 3253 1025 2328 \n",
       "Q 1025 1406 1450 917 \n",
       "Q 1875 428 2675 428 \n",
       "Q 3081 428 3442 575 \n",
       "Q 3803 722 4122 1019 \n",
       "L 4122 359 \n",
       "Q 3791 134 3420 21 \n",
       "Q 3050 -91 2638 -91 \n",
       "Q 1578 -91 968 557 \n",
       "Q 359 1206 359 2328 \n",
       "Q 359 3453 968 4101 \n",
       "Q 1578 4750 2638 4750 \n",
       "Q 3056 4750 3426 4639 \n",
       "Q 3797 4528 4122 4306 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-48\" d=\"M 628 4666 \n",
       "L 1259 4666 \n",
       "L 1259 2753 \n",
       "L 3553 2753 \n",
       "L 3553 4666 \n",
       "L 4184 4666 \n",
       "L 4184 0 \n",
       "L 3553 0 \n",
       "L 3553 2222 \n",
       "L 1259 2222 \n",
       "L 1259 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-45\" d=\"M 628 4666 \n",
       "L 3578 4666 \n",
       "L 3578 4134 \n",
       "L 1259 4134 \n",
       "L 1259 2753 \n",
       "L 3481 2753 \n",
       "L 3481 2222 \n",
       "L 1259 2222 \n",
       "L 1259 531 \n",
       "L 3634 531 \n",
       "L 3634 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-4d\" d=\"M 628 4666 \n",
       "L 1569 4666 \n",
       "L 2759 1491 \n",
       "L 3956 4666 \n",
       "L 4897 4666 \n",
       "L 4897 0 \n",
       "L 4281 0 \n",
       "L 4281 4097 \n",
       "L 3078 897 \n",
       "L 2444 897 \n",
       "L 1241 4097 \n",
       "L 1241 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-42\" d=\"M 1259 2228 \n",
       "L 1259 519 \n",
       "L 2272 519 \n",
       "Q 2781 519 3026 730 \n",
       "Q 3272 941 3272 1375 \n",
       "Q 3272 1813 3026 2020 \n",
       "Q 2781 2228 2272 2228 \n",
       "L 1259 2228 \n",
       "z\n",
       "M 1259 4147 \n",
       "L 1259 2741 \n",
       "L 2194 2741 \n",
       "Q 2656 2741 2882 2914 \n",
       "Q 3109 3088 3109 3444 \n",
       "Q 3109 3797 2882 3972 \n",
       "Q 2656 4147 2194 4147 \n",
       "L 1259 4147 \n",
       "z\n",
       "M 628 4666 \n",
       "L 2241 4666 \n",
       "Q 2963 4666 3353 4366 \n",
       "Q 3744 4066 3744 3513 \n",
       "Q 3744 3084 3544 2831 \n",
       "Q 3344 2578 2956 2516 \n",
       "Q 3422 2416 3680 2098 \n",
       "Q 3938 1781 3938 1306 \n",
       "Q 3938 681 3513 340 \n",
       "Q 3088 0 2303 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-38\" d=\"M 2034 2216 \n",
       "Q 1584 2216 1326 1975 \n",
       "Q 1069 1734 1069 1313 \n",
       "Q 1069 891 1326 650 \n",
       "Q 1584 409 2034 409 \n",
       "Q 2484 409 2743 651 \n",
       "Q 3003 894 3003 1313 \n",
       "Q 3003 1734 2745 1975 \n",
       "Q 2488 2216 2034 2216 \n",
       "z\n",
       "M 1403 2484 \n",
       "Q 997 2584 770 2862 \n",
       "Q 544 3141 544 3541 \n",
       "Q 544 4100 942 4425 \n",
       "Q 1341 4750 2034 4750 \n",
       "Q 2731 4750 3128 4425 \n",
       "Q 3525 4100 3525 3541 \n",
       "Q 3525 3141 3298 2862 \n",
       "Q 3072 2584 2669 2484 \n",
       "Q 3125 2378 3379 2068 \n",
       "Q 3634 1759 3634 1313 \n",
       "Q 3634 634 3220 271 \n",
       "Q 2806 -91 2034 -91 \n",
       "Q 1263 -91 848 271 \n",
       "Q 434 634 434 1313 \n",
       "Q 434 1759 690 2068 \n",
       "Q 947 2378 1403 2484 \n",
       "z\n",
       "M 1172 3481 \n",
       "Q 1172 3119 1398 2916 \n",
       "Q 1625 2713 2034 2713 \n",
       "Q 2441 2713 2670 2916 \n",
       "Q 2900 3119 2900 3481 \n",
       "Q 2900 3844 2670 4047 \n",
       "Q 2441 4250 2034 4250 \n",
       "Q 1625 4250 1398 4047 \n",
       "Q 1172 3844 1172 3481 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-37\" d=\"M 525 4666 \n",
       "L 3525 4666 \n",
       "L 3525 4397 \n",
       "L 1831 0 \n",
       "L 1172 0 \n",
       "L 2766 4134 \n",
       "L 525 4134 \n",
       "L 525 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (A2a) -->\n",
       "    <g transform=\"translate(66.632577 31.188564) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-41\" d=\"M 2188 4044 \n",
       "L 1331 1722 \n",
       "L 3047 1722 \n",
       "L 2188 4044 \n",
       "z\n",
       "M 1831 4666 \n",
       "L 2547 4666 \n",
       "L 4325 0 \n",
       "L 3669 0 \n",
       "L 3244 1197 \n",
       "L 1141 1197 \n",
       "L 716 0 \n",
       "L 50 0 \n",
       "L 1831 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-41\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"107.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"171.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"232.324219\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_2\">\n",
       "   <g id=\"patch_7\">\n",
       "    <path d=\"M 228.478419 44.955788 \n",
       "C 223.454764 44.956406 218.482349 45.969208 213.858683 47.933595 \n",
       "C 209.235016 49.897982 205.054189 52.77398 201.566348 56.389512 \n",
       "C 209.662674 51.42083 218.979035 48.790072 228.478419 48.790072 \n",
       "C 237.977803 48.790072 247.294165 51.42083 255.39049 56.389512 \n",
       "C 251.902649 52.77398 247.721822 49.897982 243.098156 47.933595 \n",
       "C 238.474489 45.969208 233.502074 44.956406 228.478419 44.955788 \n",
       "\" clip-path=\"url(#pc19cb5e4fa)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_8\">\n",
       "    <path d=\"M 201.543795 56.403361 \n",
       "C 196.80138 59.317121 192.563047 62.981214 188.994288 67.252567 \n",
       "C 185.425529 71.523921 182.573407 76.346207 180.549289 81.531132 \n",
       "C 178.52517 86.716057 177.355748 92.195245 177.086685 97.754751 \n",
       "C 176.817621 103.314256 177.452464 108.880765 178.966425 114.236923 \n",
       "C 180.480386 119.59308 182.8535 124.668253 185.993105 129.264271 \n",
       "C 189.132709 133.860289 192.997401 137.916544 197.436276 141.274652 \n",
       "C 201.875152 144.632759 206.829674 147.248435 212.106384 149.019546 \n",
       "C 217.383094 150.790656 222.912406 151.693844 228.478419 151.693844 \n",
       "C 234.044432 151.693844 239.573745 150.790656 244.850455 149.019546 \n",
       "C 250.127165 147.248435 255.081687 144.632759 259.520562 141.274652 \n",
       "C 263.959437 137.916544 267.824129 133.860289 270.963733 129.264271 \n",
       "C 274.103338 124.668253 276.476452 119.59308 277.990413 114.236923 \n",
       "C 279.504374 108.880765 280.139217 103.314256 279.870154 97.754751 \n",
       "C 279.60109 92.195245 278.431668 86.716057 276.40755 81.531132 \n",
       "C 274.383431 76.346207 271.53131 71.523921 267.962551 67.252567 \n",
       "C 264.393792 62.981214 260.155458 59.317121 255.413043 56.403361 \n",
       "C 260.504725 61.686888 263.930659 68.353832 265.262012 75.569675 \n",
       "C 266.593366 82.785518 265.77217 90.236076 262.901216 96.988743 \n",
       "C 260.030262 103.74141 255.234554 109.50217 249.114383 113.549933 \n",
       "C 242.994211 117.597697 235.816054 119.756222 228.478419 119.755319 \n",
       "C 221.140784 119.756222 213.962627 117.597697 207.842456 113.549933 \n",
       "C 201.722284 109.50217 196.926576 103.74141 194.055622 96.988743 \n",
       "C 191.184669 90.236076 190.363473 82.785518 191.694826 75.569675 \n",
       "C 193.026179 68.353832 196.452113 61.686888 201.543795 56.403361 \n",
       "\" clip-path=\"url(#pc19cb5e4fa)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_9\">\n",
       "    <path d=\"M 201.566348 56.389512 \n",
       "C 196.471356 61.671035 193.041801 68.337139 191.707065 75.553225 \n",
       "C 190.372329 82.769312 191.190542 90.221112 194.059262 96.975656 \n",
       "C 196.927982 103.730201 201.722274 109.493321 207.84189 113.543472 \n",
       "C 213.961506 117.593623 221.13993 119.754417 228.478419 119.755319 \n",
       "C 235.816908 119.754417 242.995332 117.593623 249.114948 113.543472 \n",
       "C 255.234564 109.493321 260.028856 103.730201 262.897577 96.975656 \n",
       "C 265.766297 90.221112 266.584509 82.769312 265.249773 75.553225 \n",
       "C 263.915037 68.337139 260.485482 61.671035 255.39049 56.389512 \n",
       "C 247.294165 51.42083 237.977803 48.790072 228.478419 48.790072 \n",
       "C 218.979035 48.790072 209.662674 51.42083 201.566348 56.389512 \n",
       "\" clip-path=\"url(#pc19cb5e4fa)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_10\">\n",
       "    <!-- 26 -->\n",
       "    <g transform=\"translate(222.115919 51.041228) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"63.623047\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_11\">\n",
       "    <!-- 716 -->\n",
       "    <g transform=\"translate(218.934669 128.503795) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-37\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_12\">\n",
       "    <!-- 747 -->\n",
       "    <g transform=\"translate(218.934669 90.552926) scale(0.1 -0.1)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-34\" d=\"M 2419 4116 \n",
       "L 825 1625 \n",
       "L 2419 1625 \n",
       "L 2419 4116 \n",
       "z\n",
       "M 2253 4666 \n",
       "L 3047 4666 \n",
       "L 3047 1625 \n",
       "L 3713 1625 \n",
       "L 3713 1100 \n",
       "L 3047 1100 \n",
       "L 3047 0 \n",
       "L 2419 0 \n",
       "L 2419 1100 \n",
       "L 313 1100 \n",
       "L 313 1709 \n",
       "L 2253 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-37\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_13\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(162.816436 44.955788) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_14\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(247.182902 44.955788) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_15\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(192.161544 165.957158) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_16\">\n",
       "    <!-- CHEMBL1862 -->\n",
       "    <g transform=\"translate(188.078732 16.318125) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (ABL1) -->\n",
       "    <g transform=\"translate(208.414982 29.7555) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-41\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"107.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"176.025391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"231.738281\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"295.361328\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_3\">\n",
       "   <g id=\"patch_10\">\n",
       "    <path d=\"M 324.320298 83.940493 \n",
       "C 323.751535 85.860135 323.320569 87.817942 323.030691 89.798974 \n",
       "C 322.740812 91.780006 322.59276 93.779211 322.587663 95.781332 \n",
       "C 322.75786 92.33815 323.273231 88.920728 324.126019 85.580485 \n",
       "C 324.978807 82.240241 326.164716 78.994013 327.665901 75.890641 \n",
       "C 326.970171 77.169516 326.341654 78.483827 325.782913 79.828211 \n",
       "C 325.224173 81.172596 324.735971 82.545223 324.320298 83.940493 \n",
       "\" clip-path=\"url(#pe1eee0bd65)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_11\">\n",
       "    <path d=\"M 322.578482 95.974419 \n",
       "C 322.290201 102.286719 323.165688 108.598528 325.161142 114.59406 \n",
       "C 327.156596 120.589591 330.238174 126.167162 334.251701 131.047719 \n",
       "C 338.265227 135.928276 343.142634 140.029046 348.639899 143.144863 \n",
       "C 354.137164 146.26068 360.161053 148.338701 366.410186 149.274958 \n",
       "C 372.659318 150.211215 379.027709 149.989831 385.196741 148.621882 \n",
       "C 391.365772 147.253932 397.230818 144.762617 402.498444 141.272581 \n",
       "C 407.766069 137.782544 412.346936 133.352976 416.011859 128.205493 \n",
       "C 419.676781 123.05801 422.363602 117.279913 423.937897 111.160287 \n",
       "C 425.512192 105.04066 425.947261 98.683292 425.221338 92.406249 \n",
       "C 424.495414 86.129206 422.620809 80.038946 419.691312 74.440171 \n",
       "C 416.761814 68.841396 412.827108 63.829061 408.084051 59.653939 \n",
       "C 403.340994 55.478817 397.870027 52.211717 391.94487 50.016097 \n",
       "C 386.019713 47.820476 379.740856 46.733572 373.422436 46.809764 \n",
       "C 367.104016 46.885955 360.853193 48.12395 354.982704 50.46181 \n",
       "C 349.112214 52.79967 343.721621 56.197745 339.080621 60.486026 \n",
       "C 334.439621 64.774307 330.626925 69.880065 327.833286 75.547853 \n",
       "C 330.165575 71.326847 333.206567 67.538254 336.82305 64.348033 \n",
       "C 340.439534 61.157813 344.577917 58.613239 349.056918 56.825779 \n",
       "C 353.535918 55.038319 358.289163 54.03446 363.108435 53.858175 \n",
       "C 367.927707 53.681891 372.741591 54.335794 377.339214 55.791241 \n",
       "C 381.936836 57.246687 386.250068 59.482108 390.089964 62.399582 \n",
       "C 393.929861 65.317055 397.239522 68.873348 399.873965 72.912675 \n",
       "C 402.508409 76.952002 404.428598 81.414507 405.550416 86.104707 \n",
       "C 406.672234 90.794908 406.979058 95.643303 406.457448 100.437506 \n",
       "C 405.935838 105.231708 404.593523 109.900677 402.489304 114.239884 \n",
       "C 400.385085 118.579091 397.550143 122.524237 394.108665 125.902503 \n",
       "C 390.667186 129.280769 386.670167 132.042094 382.2927 134.065517 \n",
       "C 377.915233 136.08894 373.222185 137.344477 368.419137 137.777129 \n",
       "C 363.61609 138.209781 358.774215 137.813136 354.105615 136.60457 \n",
       "C 349.437016 135.396004 345.010871 133.393426 341.021072 130.684559 \n",
       "C 337.031273 127.975692 333.536941 124.600678 330.691148 120.707361 \n",
       "C 327.845354 116.814044 325.69027 112.460117 324.320298 107.836305 \n",
       "C 323.747572 105.913861 323.313816 103.952723 323.022386 101.968064 \n",
       "C 322.730956 99.983405 322.582605 97.980357 322.578482 95.974419 \n",
       "\" clip-path=\"url(#pe1eee0bd65)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_12\">\n",
       "    <path d=\"M 327.665901 75.890641 \n",
       "C 329.961008 71.67183 332.965357 67.879442 336.547099 64.67991 \n",
       "C 340.128841 61.480378 344.234804 58.9212 348.684793 57.114689 \n",
       "C 353.134782 55.308178 357.862734 54.281153 362.66116 54.078685 \n",
       "C 367.459586 53.876216 372.257249 54.501311 376.8436 55.926536 \n",
       "C 381.429951 57.351761 385.736903 59.555957 389.575441 62.442393 \n",
       "C 393.413979 65.328828 396.727118 68.854651 399.369457 72.865128 \n",
       "C 402.011797 76.875605 403.944109 81.311198 405.081594 85.977247 \n",
       "C 406.21908 90.643295 406.54485 95.470529 406.04461 100.247102 \n",
       "C 405.544369 105.023674 404.225544 109.678673 402.146012 114.00781 \n",
       "C 400.066479 118.336948 397.257112 122.275954 393.841201 125.651963 \n",
       "C 390.42529 129.027972 386.453548 131.790864 382.100276 133.819389 \n",
       "C 377.747004 135.847913 373.076831 137.111954 368.294711 137.556038 \n",
       "C 363.512591 138.000122 358.689518 137.617657 354.037156 136.425427 \n",
       "C 349.384794 135.233197 344.972211 133.248903 340.993057 130.559625 \n",
       "C 337.013902 127.870347 333.52725 124.516011 330.686114 120.643824 \n",
       "C 327.844978 116.771637 325.691538 112.439085 324.320298 107.836305 \n",
       "C 325.69027 112.460117 327.845354 116.814044 330.691148 120.707361 \n",
       "C 333.536941 124.600678 337.031273 127.975692 341.021072 130.684559 \n",
       "C 345.010871 133.393426 349.437016 135.396004 354.105615 136.60457 \n",
       "C 358.774215 137.813136 363.61609 138.209781 368.419137 137.777129 \n",
       "C 373.222185 137.344477 377.915233 136.08894 382.2927 134.065517 \n",
       "C 386.670167 132.042094 390.667186 129.280769 394.108665 125.902503 \n",
       "C 397.550143 122.524237 400.385085 118.579091 402.489304 114.239884 \n",
       "C 404.593523 109.900677 405.935838 105.231708 406.457448 100.437506 \n",
       "C 406.979058 95.643303 406.672234 90.794908 405.550416 86.104707 \n",
       "C 404.428598 81.414507 402.508409 76.952002 399.873965 72.912675 \n",
       "C 397.239522 68.873348 393.929861 65.317055 390.089964 62.399582 \n",
       "C 386.250068 59.482108 381.936836 57.246687 377.339214 55.791241 \n",
       "C 372.741591 54.335794 367.927707 53.681891 363.108435 53.858175 \n",
       "C 358.289163 54.03446 353.535918 55.038319 349.056918 56.825779 \n",
       "C 344.577917 58.613239 340.439534 61.157813 336.82305 64.348033 \n",
       "C 333.206567 67.538254 330.165575 71.326847 327.833286 75.547853 \n",
       "C 327.805178 75.60488 327.777174 75.66196 327.749277 75.719092 \n",
       "C 327.721379 75.776223 327.693587 75.833407 327.665901 75.890641 \n",
       "\" clip-path=\"url(#pe1eee0bd65)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_13\">\n",
       "    <path d=\"M 322.587663 95.781332 \n",
       "C 322.582475 97.819189 322.725406 99.854731 323.015324 101.871866 \n",
       "C 323.305243 103.889001 323.741383 105.8824 324.320298 107.836305 \n",
       "C 325.691538 112.439085 327.844978 116.771637 330.686114 120.643824 \n",
       "C 333.52725 124.516011 337.013902 127.870347 340.993057 130.559625 \n",
       "C 344.972211 133.248903 349.384794 135.233197 354.037156 136.425427 \n",
       "C 358.689518 137.617657 363.512591 138.000122 368.294711 137.556038 \n",
       "C 373.076831 137.111954 377.747004 135.847913 382.100276 133.819389 \n",
       "C 386.453548 131.790864 390.42529 129.027972 393.841201 125.651963 \n",
       "C 397.257112 122.275954 400.066479 118.336948 402.146012 114.00781 \n",
       "C 404.225544 109.678673 405.544369 105.023674 406.04461 100.247102 \n",
       "C 406.54485 95.470529 406.21908 90.643295 405.081594 85.977247 \n",
       "C 403.944109 81.311198 402.011797 76.875605 399.369457 72.865128 \n",
       "C 396.727118 68.854651 393.413979 65.328828 389.575441 62.442393 \n",
       "C 385.736903 59.555957 381.429951 57.351761 376.8436 55.926536 \n",
       "C 372.257249 54.501311 367.459586 53.876216 362.66116 54.078685 \n",
       "C 357.862734 54.281153 353.134782 55.308178 348.684793 57.114689 \n",
       "C 344.234804 58.9212 340.128841 61.480378 336.547099 64.67991 \n",
       "C 332.965357 67.879442 329.961008 71.67183 327.665901 75.890641 \n",
       "C 326.164716 78.994013 324.978807 82.240241 324.126019 85.580485 \n",
       "C 323.273231 88.920728 322.75786 92.33815 322.587663 95.781332 \n",
       "\" clip-path=\"url(#pe1eee0bd65)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_17\">\n",
       "    <!-- 2 -->\n",
       "    <g transform=\"translate(320.981703 88.344226) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_18\">\n",
       "    <!-- 1599 -->\n",
       "    <g transform=\"translate(400.483322 108.638868) scale(0.1 -0.1)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-35\" d=\"M 691 4666 \n",
       "L 3169 4666 \n",
       "L 3169 4134 \n",
       "L 1269 4134 \n",
       "L 1269 2991 \n",
       "Q 1406 3038 1543 3061 \n",
       "Q 1681 3084 1819 3084 \n",
       "Q 2600 3084 3056 2656 \n",
       "Q 3513 2228 3513 1497 \n",
       "Q 3513 744 3044 326 \n",
       "Q 2575 -91 1722 -91 \n",
       "Q 1428 -91 1123 -41 \n",
       "Q 819 9 494 109 \n",
       "L 494 744 \n",
       "Q 775 591 1075 516 \n",
       "Q 1375 441 1709 441 \n",
       "Q 2250 441 2565 725 \n",
       "Q 2881 1009 2881 1497 \n",
       "Q 2881 1984 2565 2268 \n",
       "Q 2250 2553 1709 2553 \n",
       "Q 1456 2553 1204 2497 \n",
       "Q 953 2441 691 2322 \n",
       "L 691 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-39\" d=\"M 703 97 \n",
       "L 703 672 \n",
       "Q 941 559 1184 500 \n",
       "Q 1428 441 1663 441 \n",
       "Q 2288 441 2617 861 \n",
       "Q 2947 1281 2994 2138 \n",
       "Q 2813 1869 2534 1725 \n",
       "Q 2256 1581 1919 1581 \n",
       "Q 1219 1581 811 2004 \n",
       "Q 403 2428 403 3163 \n",
       "Q 403 3881 828 4315 \n",
       "Q 1253 4750 1959 4750 \n",
       "Q 2769 4750 3195 4129 \n",
       "Q 3622 3509 3622 2328 \n",
       "Q 3622 1225 3098 567 \n",
       "Q 2575 -91 1691 -91 \n",
       "Q 1453 -91 1209 -44 \n",
       "Q 966 3 703 97 \n",
       "z\n",
       "M 1959 2075 \n",
       "Q 2384 2075 2632 2365 \n",
       "Q 2881 2656 2881 3163 \n",
       "Q 2881 3666 2632 3958 \n",
       "Q 2384 4250 1959 4250 \n",
       "Q 1534 4250 1286 3958 \n",
       "Q 1038 3666 1038 3163 \n",
       "Q 1038 2656 1286 2365 \n",
       "Q 1534 2075 1959 2075 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_19\">\n",
       "    <!-- 32 -->\n",
       "    <g transform=\"translate(399.835558 103.08505) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"63.623047\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_20\">\n",
       "    <!-- 3157 -->\n",
       "    <g transform=\"translate(384.108638 102.131851) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_21\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(296.544352 54.041482) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_22\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(385.675026 53.830066) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_23\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(337.726762 164.113619) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_24\">\n",
       "    <!-- CHEMBL220 -->\n",
       "    <g transform=\"translate(337.461449 18.235267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Acetylcholinesterase) -->\n",
       "    <g transform=\"translate(307.069574 31.672642) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-63\" d=\"M 3122 3366 \n",
       "L 3122 2828 \n",
       "Q 2878 2963 2633 3030 \n",
       "Q 2388 3097 2138 3097 \n",
       "Q 1578 3097 1268 2742 \n",
       "Q 959 2388 959 1747 \n",
       "Q 959 1106 1268 751 \n",
       "Q 1578 397 2138 397 \n",
       "Q 2388 397 2633 464 \n",
       "Q 2878 531 3122 666 \n",
       "L 3122 134 \n",
       "Q 2881 22 2623 -34 \n",
       "Q 2366 -91 2075 -91 \n",
       "Q 1284 -91 818 406 \n",
       "Q 353 903 353 1747 \n",
       "Q 353 2603 823 3093 \n",
       "Q 1294 3584 2113 3584 \n",
       "Q 2378 3584 2631 3529 \n",
       "Q 2884 3475 3122 3366 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-79\" d=\"M 2059 -325 \n",
       "Q 1816 -950 1584 -1140 \n",
       "Q 1353 -1331 966 -1331 \n",
       "L 506 -1331 \n",
       "L 506 -850 \n",
       "L 844 -850 \n",
       "Q 1081 -850 1212 -737 \n",
       "Q 1344 -625 1503 -206 \n",
       "L 1606 56 \n",
       "L 191 3500 \n",
       "L 800 3500 \n",
       "L 1894 763 \n",
       "L 2988 3500 \n",
       "L 3597 3500 \n",
       "L 2059 -325 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-6f\" d=\"M 1959 3097 \n",
       "Q 1497 3097 1228 2736 \n",
       "Q 959 2375 959 1747 \n",
       "Q 959 1119 1226 758 \n",
       "Q 1494 397 1959 397 \n",
       "Q 2419 397 2687 759 \n",
       "Q 2956 1122 2956 1747 \n",
       "Q 2956 2369 2687 2733 \n",
       "Q 2419 3097 1959 3097 \n",
       "z\n",
       "M 1959 3584 \n",
       "Q 2709 3584 3137 3096 \n",
       "Q 3566 2609 3566 1747 \n",
       "Q 3566 888 3137 398 \n",
       "Q 2709 -91 1959 -91 \n",
       "Q 1206 -91 779 398 \n",
       "Q 353 888 353 1747 \n",
       "Q 353 2609 779 3096 \n",
       "Q 1206 3584 1959 3584 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-41\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"105.671875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"160.652344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"222.175781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-79\" x=\"261.384766\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"320.564453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"348.347656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"403.328125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"466.707031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"527.888672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"555.671875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"583.455078\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"646.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"708.357422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"760.457031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"799.666016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"861.189453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"902.302734\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"963.582031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"1015.681641\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"1077.205078\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_4\">\n",
       "   <g id=\"patch_14\">\n",
       "    <path d=\"M 519.608854 46.62193 \n",
       "C 516.292401 46.622251 512.98519 46.971947 509.742009 47.665225 \n",
       "C 506.498827 48.358503 503.337685 49.391514 500.310949 50.747143 \n",
       "C 506.443026 48.269663 512.995211 46.996065 519.608854 46.996065 \n",
       "C 526.222497 46.996065 532.774682 48.269663 538.906759 50.747143 \n",
       "C 535.880023 49.391514 532.718881 48.358503 529.475699 47.665225 \n",
       "C 526.232518 46.971947 522.925307 46.622251 519.608854 46.62193 \n",
       "\" clip-path=\"url(#p3546cafa0b)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_15\">\n",
       "    <path d=\"M 500.217496 50.785007 \n",
       "C 494.724009 53.017002 489.6569 56.180805 485.239825 60.136769 \n",
       "C 480.82275 64.092734 477.121666 68.781787 474.299935 73.996961 \n",
       "C 471.478204 79.212135 469.577961 84.875553 468.683079 90.737242 \n",
       "C 467.788198 96.598931 467.912041 102.571359 469.049143 108.390913 \n",
       "C 470.186245 114.210467 472.319625 119.790245 475.35512 124.883964 \n",
       "C 478.390615 129.977684 482.282896 134.509282 486.860165 138.278741 \n",
       "C 491.437433 142.0482 496.631338 144.999232 502.212628 147.001583 \n",
       "C 507.793918 149.003933 513.67925 150.027703 519.608854 150.027703 \n",
       "C 525.538458 150.027703 531.42379 149.003933 537.00508 147.001583 \n",
       "C 542.58637 144.999232 547.780275 142.0482 552.357543 138.278741 \n",
       "C 556.934812 134.509282 560.827093 129.977684 563.862588 124.883964 \n",
       "C 566.898083 119.790245 569.031463 114.210467 570.168565 108.390913 \n",
       "C 571.305667 102.571359 571.42951 96.598931 570.534629 90.737242 \n",
       "C 569.639747 84.875553 567.739504 79.212135 564.917773 73.996961 \n",
       "C 562.096041 68.781787 558.394958 64.092734 553.977883 60.136769 \n",
       "C 549.560808 56.180805 544.493699 53.017002 539.000212 50.785007 \n",
       "C 548.848255 55.218962 556.883237 62.900002 561.756048 72.538447 \n",
       "C 566.62886 82.176892 568.050611 93.201316 565.782583 103.760671 \n",
       "C 563.514556 114.320025 557.691213 123.788287 549.290319 130.575694 \n",
       "C 540.889424 137.3631 530.409035 141.067253 519.608854 141.066208 \n",
       "C 508.808673 141.067253 498.328284 137.3631 489.927389 130.575694 \n",
       "C 481.526495 123.788287 475.703152 114.320025 473.435125 103.760671 \n",
       "C 471.167097 93.201316 472.588848 82.176892 477.46166 72.538447 \n",
       "C 482.334471 62.900002 490.369453 55.218962 500.217496 50.785007 \n",
       "\" clip-path=\"url(#p3546cafa0b)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_16\">\n",
       "    <path d=\"M 500.310949 50.747143 \n",
       "C 490.447732 55.164732 482.393803 62.837158 477.503151 72.474569 \n",
       "C 472.6125 82.111979 471.175461 93.142247 473.433623 103.711015 \n",
       "C 475.691785 114.279783 481.511092 123.759634 489.913228 130.556858 \n",
       "C 498.315364 137.354083 508.801535 141.065162 519.608854 141.066208 \n",
       "C 530.416173 141.065162 540.902344 137.354083 549.30448 130.556858 \n",
       "C 557.706616 123.759634 563.525923 114.279783 565.784085 103.711015 \n",
       "C 568.042246 93.142247 566.605208 82.111979 561.714556 72.474569 \n",
       "C 556.823905 62.837158 548.769976 55.164732 538.906759 50.747143 \n",
       "C 532.774682 48.269663 526.222497 46.996065 519.608854 46.996065 \n",
       "C 512.995211 46.996065 506.443026 48.269663 500.310949 50.747143 \n",
       "\" clip-path=\"url(#p3546cafa0b)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_25\">\n",
       "    <!-- 3 -->\n",
       "    <g transform=\"translate(516.427604 50.105411) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_26\">\n",
       "    <!-- 407 -->\n",
       "    <g transform=\"translate(510.065104 129.810045) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_27\">\n",
       "    <!-- 2122 -->\n",
       "    <g transform=\"translate(506.883854 99.455545) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_28\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(449.035716 46.62193) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_29\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(543.224492 46.62193) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_30\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(483.291979 164.29741) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_31\">\n",
       "    <!-- CHEMBL4722 -->\n",
       "    <g transform=\"translate(479.209166 18.048199) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (Aurora-A) -->\n",
       "    <g transform=\"translate(488.739791 31.485574) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-75\" d=\"M 544 1381 \n",
       "L 544 3500 \n",
       "L 1119 3500 \n",
       "L 1119 1403 \n",
       "Q 1119 906 1312 657 \n",
       "Q 1506 409 1894 409 \n",
       "Q 2359 409 2629 706 \n",
       "Q 2900 1003 2900 1516 \n",
       "L 2900 3500 \n",
       "L 3475 3500 \n",
       "L 3475 0 \n",
       "L 2900 0 \n",
       "L 2900 538 \n",
       "Q 2691 219 2414 64 \n",
       "Q 2138 -91 1772 -91 \n",
       "Q 1169 -91 856 284 \n",
       "Q 544 659 544 1381 \n",
       "z\n",
       "M 1991 3584 \n",
       "L 1991 3584 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-2d\" d=\"M 313 2009 \n",
       "L 1997 2009 \n",
       "L 1997 1497 \n",
       "L 313 1497 \n",
       "L 313 2009 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-41\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-75\" x=\"107.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"170.800781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"209.664062\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"270.845703\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"311.958984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2d\" x=\"373.238281\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-41\" x=\"407.072266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"475.480469\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_5\">\n",
       "   <g id=\"patch_17\">\n",
       "    <path d=\"M 82.913202 236.70076 \n",
       "C 81.464404 236.700953 80.017067 236.79274 78.579852 236.975573 \n",
       "C 77.142638 237.158406 75.718418 237.431919 74.315718 237.794476 \n",
       "C 77.156303 237.313692 80.032217 237.072029 82.913202 237.072029 \n",
       "C 85.794186 237.072029 88.670101 237.313692 91.510685 237.794476 \n",
       "C 90.107985 237.431919 88.683766 237.158406 87.246551 236.975573 \n",
       "C 85.809336 236.79274 84.361999 236.700953 82.913202 236.70076 \n",
       "\" clip-path=\"url(#pcabc11e101)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_18\">\n",
       "    <path d=\"M 74.289231 237.798966 \n",
       "C 67.978524 238.870471 61.922434 241.108785 56.431768 244.399032 \n",
       "C 50.941102 247.68928 46.111425 251.974195 42.190604 257.033869 \n",
       "C 38.269783 262.093543 35.326059 267.839913 33.510509 273.978066 \n",
       "C 31.69496 280.116219 31.039183 286.539321 31.576836 292.917728 \n",
       "C 32.114489 299.296134 33.836212 305.51883 36.653646 311.266457 \n",
       "C 39.471079 317.014083 43.335185 322.186604 48.047651 326.518555 \n",
       "C 52.760117 330.850507 58.238923 334.266493 64.202888 336.5912 \n",
       "C 70.166853 338.915907 76.512175 340.108872 82.913202 340.108872 \n",
       "C 89.314228 340.108872 95.65955 338.915907 101.623516 336.5912 \n",
       "C 107.587481 334.266493 113.066287 330.850507 117.778753 326.518555 \n",
       "C 122.491219 322.186604 126.355324 317.014083 129.172758 311.266457 \n",
       "C 131.990191 305.51883 133.711915 299.296134 134.249568 292.917728 \n",
       "C 134.78722 286.539321 134.131444 280.116219 132.315894 273.978066 \n",
       "C 130.500344 267.839913 127.556621 262.093543 123.6358 257.033869 \n",
       "C 119.714978 251.974195 114.885302 247.68928 109.394636 244.399032 \n",
       "C 103.90397 241.108785 97.847879 238.870471 91.537173 237.798966 \n",
       "C 99.632311 239.895823 106.690527 244.876262 111.379558 251.80021 \n",
       "C 116.06859 258.724158 118.073605 267.126723 117.01615 275.421894 \n",
       "C 115.958695 283.717065 111.90977 291.347884 105.633623 296.874008 \n",
       "C 99.357476 302.400132 91.275502 305.450525 82.913202 305.449414 \n",
       "C 74.550901 305.450525 66.468928 302.400132 60.192781 296.874008 \n",
       "C 53.916634 291.347884 49.867708 283.717065 48.810253 275.421894 \n",
       "C 47.752798 267.126723 49.757813 258.724158 54.446845 251.80021 \n",
       "C 59.135877 244.876262 66.194093 239.895823 74.289231 237.798966 \n",
       "\" clip-path=\"url(#pcabc11e101)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_19\">\n",
       "    <path d=\"M 74.315718 237.794476 \n",
       "C 66.218756 239.8873 59.157424 244.864763 54.464801 251.78719 \n",
       "C 49.772177 258.709617 47.763393 267.112137 48.817679 275.408473 \n",
       "C 49.871964 283.704809 53.918519 291.337826 60.193411 296.866518 \n",
       "C 66.468303 302.395211 74.550145 305.448303 82.913202 305.449414 \n",
       "C 91.276258 305.448303 99.3581 302.395211 105.632993 296.866518 \n",
       "C 111.907885 291.337826 115.954439 283.704809 117.008725 275.408473 \n",
       "C 118.06301 267.112137 116.054226 258.709617 111.361603 251.78719 \n",
       "C 106.668979 244.864763 99.607647 239.8873 91.510685 237.794476 \n",
       "C 88.670101 237.313692 85.794186 237.072029 82.913202 237.072029 \n",
       "C 80.032217 237.072029 77.156303 237.313692 74.315718 237.794476 \n",
       "\" clip-path=\"url(#pcabc11e101)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_32\">\n",
       "    <!-- 2 -->\n",
       "    <g transform=\"translate(79.731952 239.773411) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_33\">\n",
       "    <!-- 2158 -->\n",
       "    <g transform=\"translate(70.188202 310.994519) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_34\">\n",
       "    <!-- 1728 -->\n",
       "    <g transform=\"translate(70.188202 276.064666) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_35\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(18.763971 236.70076) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_36\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(100.104932 236.70076) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_37\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(46.596327 354.37884) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_38\">\n",
       "    <!-- CHEMBL5145 -->\n",
       "    <g transform=\"translate(42.513514 208.129633) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (B-raf) -->\n",
       "    <g transform=\"translate(63.694452 221.567008) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2d\" x=\"107.617188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"143.701172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"184.814453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"246.09375\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"281.298828\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_6\">\n",
       "   <g id=\"patch_20\">\n",
       "    <path d=\"M 225.449062 236.978102 \n",
       "C 218.822432 237.368418 212.333261 239.035786 206.339281 241.888289 \n",
       "C 200.3453 244.740792 194.958716 248.725032 190.476477 253.621368 \n",
       "C 185.994238 258.517704 182.50025 264.234478 180.187127 270.456539 \n",
       "C 177.874005 276.678599 176.785049 283.289472 176.980291 289.924715 \n",
       "C 177.175533 296.559958 178.651319 303.095363 181.326291 309.170649 \n",
       "C 184.001263 315.245935 187.825348 320.747374 192.587732 325.371687 \n",
       "C 197.350117 329.995999 202.961651 333.656619 209.112986 336.151746 \n",
       "C 215.26432 338.646873 221.840304 339.929799 228.478419 339.929799 \n",
       "C 235.116535 339.929799 241.692518 338.646873 247.843852 336.151746 \n",
       "C 253.995187 333.656619 259.606721 329.995999 264.369106 325.371687 \n",
       "C 269.131491 320.747374 272.955575 315.245935 275.630547 309.170649 \n",
       "C 278.30552 303.095363 279.781305 296.559958 279.976547 289.924715 \n",
       "C 280.17179 283.289472 279.082834 276.678599 276.769711 270.456539 \n",
       "C 274.456589 264.234478 270.962601 258.517704 266.480361 253.621368 \n",
       "C 261.998122 248.725032 256.611538 244.740792 250.617558 241.888289 \n",
       "C 244.623577 239.035786 238.134406 237.368418 231.507776 236.978102 \n",
       "C 243.576004 237.763069 254.877087 243.215772 263.001861 252.173804 \n",
       "C 271.126635 261.131836 275.453591 272.909947 275.060308 284.99728 \n",
       "C 274.667026 297.084613 269.583589 308.55654 260.893685 316.967477 \n",
       "C 252.20378 325.378414 240.572149 330.084961 228.478419 330.083776 \n",
       "C 216.384689 330.084961 204.753058 325.378414 196.063153 316.967477 \n",
       "C 187.373249 308.55654 182.289813 297.084613 181.89653 284.99728 \n",
       "C 181.503247 272.909947 185.830203 261.131836 193.954977 252.173804 \n",
       "C 202.079752 243.215772 213.380834 237.763069 225.449062 236.978102 \n",
       "\" clip-path=\"url(#p3f36b21126)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_21\">\n",
       "    <path d=\"M 225.449062 236.978102 \n",
       "C 213.380834 237.763069 202.079752 243.215772 193.954977 252.173804 \n",
       "C 185.830203 261.131836 181.503247 272.909947 181.89653 284.99728 \n",
       "C 182.289813 297.084613 187.373249 308.55654 196.063153 316.967477 \n",
       "C 204.753058 325.378414 216.384689 330.084961 228.478419 330.083776 \n",
       "C 216.378021 330.08259 204.741415 325.368571 196.051856 316.947692 \n",
       "C 187.362298 308.526813 182.285242 297.043952 181.904133 284.949557 \n",
       "C 181.523025 272.855162 185.867051 261.075433 194.009193 252.124168 \n",
       "C 202.151336 243.172903 213.468062 237.735598 225.544379 236.972577 \n",
       "C 225.528492 236.973483 225.512606 236.974396 225.49672 236.975317 \n",
       "C 225.480833 236.976238 225.464948 236.977167 225.449062 236.978102 \n",
       "\" clip-path=\"url(#p3f36b21126)\" style=\"fill: #b200b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_22\">\n",
       "    <path d=\"M 231.412459 236.972577 \n",
       "C 243.488776 237.735598 254.805502 243.172903 262.947645 252.124168 \n",
       "C 271.089788 261.075433 275.433813 272.855162 275.052705 284.949557 \n",
       "C 274.671597 297.043952 269.594541 308.526813 260.904982 316.947692 \n",
       "C 252.215424 325.368571 240.578817 330.08259 228.478419 330.083776 \n",
       "C 240.572149 330.084961 252.20378 325.378414 260.893685 316.967477 \n",
       "C 269.583589 308.55654 274.667026 297.084613 275.060308 284.99728 \n",
       "C 275.453591 272.909947 271.126635 261.131836 263.001861 252.173804 \n",
       "C 254.877087 243.215772 243.576004 237.763069 231.507776 236.978102 \n",
       "C 231.491891 236.977167 231.476005 236.976238 231.460119 236.975317 \n",
       "C 231.444233 236.974396 231.428346 236.973483 231.412459 236.972577 \n",
       "\" clip-path=\"url(#p3f36b21126)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_23\">\n",
       "    <path d=\"M 225.544379 236.972577 \n",
       "C 213.468062 237.735598 202.151336 243.172903 194.009193 252.124168 \n",
       "C 185.867051 261.075433 181.523025 272.855162 181.904133 284.949557 \n",
       "C 182.285242 297.043952 187.362298 308.526813 196.051856 316.947692 \n",
       "C 204.741415 325.368571 216.378021 330.08259 228.478419 330.083776 \n",
       "C 240.578817 330.08259 252.215424 325.368571 260.904982 316.947692 \n",
       "C 269.594541 308.526813 274.671597 297.043952 275.052705 284.949557 \n",
       "C 275.433813 272.855162 271.089788 261.075433 262.947645 252.124168 \n",
       "C 254.805502 243.172903 243.488776 237.735598 231.412459 236.972577 \n",
       "C 230.435438 236.916846 229.457028 236.888963 228.478419 236.888963 \n",
       "C 227.49981 236.888963 226.5214 236.916846 225.544379 236.972577 \n",
       "\" clip-path=\"url(#p3f36b21126)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_39\">\n",
       "    <!-- 248 -->\n",
       "    <g transform=\"translate(218.934669 315.249765) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_40\">\n",
       "    <!-- 0 -->\n",
       "    <g transform=\"translate(178.732205 287.71834) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_41\">\n",
       "    <!-- 0 -->\n",
       "    <g transform=\"translate(271.862134 287.71834) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_42\">\n",
       "    <!-- 1116 -->\n",
       "    <g transform=\"translate(215.753419 286.835516) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_43\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(158.215368 236.879834) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_44\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(251.783971 236.879834) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_45\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(192.161544 354.199965) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_46\">\n",
       "    <!-- CHEMBL218 -->\n",
       "    <g transform=\"translate(191.896232 208.310702) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Cannabinoid) -->\n",
       "    <g transform=\"translate(186.222482 221.748077) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-62\" d=\"M 3116 1747 \n",
       "Q 3116 2381 2855 2742 \n",
       "Q 2594 3103 2138 3103 \n",
       "Q 1681 3103 1420 2742 \n",
       "Q 1159 2381 1159 1747 \n",
       "Q 1159 1113 1420 752 \n",
       "Q 1681 391 2138 391 \n",
       "Q 2594 391 2855 752 \n",
       "Q 3116 1113 3116 1747 \n",
       "z\n",
       "M 1159 2969 \n",
       "Q 1341 3281 1617 3432 \n",
       "Q 1894 3584 2278 3584 \n",
       "Q 2916 3584 3314 3078 \n",
       "Q 3713 2572 3713 1747 \n",
       "Q 3713 922 3314 415 \n",
       "Q 2916 -91 2278 -91 \n",
       "Q 1894 -91 1617 61 \n",
       "Q 1341 213 1159 525 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 4863 \n",
       "L 1159 4863 \n",
       "L 1159 2969 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-64\" d=\"M 2906 2969 \n",
       "L 2906 4863 \n",
       "L 3481 4863 \n",
       "L 3481 0 \n",
       "L 2906 0 \n",
       "L 2906 525 \n",
       "Q 2725 213 2448 61 \n",
       "Q 2172 -91 1784 -91 \n",
       "Q 1150 -91 751 415 \n",
       "Q 353 922 353 1747 \n",
       "Q 353 2572 751 3078 \n",
       "Q 1150 3584 1784 3584 \n",
       "Q 2172 3584 2448 3432 \n",
       "Q 2725 3281 2906 2969 \n",
       "z\n",
       "M 947 1747 \n",
       "Q 947 1113 1208 752 \n",
       "Q 1469 391 1925 391 \n",
       "Q 2381 391 2643 752 \n",
       "Q 2906 1113 2906 1747 \n",
       "Q 2906 2381 2643 2742 \n",
       "Q 2381 3103 1925 3103 \n",
       "Q 1469 3103 1208 2742 \n",
       "Q 947 2381 947 1747 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-43\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"108.837891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"170.117188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"233.496094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"296.875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-62\" x=\"358.154297\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"421.630859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"449.414062\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"512.792969\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"573.974609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"601.757812\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"665.234375\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_7\">\n",
       "   <g id=\"patch_24\">\n",
       "    <path d=\"M 325.266403 271.817626 \n",
       "C 323.129606 278.101212 322.226999 284.738905 322.608325 291.364911 \n",
       "C 322.989651 297.990916 324.647773 304.48124 327.491314 310.478209 \n",
       "C 330.334855 316.475177 334.310603 321.866568 339.199461 326.355269 \n",
       "C 344.088318 330.843969 349.798798 334.345981 356.016204 336.668313 \n",
       "C 362.23361 338.990645 368.841593 340.089838 375.475997 339.905319 \n",
       "C 382.1104 339.720799 388.647073 338.256019 394.725787 335.591701 \n",
       "C 400.804501 332.927382 406.311505 329.113384 410.943313 324.359889 \n",
       "C 415.575122 319.606395 419.245059 314.002358 421.750881 307.85661 \n",
       "C 424.256702 301.710862 425.551515 295.13841 425.563964 288.501453 \n",
       "C 425.576412 281.864495 424.306265 275.287232 421.823516 269.132127 \n",
       "C 419.340767 262.977022 415.691878 257.359257 411.077935 252.58842 \n",
       "C 406.463991 247.817584 400.971334 243.982953 394.902657 241.29585 \n",
       "C 388.833981 238.608747 382.302849 237.119456 375.669184 236.910049 \n",
       "C 369.03552 236.700643 362.423459 237.775039 356.197386 240.074031 \n",
       "C 349.971312 242.373023 344.247734 245.853588 339.342072 250.323917 \n",
       "C 334.43641 254.794246 330.440465 260.170684 327.574447 266.156943 \n",
       "C 329.872263 261.435314 332.958537 257.139929 336.70033 253.455811 \n",
       "C 340.442123 249.771693 344.784927 246.752509 349.541677 244.528308 \n",
       "C 354.298428 242.304108 359.399832 240.907292 364.626149 240.398028 \n",
       "C 369.852466 239.888763 375.127563 240.274469 380.224218 241.538531 \n",
       "C 385.320872 242.802593 390.16484 244.926598 394.547469 247.819054 \n",
       "C 398.930099 250.71151 402.787547 254.330282 405.953655 258.519494 \n",
       "C 409.119764 262.708706 411.548412 267.407332 413.134986 272.412981 \n",
       "C 414.72156 277.41863 415.442949 282.658384 415.268078 287.906542 \n",
       "C 415.093208 293.1547 414.024625 298.334811 412.10836 303.223744 \n",
       "C 410.192094 308.112677 407.45606 312.639214 404.018111 316.608376 \n",
       "C 400.580162 320.577538 396.49038 323.931506 391.92493 326.525808 \n",
       "C 387.359479 329.120111 382.384867 330.916956 377.215372 331.838946 \n",
       "C 372.045878 332.760936 366.756806 332.79464 361.575981 331.938605 \n",
       "C 356.395156 331.082571 351.398049 329.349269 346.799907 326.81336 \n",
       "C 342.201765 324.277451 338.069572 320.975876 334.581318 317.05085 \n",
       "C 331.093065 313.125824 328.299567 308.634523 326.321152 303.770408 \n",
       "C 324.260534 298.718826 323.113457 293.341161 322.933464 287.888435 \n",
       "C 322.753472 282.435708 323.543409 276.994103 325.266403 271.817626 \n",
       "\" clip-path=\"url(#p722ede2363)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_25\">\n",
       "    <path d=\"M 327.369792 266.589553 \n",
       "C 329.621829 261.851547 332.666624 257.532784 336.372632 253.81985 \n",
       "C 340.07864 250.106916 344.39171 247.054062 349.125502 244.793182 \n",
       "C 353.859295 242.532301 358.944643 241.09643 364.161841 240.547601 \n",
       "C 369.37904 239.998773 374.651858 240.345007 379.752492 241.571345 \n",
       "C 384.853126 242.797682 389.707048 244.886205 394.104553 247.746682 \n",
       "C 398.502057 250.60716 402.378889 254.197795 405.567557 258.36346 \n",
       "C 408.756225 262.529126 411.210137 267.208955 412.823276 272.200764 \n",
       "C 414.436416 277.192573 415.185212 282.423423 415.037314 287.667324 \n",
       "C 414.889416 292.911225 413.846985 298.091556 411.955058 302.984509 \n",
       "C 410.063131 307.877461 407.349352 312.411542 403.930965 316.390864 \n",
       "C 400.512577 320.370185 396.43953 323.736604 391.887792 326.344678 \n",
       "C 387.336054 328.952753 382.372133 330.764376 377.210487 331.701279 \n",
       "C 372.048841 332.638181 366.76489 332.686674 361.586919 331.844663 \n",
       "C 356.408947 331.002651 351.412613 329.282438 346.813775 326.758342 \n",
       "C 342.214936 324.234246 338.08079 320.943149 334.589945 317.027236 \n",
       "C 331.099099 313.111323 328.302562 308.627813 326.321152 303.770408 \n",
       "C 328.299567 308.634523 331.093065 313.125824 334.581318 317.05085 \n",
       "C 338.069572 320.975876 342.201765 324.277451 346.799907 326.81336 \n",
       "C 351.398049 329.349269 356.395156 331.082571 361.575981 331.938605 \n",
       "C 366.756806 332.79464 372.045878 332.760936 377.215372 331.838946 \n",
       "C 382.384867 330.916956 387.359479 329.120111 391.92493 326.525808 \n",
       "C 396.49038 323.931506 400.580162 320.577538 404.018111 316.608376 \n",
       "C 407.45606 312.639214 410.192094 308.112677 412.10836 303.223744 \n",
       "C 414.024625 298.334811 415.093208 293.1547 415.268078 287.906542 \n",
       "C 415.442949 282.658384 414.72156 277.41863 413.134986 272.412981 \n",
       "C 411.548412 267.407332 409.119764 262.708706 405.953655 258.519494 \n",
       "C 402.787547 254.330282 398.930099 250.71151 394.547469 247.819054 \n",
       "C 390.16484 244.926598 385.320872 242.802593 380.224218 241.538531 \n",
       "C 375.127563 240.274469 369.852466 239.888763 364.626149 240.398028 \n",
       "C 359.399832 240.907292 354.298428 242.304108 349.541677 244.528308 \n",
       "C 344.784927 246.752509 340.442123 249.771693 336.70033 253.455811 \n",
       "C 332.958537 257.139929 329.872263 261.435314 327.574447 266.156943 \n",
       "C 327.540003 266.228886 327.505726 266.300909 327.471617 266.373011 \n",
       "C 327.437508 266.445113 327.403566 266.517294 327.369792 266.589553 \n",
       "\" clip-path=\"url(#p722ede2363)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_26\">\n",
       "    <path d=\"M 325.400406 271.428671 \n",
       "C 323.613661 276.655679 322.779022 282.161082 322.936221 287.682799 \n",
       "C 323.093421 293.204517 324.239923 298.653518 326.321152 303.770408 \n",
       "C 328.302562 308.627813 331.099099 313.111323 334.589945 317.027236 \n",
       "C 338.08079 320.943149 342.214936 324.234246 346.813775 326.758342 \n",
       "C 351.412613 329.282438 356.408947 331.002651 361.586919 331.844663 \n",
       "C 366.76489 332.686674 372.048841 332.638181 377.210487 331.701279 \n",
       "C 382.372133 330.764376 387.336054 328.952753 391.887792 326.344678 \n",
       "C 396.43953 323.736604 400.512577 320.370185 403.930965 316.390864 \n",
       "C 407.349352 312.411542 410.063131 307.877461 411.955058 302.984509 \n",
       "C 413.846985 298.091556 414.889416 292.911225 415.037314 287.667324 \n",
       "C 415.185212 282.423423 414.436416 277.192573 412.823276 272.200764 \n",
       "C 411.210137 267.208955 408.756225 262.529126 405.567557 258.36346 \n",
       "C 402.378889 254.197795 398.502057 250.60716 394.104553 247.746682 \n",
       "C 389.707048 244.886205 384.853126 242.797682 379.752492 241.571345 \n",
       "C 374.651858 240.345007 369.37904 239.998773 364.161841 240.547601 \n",
       "C 358.944643 241.09643 353.859295 242.532301 349.125502 244.793182 \n",
       "C 344.39171 247.054062 340.07864 250.106916 336.372632 253.81985 \n",
       "C 332.666624 257.532784 329.621829 261.851547 327.369792 266.589553 \n",
       "C 327.000912 267.378774 326.652109 268.177223 326.32372 268.984132 \n",
       "C 325.99533 269.791041 325.68746 270.606149 325.400406 271.428671 \n",
       "\" clip-path=\"url(#p722ede2363)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_47\">\n",
       "    <!-- 148 -->\n",
       "    <g transform=\"translate(403.656639 300.649519) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_48\">\n",
       "    <!-- 3 -->\n",
       "    <g transform=\"translate(411.896674 290.527978) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_49\">\n",
       "    <!-- 603 -->\n",
       "    <g transform=\"translate(393.544104 290.126133) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_50\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(298.987694 240.294768) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_51\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(392.199652 240.180299) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_52\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(337.726762 354.1954) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_53\">\n",
       "    <!-- CHEMBL205 -->\n",
       "    <g transform=\"translate(337.461449 208.315267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Carbonic) -->\n",
       "    <g transform=\"translate(342.779887 221.752642) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-43\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"108.837891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"170.117188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-62\" x=\"211.230469\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"274.707031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"335.888672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"399.267578\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"427.050781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"482.03125\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_8\">\n",
       "   <g id=\"patch_27\">\n",
       "    <path d=\"M 472.776345 266.932287 \n",
       "C 470.09161 272.787809 468.528719 279.095239 468.168882 285.526837 \n",
       "C 467.809045 291.958435 468.658605 298.400838 470.673416 304.519292 \n",
       "C 472.688227 310.637745 475.832777 316.324406 479.943672 321.283788 \n",
       "C 484.054568 326.243171 489.05935 330.387862 494.697964 333.502499 \n",
       "C 500.336578 336.617136 506.50964 338.64682 512.896389 339.486087 \n",
       "C 519.283138 340.325354 525.771004 339.959411 532.022868 338.407273 \n",
       "C 538.274731 336.855135 544.1804 334.144159 549.433007 330.415211 \n",
       "C 554.685614 326.686264 559.192579 322.00507 562.719714 316.61487 \n",
       "C 566.246849 311.22467 568.731986 305.220471 570.045994 298.914259 \n",
       "C 571.360001 292.608046 571.479719 286.110971 570.398927 279.760631 \n",
       "C 569.318135 273.410291 567.055882 267.318614 563.729718 261.802133 \n",
       "C 560.403555 256.285651 556.072106 251.441597 550.960441 247.521672 \n",
       "C 545.848775 243.601748 540.046989 240.675045 533.85655 238.89364 \n",
       "C 527.666112 237.112234 521.196132 236.507524 514.7828 237.110931 \n",
       "C 508.369467 237.714338 502.125821 239.515227 496.37629 242.42002 \n",
       "C 490.626759 245.324814 485.472683 249.282314 481.181873 254.086883 \n",
       "C 484.688873 250.18052 488.783021 246.84413 493.316888 244.197855 \n",
       "C 497.850755 241.551579 502.769262 239.627566 507.895298 238.495098 \n",
       "C 513.021334 237.362629 518.292624 237.035464 523.519354 237.525381 \n",
       "C 528.746084 238.015299 533.864757 239.316348 538.691053 241.38168 \n",
       "C 543.517349 243.447011 547.992636 246.251533 551.955762 249.694259 \n",
       "C 555.918888 253.136984 559.321708 257.176087 562.041688 261.666125 \n",
       "C 564.761668 266.156162 566.765764 271.042586 567.981812 276.14944 \n",
       "C 569.197859 281.256294 569.611084 286.521536 569.206606 291.755572 \n",
       "C 568.802129 296.989607 567.584863 302.128848 565.598641 306.988236 \n",
       "C 563.61242 311.847624 560.881372 316.368123 557.503841 320.386955 \n",
       "C 554.12631 324.405788 550.143328 327.874129 545.698318 330.667087 \n",
       "C 541.253309 333.460046 536.400273 335.543692 531.313964 336.842994 \n",
       "C 526.227654 338.142296 520.969864 338.641469 515.72992 338.32254 \n",
       "C 510.489976 338.003611 505.331537 336.870453 500.440354 334.963871 \n",
       "C 495.549171 333.057289 490.984665 330.400445 486.9112 327.089009 \n",
       "C 482.837734 323.777573 479.304796 319.851776 476.439604 315.45298 \n",
       "C 471.792898 308.328588 469.020278 300.144519 468.379921 291.662845 \n",
       "C 467.739563 283.181171 469.251982 274.673586 472.776345 266.932287 \n",
       "\" clip-path=\"url(#p021fa57465)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_28\">\n",
       "    <path d=\"M 480.035603 255.415254 \n",
       "C 483.42737 251.368621 487.4328 247.878758 491.905732 245.073014 \n",
       "C 496.378664 242.267269 501.264021 240.18019 506.383533 238.887937 \n",
       "C 511.503045 237.595683 516.793673 237.114166 522.06236 237.460956 \n",
       "C 527.331047 237.807747 532.512916 238.978575 537.418879 240.930717 \n",
       "C 542.324841 242.882858 546.894487 245.592276 550.961068 248.960101 \n",
       "C 555.027649 252.327925 558.541091 256.312688 561.373186 260.768982 \n",
       "C 564.205282 265.225277 566.321158 270.09823 567.643605 275.210026 \n",
       "C 568.966052 280.321822 569.478786 285.609517 569.163098 290.880158 \n",
       "C 568.847409 296.1508 567.707185 301.33949 565.784033 306.256888 \n",
       "C 563.860881 311.174287 561.178481 315.759845 557.834716 319.846232 \n",
       "C 554.490951 323.932619 550.526994 327.469518 546.087493 330.327865 \n",
       "C 541.647992 333.186213 536.787611 335.330813 531.683709 336.683407 \n",
       "C 526.579808 338.036001 521.295231 338.579935 516.022818 338.29536 \n",
       "C 510.750405 338.010784 505.555076 336.901204 500.626413 335.007108 \n",
       "C 495.697749 333.113012 491.09644 330.457724 486.990388 327.138135 \n",
       "C 482.884337 323.818547 479.324104 319.875534 476.439604 315.45298 \n",
       "C 479.304796 319.851776 482.837734 323.777573 486.9112 327.089009 \n",
       "C 490.984665 330.400445 495.549171 333.057289 500.440354 334.963871 \n",
       "C 505.331537 336.870453 510.489976 338.003611 515.72992 338.32254 \n",
       "C 520.969864 338.641469 526.227654 338.142296 531.313964 336.842994 \n",
       "C 536.400273 335.543692 541.253309 333.460046 545.698318 330.667087 \n",
       "C 550.143328 327.874129 554.12631 324.405788 557.503841 320.386955 \n",
       "C 560.881372 316.368123 563.61242 311.847624 565.598641 306.988236 \n",
       "C 567.584863 302.128848 568.802129 296.989607 569.206606 291.755572 \n",
       "C 569.611084 286.521536 569.197859 281.256294 567.981812 276.14944 \n",
       "C 566.765764 271.042586 564.761668 266.156162 562.041688 261.666125 \n",
       "C 559.321708 257.176087 555.918888 253.136984 551.955762 249.694259 \n",
       "C 547.992636 246.251533 543.517349 243.447011 538.691053 241.38168 \n",
       "C 533.864757 239.316348 528.746084 238.015299 523.519354 237.525381 \n",
       "C 518.292624 237.035464 513.021334 237.362629 507.895298 238.495098 \n",
       "C 502.769262 239.627566 497.850755 241.551579 493.316888 244.197855 \n",
       "C 488.783021 246.84413 484.688873 250.18052 481.181873 254.086883 \n",
       "C 480.987075 254.305005 480.794138 254.524781 480.603082 254.746188 \n",
       "C 480.412027 254.967595 480.22286 255.190625 480.035603 255.415254 \n",
       "\" clip-path=\"url(#p021fa57465)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_29\">\n",
       "    <path d=\"M 473.386327 265.648905 \n",
       "C 469.544142 273.504895 467.805323 282.225039 468.340451 290.953876 \n",
       "C 468.875579 299.682713 471.666564 308.125154 476.439604 315.45298 \n",
       "C 479.324104 319.875534 482.884337 323.818547 486.990388 327.138135 \n",
       "C 491.09644 330.457724 495.697749 333.113012 500.626413 335.007108 \n",
       "C 505.555076 336.901204 510.750405 338.010784 516.022818 338.29536 \n",
       "C 521.295231 338.579935 526.579808 338.036001 531.683709 336.683407 \n",
       "C 536.787611 335.330813 541.647992 333.186213 546.087493 330.327865 \n",
       "C 550.526994 327.469518 554.490951 323.932619 557.834716 319.846232 \n",
       "C 561.178481 315.759845 563.860881 311.174287 565.784033 306.256888 \n",
       "C 567.707185 301.33949 568.847409 296.1508 569.163098 290.880158 \n",
       "C 569.478786 285.609517 568.966052 280.321822 567.643605 275.210026 \n",
       "C 566.321158 270.09823 564.205282 265.225277 561.373186 260.768982 \n",
       "C 558.541091 256.312688 555.027649 252.327925 550.961068 248.960101 \n",
       "C 546.894487 245.592276 542.324841 242.882858 537.418879 240.930717 \n",
       "C 532.512916 238.978575 527.331047 237.807747 522.06236 237.460956 \n",
       "C 516.793673 237.114166 511.503045 237.595683 506.383533 238.887937 \n",
       "C 501.264021 240.18019 496.378664 242.267269 491.905732 245.073014 \n",
       "C 487.4328 247.878758 483.42737 251.368621 480.035603 255.415254 \n",
       "C 478.729731 256.981736 477.518024 258.624376 476.406877 260.3345 \n",
       "C 475.295731 262.044623 474.287106 263.819215 473.386327 265.648905 \n",
       "\" clip-path=\"url(#p021fa57465)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_54\">\n",
       "    <!-- 62 -->\n",
       "    <g transform=\"translate(551.128053 306.941657) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"63.623047\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_55\">\n",
       "    <!-- 3 -->\n",
       "    <g transform=\"translate(565.702325 293.951426) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_56\">\n",
       "    <!-- 1606 -->\n",
       "    <g transform=\"translate(536.350965 292.496276) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_57\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(446.5333 237.351899) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_58\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(544.079097 237.304746) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_59\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(483.291979 354.1954) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_60\">\n",
       "    <!-- CHEMBL2334 -->\n",
       "    <g transform=\"translate(479.209166 208.315267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (Caspase) -->\n",
       "    <g transform=\"translate(489.631354 221.752642) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-70\" d=\"M 1159 525 \n",
       "L 1159 -1331 \n",
       "L 581 -1331 \n",
       "L 581 3500 \n",
       "L 1159 3500 \n",
       "L 1159 2969 \n",
       "Q 1341 3281 1617 3432 \n",
       "Q 1894 3584 2278 3584 \n",
       "Q 2916 3584 3314 3078 \n",
       "Q 3713 2572 3713 1747 \n",
       "Q 3713 922 3314 415 \n",
       "Q 2916 -91 2278 -91 \n",
       "Q 1894 -91 1617 61 \n",
       "Q 1341 213 1159 525 \n",
       "z\n",
       "M 3116 1747 \n",
       "Q 3116 2381 2855 2742 \n",
       "Q 2594 3103 2138 3103 \n",
       "Q 1681 3103 1420 2742 \n",
       "Q 1159 2381 1159 1747 \n",
       "Q 1159 1113 1420 752 \n",
       "Q 1681 391 2138 391 \n",
       "Q 2594 391 2855 752 \n",
       "Q 3116 1113 3116 1747 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-43\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"108.837891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"170.117188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-70\" x=\"222.216797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"285.693359\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"346.972656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"399.072266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"460.595703\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_9\">\n",
       "   <g id=\"patch_30\">\n",
       "    <path d=\"M 36.986585 454.750129 \n",
       "C 35.418616 457.767974 34.169358 460.941001 33.25906 464.21778 \n",
       "C 32.348763 467.494558 31.78237 470.857287 31.569064 474.251461 \n",
       "C 32.06131 468.281269 33.591107 462.442425 36.089566 456.997868 \n",
       "C 38.588024 451.553311 42.017068 446.586015 46.222277 442.319669 \n",
       "C 44.365494 444.13003 42.655702 446.08527 41.109096 448.16687 \n",
       "C 39.56249 450.248471 38.183968 452.449841 36.986585 454.750129 \n",
       "\" clip-path=\"url(#p6d1c4f1438)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_31\">\n",
       "    <path d=\"M 31.533529 474.707112 \n",
       "C 31.09462 480.676616 31.699392 486.677197 33.320655 492.439065 \n",
       "C 34.941917 498.200933 37.555002 503.63642 41.042423 508.50114 \n",
       "C 44.529844 513.365861 48.83854 517.585798 53.774786 520.97122 \n",
       "C 58.711033 524.356642 64.199725 526.856039 69.994087 528.357035 \n",
       "C 75.788448 529.858032 81.800316 530.33779 87.759392 529.774739 \n",
       "C 93.718468 529.211689 99.534084 527.614397 104.944764 525.054678 \n",
       "C 110.355444 522.49496 115.278863 519.011762 119.493661 514.761693 \n",
       "C 123.708459 510.511623 127.150507 505.559347 129.665047 500.127524 \n",
       "C 132.179586 494.695701 133.728359 488.866976 134.24173 482.903415 \n",
       "C 134.755101 476.939854 134.22526 470.932192 132.676028 465.15054 \n",
       "C 131.126797 459.368889 128.581747 453.901216 125.155306 448.993353 \n",
       "C 121.728866 444.08549 117.473168 439.812111 112.579554 436.365351 \n",
       "C 107.68594 432.918591 102.228866 430.350893 96.453688 428.777703 \n",
       "C 90.678509 427.204514 84.673096 426.649768 78.707458 427.138409 \n",
       "C 72.741819 427.62705 66.906723 429.151642 61.464521 431.643639 \n",
       "C 56.022318 434.135636 51.055814 437.557121 46.788305 441.754261 \n",
       "C 50.493954 438.24923 54.724701 435.344742 59.327196 433.146077 \n",
       "C 63.92969 430.947413 68.847642 429.481461 73.902791 428.801357 \n",
       "C 78.957941 428.121254 84.088463 428.235317 89.108393 429.139412 \n",
       "C 94.128322 430.043507 98.976264 431.726577 103.476497 434.127615 \n",
       "C 107.976729 436.528654 112.074213 439.618297 115.620428 443.284553 \n",
       "C 119.166643 446.95081 122.118218 451.148842 124.368168 455.726484 \n",
       "C 126.618119 460.304125 128.138926 465.205392 128.875467 470.252627 \n",
       "C 129.612008 475.299863 129.555275 480.431339 128.707322 485.461056 \n",
       "C 127.85937 490.490773 126.23057 495.357218 123.879961 499.883995 \n",
       "C 121.529353 504.410773 118.485683 508.542521 114.859276 512.129477 \n",
       "C 111.23287 515.716433 107.068077 518.714728 102.515859 521.015682 \n",
       "C 97.963641 523.316637 93.079672 524.892111 88.040981 525.684997 \n",
       "C 83.00229 526.477884 77.8705 526.478486 72.831623 525.686783 \n",
       "C 67.792746 524.89508 62.908407 523.320753 58.355649 521.020867 \n",
       "C 53.802891 518.720982 49.637394 515.723665 46.010145 512.137561 \n",
       "C 42.382896 508.551457 39.338257 504.420423 36.986585 499.894198 \n",
       "C 34.976738 496.033087 33.491563 491.920775 32.570492 487.666449 \n",
       "C 31.649422 483.412123 31.300681 479.053771 31.533529 474.707112 \n",
       "\" clip-path=\"url(#p6d1c4f1438)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_32\">\n",
       "    <path d=\"M 46.222277 442.319669 \n",
       "C 49.879579 438.753806 54.073264 435.783086 58.650453 433.515805 \n",
       "C 63.227643 431.248523 68.132031 429.712571 73.184831 428.963942 \n",
       "C 78.23763 428.215312 83.376685 428.263214 88.414651 429.1059 \n",
       "C 93.452617 429.948587 98.327523 431.575692 102.861654 433.927901 \n",
       "C 107.395784 436.28011 111.533365 439.328487 115.123561 442.961904 \n",
       "C 118.713757 446.595321 121.712405 450.769083 124.010189 455.331036 \n",
       "C 126.307973 459.892989 127.876628 464.787016 128.658969 469.834705 \n",
       "C 129.44131 474.882395 129.427714 480.021654 128.618675 485.065134 \n",
       "C 127.809636 490.108613 126.215108 494.994271 123.893217 499.544002 \n",
       "C 121.571327 504.093733 118.550637 508.25157 114.941266 511.865939 \n",
       "C 111.331895 515.480309 107.178242 518.50675 102.631729 520.834935 \n",
       "C 98.085215 523.163119 93.201768 524.764408 88.159414 525.580426 \n",
       "C 83.117059 526.396443 77.977823 526.417152 72.929055 525.641797 \n",
       "C 67.880288 524.866442 62.984095 523.304562 58.418967 521.013093 \n",
       "C 53.853838 518.721624 49.67593 515.728756 46.037548 512.143591 \n",
       "C 42.399166 508.558427 39.345066 504.425069 36.986585 499.894198 \n",
       "C 39.338257 504.420423 42.382896 508.551457 46.010145 512.137561 \n",
       "C 49.637394 515.723665 53.802891 518.720982 58.355649 521.020867 \n",
       "C 62.908407 523.320753 67.792746 524.89508 72.831623 525.686783 \n",
       "C 77.8705 526.478486 83.00229 526.477884 88.040981 525.684997 \n",
       "C 93.079672 524.892111 97.963641 523.316637 102.515859 521.015682 \n",
       "C 107.068077 518.714728 111.23287 515.716433 114.859276 512.129477 \n",
       "C 118.485683 508.542521 121.529353 504.410773 123.879961 499.883995 \n",
       "C 126.23057 495.357218 127.85937 490.490773 128.707322 485.461056 \n",
       "C 129.555275 480.431339 129.612008 475.299863 128.875467 470.252627 \n",
       "C 128.138926 465.205392 126.618119 460.304125 124.368168 455.726484 \n",
       "C 122.118218 451.148842 119.166643 446.95081 115.620428 443.284553 \n",
       "C 112.074213 439.618297 107.976729 436.528654 103.476497 434.127615 \n",
       "C 98.976264 431.726577 94.128322 430.043507 89.108393 429.139412 \n",
       "C 84.088463 428.235317 78.957941 428.121254 73.902791 428.801357 \n",
       "C 68.847642 429.481461 63.92969 430.947413 59.327196 433.146077 \n",
       "C 54.724701 435.344742 50.493954 438.24923 46.788305 441.754261 \n",
       "C 46.693238 441.847761 46.598533 441.94163 46.504194 442.035866 \n",
       "C 46.409855 442.130102 46.315882 442.224703 46.222277 442.319669 \n",
       "\" clip-path=\"url(#p6d1c4f1438)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_33\">\n",
       "    <path d=\"M 31.569064 474.251461 \n",
       "C 31.291284 478.671538 31.614553 483.108939 32.530014 487.442088 \n",
       "C 33.445475 491.775237 34.94469 495.964196 36.986585 499.894198 \n",
       "C 39.345066 504.425069 42.399166 508.558427 46.037548 512.143591 \n",
       "C 49.67593 515.728756 53.853838 518.721624 58.418967 521.013093 \n",
       "C 62.984095 523.304562 67.880288 524.866442 72.929055 525.641797 \n",
       "C 77.977823 526.417152 83.117059 526.396443 88.159414 525.580426 \n",
       "C 93.201768 524.764408 98.085215 523.163119 102.631729 520.834935 \n",
       "C 107.178242 518.50675 111.331895 515.480309 114.941266 511.865939 \n",
       "C 118.550637 508.25157 121.571327 504.093733 123.893217 499.544002 \n",
       "C 126.215108 494.994271 127.809636 490.108613 128.618675 485.065134 \n",
       "C 129.427714 480.021654 129.44131 474.882395 128.658969 469.834705 \n",
       "C 127.876628 464.787016 126.307973 459.892989 124.010189 455.331036 \n",
       "C 121.712405 450.769083 118.713757 446.595321 115.123561 442.961904 \n",
       "C 111.533365 439.328487 107.395784 436.28011 102.861654 433.927901 \n",
       "C 98.327523 431.575692 93.452617 429.948587 88.414651 429.1059 \n",
       "C 83.376685 428.263214 78.23763 428.215312 73.184831 428.963942 \n",
       "C 68.132031 429.712571 63.227643 431.248523 58.650453 433.515805 \n",
       "C 54.073264 435.783086 49.879579 438.753806 46.222277 442.319669 \n",
       "C 42.017068 446.586015 38.588024 451.553311 36.089566 456.997868 \n",
       "C 33.591107 462.442425 32.06131 468.281269 31.569064 474.251461 \n",
       "\" clip-path=\"url(#p6d1c4f1438)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_61\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(33.20062 459.895104) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_62\">\n",
       "    <!-- 184 -->\n",
       "    <g transform=\"translate(115.018457 495.685318) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_63\">\n",
       "    <!-- 5 -->\n",
       "    <g transform=\"translate(125.354243 487.955133) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_64\">\n",
       "    <!-- 1699 -->\n",
       "    <g transform=\"translate(97.238216 484.902165) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_65\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(8.949094 428.436048) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_66\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(104.9096 428.36421) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_67\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(46.596327 544.273141) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_68\">\n",
       "    <!-- CHEMBL204 -->\n",
       "    <g transform=\"translate(46.331014 398.395267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Coagulation) -->\n",
       "    <g transform=\"translate(42.245389 411.832642) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-43\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"108.837891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"170.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"231.298828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-75\" x=\"294.775391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"358.154297\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"385.9375\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"447.216797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"486.425781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"514.208984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"575.390625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"638.769531\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_10\">\n",
       "   <g id=\"patch_34\">\n",
       "    <path d=\"M 191.650011 442.456747 \n",
       "C 187.029447 447.179954 183.360351 452.748234 180.843156 458.857409 \n",
       "C 178.32596 464.966584 177.007351 471.503348 176.95936 478.110616 \n",
       "C 176.91137 484.717884 178.134887 491.273112 180.563076 497.418207 \n",
       "C 182.991264 503.563302 186.579089 509.184292 191.130556 513.974118 \n",
       "C 195.682024 518.763945 201.11272 522.633771 207.12598 525.3722 \n",
       "C 213.13924 528.110629 219.623538 529.666872 226.224655 529.955915 \n",
       "C 232.825772 530.244958 239.421279 529.26144 245.650881 527.059089 \n",
       "C 251.880483 524.856738 257.628642 521.4764 262.581351 517.102733 \n",
       "C 267.53406 512.729066 271.599463 507.443187 274.555479 501.533851 \n",
       "C 277.511495 495.624514 279.303298 489.201317 279.833008 482.615142 \n",
       "C 280.362719 476.028967 279.620511 469.401966 277.646931 463.096154 \n",
       "C 275.67335 456.790341 272.505 450.92267 268.314958 445.813673 \n",
       "C 264.124917 440.704677 258.990896 436.449111 253.193352 433.279446 \n",
       "C 247.395808 430.10978 241.042268 428.084802 234.479807 427.31513 \n",
       "C 227.917346 426.545458 221.267676 427.045367 214.894051 428.787549 \n",
       "C 208.520426 430.52973 202.541056 433.481873 197.282577 437.482708 \n",
       "C 204.54724 432.013191 213.216992 428.715828 222.28025 427.975354 \n",
       "C 231.343508 427.234879 240.433508 429.081258 248.489632 433.299057 \n",
       "C 256.545755 437.516855 263.241995 443.93539 267.797035 451.805749 \n",
       "C 272.352076 459.676108 274.581588 468.679801 274.225433 477.76628 \n",
       "C 273.869278 486.85276 270.941869 495.654321 265.784774 503.144002 \n",
       "C 260.627679 510.633683 253.449592 516.508398 245.088048 520.082687 \n",
       "C 236.726505 523.656976 227.519873 524.786198 218.542379 523.338596 \n",
       "C 209.564885 521.890994 201.179823 517.925147 194.365557 511.903791 \n",
       "C 189.495787 507.60432 185.548119 502.36161 182.761774 496.493357 \n",
       "C 179.975429 490.625104 178.40785 484.252287 178.154028 477.761086 \n",
       "C 177.900206 471.269886 178.965375 464.794122 181.284988 458.726214 \n",
       "C 183.6046 452.658306 187.130835 447.123348 191.650011 442.456747 \n",
       "\" clip-path=\"url(#p5df63ca0f1)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_35\">\n",
       "    <path d=\"M 197.035969 437.671512 \n",
       "C 204.273995 432.153531 212.932998 428.803987 222.000196 428.014653 \n",
       "C 231.067394 427.225319 240.174937 429.028218 248.257579 433.212477 \n",
       "C 256.340221 437.396735 263.070056 443.792602 267.659941 451.651997 \n",
       "C 272.249826 459.511391 274.513553 468.515463 274.186351 477.611071 \n",
       "C 273.859148 486.706678 270.954289 495.524817 265.811536 503.034092 \n",
       "C 260.668782 510.543367 253.496772 516.439133 245.134364 520.031802 \n",
       "C 236.771957 523.624471 227.55841 524.768292 218.571366 523.329479 \n",
       "C 209.584323 521.890667 201.188382 517.927593 194.365557 511.903791 \n",
       "C 201.179823 517.925147 209.564885 521.890994 218.542379 523.338596 \n",
       "C 227.519873 524.786198 236.726505 523.656976 245.088048 520.082687 \n",
       "C 253.449592 516.508398 260.627679 510.633683 265.784774 503.144002 \n",
       "C 270.941869 495.654321 273.869278 486.85276 274.225433 477.76628 \n",
       "C 274.581588 468.679801 272.352076 459.676108 267.797035 451.805749 \n",
       "C 263.241995 443.93539 256.545755 437.516855 248.489632 433.299057 \n",
       "C 240.433508 429.081258 231.343508 427.234879 222.28025 427.975354 \n",
       "C 213.216992 428.715828 204.54724 432.013191 197.282577 437.482708 \n",
       "C 197.241381 437.514052 197.200232 437.545457 197.15913 437.576925 \n",
       "C 197.118029 437.608392 197.076975 437.639921 197.035969 437.671512 \n",
       "\" clip-path=\"url(#p5df63ca0f1)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_36\">\n",
       "    <path d=\"M 191.85383 442.249572 \n",
       "C 187.291827 446.9074 183.724813 452.445061 181.370326 458.524833 \n",
       "C 179.01584 464.604605 177.92274 471.100328 178.157689 477.61585 \n",
       "C 178.392638 484.131372 179.950762 490.531492 182.737036 496.425888 \n",
       "C 185.52331 502.320285 189.479917 507.586644 194.365557 511.903791 \n",
       "C 201.188382 517.927593 209.584323 521.890667 218.571366 523.329479 \n",
       "C 227.55841 524.768292 236.771957 523.624471 245.134364 520.031802 \n",
       "C 253.496772 516.439133 260.668782 510.543367 265.811536 503.034092 \n",
       "C 270.954289 495.524817 273.859148 486.706678 274.186351 477.611071 \n",
       "C 274.513553 468.515463 272.249826 459.511391 267.659941 451.651997 \n",
       "C 263.070056 443.792602 256.340221 437.396735 248.257579 433.212477 \n",
       "C 240.174937 429.028218 231.067394 427.225319 222.000196 428.014653 \n",
       "C 212.932998 428.803987 204.273995 432.153531 197.035969 437.671512 \n",
       "C 196.122251 438.375438 195.232429 439.10985 194.368008 439.873505 \n",
       "C 193.503588 440.637161 192.665056 441.42963 191.85383 442.249572 \n",
       "\" clip-path=\"url(#p5df63ca0f1)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_69\">\n",
       "    <!-- 200 -->\n",
       "    <g transform=\"translate(246.189883 500.208738) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_70\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(270.97321 480.421233) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_71\">\n",
       "    <!-- 1343 -->\n",
       "    <g transform=\"translate(234.919351 479.563621) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_72\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(155.184855 427.833611) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_73\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(250.228353 427.815726) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_74\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(192.161544 544.2754) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_75\">\n",
       "    <!-- CHEMBL221 -->\n",
       "    <g transform=\"translate(191.896232 398.395267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (COX-1) -->\n",
       "    <g transform=\"translate(205.474044 411.832642) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-58\" d=\"M 403 4666 \n",
       "L 1081 4666 \n",
       "L 2241 2931 \n",
       "L 3406 4666 \n",
       "L 4084 4666 \n",
       "L 2584 2425 \n",
       "L 4184 0 \n",
       "L 3506 0 \n",
       "L 2194 1984 \n",
       "L 872 0 \n",
       "L 191 0 \n",
       "L 1856 2491 \n",
       "L 403 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-43\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4f\" x=\"108.837891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-58\" x=\"181.173828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2d\" x=\"244.679688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"280.763672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"344.386719\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_11\">\n",
       "   <g id=\"patch_37\">\n",
       "    <path d=\"M 332.220535 448.39858 \n",
       "C 328.339743 453.793297 325.539146 459.888276 323.973472 466.346773 \n",
       "C 322.407799 472.80527 322.106425 479.506113 323.086002 486.079084 \n",
       "C 324.065578 492.652055 326.307726 498.973834 329.688569 504.695147 \n",
       "C 333.069412 510.41646 337.525518 515.429965 342.810692 519.458669 \n",
       "C 348.095866 523.487373 354.110947 526.455691 360.523608 528.199625 \n",
       "C 366.936268 529.943559 373.626194 530.43039 380.223773 529.633221 \n",
       "C 386.821351 528.836052 393.202799 526.769839 399.015547 523.548739 \n",
       "C 404.828294 520.327639 409.963283 516.012085 414.13681 510.84051 \n",
       "C 418.310336 505.668934 421.444097 499.738364 423.364954 493.37646 \n",
       "C 425.285812 487.014555 425.957726 480.340677 425.343576 473.723553 \n",
       "C 424.729426 467.106428 422.840733 460.670206 419.781846 454.770483 \n",
       "C 416.72296 448.87076 412.55127 443.618225 407.497259 439.303078 \n",
       "C 402.443248 434.987931 396.601739 431.691131 390.295471 429.594824 \n",
       "C 383.989203 427.498517 377.336493 426.642034 370.704898 427.072694 \n",
       "C 364.073303 427.503355 357.587244 429.213079 351.605071 432.107405 \n",
       "C 345.622898 435.001732 340.256848 439.026359 335.80339 443.958927 \n",
       "C 338.942017 440.528831 342.584745 437.596586 346.606144 435.263158 \n",
       "C 350.627543 432.92973 354.980922 431.222213 359.516381 430.1994 \n",
       "C 364.051841 429.176587 368.71672 428.850355 373.350394 429.231936 \n",
       "C 377.984068 429.613518 382.532735 430.698482 386.839773 432.449472 \n",
       "C 391.146811 434.200461 395.16221 436.597145 398.74771 439.556998 \n",
       "C 402.333209 442.516852 405.447178 446.005508 407.982393 449.902843 \n",
       "C 410.517608 453.800179 412.444634 458.060941 413.697116 462.538421 \n",
       "C 414.949599 467.015901 415.512997 471.65811 415.367911 476.305205 \n",
       "C 415.222824 480.952299 414.370938 485.550322 412.841585 489.94095 \n",
       "C 411.312231 494.331579 409.123168 498.463833 406.349771 502.195429 \n",
       "C 403.576374 505.927024 400.250844 509.214634 396.487689 511.945056 \n",
       "C 392.724534 514.675477 388.567448 516.817009 384.15957 518.295911 \n",
       "C 379.751692 519.774813 375.144202 520.573914 370.495749 520.665699 \n",
       "C 365.847296 520.757484 361.211853 520.140887 356.749031 518.83714 \n",
       "C 352.286209 517.533392 348.047825 515.557632 344.17982 512.97789 \n",
       "C 340.311814 510.398148 336.859097 507.244377 333.940556 503.62517 \n",
       "C 327.67632 495.866027 324.116503 486.268103 323.806071 476.300726 \n",
       "C 323.495639 466.33335 326.451285 456.532503 332.220535 448.39858 \n",
       "\" clip-path=\"url(#p56ce42a5f5)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_38\">\n",
       "    <path d=\"M 335.64269 444.137753 \n",
       "C 338.765791 440.692624 342.395784 437.743504 346.407468 435.392109 \n",
       "C 350.419153 433.040714 354.765872 431.314391 359.297706 430.272683 \n",
       "C 363.82954 429.230974 368.493781 428.885996 373.129558 429.249645 \n",
       "C 377.765335 429.613295 382.318733 430.681343 386.632702 432.416952 \n",
       "C 390.946672 434.152561 394.97104 436.535546 398.567005 439.483717 \n",
       "C 402.16297 442.431887 405.288709 445.910954 407.836415 449.800925 \n",
       "C 410.384121 453.690895 412.324162 457.946526 413.589626 462.42104 \n",
       "C 414.85509 466.895554 415.431259 471.536909 415.298261 476.185026 \n",
       "C 415.165263 480.833142 414.324645 485.433959 412.805399 489.828793 \n",
       "C 411.286153 494.223627 409.105949 498.361364 406.339984 502.099292 \n",
       "C 403.574018 505.83722 400.254461 509.131866 396.495803 511.869596 \n",
       "C 392.737145 514.607326 388.583103 516.756299 384.176949 518.242397 \n",
       "C 379.770796 519.728494 375.163778 520.534432 370.514791 520.632414 \n",
       "C 365.865805 520.730395 361.228921 520.11928 356.764067 518.820146 \n",
       "C 352.299212 517.521012 348.058316 515.54897 344.187647 512.972034 \n",
       "C 340.316979 510.395098 336.861555 507.243241 333.940556 503.62517 \n",
       "C 336.859097 507.244377 340.311814 510.398148 344.17982 512.97789 \n",
       "C 348.047825 515.557632 352.286209 517.533392 356.749031 518.83714 \n",
       "C 361.211853 520.140887 365.847296 520.757484 370.495749 520.665699 \n",
       "C 375.144202 520.573914 379.751692 519.774813 384.15957 518.295911 \n",
       "C 388.567448 516.817009 392.724534 514.675477 396.487689 511.945056 \n",
       "C 400.250844 509.214634 403.576374 505.927024 406.349771 502.195429 \n",
       "C 409.123168 498.463833 411.312231 494.331579 412.841585 489.94095 \n",
       "C 414.370938 485.550322 415.222824 480.952299 415.367911 476.305205 \n",
       "C 415.512997 471.65811 414.949599 467.015901 413.697116 462.538421 \n",
       "C 412.444634 458.060941 410.517608 453.800179 407.982393 449.902843 \n",
       "C 405.447178 446.005508 402.333209 442.516852 398.74771 439.556998 \n",
       "C 395.16221 436.597145 391.146811 434.200461 386.839773 432.449472 \n",
       "C 382.532735 430.698482 377.984068 429.613518 373.350394 429.231936 \n",
       "C 368.71672 428.850355 364.051841 429.176587 359.516381 430.1994 \n",
       "C 354.980922 431.222213 350.627543 432.92973 346.606144 435.263158 \n",
       "C 342.584745 437.596586 338.942017 440.528831 335.80339 443.958927 \n",
       "C 335.776537 443.988669 335.749719 444.018442 335.722936 444.048246 \n",
       "C 335.696153 444.078051 335.669404 444.107886 335.64269 444.137753 \n",
       "\" clip-path=\"url(#p56ce42a5f5)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_39\">\n",
       "    <path d=\"M 332.351288 448.217647 \n",
       "C 326.525344 456.35618 323.524882 466.184392 323.81185 476.18914 \n",
       "C 324.098819 486.193889 327.657695 495.833957 333.940556 503.62517 \n",
       "C 336.861555 507.243241 340.316979 510.395098 344.187647 512.972034 \n",
       "C 348.058316 515.54897 352.299212 517.521012 356.764067 518.820146 \n",
       "C 361.228921 520.11928 365.865805 520.730395 370.514791 520.632414 \n",
       "C 375.163778 520.534432 379.770796 519.728494 384.176949 518.242397 \n",
       "C 388.583103 516.756299 392.737145 514.607326 396.495803 511.869596 \n",
       "C 400.254461 509.131866 403.574018 505.83722 406.339984 502.099292 \n",
       "C 409.105949 498.361364 411.286153 494.223627 412.805399 489.828793 \n",
       "C 414.324645 485.433959 415.165263 480.833142 415.298261 476.185026 \n",
       "C 415.431259 471.536909 414.85509 466.895554 413.589626 462.42104 \n",
       "C 412.324162 457.946526 410.384121 453.690895 407.836415 449.800925 \n",
       "C 405.288709 445.910954 402.16297 442.431887 398.567005 439.483717 \n",
       "C 394.97104 436.535546 390.946672 434.152561 386.632702 432.416952 \n",
       "C 382.318733 430.681343 377.765335 429.613295 373.129558 429.249645 \n",
       "C 368.493781 428.885996 363.82954 429.230974 359.297706 430.272683 \n",
       "C 354.765872 431.314391 350.419153 433.040714 346.407468 435.392109 \n",
       "C 342.395784 437.743504 338.765791 440.692624 335.64269 444.137753 \n",
       "C 335.059958 444.789264 334.4939 445.455499 333.945066 446.135812 \n",
       "C 333.396232 446.816125 332.864801 447.510295 332.351288 448.217647 \n",
       "\" clip-path=\"url(#p56ce42a5f5)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_76\">\n",
       "    <!-- 759 -->\n",
       "    <g transform=\"translate(395.584588 496.349644) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-37\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_77\">\n",
       "    <!-- 4 -->\n",
       "    <g transform=\"translate(412.113663 478.989032) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_78\">\n",
       "    <!-- 2855 -->\n",
       "    <g transform=\"translate(382.282966 478.457363) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_79\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(299.709664 429.10948) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_80\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(392.490917 429.077431) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_81\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(337.726762 544.2754) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_82\">\n",
       "    <!-- CHEMBL230 -->\n",
       "    <g transform=\"translate(337.461449 398.395267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (COX-2) -->\n",
       "    <g transform=\"translate(351.039262 411.832642) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-43\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4f\" x=\"108.837891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-58\" x=\"181.173828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2d\" x=\"244.679688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"280.763672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"344.386719\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_12\">\n",
       "   <g id=\"patch_40\">\n",
       "    <path d=\"M 470.942968 461.573726 \n",
       "C 468.759279 467.857836 467.813298 474.505829 468.157399 481.149633 \n",
       "C 468.501501 487.793437 470.129215 494.308131 472.950422 500.333024 \n",
       "C 475.771629 506.357916 479.733283 511.779723 484.616043 516.298261 \n",
       "C 489.498803 520.8168 495.210862 524.347109 501.435964 526.693731 \n",
       "C 507.661067 529.040353 514.282166 530.159165 520.932678 529.988223 \n",
       "C 527.583191 529.817281 534.13807 528.359798 540.234399 525.696471 \n",
       "C 546.330727 523.033143 551.853879 519.214048 556.498059 514.450633 \n",
       "C 561.14224 509.687217 564.820126 504.069046 567.328089 497.907175 \n",
       "C 569.836052 491.745304 571.126936 485.155591 571.129268 478.502882 \n",
       "C 571.131601 471.850174 569.84534 465.259557 567.341699 459.095928 \n",
       "C 564.838058 452.9323 561.164112 447.311551 556.523274 442.54488 \n",
       "C 551.882435 437.778208 546.361963 433.95524 540.267504 431.287638 \n",
       "C 534.173045 428.620036 527.619189 427.157957 520.968798 426.98235 \n",
       "C 514.318408 426.806744 507.696525 427.920912 501.469779 430.263168 \n",
       "C 495.243032 432.605423 489.528499 436.131726 484.642571 440.646839 \n",
       "C 479.756643 445.161952 475.791188 450.580979 472.965756 456.603892 \n",
       "C 475.168632 451.9953 478.142433 447.796557 481.758712 444.189022 \n",
       "C 485.374991 440.581487 489.58092 437.617859 494.194831 435.426146 \n",
       "C 498.808742 433.234434 503.763235 431.846654 508.844308 431.322749 \n",
       "C 513.925382 430.798845 519.05881 431.146469 524.022864 432.350607 \n",
       "C 528.986919 433.554744 533.709083 435.597806 537.985391 438.391544 \n",
       "C 542.261698 441.185282 546.029681 444.688885 549.126587 448.751022 \n",
       "C 552.223493 452.813158 554.604083 457.374488 556.165529 462.237991 \n",
       "C 557.726976 467.101495 558.446471 472.196125 558.292936 477.301829 \n",
       "C 558.139401 482.407532 557.115079 487.449724 555.264214 492.210615 \n",
       "C 553.41335 496.971505 550.76298 501.381547 547.427583 505.250256 \n",
       "C 544.092186 509.118965 540.120486 512.389827 535.684035 514.921561 \n",
       "C 531.247583 517.453295 526.411188 519.208918 521.383749 520.112599 \n",
       "C 516.35631 521.01628 511.211269 521.054817 506.170857 520.226546 \n",
       "C 501.130446 519.398276 496.268294 517.715297 491.794416 515.250303 \n",
       "C 487.320538 512.785309 483.300288 509.574309 479.907314 505.755996 \n",
       "C 476.51434 501.937684 473.798207 497.567838 471.876234 492.835207 \n",
       "C 469.862183 487.89063 468.749135 482.625299 468.589817 477.288647 \n",
       "C 468.430499 471.951994 469.227467 466.629643 470.942968 461.573726 \n",
       "\" clip-path=\"url(#pd84bf2aa93)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_41\">\n",
       "    <path d=\"M 472.804553 456.95087 \n",
       "C 474.970443 452.332668 477.910051 448.118578 481.496113 444.49104 \n",
       "C 485.082175 440.863502 489.262184 437.875632 493.855176 435.656781 \n",
       "C 498.448168 433.43793 503.386891 432.020588 508.457535 431.466115 \n",
       "C 513.52818 430.911642 518.6565 431.228157 523.620477 432.401957 \n",
       "C 528.584453 433.575757 533.311404 435.589656 537.596685 438.356465 \n",
       "C 541.881967 441.123275 545.662834 444.602483 548.775603 448.643466 \n",
       "C 551.888371 452.68445 554.287463 457.228039 555.869016 462.07753 \n",
       "C 557.450569 466.927021 558.191426 472.011407 558.059512 477.110571 \n",
       "C 557.927597 482.209734 556.924845 487.249013 555.094665 492.010244 \n",
       "C 553.264485 496.771474 550.633676 501.184941 547.316132 505.059574 \n",
       "C 543.998589 508.934207 540.042887 512.213272 535.620279 514.754811 \n",
       "C 531.197672 517.296349 526.372916 519.063147 521.354888 519.978715 \n",
       "C 516.336859 520.894284 511.199034 520.945216 506.163841 520.129308 \n",
       "C 501.128648 519.313399 496.269814 517.642597 491.797691 515.189234 \n",
       "C 487.325569 512.735871 483.305638 509.535869 479.911934 505.727767 \n",
       "C 476.51823 501.919664 473.800443 497.559219 471.876234 492.835207 \n",
       "C 473.798207 497.567838 476.51434 501.937684 479.907314 505.755996 \n",
       "C 483.300288 509.574309 487.320538 512.785309 491.794416 515.250303 \n",
       "C 496.268294 517.715297 501.130446 519.398276 506.170857 520.226546 \n",
       "C 511.211269 521.054817 516.35631 521.01628 521.383749 520.112599 \n",
       "C 526.411188 519.208918 531.247583 517.453295 535.684035 514.921561 \n",
       "C 540.120486 512.389827 544.092186 509.118965 547.427583 505.250256 \n",
       "C 550.76298 501.381547 553.41335 496.971505 555.264214 492.210615 \n",
       "C 557.115079 487.449724 558.139401 482.407532 558.292936 477.301829 \n",
       "C 558.446471 472.196125 557.726976 467.101495 556.165529 462.237991 \n",
       "C 554.604083 457.374488 552.223493 452.813158 549.126587 448.751022 \n",
       "C 546.029681 444.688885 542.261698 441.185282 537.985391 438.391544 \n",
       "C 533.709083 435.597806 528.986919 433.554744 524.022864 432.350607 \n",
       "C 519.05881 431.146469 513.925382 430.798845 508.844308 431.322749 \n",
       "C 503.763235 431.846654 498.808742 433.234434 494.194831 435.426146 \n",
       "C 489.58092 437.617859 485.374991 440.581487 481.758712 444.189022 \n",
       "C 478.142433 447.796557 475.168632 451.9953 472.965756 456.603892 \n",
       "C 472.938674 456.661621 472.9117 456.719401 472.884832 456.777231 \n",
       "C 472.857965 456.835061 472.831205 456.892941 472.804553 456.95087 \n",
       "\" clip-path=\"url(#pd84bf2aa93)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_42\">\n",
       "    <path d=\"M 471.053413 461.259179 \n",
       "C 469.286808 466.355878 468.453729 471.729641 468.594245 477.121996 \n",
       "C 468.734761 482.51435 469.846583 487.837432 471.876234 492.835207 \n",
       "C 473.800443 497.559219 476.51823 501.919664 479.911934 505.727767 \n",
       "C 483.305638 509.535869 487.325569 512.735871 491.797691 515.189234 \n",
       "C 496.269814 517.642597 501.128648 519.313399 506.163841 520.129308 \n",
       "C 511.199034 520.945216 516.336859 520.894284 521.354888 519.978715 \n",
       "C 526.372916 519.063147 531.197672 517.296349 535.620279 514.754811 \n",
       "C 540.042887 512.213272 543.998589 508.934207 547.316132 505.059574 \n",
       "C 550.633676 501.184941 553.264485 496.771474 555.094665 492.010244 \n",
       "C 556.924845 487.249013 557.927597 482.209734 558.059512 477.110571 \n",
       "C 558.191426 472.011407 557.450569 466.927021 555.869016 462.07753 \n",
       "C 554.287463 457.228039 551.888371 452.68445 548.775603 448.643466 \n",
       "C 545.662834 444.602483 541.881967 441.123275 537.596685 438.356465 \n",
       "C 533.311404 435.589656 528.584453 433.575757 523.620477 432.401957 \n",
       "C 518.6565 431.228157 513.52818 430.911642 508.457535 431.466115 \n",
       "C 503.386891 432.020588 498.448168 433.43793 493.855176 435.656781 \n",
       "C 489.262184 437.875632 485.082175 440.863502 481.496113 444.49104 \n",
       "C 477.910051 448.118578 474.970443 452.332668 472.804553 456.95087 \n",
       "C 472.480461 457.655287 472.172314 458.36693 471.880346 459.085256 \n",
       "C 471.588378 459.803582 471.312663 460.528407 471.053413 461.259179 \n",
       "\" clip-path=\"url(#pd84bf2aa93)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_83\">\n",
       "    <!-- 187 -->\n",
       "    <g transform=\"translate(548.083881 490.374411) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_84\">\n",
       "    <!-- 3 -->\n",
       "    <g transform=\"translate(554.936887 479.951622) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_85\">\n",
       "    <!-- 584 -->\n",
       "    <g transform=\"translate(537.004912 479.611564) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_86\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(443.988536 431.200931) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_87\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(535.879661 431.086133) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_88\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(483.291979 544.2754) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_89\">\n",
       "    <!-- CHEMBL202 -->\n",
       "    <g transform=\"translate(483.026666 398.395267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Dihydrofolate) -->\n",
       "    <g transform=\"translate(474.303229 411.832642) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-44\" d=\"M 1259 4147 \n",
       "L 1259 519 \n",
       "L 2022 519 \n",
       "Q 2988 519 3436 956 \n",
       "Q 3884 1394 3884 2338 \n",
       "Q 3884 3275 3436 3711 \n",
       "Q 2988 4147 2022 4147 \n",
       "L 1259 4147 \n",
       "z\n",
       "M 628 4666 \n",
       "L 1925 4666 \n",
       "Q 3281 4666 3915 4102 \n",
       "Q 4550 3538 4550 2338 \n",
       "Q 4550 1131 3912 565 \n",
       "Q 3275 0 1925 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-44\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"116.015625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"143.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-79\" x=\"207.177734\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"266.357422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"329.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"368.697266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"429.878906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"465.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"526.265625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"554.048828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"615.328125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"654.537109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"716.060547\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_13\">\n",
       "   <g id=\"patch_43\">\n",
       "    <path d=\"M 39.014168 641.597646 \n",
       "C 35.521045 647.283995 33.165818 653.595258 32.079692 660.179847 \n",
       "C 30.993566 666.764435 31.197093 673.497764 32.678933 680.004731 \n",
       "C 34.160773 686.511699 36.892889 692.669188 40.723081 698.134178 \n",
       "C 44.553273 703.599167 49.409069 708.268254 55.019963 711.881334 \n",
       "C 60.630858 715.494413 66.890687 717.983122 73.450728 719.208819 \n",
       "C 80.01077 720.434516 86.746902 720.374011 93.283868 719.030673 \n",
       "C 99.820833 717.687335 106.034948 715.086583 111.580035 711.373298 \n",
       "C 117.125122 707.660013 121.896265 702.904454 125.62767 697.371545 \n",
       "C 129.359076 691.838635 131.980145 685.633062 133.344861 679.100526 \n",
       "C 134.709577 672.56799 134.79212 665.832092 133.58789 659.268076 \n",
       "C 132.383661 652.70406 129.915444 646.436122 126.320741 640.813438 \n",
       "C 122.726037 635.190753 118.07286 630.319707 112.620431 626.471658 \n",
       "C 107.168001 622.623608 101.019483 619.871362 94.517398 618.368242 \n",
       "C 88.015313 616.865122 81.282686 616.639569 74.69458 617.704147 \n",
       "C 68.106473 618.768725 61.787538 621.103292 56.089792 624.577794 \n",
       "C 50.392046 628.052296 45.423293 632.600992 41.460335 637.970483 \n",
       "C 44.150672 634.390668 47.389825 631.258323 51.057802 628.689485 \n",
       "C 54.725779 626.120646 58.77672 624.14743 63.060559 622.842935 \n",
       "C 67.344398 621.53844 71.807577 620.918975 76.284758 621.007487 \n",
       "C 80.76194 621.096 85.197147 621.891383 89.42608 623.364173 \n",
       "C 93.655014 624.836963 97.6248 626.968745 101.18838 629.68055 \n",
       "C 104.751961 632.392354 107.864781 635.650275 110.411528 639.333625 \n",
       "C 112.958274 643.016975 114.907107 647.079703 116.185832 651.371305 \n",
       "C 117.464556 655.662907 118.057185 660.129728 117.941766 664.606297 \n",
       "C 117.826346 669.082865 117.00432 673.513212 115.50614 677.733217 \n",
       "C 114.007959 681.953222 111.852356 685.910124 109.119182 689.457341 \n",
       "C 106.386009 693.004559 103.109438 696.097742 99.410848 698.622305 \n",
       "C 95.712257 701.146868 91.637891 703.071247 87.33868 704.324155 \n",
       "C 83.03947 705.577063 78.569168 706.142834 74.093374 706.000511 \n",
       "C 69.61758 705.858188 65.192254 705.00955 60.981329 703.486033 \n",
       "C 56.770405 701.962516 52.82653 699.78317 49.295804 697.028726 \n",
       "C 45.765078 694.274282 42.691644 690.979179 40.189356 687.265483 \n",
       "C 35.662561 680.557357 33.146188 672.693007 32.938006 664.603045 \n",
       "C 32.729823 656.513084 34.838382 648.529718 39.014168 641.597646 \n",
       "\" clip-path=\"url(#p8eaed4fdc9)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_44\">\n",
       "    <path d=\"M 41.355759 638.112683 \n",
       "C 44.032553 634.525557 47.25969 631.384058 50.917494 628.804685 \n",
       "C 54.575298 626.225312 58.617989 624.240348 62.895646 622.923404 \n",
       "C 67.173304 621.60646 71.632389 620.974018 76.107542 621.049532 \n",
       "C 80.582695 621.125047 85.017905 621.907572 89.248695 623.368089 \n",
       "C 93.479485 624.828606 97.452904 626.948835 101.021601 629.650149 \n",
       "C 104.590298 632.351463 107.709607 635.600053 110.263853 639.275448 \n",
       "C 112.818098 642.950843 114.77531 647.007041 116.062908 651.293624 \n",
       "C 117.350506 655.580206 117.952375 660.043521 117.846193 664.518052 \n",
       "C 117.740012 668.992582 116.92711 673.422324 115.437634 677.643006 \n",
       "C 113.948157 681.863688 111.800748 685.822483 109.07504 689.372584 \n",
       "C 106.349333 692.922685 103.079442 696.019658 99.386629 698.548656 \n",
       "C 95.693816 701.077653 91.6243 703.007022 87.328994 704.265214 \n",
       "C 83.033689 705.523405 78.566354 706.094672 74.092656 705.957828 \n",
       "C 69.618958 705.820985 65.194891 704.977745 60.984516 703.459379 \n",
       "C 56.77414 701.941012 52.830155 699.766523 49.298817 697.016551 \n",
       "C 45.767479 694.266578 42.692987 690.975541 40.189356 687.265483 \n",
       "C 42.691644 690.979179 45.765078 694.274282 49.295804 697.028726 \n",
       "C 52.82653 699.78317 56.770405 701.962516 60.981329 703.486033 \n",
       "C 65.192254 705.00955 69.61758 705.858188 74.093374 706.000511 \n",
       "C 78.569168 706.142834 83.03947 705.577063 87.33868 704.324155 \n",
       "C 91.637891 703.071247 95.712257 701.146868 99.410848 698.622305 \n",
       "C 103.109438 696.097742 106.386009 693.004559 109.119182 689.457341 \n",
       "C 111.852356 685.910124 114.007959 681.953222 115.50614 677.733217 \n",
       "C 117.00432 673.513212 117.826346 669.082865 117.941766 664.606297 \n",
       "C 118.057185 660.129728 117.464556 655.662907 116.185832 651.371305 \n",
       "C 114.907107 647.079703 112.958274 643.016975 110.411528 639.333625 \n",
       "C 107.864781 635.650275 104.751961 632.392354 101.18838 629.68055 \n",
       "C 97.6248 626.968745 93.655014 624.836963 89.42608 623.364173 \n",
       "C 85.197147 621.891383 80.76194 621.096 76.284758 621.007487 \n",
       "C 71.807577 620.918975 67.344398 621.53844 63.060559 622.842935 \n",
       "C 58.77672 624.14743 54.725779 626.120646 51.057802 628.689485 \n",
       "C 47.389825 631.258323 44.150672 634.390668 41.460335 637.970483 \n",
       "C 41.442865 637.994153 41.425415 638.017838 41.407986 638.041538 \n",
       "C 41.390557 638.065238 41.373148 638.088953 41.355759 638.112683 \n",
       "\" clip-path=\"url(#p8eaed4fdc9)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_45\">\n",
       "    <path d=\"M 39.100238 641.458033 \n",
       "C 34.888452 648.39937 32.752107 656.404151 32.945094 664.52105 \n",
       "C 33.138081 672.63795 35.652441 680.532155 40.189356 687.265483 \n",
       "C 42.692987 690.975541 45.767479 694.266578 49.298817 697.016551 \n",
       "C 52.830155 699.766523 56.77414 701.941012 60.984516 703.459379 \n",
       "C 65.194891 704.977745 69.618958 705.820985 74.092656 705.957828 \n",
       "C 78.566354 706.094672 83.033689 705.523405 87.328994 704.265214 \n",
       "C 91.6243 703.007022 95.693816 701.077653 99.386629 698.548656 \n",
       "C 103.079442 696.019658 106.349333 692.922685 109.07504 689.372584 \n",
       "C 111.800748 685.822483 113.948157 681.863688 115.437634 677.643006 \n",
       "C 116.92711 673.422324 117.740012 668.992582 117.846193 664.518052 \n",
       "C 117.952375 660.043521 117.350506 655.580206 116.062908 651.293624 \n",
       "C 114.77531 647.007041 112.818098 642.950843 110.263853 639.275448 \n",
       "C 107.709607 635.600053 104.590298 632.351463 101.021601 629.650149 \n",
       "C 97.452904 626.948835 93.479485 624.828606 89.248695 623.368089 \n",
       "C 85.017905 621.907572 80.582695 621.125047 76.107542 621.049532 \n",
       "C 71.632389 620.974018 67.173304 621.60646 62.895646 622.923404 \n",
       "C 58.617989 624.240348 54.575298 626.225312 50.917494 628.804685 \n",
       "C 47.25969 631.384058 44.032553 634.525557 41.355759 638.112683 \n",
       "C 40.958181 638.65525 40.571267 639.205551 40.195238 639.76327 \n",
       "C 39.81921 640.320989 39.45414 640.886018 39.100238 641.458033 \n",
       "\" clip-path=\"url(#p8eaed4fdc9)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_90\">\n",
       "    <!-- 225 -->\n",
       "    <g transform=\"translate(104.44738 683.770047) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_91\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(114.686766 667.312539) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_92\">\n",
       "    <!-- 479 -->\n",
       "    <g transform=\"translate(91.905934 666.968463) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_93\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(7.2 621.043488) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_94\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(96.700187 620.999182) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_95\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(46.596327 734.3554) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_96\">\n",
       "    <!-- CHEMBL217 -->\n",
       "    <g transform=\"translate(46.331014 588.475267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Dopamine) -->\n",
       "    <g transform=\"translate(47.448514 601.912642) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-6d\" d=\"M 3328 2828 \n",
       "Q 3544 3216 3844 3400 \n",
       "Q 4144 3584 4550 3584 \n",
       "Q 5097 3584 5394 3201 \n",
       "Q 5691 2819 5691 2113 \n",
       "L 5691 0 \n",
       "L 5113 0 \n",
       "L 5113 2094 \n",
       "Q 5113 2597 4934 2840 \n",
       "Q 4756 3084 4391 3084 \n",
       "Q 3944 3084 3684 2787 \n",
       "Q 3425 2491 3425 1978 \n",
       "L 3425 0 \n",
       "L 2847 0 \n",
       "L 2847 2094 \n",
       "Q 2847 2600 2669 2842 \n",
       "Q 2491 3084 2119 3084 \n",
       "Q 1678 3084 1418 2786 \n",
       "Q 1159 2488 1159 1978 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 3500 \n",
       "L 1159 3500 \n",
       "L 1159 2956 \n",
       "Q 1356 3278 1631 3431 \n",
       "Q 1906 3584 2284 3584 \n",
       "Q 2666 3584 2933 3390 \n",
       "Q 3200 3197 3328 2828 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-44\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"116.015625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-70\" x=\"177.197266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"240.673828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6d\" x=\"301.953125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"399.365234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"427.148438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"490.527344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"552.050781\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_14\">\n",
       "   <g id=\"patch_46\">\n",
       "    <path d=\"M 196.330987 628.529368 \n",
       "C 202.776548 623.056659 210.535853 619.353041 218.844408 617.783417 \n",
       "C 227.152963 616.213792 235.728631 616.831461 243.726486 619.575567 \n",
       "C 244.423887 619.791688 245.116613 620.022612 245.804197 620.268182 \n",
       "C 246.49178 620.513752 247.174065 620.773912 247.850589 621.048487 \n",
       "C 239.293216 617.24587 229.820549 615.981757 220.565482 617.407329 \n",
       "C 211.310415 618.832902 202.657224 622.88897 195.640798 629.090444 \n",
       "C 195.755019 628.99594 195.869648 628.90193 195.984681 628.808416 \n",
       "C 196.099714 628.714902 196.21515 628.621885 196.330987 628.529368 \n",
       "\" clip-path=\"url(#pfc27087ae2)\" style=\"fill: #008000; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_47\">\n",
       "    <path d=\"M 243.726486 619.575567 \n",
       "C 235.728631 616.831461 227.152963 616.213792 218.844408 617.783417 \n",
       "C 210.535853 619.353041 202.776548 623.056659 196.330987 628.529368 \n",
       "C 202.900117 623.28266 210.654905 619.72306 218.916004 618.1624 \n",
       "C 227.177104 616.60174 235.696026 617.086965 243.726486 619.575567 \n",
       "\" clip-path=\"url(#pfc27087ae2)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_48\">\n",
       "    <path d=\"M 183.294899 685.438569 \n",
       "C 180.545934 679.224182 179.125803 672.503333 179.125803 665.708084 \n",
       "C 179.125803 658.912834 180.545934 652.191986 183.294899 645.977599 \n",
       "C 184.714843 642.759925 186.477996 639.704915 188.553695 636.8657 \n",
       "C 190.629394 634.026486 193.005537 631.419621 195.640798 629.090444 \n",
       "C 191.326362 632.660088 187.622715 636.909472 184.675868 641.671069 \n",
       "C 181.729021 646.432666 179.578215 651.64307 178.308243 657.096865 \n",
       "C 177.038272 662.550661 176.666046 668.175225 177.20624 673.748815 \n",
       "C 177.746434 679.322405 179.191855 684.770801 181.485518 689.879208 \n",
       "C 183.779182 694.987615 186.890545 699.688008 190.696946 703.795078 \n",
       "C 194.503347 707.902148 198.954099 711.361205 203.873736 714.03588 \n",
       "C 208.793373 716.710555 214.116384 718.565231 219.632916 719.52679 \n",
       "C 225.149447 720.488349 230.786039 720.543986 236.320477 719.691507 \n",
       "C 241.854914 718.839029 247.213498 717.089788 252.184973 714.512745 \n",
       "C 257.156448 711.935702 261.674613 708.565174 265.561343 704.53404 \n",
       "C 269.448074 700.502906 272.651614 695.864846 275.045668 690.80271 \n",
       "C 277.439721 685.740574 278.992409 680.321771 279.642517 674.75993 \n",
       "C 280.292625 669.198089 280.031498 663.567274 278.869428 658.089472 \n",
       "C 277.707359 652.611671 275.659823 647.359827 272.807541 642.540989 \n",
       "C 269.955259 637.72215 266.336214 633.400486 262.093082 629.746373 \n",
       "C 257.84995 626.09226 253.039233 623.154357 247.850589 621.048487 \n",
       "C 255.103179 624.271301 261.462714 629.212827 266.377458 635.444351 \n",
       "C 271.292201 641.675876 274.615791 649.011822 276.059881 656.815744 \n",
       "C 277.503972 664.619667 277.025557 672.659162 274.666144 680.236745 \n",
       "C 272.306731 687.814329 268.136584 694.704338 262.517492 700.309015 \n",
       "C 256.8984 705.913692 249.997702 710.066128 242.414083 712.406069 \n",
       "C 234.830464 714.74601 226.789766 715.203772 218.989579 713.739641 \n",
       "C 211.189392 712.27551 203.862007 708.933088 197.643127 704.002354 \n",
       "C 191.424247 699.07162 186.499073 692.699413 183.294899 685.438569 \n",
       "\" clip-path=\"url(#pfc27087ae2)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_49\">\n",
       "    <path d=\"M 183.294899 645.977599 \n",
       "C 184.777453 642.626096 186.633044 639.452346 188.826509 636.51649 \n",
       "C 191.019973 633.580634 193.537368 630.901335 196.330987 628.529368 \n",
       "C 196.21515 628.621885 196.099714 628.714902 195.984681 628.808416 \n",
       "C 195.869648 628.90193 195.755019 628.99594 195.640798 629.090444 \n",
       "C 193.005537 631.419621 190.629394 634.026486 188.553695 636.8657 \n",
       "C 186.477996 639.704915 184.714843 642.759925 183.294899 645.977599 \n",
       "M 183.294899 685.438569 \n",
       "C 186.499073 692.699413 191.424247 699.07162 197.643127 704.002354 \n",
       "C 203.862007 708.933088 211.189392 712.27551 218.989579 713.739641 \n",
       "C 226.789766 715.203772 234.830464 714.74601 242.414083 712.406069 \n",
       "C 249.997702 710.066128 256.8984 705.913692 262.517492 700.309015 \n",
       "C 268.136584 694.704338 272.306731 687.814329 274.666144 680.236745 \n",
       "C 277.025557 672.659162 277.503972 664.619667 276.059881 656.815744 \n",
       "C 274.615791 649.011822 271.292201 641.675876 266.377458 635.444351 \n",
       "C 261.462714 629.212827 255.103179 624.271301 247.850589 621.048487 \n",
       "C 247.174065 620.773912 246.49178 620.513752 245.804197 620.268182 \n",
       "C 245.116613 620.022612 244.423887 619.791688 243.726486 619.575567 \n",
       "C 251.387514 622.204106 258.27447 626.70006 263.763283 632.656023 \n",
       "C 269.252095 638.611986 273.171808 645.842451 275.167231 653.692218 \n",
       "C 277.162654 661.541985 277.171637 669.766563 275.193365 677.620671 \n",
       "C 273.215093 685.474778 269.311183 692.713787 263.835393 698.681725 \n",
       "C 258.359603 704.649663 251.482484 709.16065 243.827217 711.805917 \n",
       "C 236.171949 714.451183 227.976966 715.148339 219.984869 713.83421 \n",
       "C 211.992771 712.520081 204.452483 709.235598 198.04728 704.278388 \n",
       "C 191.642076 699.321179 186.571455 692.845642 183.294899 685.438569 \n",
       "\" clip-path=\"url(#pfc27087ae2)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_50\">\n",
       "    <path d=\"M 183.294899 685.438569 \n",
       "C 186.571455 692.845642 191.642076 699.321179 198.04728 704.278388 \n",
       "C 204.452483 709.235598 211.992771 712.520081 219.984869 713.83421 \n",
       "C 227.976966 715.148339 236.171949 714.451183 243.827217 711.805917 \n",
       "C 251.482484 709.16065 258.359603 704.649663 263.835393 698.681725 \n",
       "C 269.311183 692.713787 273.215093 685.474778 275.193365 677.620671 \n",
       "C 277.171637 669.766563 277.162654 661.541985 275.167231 653.692218 \n",
       "C 273.171808 645.842451 269.252095 638.611986 263.763283 632.656023 \n",
       "C 258.27447 626.70006 251.387514 622.204106 243.726486 619.575567 \n",
       "C 235.696026 617.086965 227.177104 616.60174 218.916004 618.1624 \n",
       "C 210.654905 619.72306 202.900117 623.28266 196.330987 628.529368 \n",
       "C 193.537368 630.901335 191.019973 633.580634 188.826509 636.51649 \n",
       "C 186.633044 639.452346 184.777453 642.626096 183.294899 645.977599 \n",
       "C 180.55183 652.193554 179.134943 658.913783 179.134943 665.708084 \n",
       "C 179.134943 672.502385 180.55183 679.222614 183.294899 685.438569 \n",
       "\" clip-path=\"url(#pfc27087ae2)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_97\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(217.358526 620.530588) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_98\">\n",
       "    <!-- 3 -->\n",
       "    <g transform=\"translate(215.698956 620.732283) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_99\">\n",
       "    <!-- 198 -->\n",
       "    <g transform=\"translate(230.000316 707.389799) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_100\">\n",
       "    <!-- 6 -->\n",
       "    <g transform=\"translate(259.816086 701.396135) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_101\">\n",
       "    <!-- 1737 -->\n",
       "    <g transform=\"translate(227.328768 679.923971) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_102\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(156.554491 616.93571) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_103\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(252.440515 616.837703) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_104\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(192.161544 734.561297) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_105\">\n",
       "    <!-- CHEMBL222 -->\n",
       "    <g transform=\"translate(191.896232 588.260584) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Ephrin) -->\n",
       "    <g transform=\"translate(204.457794 601.697959) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-70\" x=\"102.197266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"165.673828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"229.052734\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"270.166016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"297.949219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"361.328125\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_15\">\n",
       "   <g id=\"patch_51\">\n",
       "    <path d=\"M 331.779514 639.110212 \n",
       "C 334.519114 634.637004 338.047477 630.697565 342.192959 627.483536 \n",
       "C 346.338441 624.269508 351.032712 621.833866 356.04741 620.295099 \n",
       "C 356.240516 620.223104 356.434051 620.152269 356.628007 620.082597 \n",
       "C 356.821963 620.012924 357.016335 619.944417 357.211113 619.877077 \n",
       "C 351.933009 621.348491 346.980242 623.804298 342.614109 627.114935 \n",
       "C 338.247975 630.425572 334.54663 634.531778 331.705347 639.21692 \n",
       "C 331.717686 639.19912 331.730036 639.181327 331.742397 639.163543 \n",
       "C 331.754758 639.145758 331.76713 639.127981 331.779514 639.110212 \n",
       "\" clip-path=\"url(#p4121c6a7af)\" style=\"fill: #008000; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_52\">\n",
       "    <path d=\"M 356.04741 620.295099 \n",
       "C 351.032712 621.833866 346.338441 624.269508 342.192959 627.483536 \n",
       "C 338.047477 630.697565 334.519114 634.637004 331.779514 639.110212 \n",
       "C 334.756545 634.838499 338.36407 631.042709 342.478948 627.852408 \n",
       "C 346.593827 624.662106 351.1687 622.114011 356.04741 620.295099 \n",
       "\" clip-path=\"url(#p4121c6a7af)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_53\">\n",
       "    <path d=\"M 328.82025 678.666926 \n",
       "C 326.5584 673.319799 325.392854 667.572608 325.392854 661.766772 \n",
       "C 325.392854 655.960937 326.5584 650.213746 328.82025 644.866619 \n",
       "C 329.23155 643.891464 329.678311 642.931649 330.159641 641.989091 \n",
       "C 330.640972 641.046533 331.15655 640.12186 331.705347 639.21692 \n",
       "C 328.241055 644.214628 325.68888 649.786486 324.16722 655.674012 \n",
       "C 322.64556 661.561537 322.178316 667.672257 322.787163 673.722687 \n",
       "C 323.396009 679.773118 325.071385 685.668228 327.735566 691.134538 \n",
       "C 330.399747 696.600848 334.010889 701.5525 338.401467 705.759782 \n",
       "C 342.792045 709.967065 347.893099 713.363896 353.467985 715.792693 \n",
       "C 359.042871 718.221489 365.004026 719.644104 371.074907 719.994539 \n",
       "C 377.145789 720.344975 383.231043 719.617727 389.048369 717.846534 \n",
       "C 394.865695 716.075342 400.323722 713.288023 405.169247 709.613886 \n",
       "C 410.014773 705.939748 414.17169 701.436499 417.447154 696.313049 \n",
       "C 420.722618 691.189599 423.065184 685.526421 424.366177 679.586234 \n",
       "C 425.667171 673.646047 425.906157 667.522152 425.07205 661.498642 \n",
       "C 424.237942 655.475132 422.343842 649.646617 419.477619 644.283486 \n",
       "C 416.611396 638.920356 412.818068 634.106847 408.273611 630.066263 \n",
       "C 403.729154 626.025679 398.504947 622.821484 392.843346 620.602323 \n",
       "C 387.181744 618.383163 381.171673 617.183893 375.091945 617.060148 \n",
       "C 369.012217 616.936404 362.958324 617.890128 357.211113 619.877077 \n",
       "C 365.268364 617.630901 373.805119 617.756367 381.79288 620.238358 \n",
       "C 389.780641 622.720349 396.885203 627.45502 402.250619 633.871944 \n",
       "C 407.616036 640.288868 411.017818 648.119564 412.046125 656.420599 \n",
       "C 413.074432 664.721635 411.686239 673.145698 408.048794 680.677869 \n",
       "C 404.411349 688.21004 398.676842 694.535176 391.536157 698.891232 \n",
       "C 384.395472 703.247289 376.147374 705.45201 367.785582 705.239775 \n",
       "C 359.42379 705.02754 351.298159 702.407228 344.387654 697.69453 \n",
       "C 337.477148 692.981832 332.070901 686.373927 328.82025 678.666926 \n",
       "\" clip-path=\"url(#p4121c6a7af)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_54\">\n",
       "    <path d=\"M 328.82025 644.866619 \n",
       "C 329.240952 643.872058 329.698645 642.893552 330.192372 641.933147 \n",
       "C 330.686098 640.972742 331.215515 640.031108 331.779514 639.110212 \n",
       "C 331.76713 639.127981 331.754758 639.145758 331.742397 639.163543 \n",
       "C 331.730036 639.181327 331.717686 639.19912 331.705347 639.21692 \n",
       "C 331.15655 640.12186 330.640972 641.046533 330.159641 641.989091 \n",
       "C 329.678311 642.931649 329.23155 643.891464 328.82025 644.866619 \n",
       "M 328.82025 678.666926 \n",
       "C 332.070901 686.373927 337.477148 692.981832 344.387654 697.69453 \n",
       "C 351.298159 702.407228 359.42379 705.02754 367.785582 705.239775 \n",
       "C 376.147374 705.45201 384.395472 703.247289 391.536157 698.891232 \n",
       "C 398.676842 694.535176 404.411349 688.21004 408.048794 680.677869 \n",
       "C 411.686239 673.145698 413.074432 664.721635 412.046125 656.420599 \n",
       "C 411.017818 648.119564 407.616036 640.288868 402.250619 633.871944 \n",
       "C 396.885203 627.45502 389.780641 622.720349 381.79288 620.238358 \n",
       "C 373.805119 617.756367 365.268364 617.630901 357.211113 619.877077 \n",
       "C 357.016335 619.944417 356.821963 620.012924 356.628007 620.082597 \n",
       "C 356.434051 620.152269 356.240516 620.223104 356.04741 620.295099 \n",
       "C 364.068016 617.833964 372.63295 617.751659 380.699371 620.058204 \n",
       "C 388.765793 622.36475 395.992471 626.962573 401.499509 633.291857 \n",
       "C 407.006547 639.621142 410.560982 647.414142 411.730038 655.722007 \n",
       "C 412.899093 664.029871 411.633315 672.501156 408.08682 680.104424 \n",
       "C 404.540325 687.707692 398.863139 694.121304 391.7465 698.56436 \n",
       "C 384.62986 703.007416 376.374818 705.291963 367.986483 705.13984 \n",
       "C 359.598148 704.987718 351.431368 702.405362 344.480504 697.707192 \n",
       "C 337.529641 693.009022 332.088733 686.393783 328.82025 678.666926 \n",
       "\" clip-path=\"url(#p4121c6a7af)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_55\">\n",
       "    <path d=\"M 328.82025 678.666926 \n",
       "C 332.088733 686.393783 337.529641 693.009022 344.480504 697.707192 \n",
       "C 351.431368 702.405362 359.598148 704.987718 367.986483 705.13984 \n",
       "C 376.374818 705.291963 384.62986 703.007416 391.7465 698.56436 \n",
       "C 398.863139 694.121304 404.540325 687.707692 408.08682 680.104424 \n",
       "C 411.633315 672.501156 412.899093 664.029871 411.730038 655.722007 \n",
       "C 410.560982 647.414142 407.006547 639.621142 401.499509 633.291857 \n",
       "C 395.992471 626.962573 388.765793 622.36475 380.699371 620.058204 \n",
       "C 372.63295 617.751659 364.068016 617.833964 356.04741 620.295099 \n",
       "C 351.1687 622.114011 346.593827 624.662106 342.478948 627.852408 \n",
       "C 338.36407 631.042709 334.756545 634.838499 331.779514 639.110212 \n",
       "C 331.215515 640.031108 330.686098 640.972742 330.192372 641.933147 \n",
       "C 329.698645 642.893552 329.240952 643.872058 328.82025 644.866619 \n",
       "C 326.564309 650.215253 325.401991 655.961848 325.401991 661.766772 \n",
       "C 325.401991 667.571697 326.564309 673.318292 328.82025 678.666926 \n",
       "\" clip-path=\"url(#p4121c6a7af)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_106\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(339.435674 629.95962) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_107\">\n",
       "    <!-- 8 -->\n",
       "    <g transform=\"translate(339.154704 630.427347) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-38\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_108\">\n",
       "    <!-- 1982 -->\n",
       "    <g transform=\"translate(386.935975 696.201775) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_109\">\n",
       "    <!-- 23 -->\n",
       "    <g transform=\"translate(401.571427 682.992727) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"63.623047\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_110\">\n",
       "    <!-- 4860 -->\n",
       "    <g transform=\"translate(376.320352 674.431619) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_111\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(300.125454 618.386573) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_112\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(390.632496 618.279769) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_113\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(337.726762 734.34981) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_114\">\n",
       "    <!-- CHEMBL203 -->\n",
       "    <g transform=\"translate(337.461449 588.475267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (erbB1) -->\n",
       "    <g transform=\"translate(351.460199 601.912642) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"100.537109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-62\" x=\"141.650391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"205.126953\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"273.730469\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"337.353516\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_16\">\n",
       "   <g id=\"patch_56\">\n",
       "    <path d=\"M 477.540448 637.995128 \n",
       "C 475.853077 640.292624 474.397541 642.7517 473.195192 645.336283 \n",
       "C 471.992843 647.920866 471.049588 650.618255 470.379266 653.388883 \n",
       "C 471.914573 648.408461 474.196812 643.689738 477.147935 639.394083 \n",
       "C 480.099058 635.098429 483.685035 631.275377 487.783234 628.055666 \n",
       "C 485.815229 629.413805 483.963635 630.933339 482.247621 632.598536 \n",
       "C 480.531607 634.263733 478.957115 636.068826 477.540448 637.995128 \n",
       "\" clip-path=\"url(#p2fe254bcf8)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_57\">\n",
       "    <path d=\"M 470.342031 653.5102 \n",
       "C 468.558643 659.346408 467.826406 665.45335 468.179529 671.545731 \n",
       "C 468.532652 677.638112 469.965548 683.61956 472.411278 689.210642 \n",
       "C 474.857008 694.801725 478.276884 699.914 482.511141 704.308641 \n",
       "C 486.745399 708.703281 491.727058 712.310771 497.223394 714.96258 \n",
       "C 502.71973 717.614389 508.643799 719.26857 514.718849 719.847846 \n",
       "C 520.7939 720.427122 526.923834 719.922329 532.822283 718.35705 \n",
       "C 538.720732 716.791771 544.294392 714.190766 549.28288 710.675545 \n",
       "C 554.271369 707.160323 558.595776 702.786491 562.054081 697.758377 \n",
       "C 565.512386 692.730263 568.049884 687.127406 569.548031 681.21155 \n",
       "C 571.046179 675.295693 571.481278 669.160419 570.833002 663.092343 \n",
       "C 570.184726 657.024268 568.46333 651.11938 565.749232 645.653534 \n",
       "C 563.035133 640.187688 559.371265 635.247347 554.92879 631.063304 \n",
       "C 550.486314 626.879261 545.335506 623.517702 539.716991 621.135668 \n",
       "C 534.098476 618.753633 528.101131 617.388803 522.00513 617.104937 \n",
       "C 515.90913 616.821071 509.810904 617.62266 503.995339 619.472256 \n",
       "C 498.179774 621.321852 492.738864 624.190198 487.926789 627.943294 \n",
       "C 494.91569 623.154366 503.162739 620.528439 511.633908 620.394757 \n",
       "C 520.105076 620.261075 528.430878 622.625468 535.567407 627.191485 \n",
       "C 542.703937 631.757501 548.339923 638.325986 551.768713 646.07337 \n",
       "C 555.197504 653.820755 556.269546 662.409122 554.850426 670.761646 \n",
       "C 553.431306 679.11417 549.582922 686.866541 543.787789 693.046752 \n",
       "C 537.992657 699.226963 530.503543 703.565453 522.259446 705.518253 \n",
       "C 514.015348 707.471053 505.37585 706.952989 497.424187 704.029017 \n",
       "C 489.472523 701.105044 482.555521 695.902698 477.540448 689.074257 \n",
       "C 473.827803 684.02602 471.260202 678.228418 470.017037 672.086515 \n",
       "C 468.773872 665.944612 468.884787 659.604859 470.342031 653.5102 \n",
       "\" clip-path=\"url(#p2fe254bcf8)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_58\">\n",
       "    <path d=\"M 487.783234 628.055666 \n",
       "C 494.754106 623.245001 502.990567 620.593813 511.45876 620.434883 \n",
       "C 519.926953 620.275954 528.257092 622.616224 535.403563 627.161937 \n",
       "C 542.550033 631.707651 548.200765 638.260308 551.646468 645.997406 \n",
       "C 555.092171 653.734504 556.182378 662.318182 554.780246 670.671 \n",
       "C 553.378114 679.023819 549.544869 686.78103 543.761669 692.968933 \n",
       "C 537.978468 699.156836 530.497851 703.50522 522.258798 705.468268 \n",
       "C 514.019745 707.431316 505.382036 706.923305 497.429894 704.008003 \n",
       "C 489.477752 701.092701 482.558427 695.897411 477.540448 689.074257 \n",
       "C 482.555521 695.902698 489.472523 701.105044 497.424187 704.029017 \n",
       "C 505.37585 706.952989 514.015348 707.471053 522.259446 705.518253 \n",
       "C 530.503543 703.565453 537.992657 699.226963 543.787789 693.046752 \n",
       "C 549.582922 686.866541 553.431306 679.11417 554.850426 670.761646 \n",
       "C 556.269546 662.409122 555.197504 653.820755 551.768713 646.07337 \n",
       "C 548.339923 638.325986 542.703937 631.757501 535.567407 627.191485 \n",
       "C 528.430878 622.625468 520.105076 620.261075 511.633908 620.394757 \n",
       "C 503.162739 620.528439 494.91569 623.154366 487.926789 627.943294 \n",
       "C 487.90283 627.961981 487.878888 627.980688 487.854962 627.999417 \n",
       "C 487.831036 628.018145 487.807127 628.036895 487.783234 628.055666 \n",
       "\" clip-path=\"url(#p2fe254bcf8)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_59\">\n",
       "    <path d=\"M 470.379266 653.388883 \n",
       "C 468.900903 659.499364 468.775802 665.859771 470.012743 672.023659 \n",
       "C 471.249685 678.187547 473.819035 684.007244 477.540448 689.074257 \n",
       "C 482.558427 695.897411 489.477752 701.092701 497.429894 704.008003 \n",
       "C 505.382036 706.923305 514.019745 707.431316 522.258798 705.468268 \n",
       "C 530.497851 703.50522 537.978468 699.156836 543.761669 692.968933 \n",
       "C 549.544869 686.78103 553.378114 679.023819 554.780246 670.671 \n",
       "C 556.182378 662.318182 555.092171 653.734504 551.646468 645.997406 \n",
       "C 548.200765 638.260308 542.550033 631.707651 535.403563 627.161937 \n",
       "C 528.257092 622.616224 519.926953 620.275954 511.45876 620.434883 \n",
       "C 502.990567 620.593813 494.754106 623.245001 487.783234 628.055666 \n",
       "C 483.685035 631.275377 480.099058 635.098429 477.147935 639.394083 \n",
       "C 474.196812 643.689738 471.914573 648.408461 470.379266 653.388883 \n",
       "\" clip-path=\"url(#p2fe254bcf8)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_115\">\n",
       "    <!-- 3 -->\n",
       "    <g transform=\"translate(474.064577 642.223349) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_116\">\n",
       "    <!-- 730 -->\n",
       "    <g transform=\"translate(542.378846 687.269799) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-37\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_117\">\n",
       "    <!-- 3 -->\n",
       "    <g transform=\"translate(551.608775 673.459544) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_118\">\n",
       "    <!-- 1702 -->\n",
       "    <g transform=\"translate(522.433196 670.545002) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_119\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(443.756449 620.427293) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_120\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(533.887346 620.389386) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_121\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(483.291979 734.350146) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_122\">\n",
       "    <!-- CHEMBL206 -->\n",
       "    <g transform=\"translate(483.026666 588.475267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Estrogen) -->\n",
       "    <g transform=\"translate(488.351666 601.912642) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"102.197266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"154.296875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"193.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"232.369141\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"293.550781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"357.027344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"418.550781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"481.929688\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_17\">\n",
       "   <g id=\"patch_60\">\n",
       "    <path d=\"M 82.913202 807.018235 \n",
       "C 80.011781 807.01851 77.116312 807.280994 74.26214 807.802484 \n",
       "C 71.407969 808.323974 68.606757 809.102338 65.892699 810.128074 \n",
       "C 71.363017 808.213276 77.117442 807.235246 82.913202 807.235246 \n",
       "C 88.708961 807.235246 94.463387 808.213276 99.933704 810.128074 \n",
       "C 97.219646 809.102338 94.418434 808.323974 91.564263 807.802484 \n",
       "C 88.710092 807.280994 85.814623 807.01851 82.913202 807.018235 \n",
       "\" clip-path=\"url(#pd2dca8678b)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_61\">\n",
       "    <path d=\"M 65.768609 810.171688 \n",
       "C 60.081565 812.178662 54.790852 815.168737 50.137904 819.005466 \n",
       "C 45.484957 822.842194 41.541645 827.466314 38.487916 832.666809 \n",
       "C 35.434187 837.867304 33.31721 843.563847 32.233589 849.496483 \n",
       "C 31.149969 855.42912 31.116444 861.506213 32.134543 867.450444 \n",
       "C 33.152642 873.394675 35.20664 879.114228 38.202805 884.348099 \n",
       "C 41.198971 889.581969 45.091025 894.249314 49.701358 898.137146 \n",
       "C 54.311691 902.024977 59.569093 905.073243 65.233647 907.14284 \n",
       "C 70.898201 909.212437 76.882413 910.271398 82.913202 910.271398 \n",
       "C 88.94399 910.271398 94.928202 909.212437 100.592757 907.14284 \n",
       "C 106.257311 905.073243 111.514712 902.024977 116.125046 898.137146 \n",
       "C 120.735379 894.249314 124.627433 889.581969 127.623598 884.348099 \n",
       "C 130.619764 879.114228 132.673762 873.394675 133.691861 867.450444 \n",
       "C 134.70996 861.506213 134.676434 855.42912 133.592814 849.496483 \n",
       "C 132.509194 843.563847 130.392216 837.867304 127.338488 832.666809 \n",
       "C 124.284759 827.466314 120.341447 822.842194 115.688499 819.005466 \n",
       "C 111.035551 815.168737 105.744839 812.178662 100.057795 810.171688 \n",
       "C 110.578945 814.178725 119.368956 821.751102 124.889131 831.563269 \n",
       "C 130.409305 841.375436 132.31758 852.819373 130.279909 863.891809 \n",
       "C 128.242239 874.964245 122.38489 884.979067 113.733196 892.183173 \n",
       "C 105.081503 899.387278 94.171574 903.334258 82.913202 903.33319 \n",
       "C 71.65483 903.334258 60.744901 899.387278 52.093207 892.183173 \n",
       "C 43.441513 884.979067 37.584164 874.964245 35.546494 863.891809 \n",
       "C 33.508824 852.819373 35.417099 841.375436 40.937273 831.563269 \n",
       "C 46.457447 821.751102 55.247458 814.178725 65.768609 810.171688 \n",
       "\" clip-path=\"url(#pd2dca8678b)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_62\">\n",
       "    <path d=\"M 65.768609 810.171688 \n",
       "C 55.247458 814.178725 46.457447 821.751102 40.937273 831.563269 \n",
       "C 35.417099 841.375436 33.508824 852.819373 35.546494 863.891809 \n",
       "C 37.584164 874.964245 43.441513 884.979067 52.093207 892.183173 \n",
       "C 60.744901 899.387278 71.65483 903.334258 82.913202 903.33319 \n",
       "C 71.645064 903.332122 60.727033 899.37622 52.073465 892.159109 \n",
       "C 43.419897 884.941998 37.567957 874.911675 35.54372 863.826848 \n",
       "C 33.519482 852.742021 35.448599 841.290774 40.992822 831.480956 \n",
       "C 46.537044 821.671138 55.352218 814.111689 65.892699 810.128074 \n",
       "C 65.872008 810.135317 65.851322 810.142573 65.83064 810.149842 \n",
       "C 65.809958 810.157111 65.789281 810.164393 65.768609 810.171688 \n",
       "\" clip-path=\"url(#pd2dca8678b)\" style=\"fill: #b200b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_63\">\n",
       "    <path d=\"M 99.933704 810.128074 \n",
       "C 110.474185 814.111689 119.289359 821.671138 124.833582 831.480956 \n",
       "C 130.377805 841.290774 132.306922 852.742021 130.282684 863.826848 \n",
       "C 128.258446 874.911675 122.406507 884.941998 113.752939 892.159109 \n",
       "C 105.099371 899.37622 94.181339 903.332122 82.913202 903.33319 \n",
       "C 94.171574 903.334258 105.081503 899.387278 113.733196 892.183173 \n",
       "C 122.38489 884.979067 128.242239 874.964245 130.279909 863.891809 \n",
       "C 132.31758 852.819373 130.409305 841.375436 124.889131 831.563269 \n",
       "C 119.368956 821.751102 110.578945 814.178725 100.057795 810.171688 \n",
       "C 100.037122 810.164393 100.016445 810.157111 99.995763 810.149842 \n",
       "C 99.975082 810.142573 99.954395 810.135317 99.933704 810.128074 \n",
       "\" clip-path=\"url(#pd2dca8678b)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_64\">\n",
       "    <path d=\"M 65.892699 810.128074 \n",
       "C 55.352218 814.111689 46.537044 821.671138 40.992822 831.480956 \n",
       "C 35.448599 841.290774 33.519482 852.742021 35.54372 863.826848 \n",
       "C 37.567957 874.911675 43.419897 884.941998 52.073465 892.159109 \n",
       "C 60.727033 899.37622 71.645064 903.332122 82.913202 903.33319 \n",
       "C 94.181339 903.332122 105.099371 899.37622 113.752939 892.159109 \n",
       "C 122.406507 884.941998 128.258446 874.911675 130.282684 863.826848 \n",
       "C 132.306922 852.742021 130.377805 841.290774 124.833582 831.480956 \n",
       "C 119.289359 821.671138 110.474185 814.111689 99.933704 810.128074 \n",
       "C 94.463387 808.213276 88.708961 807.235246 82.913202 807.235246 \n",
       "C 77.117442 807.235246 71.363017 808.213276 65.892699 810.128074 \n",
       "\" clip-path=\"url(#pd2dca8678b)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_123\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(79.731952 810.288212) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_124\">\n",
       "    <!-- 210 -->\n",
       "    <g transform=\"translate(73.369452 889.942965) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_125\">\n",
       "    <!-- 0 -->\n",
       "    <g transform=\"translate(32.377762 866.594029) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_126\">\n",
       "    <!-- 0 -->\n",
       "    <g transform=\"translate(127.086141 866.594029) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_127\">\n",
       "    <!-- 1446 -->\n",
       "    <g transform=\"translate(70.188202 860.472801) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_128\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(11.872396 807.018235) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_129\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(106.996508 807.018235) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_130\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(46.596327 924.54133) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_131\">\n",
       "    <!-- CHEMBL2034 -->\n",
       "    <g transform=\"translate(42.513514 778.446762) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (Glucocorticoid) -->\n",
       "    <g transform=\"translate(35.240389 791.884137) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-47\" d=\"M 3809 666 \n",
       "L 3809 1919 \n",
       "L 2778 1919 \n",
       "L 2778 2438 \n",
       "L 4434 2438 \n",
       "L 4434 434 \n",
       "Q 4069 175 3628 42 \n",
       "Q 3188 -91 2688 -91 \n",
       "Q 1594 -91 976 548 \n",
       "Q 359 1188 359 2328 \n",
       "Q 359 3472 976 4111 \n",
       "Q 1594 4750 2688 4750 \n",
       "Q 3144 4750 3555 4637 \n",
       "Q 3966 4525 4313 4306 \n",
       "L 4313 3634 \n",
       "Q 3963 3931 3569 4081 \n",
       "Q 3175 4231 2741 4231 \n",
       "Q 1884 4231 1454 3753 \n",
       "Q 1025 3275 1025 2328 \n",
       "Q 1025 1384 1454 906 \n",
       "Q 1884 428 2741 428 \n",
       "Q 3075 428 3337 486 \n",
       "Q 3600 544 3809 666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-47\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"116.503906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-75\" x=\"144.287109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"207.666016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"262.646484\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"323.828125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"378.808594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"439.990234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"481.103516\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"520.3125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"548.095703\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"603.076172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"664.257812\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"692.041016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"755.517578\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_18\">\n",
       "   <g id=\"patch_65\">\n",
       "    <path d=\"M 189.45298 825.008994 \n",
       "C 185.097785 830.062042 181.765168 835.913195 179.640638 842.236753 \n",
       "C 177.516108 848.560311 176.63983 855.236722 177.060582 861.894348 \n",
       "C 177.481334 868.551974 179.191162 875.064947 182.094888 881.070726 \n",
       "C 184.998614 887.076506 189.041342 892.461548 193.998035 896.926098 \n",
       "C 198.954728 901.390648 204.731677 904.8503 211.007311 907.112474 \n",
       "C 217.282945 909.374648 223.938619 910.396576 230.603848 910.121374 \n",
       "C 237.269077 909.846171 243.81785 908.279041 249.885634 905.507217 \n",
       "C 255.953418 902.735392 261.425497 898.811276 265.99727 893.953303 \n",
       "C 270.569043 889.09533 274.154079 883.395343 276.552817 877.170629 \n",
       "C 278.951555 870.945915 280.118646 864.314155 279.989125 857.644505 \n",
       "C 279.859604 850.974855 278.435919 844.393407 275.797319 838.266515 \n",
       "C 273.158719 832.139624 269.355089 826.58312 264.598155 821.906306 \n",
       "C 259.841221 817.229492 254.220917 813.520784 248.050094 810.986627 \n",
       "C 241.87927 808.45247 235.274592 807.140773 228.603703 807.124551 \n",
       "C 221.932815 807.108329 215.321835 808.387889 209.13876 810.892004 \n",
       "C 202.955685 813.39612 197.31741 817.07745 192.537787 821.731073 \n",
       "C 195.600799 818.798302 199.080546 816.334309 202.864074 814.419078 \n",
       "C 206.647602 812.503847 210.693523 811.158328 214.870505 810.426197 \n",
       "C 219.047486 809.694065 223.309838 809.583331 227.5192 810.097588 \n",
       "C 231.728562 810.611845 235.838891 811.745467 239.716762 813.461658 \n",
       "C 243.594632 815.177849 247.197626 817.457834 250.408789 820.227605 \n",
       "C 253.619951 822.997375 256.404155 826.226634 258.671024 829.810556 \n",
       "C 260.937893 833.394477 262.66263 837.29386 263.78925 841.382126 \n",
       "C 264.91587 845.470392 265.432048 849.702822 265.32103 853.942027 \n",
       "C 265.210011 858.181233 264.47301 862.380844 263.13395 866.404538 \n",
       "C 261.79489 870.428231 259.868419 874.231994 257.41707 877.692352 \n",
       "C 254.965722 881.152711 252.016311 884.231814 248.664578 886.829713 \n",
       "C 245.312844 889.427611 241.595452 891.515886 237.633069 893.026752 \n",
       "C 233.670687 894.537618 229.506657 895.454548 225.276148 895.747777 \n",
       "C 221.045639 896.041006 216.794926 895.707327 212.661991 894.757571 \n",
       "C 208.529055 893.807816 204.559106 892.252372 200.88101 890.141733 \n",
       "C 197.202914 888.031093 193.856904 885.388343 190.951596 882.29927 \n",
       "C 183.707305 874.605027 179.546895 864.504403 179.27055 853.940088 \n",
       "C 178.994206 843.375773 182.620858 833.071453 189.45298 825.008994 \n",
       "\" clip-path=\"url(#p00eef3b23f)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_66\">\n",
       "    <path d=\"M 192.435296 821.83114 \n",
       "C 195.489895 818.890187 198.962675 816.417043 202.740802 814.492064 \n",
       "C 206.518928 812.567085 210.561033 811.211347 214.735785 810.468901 \n",
       "C 218.910538 809.726454 223.172227 809.605427 227.382386 810.109753 \n",
       "C 231.592545 810.614079 235.705076 811.738235 239.586359 813.445696 \n",
       "C 243.467642 815.153158 247.07518 817.425229 250.291761 820.188089 \n",
       "C 253.508341 822.950948 256.298745 826.174345 258.572309 829.753548 \n",
       "C 260.845873 833.33275 262.577704 837.228569 263.711532 841.314424 \n",
       "C 264.845361 845.40028 265.368772 849.631436 265.264761 853.870418 \n",
       "C 265.160749 858.109399 264.430454 862.309793 263.097602 866.335124 \n",
       "C 261.76475 870.360455 259.843936 874.166649 257.397568 877.630039 \n",
       "C 254.951201 881.093429 252.006066 884.176093 248.657854 886.777873 \n",
       "C 245.309642 889.379653 241.595013 891.472062 237.634659 892.987113 \n",
       "C 233.674306 894.502165 229.51159 895.423273 225.281763 895.720507 \n",
       "C 221.051936 896.017742 216.801311 895.687849 212.667996 894.741548 \n",
       "C 208.53468 893.795247 204.56393 892.242899 200.88476 890.134941 \n",
       "C 197.205589 888.026983 193.858282 885.386495 190.951596 882.29927 \n",
       "C 193.856904 885.388343 197.202914 888.031093 200.88101 890.141733 \n",
       "C 204.559106 892.252372 208.529055 893.807816 212.661991 894.757571 \n",
       "C 216.794926 895.707327 221.045639 896.041006 225.276148 895.747777 \n",
       "C 229.506657 895.454548 233.670687 894.537618 237.633069 893.026752 \n",
       "C 241.595452 891.515886 245.312844 889.427611 248.664578 886.829713 \n",
       "C 252.016311 884.231814 254.965722 881.152711 257.41707 877.692352 \n",
       "C 259.868419 874.231994 261.79489 870.428231 263.13395 866.404538 \n",
       "C 264.47301 862.380844 265.210011 858.181233 265.32103 853.942027 \n",
       "C 265.432048 849.702822 264.91587 845.470392 263.78925 841.382126 \n",
       "C 262.66263 837.29386 260.937893 833.394477 258.671024 829.810556 \n",
       "C 256.404155 826.226634 253.619951 822.997375 250.408789 820.227605 \n",
       "C 247.197626 817.457834 243.594632 815.177849 239.716762 813.461658 \n",
       "C 235.838891 811.745467 231.728562 810.611845 227.5192 810.097588 \n",
       "C 223.309838 809.583331 219.047486 809.694065 214.870505 810.426197 \n",
       "C 210.693523 811.158328 206.647602 812.503847 202.864074 814.419078 \n",
       "C 199.080546 816.334309 195.600799 818.798302 192.537787 821.731073 \n",
       "C 192.520682 821.747727 192.503589 821.764393 192.486507 821.781071 \n",
       "C 192.469425 821.797749 192.452355 821.814439 192.435296 821.83114 \n",
       "\" clip-path=\"url(#p00eef3b23f)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_67\">\n",
       "    <path d=\"M 189.541723 824.906305 \n",
       "C 182.674219 832.967131 179.017896 843.285836 179.277953 853.872237 \n",
       "C 179.538011 864.458638 183.696581 874.585368 190.951596 882.29927 \n",
       "C 193.858282 885.386495 197.205589 888.026983 200.88476 890.134941 \n",
       "C 204.56393 892.242899 208.53468 893.795247 212.667996 894.741548 \n",
       "C 216.801311 895.687849 221.051936 896.017742 225.281763 895.720507 \n",
       "C 229.51159 895.423273 233.674306 894.502165 237.634659 892.987113 \n",
       "C 241.595013 891.472062 245.309642 889.379653 248.657854 886.777873 \n",
       "C 252.006066 884.176093 254.951201 881.093429 257.397568 877.630039 \n",
       "C 259.843936 874.166649 261.76475 870.360455 263.097602 866.335124 \n",
       "C 264.430454 862.309793 265.160749 858.109399 265.264761 853.870418 \n",
       "C 265.368772 849.631436 264.845361 845.40028 263.711532 841.314424 \n",
       "C 262.577704 837.228569 260.845873 833.33275 258.572309 829.753548 \n",
       "C 256.298745 826.174345 253.508341 822.950948 250.291761 820.188089 \n",
       "C 247.07518 817.425229 243.467642 815.153158 239.586359 813.445696 \n",
       "C 235.705076 811.738235 231.592545 810.614079 227.382386 810.109753 \n",
       "C 223.172227 809.605427 218.910538 809.726454 214.735785 810.468901 \n",
       "C 210.561033 811.211347 206.518928 812.567085 202.740802 814.492064 \n",
       "C 198.962675 816.417043 195.489895 818.890187 192.435296 821.83114 \n",
       "C 191.932278 822.32363 191.439406 822.826378 190.956992 823.339067 \n",
       "C 190.474578 823.851756 190.002722 824.374278 189.541723 824.906305 \n",
       "\" clip-path=\"url(#p00eef3b23f)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_132\">\n",
       "    <!-- 762 -->\n",
       "    <g transform=\"translate(245.975968 876.733007) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-37\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_133\">\n",
       "    <!-- 2 -->\n",
       "    <g transform=\"translate(262.090213 856.656135) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_134\">\n",
       "    <!-- 1757 -->\n",
       "    <g transform=\"translate(231.526784 856.230757) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_135\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(153.803808 809.80445) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_136\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(243.818078 809.779977) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_137\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(192.161544 924.4354) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_138\">\n",
       "    <!-- CHEMBL262 -->\n",
       "    <g transform=\"translate(191.896232 778.555267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (Glycogen) -->\n",
       "    <g transform=\"translate(195.655607 791.992642) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-47\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"116.503906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-79\" x=\"144.287109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"203.466797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"258.447266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"319.628906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"383.105469\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"444.628906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"508.007812\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_19\">\n",
       "   <g id=\"patch_68\">\n",
       "    <path d=\"M 349.341635 813.116008 \n",
       "C 347.530663 814.096198 345.79211 815.204654 344.139286 816.43289 \n",
       "C 342.486461 817.661125 340.923593 819.005999 339.462646 820.457214 \n",
       "C 342.42891 817.771098 345.698069 815.439718 349.203944 813.510267 \n",
       "C 352.709819 811.580817 356.428594 810.066405 360.28499 808.997687 \n",
       "C 358.378374 809.432313 356.503484 809.995956 354.67327 810.684722 \n",
       "C 352.843056 811.373488 351.061743 812.185787 349.341635 813.116008 \n",
       "\" clip-path=\"url(#pdd08625bb9)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_69\">\n",
       "    <path d=\"M 339.398505 820.515396 \n",
       "C 334.767324 824.723377 330.941303 829.740117 328.108211 835.319411 \n",
       "C 325.275119 840.898705 323.482073 846.947764 322.81707 853.169717 \n",
       "C 322.152067 859.39167 322.626167 865.683041 324.216103 871.735069 \n",
       "C 325.806039 877.787096 328.485368 883.499129 332.122597 888.590838 \n",
       "C 335.759826 893.682547 340.294464 898.069251 345.503965 901.535665 \n",
       "C 350.713467 905.00208 356.511192 907.490554 362.612606 908.878961 \n",
       "C 368.71402 910.267369 375.017651 910.532618 381.214136 909.661693 \n",
       "C 387.410621 908.790768 393.396905 906.798152 398.879201 903.781636 \n",
       "C 404.361497 900.765121 409.248628 896.774874 413.300749 892.006725 \n",
       "C 417.35287 887.238575 420.50259 881.771823 422.59533 875.874758 \n",
       "C 424.68807 869.977693 425.689026 863.748391 425.549074 857.492566 \n",
       "C 425.409123 851.236741 424.130591 845.058434 421.776225 839.260858 \n",
       "C 419.421859 833.463281 416.030814 828.142855 411.769513 823.560688 \n",
       "C 407.508213 818.978522 402.447525 815.210822 396.835814 812.442495 \n",
       "C 391.224103 809.674169 385.154697 807.951256 378.925463 807.358311 \n",
       "C 372.69623 806.765367 366.410768 807.312253 360.377548 808.972129 \n",
       "C 367.1855 807.433291 374.266101 807.567484 381.010856 809.363175 \n",
       "C 387.755611 811.158867 393.965612 814.5631 399.107183 819.283321 \n",
       "C 404.248753 824.003542 408.170263 829.900548 410.534705 836.46756 \n",
       "C 412.899147 843.034571 413.636792 850.077923 412.684247 856.99232 \n",
       "C 411.731702 863.906717 409.117059 870.488249 405.065017 876.17131 \n",
       "C 401.012974 881.854371 395.643029 886.471363 389.416666 889.625509 \n",
       "C 383.190303 892.779655 376.291143 894.377937 369.312087 894.283001 \n",
       "C 362.333032 894.188066 355.479899 892.402712 349.341635 889.080371 \n",
       "C 343.421358 885.878732 338.330825 881.336808 334.4777 875.818329 \n",
       "C 330.624575 870.29985 328.114536 863.956168 327.148593 857.295302 \n",
       "C 326.18265 850.634436 326.787296 843.839069 328.914108 837.453394 \n",
       "C 331.040921 831.067719 334.631569 825.26687 339.398505 820.515396 \n",
       "\" clip-path=\"url(#pdd08625bb9)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_70\">\n",
       "    <path d=\"M 360.28499 808.997687 \n",
       "C 367.091432 807.44611 374.173701 807.568038 380.922702 809.352986 \n",
       "C 387.671702 811.137934 393.888247 814.533222 399.037695 819.246844 \n",
       "C 404.187143 823.960466 408.117515 829.853307 410.490789 836.418566 \n",
       "C 412.864062 842.983824 413.610193 850.027736 412.665012 856.944504 \n",
       "C 411.719831 863.861272 409.111233 870.446758 405.063566 876.134591 \n",
       "C 401.015899 881.822423 395.648624 886.444734 389.423342 889.603992 \n",
       "C 383.198059 892.763249 376.2985 894.366212 369.318047 894.27502 \n",
       "C 362.337593 894.183829 355.482263 892.401175 349.341635 889.080371 \n",
       "C 355.479899 892.402712 362.333032 894.188066 369.312087 894.283001 \n",
       "C 376.291143 894.377937 383.190303 892.779655 389.416666 889.625509 \n",
       "C 395.643029 886.471363 401.012974 881.854371 405.065017 876.17131 \n",
       "C 409.117059 870.488249 411.731702 863.906717 412.684247 856.99232 \n",
       "C 413.636792 850.077923 412.899147 843.034571 410.534705 836.46756 \n",
       "C 408.170263 829.900548 404.248753 824.003542 399.107183 819.283321 \n",
       "C 393.965612 814.5631 387.755611 811.158867 381.010856 809.363175 \n",
       "C 374.266101 807.567484 367.1855 807.433291 360.377548 808.972129 \n",
       "C 360.362117 808.976374 360.346689 808.980627 360.331263 808.984886 \n",
       "C 360.315836 808.989146 360.300412 808.993413 360.28499 808.997687 \n",
       "\" clip-path=\"url(#pdd08625bb9)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_71\">\n",
       "    <path d=\"M 339.462646 820.457214 \n",
       "C 334.683117 825.204908 331.08008 831.005702 328.942492 837.394381 \n",
       "C 326.804905 843.78306 326.19148 850.584147 327.151414 857.252207 \n",
       "C 328.111348 863.920268 330.618274 870.272149 334.471141 875.798443 \n",
       "C 338.324007 881.324736 343.416988 885.873651 349.341635 889.080371 \n",
       "C 355.482263 892.401175 362.337593 894.183829 369.318047 894.27502 \n",
       "C 376.2985 894.366212 383.198059 892.763249 389.423342 889.603992 \n",
       "C 395.648624 886.444734 401.015899 881.822423 405.063566 876.134591 \n",
       "C 409.111233 870.446758 411.719831 863.861272 412.665012 856.944504 \n",
       "C 413.610193 850.027736 412.864062 842.983824 410.490789 836.418566 \n",
       "C 408.117515 829.853307 404.187143 823.960466 399.037695 819.246844 \n",
       "C 393.888247 814.533222 387.671702 811.137934 380.922702 809.352986 \n",
       "C 374.173701 807.568038 367.091432 807.44611 360.28499 808.997687 \n",
       "C 356.428594 810.066405 352.709819 811.580817 349.203944 813.510267 \n",
       "C 345.698069 815.439718 342.42891 817.771098 339.462646 820.457214 \n",
       "\" clip-path=\"url(#pdd08625bb9)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_139\">\n",
       "    <!-- 4 -->\n",
       "    <g transform=\"translate(346.059158 816.336368) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_140\">\n",
       "    <!-- 2207 -->\n",
       "    <g transform=\"translate(379.195204 883.381915) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_141\">\n",
       "    <!-- 2 -->\n",
       "    <g transform=\"translate(409.480746 859.716203) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_142\">\n",
       "    <!-- 5203 -->\n",
       "    <g transform=\"translate(369.426451 856.53017) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_143\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(301.334343 807.917675) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_144\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(391.49393 807.909383) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_145\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(337.726762 924.433099) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_146\">\n",
       "    <!-- CHEMBL240 -->\n",
       "    <g transform=\"translate(337.461449 778.555267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (HERG) -->\n",
       "    <g transform=\"translate(352.240199 791.992642) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"114.208984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-52\" x=\"177.392578\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-47\" x=\"246.875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"324.365234\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_20\">\n",
       "   <g id=\"patch_72\">\n",
       "    <path d=\"M 549.114951 816.425075 \n",
       "C 554.053962 818.97922 558.353074 822.615958 561.690653 827.06321 \n",
       "C 565.028233 831.510462 567.318919 836.654485 568.391337 842.110437 \n",
       "C 568.400499 842.137467 568.409638 842.164506 568.418755 842.191552 \n",
       "C 568.427872 842.218598 568.436966 842.245651 568.446038 842.272712 \n",
       "C 567.388894 836.763239 565.090572 831.566255 561.725967 827.077237 \n",
       "C 558.361363 822.588219 554.018044 818.923999 549.026526 816.363414 \n",
       "C 549.041274 816.373675 549.056017 816.383945 549.070755 816.394221 \n",
       "C 549.085492 816.404498 549.100225 816.414782 549.114951 816.425075 \n",
       "\" clip-path=\"url(#p55b21ce138)\" style=\"fill: #008000; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_73\">\n",
       "    <path d=\"M 568.391337 842.110437 \n",
       "C 567.318919 836.654485 565.028233 831.510462 561.690653 827.06321 \n",
       "C 558.353074 822.615958 554.053962 818.97922 549.114951 816.425075 \n",
       "C 553.585776 819.549599 557.532053 823.364535 560.806062 827.727079 \n",
       "C 564.08007 832.089624 566.640442 836.944655 568.391337 842.110437 \n",
       "\" clip-path=\"url(#p55b21ce138)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_74\">\n",
       "    <path d=\"M 516.196555 882.549226 \n",
       "C 509.913426 879.540799 504.60772 874.815385 500.89484 868.921077 \n",
       "C 497.18196 863.026769 495.211228 856.200623 495.211228 849.234394 \n",
       "C 495.211228 842.268165 497.18196 835.442019 500.89484 829.547711 \n",
       "C 504.60772 823.653403 509.913426 818.927989 516.196555 815.919563 \n",
       "C 521.332466 813.457954 526.96872 812.217015 532.663557 812.294008 \n",
       "C 538.358394 812.371 543.95904 813.763859 549.026526 816.363414 \n",
       "C 544.042327 812.895613 538.483979 810.336288 532.608648 808.803852 \n",
       "C 526.733316 807.271416 520.63303 806.789871 514.590029 807.381498 \n",
       "C 508.547028 807.973125 502.655968 809.628656 497.189408 812.271496 \n",
       "C 491.722848 814.914336 486.766414 818.503087 482.549424 822.871712 \n",
       "C 478.332434 827.240336 474.920941 832.320404 472.472784 837.876878 \n",
       "C 470.024626 843.433353 468.578152 849.379199 468.200283 855.439322 \n",
       "C 467.822414 861.499446 468.51907 867.578923 470.25802 873.396477 \n",
       "C 471.996969 879.214032 474.750972 884.678539 478.392612 889.537174 \n",
       "C 482.034253 894.39581 486.506487 898.57247 491.602402 901.873915 \n",
       "C 496.698316 905.17536 502.338089 907.549877 508.260789 908.887604 \n",
       "C 514.183488 910.225332 520.296342 910.505317 526.316529 909.714606 \n",
       "C 532.336717 908.923895 538.16994 907.074872 543.546315 904.253086 \n",
       "C 548.92269 901.431301 553.758003 897.680951 557.828541 893.175554 \n",
       "C 561.899079 888.670157 565.141082 883.480284 567.404554 877.846051 \n",
       "C 569.668026 872.211818 570.917512 866.22148 571.095203 860.152187 \n",
       "C 571.272895 854.082895 570.376008 848.029717 568.446038 842.272712 \n",
       "C 569.734658 848.988559 569.133649 855.932131 566.710244 862.326678 \n",
       "C 564.286838 868.721226 560.134902 874.319068 554.718897 878.493995 \n",
       "C 549.302892 882.668923 542.832596 885.259228 536.031817 885.975143 \n",
       "C 529.231038 886.691058 522.363191 885.504853 516.196555 882.549226 \n",
       "\" clip-path=\"url(#p55b21ce138)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_75\">\n",
       "    <path d=\"M 516.196555 815.919563 \n",
       "C 521.348707 813.45266 527.003571 812.214231 532.715189 812.301942 \n",
       "C 538.426807 812.389652 544.040978 813.801135 549.114951 816.425075 \n",
       "C 549.100225 816.414782 549.085492 816.404498 549.070755 816.394221 \n",
       "C 549.056017 816.383945 549.041274 816.373675 549.026526 816.363414 \n",
       "C 543.95904 813.763859 538.358394 812.371 532.663557 812.294008 \n",
       "C 526.96872 812.217015 521.332466 813.457954 516.196555 815.919563 \n",
       "M 516.196555 882.549226 \n",
       "C 522.363191 885.504853 529.231038 886.691058 536.031817 885.975143 \n",
       "C 542.832596 885.259228 549.302892 882.668923 554.718897 878.493995 \n",
       "C 560.134902 874.319068 564.286838 868.721226 566.710244 862.326678 \n",
       "C 569.133649 855.932131 569.734658 848.988559 568.446038 842.272712 \n",
       "C 568.436966 842.245651 568.427872 842.218598 568.418755 842.191552 \n",
       "C 568.409638 842.164506 568.400499 842.137467 568.391337 842.110437 \n",
       "C 569.712486 848.831811 569.138218 855.790034 566.733009 862.203869 \n",
       "C 564.327801 868.617704 560.185167 874.237779 554.770224 878.433098 \n",
       "C 549.355281 882.628416 542.878563 885.235863 536.067247 885.962687 \n",
       "C 529.25593 886.689511 522.37484 885.507451 516.196555 882.549226 \n",
       "\" clip-path=\"url(#p55b21ce138)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_76\">\n",
       "    <path d=\"M 516.196555 882.549226 \n",
       "C 522.37484 885.507451 529.25593 886.689511 536.067247 885.962687 \n",
       "C 542.878563 885.235863 549.355281 882.628416 554.770224 878.433098 \n",
       "C 560.185167 874.237779 564.327801 868.617704 566.733009 862.203869 \n",
       "C 569.138218 855.790034 569.712486 848.831811 568.391337 842.110437 \n",
       "C 566.640442 836.944655 564.08007 832.089624 560.806062 827.727079 \n",
       "C 557.532053 823.364535 553.585776 819.549599 549.114951 816.425075 \n",
       "C 544.040978 813.801135 538.426807 812.389652 532.715189 812.301942 \n",
       "C 527.003571 812.214231 521.348707 813.45266 516.196555 815.919563 \n",
       "C 509.915651 818.929959 504.612291 823.656088 500.901185 829.550148 \n",
       "C 497.190079 835.444207 495.220372 842.269321 495.220372 849.234394 \n",
       "C 495.220372 856.199468 497.190079 863.024581 500.901185 868.918641 \n",
       "C 504.612291 874.812701 509.915651 879.53883 516.196555 882.549226 \n",
       "\" clip-path=\"url(#p55b21ce138)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_147\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(558.524852 829.845041) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_148\">\n",
       "    <!-- 15 -->\n",
       "    <g transform=\"translate(554.885857 830.15452) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_149\">\n",
       "    <!-- 2523 -->\n",
       "    <g transform=\"translate(488.921844 875.406913) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_150\">\n",
       "    <!-- 0 -->\n",
       "    <g transform=\"translate(551.573615 881.195623) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_151\">\n",
       "    <!-- 2640 -->\n",
       "    <g transform=\"translate(517.049657 854.788474) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_152\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(466.722132 812.297587) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_153\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(550.636015 812.290632) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_154\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(483.291979 924.422193) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_155\">\n",
       "    <!-- CHEMBL2971 -->\n",
       "    <g transform=\"translate(479.209166 778.555267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (JAK2) -->\n",
       "    <g transform=\"translate(501.405416 791.992642) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-4a\" d=\"M 628 4666 \n",
       "L 1259 4666 \n",
       "L 1259 325 \n",
       "Q 1259 -519 939 -900 \n",
       "Q 619 -1281 -91 -1281 \n",
       "L -331 -1281 \n",
       "L -331 -750 \n",
       "L -134 -750 \n",
       "Q 284 -750 456 -515 \n",
       "Q 628 -281 628 325 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-4b\" d=\"M 628 4666 \n",
       "L 1259 4666 \n",
       "L 1259 2694 \n",
       "L 3353 4666 \n",
       "L 4166 4666 \n",
       "L 1850 2491 \n",
       "L 4331 0 \n",
       "L 3500 0 \n",
       "L 1259 2247 \n",
       "L 1259 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4a\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-41\" x=\"66.755859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4b\" x=\"135.164062\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"200.740234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"264.363281\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_21\">\n",
       "   <g id=\"patch_77\">\n",
       "    <path d=\"M 82.913202 997.095688 \n",
       "C 79.849484 997.095977 76.792695 997.386994 73.783961 997.964824 \n",
       "C 70.775227 998.542654 67.828103 999.404693 64.98224 1000.539344 \n",
       "C 70.720324 998.408985 76.792415 997.318178 82.913202 997.318178 \n",
       "C 89.033989 997.318178 95.10608 998.408985 100.844164 1000.539344 \n",
       "C 97.998301 999.404693 95.051177 998.542654 92.042443 997.964824 \n",
       "C 89.033709 997.386994 85.97692 997.095977 82.913202 997.095688 \n",
       "\" clip-path=\"url(#p5f1b76ab5b)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_78\">\n",
       "    <path d=\"M 64.849106 1000.588981 \n",
       "C 59.239697 1002.689189 54.039289 1005.751658 49.482016 1009.638509 \n",
       "C 44.924743 1013.52536 41.080041 1018.177372 38.121005 1023.385101 \n",
       "C 35.161969 1028.592831 33.133684 1034.276933 32.127467 1040.181497 \n",
       "C 31.121251 1046.08606 31.152435 1052.121123 32.219614 1058.014974 \n",
       "C 33.286793 1063.908824 35.373708 1069.571663 38.386401 1074.748536 \n",
       "C 41.399095 1079.92541 45.291666 1084.537443 49.888861 1088.376992 \n",
       "C 54.486056 1092.216541 59.717833 1095.225107 65.348646 1097.267236 \n",
       "C 70.979459 1099.309365 76.923515 1100.353945 82.913202 1100.353945 \n",
       "C 88.902888 1100.353945 94.846945 1099.309365 100.477757 1097.267236 \n",
       "C 106.10857 1095.225107 111.340347 1092.216541 115.937543 1088.376992 \n",
       "C 120.534738 1084.537443 124.427308 1079.92541 127.440002 1074.748536 \n",
       "C 130.452696 1069.571663 132.539611 1063.908824 133.60679 1058.014974 \n",
       "C 134.673969 1052.121123 134.705152 1046.08606 133.698936 1040.181497 \n",
       "C 132.69272 1034.276933 130.664435 1028.592831 127.705399 1023.385101 \n",
       "C 124.746363 1018.177372 120.90166 1013.52536 116.344387 1009.638509 \n",
       "C 111.787115 1005.751658 106.586707 1002.689189 100.977298 1000.588981 \n",
       "C 111.411999 1004.782708 120.06697 1012.482918 125.446359 1022.358772 \n",
       "C 130.825749 1032.234626 132.600702 1043.68239 130.46445 1054.723529 \n",
       "C 128.328198 1065.764669 122.411336 1075.724212 113.736484 1082.880836 \n",
       "C 105.061632 1090.03746 94.159104 1093.953664 82.913202 1093.952603 \n",
       "C 71.667299 1093.953664 60.764771 1090.03746 52.089919 1082.880836 \n",
       "C 43.415067 1075.724212 37.498205 1065.764669 35.361954 1054.723529 \n",
       "C 33.225702 1043.68239 35.000655 1032.234626 40.380044 1022.358772 \n",
       "C 45.759433 1012.482918 54.414405 1004.782708 64.849106 1000.588981 \n",
       "\" clip-path=\"url(#p5f1b76ab5b)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_79\">\n",
       "    <path d=\"M 64.849106 1000.588981 \n",
       "C 54.414405 1004.782708 45.759433 1012.482918 40.380044 1022.358772 \n",
       "C 35.000655 1032.234626 33.225702 1043.68239 35.361954 1054.723529 \n",
       "C 37.498205 1065.764669 43.415067 1075.724212 52.089919 1082.880836 \n",
       "C 60.764771 1090.03746 71.667299 1093.953664 82.913202 1093.952603 \n",
       "C 71.656627 1093.951542 60.745151 1090.025843 52.068022 1082.855214 \n",
       "C 43.390894 1075.684586 37.47958 1065.708224 35.357586 1054.653469 \n",
       "C 33.235592 1043.598713 35.032887 1032.14266 40.438283 1022.268848 \n",
       "C 45.84368 1012.395036 54.526099 1004.708228 64.98224 1000.539344 \n",
       "C 64.96004 1000.547586 64.937845 1000.555844 64.915656 1000.564117 \n",
       "C 64.893467 1000.57239 64.871283 1000.580678 64.849106 1000.588981 \n",
       "\" clip-path=\"url(#p5f1b76ab5b)\" style=\"fill: #b200b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_80\">\n",
       "    <path d=\"M 100.844164 1000.539344 \n",
       "C 111.300305 1004.708228 119.982724 1012.395036 125.38812 1022.268848 \n",
       "C 130.793516 1032.14266 132.590812 1043.598713 130.468818 1054.653469 \n",
       "C 128.346823 1065.708224 122.43551 1075.684586 113.758381 1082.855214 \n",
       "C 105.081252 1090.025843 94.169777 1093.951542 82.913202 1093.952603 \n",
       "C 94.159104 1093.953664 105.061632 1090.03746 113.736484 1082.880836 \n",
       "C 122.411336 1075.724212 128.328198 1065.764669 130.46445 1054.723529 \n",
       "C 132.600702 1043.68239 130.825749 1032.234626 125.446359 1022.358772 \n",
       "C 120.06697 1012.482918 111.411999 1004.782708 100.977298 1000.588981 \n",
       "C 100.95512 1000.580678 100.932937 1000.57239 100.910748 1000.564117 \n",
       "C 100.888559 1000.555844 100.866364 1000.547586 100.844164 1000.539344 \n",
       "\" clip-path=\"url(#p5f1b76ab5b)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_81\">\n",
       "    <path d=\"M 64.98224 1000.539344 \n",
       "C 54.526099 1004.708228 45.84368 1012.395036 40.438283 1022.268848 \n",
       "C 35.032887 1032.14266 33.235592 1043.598713 35.357586 1054.653469 \n",
       "C 37.47958 1065.708224 43.390894 1075.684586 52.068022 1082.855214 \n",
       "C 60.745151 1090.025843 71.656627 1093.951542 82.913202 1093.952603 \n",
       "C 94.169777 1093.951542 105.081252 1090.025843 113.758381 1082.855214 \n",
       "C 122.43551 1075.684586 128.346823 1065.708224 130.468818 1054.653469 \n",
       "C 132.590812 1043.598713 130.793516 1032.14266 125.38812 1022.268848 \n",
       "C 119.982724 1012.395036 111.300305 1004.708228 100.844164 1000.539344 \n",
       "C 95.10608 998.408985 89.033989 997.318178 82.913202 997.318178 \n",
       "C 76.792415 997.318178 70.720324 998.408985 64.98224 1000.539344 \n",
       "\" clip-path=\"url(#p5f1b76ab5b)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_156\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(79.731952 1000.411348) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_157\">\n",
       "    <!-- 179 -->\n",
       "    <g transform=\"translate(73.369452 1080.396072) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_158\">\n",
       "    <!-- 0 -->\n",
       "    <g transform=\"translate(32.193274 1057.420837) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_159\">\n",
       "    <!-- 0 -->\n",
       "    <g transform=\"translate(127.270629 1057.420837) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_160\">\n",
       "    <!-- 1351 -->\n",
       "    <g transform=\"translate(70.188202 1050.875027) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_161\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(11.736906 997.095687) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_162\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(107.131998 997.095687) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_163\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(46.596327 1114.623858) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_164\">\n",
       "    <!-- CHEMBL258 -->\n",
       "    <g transform=\"translate(46.331014 968.524022) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (LCK) -->\n",
       "    <g transform=\"translate(66.763827 981.961397) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-43\" x=\"94.726562\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4b\" x=\"164.550781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"230.126953\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_22\">\n",
       "   <g id=\"patch_82\">\n",
       "    <path d=\"M 228.478419 997.067941 \n",
       "C 226.764085 997.068133 225.051468 997.176454 223.350771 997.392259 \n",
       "C 221.650074 997.608065 219.96468 997.930925 218.304631 998.358917 \n",
       "C 221.653859 997.684232 225.061911 997.344379 228.478419 997.344379 \n",
       "C 231.894928 997.344379 235.302979 997.684232 238.652208 998.358917 \n",
       "C 236.992158 997.930925 235.306764 997.608065 233.606067 997.392259 \n",
       "C 231.90537 997.176454 230.192754 997.068133 228.478419 997.067941 \n",
       "\" clip-path=\"url(#pcdf0e785fa)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_83\">\n",
       "    <path d=\"M 218.262796 998.367362 \n",
       "C 212.055523 999.623136 206.132677 1002.012774 200.791894 1005.416191 \n",
       "C 195.451111 1008.819608 190.783378 1013.178822 187.02326 1018.274773 \n",
       "C 183.263142 1023.370724 180.474697 1029.116597 178.79805 1035.223647 \n",
       "C 177.121403 1041.330697 176.585119 1047.694884 177.216146 1053.996393 \n",
       "C 177.847174 1060.297902 179.634763 1066.429378 182.489083 1072.082702 \n",
       "C 185.343403 1077.736025 189.215827 1082.814884 193.911757 1087.064054 \n",
       "C 198.607687 1091.313224 204.047122 1094.660316 209.956718 1096.93713 \n",
       "C 215.866314 1099.213944 222.145394 1100.381692 228.478419 1100.381692 \n",
       "C 234.811444 1100.381692 241.090524 1099.213944 247.00012 1096.93713 \n",
       "C 252.909716 1094.660316 258.349151 1091.313224 263.045081 1087.064054 \n",
       "C 267.741011 1082.814884 271.613436 1077.736025 274.467756 1072.082702 \n",
       "C 277.322076 1066.429378 279.109665 1060.297902 279.740692 1053.996393 \n",
       "C 280.371719 1047.694884 279.835435 1041.330697 278.158788 1035.223647 \n",
       "C 276.482141 1029.116597 273.693696 1023.370724 269.933578 1018.274773 \n",
       "C 266.17346 1013.178822 261.505727 1008.819608 256.164945 1005.416191 \n",
       "C 250.824162 1002.012774 244.901315 999.623136 238.694042 998.367362 \n",
       "C 248.297016 1000.851672 256.670909 1006.757112 262.234818 1014.968799 \n",
       "C 267.798728 1023.180487 270.179007 1033.146959 268.926284 1042.986654 \n",
       "C 267.67356 1052.826348 262.871962 1061.878472 255.42798 1068.434083 \n",
       "C 247.983998 1074.989694 238.397537 1078.608543 228.478419 1078.607432 \n",
       "C 218.559301 1078.608543 208.972841 1074.989694 201.528858 1068.434083 \n",
       "C 194.084876 1061.878472 189.283278 1052.826348 188.030555 1042.986654 \n",
       "C 186.777831 1033.146959 189.15811 1023.180487 194.72202 1014.968799 \n",
       "C 200.28593 1006.757112 208.659822 1000.851672 218.262796 998.367362 \n",
       "\" clip-path=\"url(#pcdf0e785fa)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_84\">\n",
       "    <path d=\"M 218.304631 998.358917 \n",
       "C 208.69755 1000.835799 200.317311 1006.736274 194.746651 1014.945944 \n",
       "C 189.17599 1023.155615 186.789173 1033.122916 188.036984 1042.965371 \n",
       "C 189.284796 1052.807825 194.083404 1061.86417 201.526516 1068.423973 \n",
       "C 208.969629 1074.983777 218.557182 1078.606321 228.478419 1078.607432 \n",
       "C 238.399656 1078.606321 247.98721 1074.983777 255.430322 1068.423973 \n",
       "C 262.873434 1061.86417 267.672042 1052.807825 268.919854 1042.965371 \n",
       "C 270.167666 1033.122916 267.780848 1023.155615 262.210188 1014.945944 \n",
       "C 256.639527 1006.736274 248.259288 1000.835799 238.652208 998.358917 \n",
       "C 235.302979 997.684232 231.894928 997.344379 228.478419 997.344379 \n",
       "C 225.061911 997.344379 221.653859 997.684232 218.304631 998.358917 \n",
       "\" clip-path=\"url(#pcdf0e785fa)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_165\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(225.297169 1000.13053) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_166\">\n",
       "    <!-- 824 -->\n",
       "    <g transform=\"translate(218.934669 1074.706513) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-38\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_167\">\n",
       "    <!-- 1378 -->\n",
       "    <g transform=\"translate(215.753419 1042.787922) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_168\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(161.131479 997.06794) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_169\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(248.867859 997.06794) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_170\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(192.161544 1114.651682) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_171\">\n",
       "    <!-- CHEMBL1951 -->\n",
       "    <g transform=\"translate(188.078732 968.497048) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (Monoamine) -->\n",
       "    <g transform=\"translate(188.792169 981.934423) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"125.292969\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"186.474609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"249.853516\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"311.035156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6d\" x=\"372.314453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"469.726562\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"497.509766\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"560.888672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"622.412109\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_23\">\n",
       "   <g id=\"patch_85\">\n",
       "    <path d=\"M 334.087011 1015.00142 \n",
       "C 328.703078 1021.243199 325.027673 1028.775112 323.420563 1036.859897 \n",
       "C 321.813454 1044.944682 322.328846 1053.309649 324.916291 1061.135994 \n",
       "C 321.638786 1048.045045 323.676659 1034.17448 330.581043 1022.579462 \n",
       "C 337.485427 1010.984443 348.709229 1002.583743 361.780268 999.227719 \n",
       "C 356.436028 1000.183502 351.294088 1002.045114 346.576627 1004.732116 \n",
       "C 341.859165 1007.419118 337.635121 1010.892243 334.087011 1015.00142 \n",
       "\" clip-path=\"url(#pb38f72d9a1)\" style=\"fill: #b25900; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_86\">\n",
       "    <path d=\"M 324.939971 1061.230195 \n",
       "C 327.412114 1071.025319 332.734155 1079.870861 340.230127 1086.64333 \n",
       "C 347.7261 1093.415798 357.064614 1097.815786 367.059562 1099.284441 \n",
       "C 377.054511 1100.753095 387.264024 1099.225489 396.391367 1094.895646 \n",
       "C 405.51871 1090.565803 413.160371 1083.625143 418.345763 1074.955215 \n",
       "C 423.531155 1066.285288 426.031037 1056.269384 425.527892 1046.179648 \n",
       "C 425.024747 1036.089911 421.540819 1026.372402 415.51861 1018.261364 \n",
       "C 409.496401 1010.150327 401.202148 1004.004343 391.689325 1000.604029 \n",
       "C 382.176502 997.203716 371.865663 996.699398 362.066412 999.155131 \n",
       "C 370.284064 997.731198 378.73323 998.486784 386.567831 1001.346226 \n",
       "C 394.402432 1004.205668 401.351923 1009.070224 406.720397 1015.452767 \n",
       "C 412.088871 1021.835311 415.690944 1029.515441 417.165913 1037.724085 \n",
       "C 418.640883 1045.932729 417.937814 1054.386428 415.127111 1062.238646 \n",
       "C 412.316407 1070.090864 407.495129 1077.070448 401.146068 1082.47848 \n",
       "C 394.797007 1087.886511 387.139409 1091.536238 378.940088 1093.062187 \n",
       "C 370.740767 1094.588135 362.282863 1093.937611 354.413331 1091.175755 \n",
       "C 346.5438 1088.413899 339.534391 1083.636085 334.087011 1077.320751 \n",
       "C 332.056475 1074.969122 330.260659 1072.424633 328.725195 1069.723598 \n",
       "C 327.189731 1067.022564 325.921958 1064.177896 324.939971 1061.230195 \n",
       "\" clip-path=\"url(#pb38f72d9a1)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_87\">\n",
       "    <path d=\"M 361.780268 999.227719 \n",
       "C 369.994944 997.758576 378.453162 998.471563 386.305984 1001.29512 \n",
       "C 394.158806 1004.118676 401.134415 1008.955066 406.532681 1015.31887 \n",
       "C 411.930947 1021.682675 415.565015 1029.353616 417.070139 1037.561776 \n",
       "C 418.575263 1045.769936 417.899346 1054.231196 415.110227 1062.096315 \n",
       "C 412.321108 1069.961434 407.51533 1076.958169 401.175241 1082.384268 \n",
       "C 394.835152 1087.810368 387.180209 1091.478014 378.978723 1093.019091 \n",
       "C 370.777237 1094.560167 362.313096 1093.921332 354.435831 1091.166704 \n",
       "C 346.558566 1088.412075 339.540841 1083.637003 334.087011 1077.320751 \n",
       "C 339.534391 1083.636085 346.5438 1088.413899 354.413331 1091.175755 \n",
       "C 362.282863 1093.937611 370.740767 1094.588135 378.940088 1093.062187 \n",
       "C 387.139409 1091.536238 394.797007 1087.886511 401.146068 1082.47848 \n",
       "C 407.495129 1077.070448 412.316407 1070.090864 415.127111 1062.238646 \n",
       "C 417.937814 1054.386428 418.640883 1045.932729 417.165913 1037.724085 \n",
       "C 415.690944 1029.515441 412.088871 1021.835311 406.720397 1015.452767 \n",
       "C 401.351923 1009.070224 394.402432 1004.205668 386.567831 1001.346226 \n",
       "C 378.73323 998.486784 370.284064 997.731198 362.066412 999.155131 \n",
       "C 362.018687 999.167091 361.970979 999.17912 361.923288 999.191218 \n",
       "C 361.875597 999.203316 361.827924 999.215483 361.780268 999.227719 \n",
       "\" clip-path=\"url(#pb38f72d9a1)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_88\">\n",
       "    <path d=\"M 324.916291 1061.135994 \n",
       "C 325.896555 1064.101037 327.165595 1066.962677 328.705134 1069.679701 \n",
       "C 330.244673 1072.396725 332.047286 1074.956027 334.087011 1077.320751 \n",
       "C 339.540841 1083.637003 346.558566 1088.412075 354.435831 1091.166704 \n",
       "C 362.313096 1093.921332 370.777237 1094.560167 378.978723 1093.019091 \n",
       "C 387.180209 1091.478014 394.835152 1087.810368 401.175241 1082.384268 \n",
       "C 407.51533 1076.958169 412.321108 1069.961434 415.110227 1062.096315 \n",
       "C 417.899346 1054.231196 418.575263 1045.769936 417.070139 1037.561776 \n",
       "C 415.565015 1029.353616 411.930947 1021.682675 406.532681 1015.31887 \n",
       "C 401.134415 1008.955066 394.158806 1004.118676 386.305984 1001.29512 \n",
       "C 378.453162 998.471563 369.994944 997.758576 361.780268 999.227719 \n",
       "C 348.709229 1002.583743 337.485427 1010.984443 330.581043 1022.579462 \n",
       "C 323.676659 1034.17448 321.638786 1048.045045 324.916291 1061.135994 \n",
       "\" clip-path=\"url(#pb38f72d9a1)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_172\">\n",
       "    <!-- 10 -->\n",
       "    <g transform=\"translate(325.292364 1026.119793) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_173\">\n",
       "    <!-- 134 -->\n",
       "    <g transform=\"translate(403.57836 1071.772979) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_174\">\n",
       "    <!-- 1 -->\n",
       "    <g transform=\"translate(411.900634 1064.883272) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_175\">\n",
       "    <!-- 830 -->\n",
       "    <g transform=\"translate(378.476346 1055.260595) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-38\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_176\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(299.377482 998.483043) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_177\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(394.064686 998.454672) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_178\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(338.171904 1114.055727) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_179\">\n",
       "    <!-- CHEMBL233 -->\n",
       "    <g transform=\"translate(337.461449 969.08041) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- (opioid) -->\n",
       "    <g transform=\"translate(351.067387 982.517785) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-70\" x=\"100.195312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"163.671875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"191.455078\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"252.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"280.419922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"343.896484\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_24\">\n",
       "   <g id=\"patch_89\">\n",
       "    <path d=\"M 469.383121 1037.247483 \n",
       "C 467.901324 1043.731946 467.689231 1050.442431 468.758582 1057.007526 \n",
       "C 469.827933 1063.572621 472.158627 1069.868926 475.621665 1075.547953 \n",
       "C 479.084704 1081.22698 483.614994 1086.181984 488.961793 1090.138716 \n",
       "C 494.308592 1094.095447 500.3714 1096.979534 506.814652 1098.631347 \n",
       "C 513.257904 1100.28316 519.960491 1100.671652 526.551437 1099.77532 \n",
       "C 533.142383 1098.878989 539.497803 1096.714681 545.265937 1093.402187 \n",
       "C 551.034071 1090.089694 556.1065 1085.691278 560.202473 1080.450382 \n",
       "C 564.298446 1075.209487 567.340975 1069.224621 569.161662 1062.827037 \n",
       "C 570.982349 1056.429454 571.546971 1049.739401 570.824278 1043.127163 \n",
       "C 570.101586 1036.514924 568.105162 1030.104785 564.945505 1024.251534 \n",
       "C 561.785848 1018.398283 557.522347 1013.211939 552.39098 1008.979557 \n",
       "C 547.259614 1004.747175 541.356831 1001.548308 535.00934 999.560007 \n",
       "C 528.661849 997.571706 521.988959 996.831343 515.360002 997.379897 \n",
       "C 508.731045 997.928451 502.270621 999.755611 496.336301 1002.760246 \n",
       "C 490.401981 1005.764881 485.10531 1009.890516 480.739447 1014.908805 \n",
       "C 476.373584 1019.927094 473.020591 1025.743711 470.866051 1032.036718 \n",
       "C 472.618925 1027.036871 475.246158 1022.387945 478.625074 1018.307018 \n",
       "C 482.00399 1014.226091 486.081166 1010.777685 490.666221 1008.122821 \n",
       "C 495.251276 1005.467956 500.271718 1003.648608 505.493122 1002.749729 \n",
       "C 510.714525 1001.850851 516.054336 1001.886653 521.263217 1002.855466 \n",
       "C 526.472098 1003.824278 531.467693 1005.710782 536.016737 1008.426889 \n",
       "C 540.56578 1011.142997 544.596349 1014.645764 547.92024 1018.771633 \n",
       "C 551.24413 1022.897501 553.808789 1027.581238 555.494462 1032.60414 \n",
       "C 557.180135 1037.627042 557.960171 1042.909693 557.798145 1048.205426 \n",
       "C 557.63612 1053.501159 556.534595 1058.726244 554.545006 1063.636699 \n",
       "C 552.555418 1068.547155 549.709222 1073.065344 546.139318 1076.980293 \n",
       "C 542.569415 1080.895243 538.332248 1084.145055 533.625667 1086.577982 \n",
       "C 528.919086 1089.010909 523.817506 1090.588486 518.559141 1091.237048 \n",
       "C 513.300776 1091.885609 507.968764 1091.594903 502.812078 1090.378501 \n",
       "C 497.655392 1089.1621 492.755564 1087.039237 488.341387 1084.109036 \n",
       "C 483.927209 1081.178836 480.068474 1077.487627 476.94536 1073.207767 \n",
       "C 473.822246 1068.927908 471.484133 1064.127065 470.040197 1059.02941 \n",
       "C 469.033734 1055.496016 468.468659 1051.851554 468.357881 1048.179284 \n",
       "C 468.247103 1044.507015 468.591472 1040.835118 469.383121 1037.247483 \n",
       "\" clip-path=\"url(#p5992e95bfb)\" style=\"fill: #0000ff; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_90\">\n",
       "    <path d=\"M 470.694883 1032.545295 \n",
       "C 472.390167 1027.545806 474.961545 1022.887598 478.288581 1018.788853 \n",
       "C 481.615616 1014.690108 485.645541 1011.215832 490.189601 1008.528753 \n",
       "C 494.733661 1005.841674 499.719788 1003.98441 504.91444 1003.043952 \n",
       "C 510.109093 1002.103493 515.429883 1002.094756 520.627596 1003.018149 \n",
       "C 525.825309 1003.941542 530.817509 1005.782421 535.370369 1008.454561 \n",
       "C 539.92323 1011.126702 543.964543 1014.587724 547.305022 1018.675521 \n",
       "C 550.6455 1022.763317 553.232163 1027.413055 554.943857 1032.406949 \n",
       "C 556.655551 1037.400843 557.465128 1042.65969 557.334669 1047.937176 \n",
       "C 557.20421 1053.214662 556.135783 1058.427085 554.179433 1063.330305 \n",
       "C 552.223083 1068.233526 549.409837 1072.749778 545.871462 1076.667529 \n",
       "C 542.333086 1080.585281 538.125701 1083.842396 533.446371 1086.286317 \n",
       "C 528.767042 1088.730238 523.689983 1090.322205 518.452994 1090.987653 \n",
       "C 513.216004 1091.6531 507.902145 1091.381475 502.760305 1090.185499 \n",
       "C 497.618465 1088.989522 492.730195 1086.888164 488.324453 1083.979846 \n",
       "C 483.918711 1081.071529 480.065371 1077.402379 476.944918 1073.144252 \n",
       "C 473.824464 1068.886125 471.486387 1064.106556 470.040197 1059.02941 \n",
       "C 471.484133 1064.127065 473.822246 1068.927908 476.94536 1073.207767 \n",
       "C 480.068474 1077.487627 483.927209 1081.178836 488.341387 1084.109036 \n",
       "C 492.755564 1087.039237 497.655392 1089.1621 502.812078 1090.378501 \n",
       "C 507.968764 1091.594903 513.300776 1091.885609 518.559141 1091.237048 \n",
       "C 523.817506 1090.588486 528.919086 1089.010909 533.625667 1086.577982 \n",
       "C 538.332248 1084.145055 542.569415 1080.895243 546.139318 1076.980293 \n",
       "C 549.709222 1073.065344 552.555418 1068.547155 554.545006 1063.636699 \n",
       "C 556.534595 1058.726244 557.63612 1053.501159 557.798145 1048.205426 \n",
       "C 557.960171 1042.909693 557.180135 1037.627042 555.494462 1032.60414 \n",
       "C 553.808789 1027.581238 551.24413 1022.897501 547.92024 1018.771633 \n",
       "C 544.596349 1014.645764 540.56578 1011.142997 536.016737 1008.426889 \n",
       "C 531.467693 1005.710782 526.472098 1003.824278 521.263217 1002.855466 \n",
       "C 516.054336 1001.886653 510.714525 1001.850851 505.493122 1002.749729 \n",
       "C 500.271718 1003.648608 495.251276 1005.467956 490.666221 1008.122821 \n",
       "C 486.081166 1010.777685 482.00399 1014.226091 478.625074 1018.307018 \n",
       "C 475.246158 1022.387945 472.618925 1027.036871 470.866051 1032.036718 \n",
       "C 470.837082 1032.121332 470.808333 1032.206021 470.779805 1032.290784 \n",
       "C 470.751277 1032.375547 470.72297 1032.460384 470.694883 1032.545295 \n",
       "\" clip-path=\"url(#p5992e95bfb)\" style=\"fill: #0059b2; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_91\">\n",
       "    <path d=\"M 469.483307 1036.817551 \n",
       "C 468.644026 1040.469554 468.266911 1044.21258 468.360831 1047.958604 \n",
       "C 468.45475 1051.704628 469.018962 1055.424053 470.040197 1059.02941 \n",
       "C 471.486387 1064.106556 473.824464 1068.886125 476.944918 1073.144252 \n",
       "C 480.065371 1077.402379 483.918711 1081.071529 488.324453 1083.979846 \n",
       "C 492.730195 1086.888164 497.618465 1088.989522 502.760305 1090.185499 \n",
       "C 507.902145 1091.381475 513.216004 1091.6531 518.452994 1090.987653 \n",
       "C 523.689983 1090.322205 528.767042 1088.730238 533.446371 1086.286317 \n",
       "C 538.125701 1083.842396 542.333086 1080.585281 545.871462 1076.667529 \n",
       "C 549.409837 1072.749778 552.223083 1068.233526 554.179433 1063.330305 \n",
       "C 556.135783 1058.427085 557.20421 1053.214662 557.334669 1047.937176 \n",
       "C 557.465128 1042.65969 556.655551 1037.400843 554.943857 1032.406949 \n",
       "C 553.232163 1027.413055 550.6455 1022.763317 547.305022 1018.675521 \n",
       "C 543.964543 1014.587724 539.92323 1011.126702 535.370369 1008.454561 \n",
       "C 530.817509 1005.782421 525.825309 1003.941542 520.627596 1003.018149 \n",
       "C 515.429883 1002.094756 510.109093 1002.103493 504.91444 1003.043952 \n",
       "C 499.719788 1003.98441 494.733661 1005.841674 490.189601 1008.528753 \n",
       "C 485.645541 1011.215832 481.615616 1014.690108 478.288581 1018.788853 \n",
       "C 474.961545 1022.887598 472.390167 1027.545806 470.694883 1032.545295 \n",
       "C 470.462374 1033.248219 470.245043 1033.956072 470.043043 1034.668363 \n",
       "C 469.841044 1035.380654 469.654421 1036.097217 469.483307 1036.817551 \n",
       "\" clip-path=\"url(#p5992e95bfb)\" style=\"fill: #663366; opacity: 0.4\"/>\n",
       "   </g>\n",
       "   <g id=\"text_180\">\n",
       "    <!-- 634 -->\n",
       "    <g transform=\"translate(550.357661 1058.282462) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"127.246094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_181\">\n",
       "    <!-- 20 -->\n",
       "    <g transform=\"translate(551.12415 1050.816103) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_182\">\n",
       "    <!-- 1923 -->\n",
       "    <g transform=\"translate(536.282797 1050.515715) scale(0.1 -0.1)\">\n",
       "     <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"63.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"127.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"190.869141\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_183\">\n",
       "    <!-- Original -->\n",
       "    <g transform=\"translate(443.632799 1002.332035) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"78.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"119.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"147.607422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"211.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"238.867188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"302.246094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"363.525391\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_184\">\n",
       "    <!-- Refresh -->\n",
       "    <g transform=\"translate(535.450996 1002.101197) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-52\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"64.982422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"126.505859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"161.710938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"200.574219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"262.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"314.197266\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_185\">\n",
       "    <!-- Latest (v31) -->\n",
       "    <g transform=\"translate(483.291979 1114.5154) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"116.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"156.201172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"217.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"269.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"309.033203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"340.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-76\" x=\"379.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"502.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.259766\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"text_186\">\n",
       "    <!-- CHEMBL4794 -->\n",
       "    <g transform=\"translate(479.209166 968.635267) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- (Vanilloid) -->\n",
       "    <g transform=\"translate(489.660416 982.072642) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-56\" d=\"M 1831 0 \n",
       "L 50 4666 \n",
       "L 709 4666 \n",
       "L 2188 738 \n",
       "L 3669 4666 \n",
       "L 4325 4666 \n",
       "L 2547 0 \n",
       "L 1831 0 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-28\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-56\" x=\"39.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"99.671875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"160.951172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"224.330078\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"252.113281\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"279.896484\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"307.679688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"368.861328\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"396.644531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"460.121094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       " </g>\n",
       " <defs>\n",
       "  <clipPath id=\"pf705a46604\">\n",
       "   <rect x=\"22.261028\" y=\"37.188564\" width=\"121.304348\" height=\"122.272504\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pc19cb5e4fa\">\n",
       "   <rect x=\"167.826245\" y=\"35.7555\" width=\"121.304348\" height=\"125.138632\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pe1eee0bd65\">\n",
       "   <rect x=\"313.391463\" y=\"37.672642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p3546cafa0b\">\n",
       "   <rect x=\"458.95668\" y=\"37.485574\" width=\"121.304348\" height=\"121.678484\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pcabc11e101\">\n",
       "   <rect x=\"22.261028\" y=\"227.567008\" width=\"121.304348\" height=\"121.675617\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p3f36b21126\">\n",
       "   <rect x=\"167.826245\" y=\"227.748077\" width=\"121.304348\" height=\"121.313477\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p722ede2363\">\n",
       "   <rect x=\"313.391463\" y=\"227.752642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p021fa57465\">\n",
       "   <rect x=\"458.95668\" y=\"227.752642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p6d1c4f1438\">\n",
       "   <rect x=\"22.261028\" y=\"417.832642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p5df63ca0f1\">\n",
       "   <rect x=\"167.826245\" y=\"417.832642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p56ce42a5f5\">\n",
       "   <rect x=\"313.391463\" y=\"417.832642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pd84bf2aa93\">\n",
       "   <rect x=\"458.95668\" y=\"417.832642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p8eaed4fdc9\">\n",
       "   <rect x=\"22.261028\" y=\"607.912642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pfc27087ae2\">\n",
       "   <rect x=\"167.826245\" y=\"607.697959\" width=\"121.304348\" height=\"121.733714\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p4121c6a7af\">\n",
       "   <rect x=\"313.391463\" y=\"607.912642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p2fe254bcf8\">\n",
       "   <rect x=\"458.95668\" y=\"607.912642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pd2dca8678b\">\n",
       "   <rect x=\"22.261028\" y=\"797.884137\" width=\"121.304348\" height=\"121.521359\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p00eef3b23f\">\n",
       "   <rect x=\"167.826245\" y=\"797.992642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pdd08625bb9\">\n",
       "   <rect x=\"313.391463\" y=\"797.992642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p55b21ce138\">\n",
       "   <rect x=\"458.95668\" y=\"797.992642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p5f1b76ab5b\">\n",
       "   <rect x=\"22.261028\" y=\"987.961397\" width=\"121.304348\" height=\"121.526839\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pcdf0e785fa\">\n",
       "   <rect x=\"167.826245\" y=\"987.934423\" width=\"121.304348\" height=\"121.580786\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pb38f72d9a1\">\n",
       "   <rect x=\"313.391463\" y=\"988.517785\" width=\"121.304348\" height=\"120.414063\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p5992e95bfb\">\n",
       "   <rect x=\"458.95668\" y=\"988.072642\" width=\"121.304348\" height=\"121.304348\"/>\n",
       "  </clipPath>\n",
       " </defs>\n",
       "</svg>\n"
      ],
      "text/plain": [
       "<Figure size 1000x2000 with 24 Axes>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "fig, axes = plt.subplots(6, 4, figsize=(10.0, 20.0))\n",
    "\n",
    "for (name, target_id, _), ax in zip(mappings, axes.ravel()):\n",
    "    venn3(\n",
    "        subsets=[\n",
    "            set(reference_dfs[target_id].molecule_chembl_id),\n",
    "            set(refresh_dfs[target_id].molecule_chembl_id),\n",
    "            set(latest_dfs[target_id].molecule_chembl_id),\n",
    "        ],\n",
    "        set_labels=[\n",
    "            \"Original\",\n",
    "            \"Refresh\",\n",
    "            f\"Latest (v{version})\",\n",
    "        ],\n",
    "        ax=ax,\n",
    "    )\n",
    "    ax.set_title(f\"{target_id}\\n({name})\")\n",
    "\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "93966825",
   "metadata": {},
   "source": [
    "## Value Comparison\n",
    "\n",
    "The following histgrams show the differences between the reference datasets' pChEMBL values and the latest version of ChEMBL (post-aggregation)."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "id": "bc051923",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "application/vnd.jupyter.widget-view+json": {
       "model_id": "c11e2c8dab374b6ebba184989a9d03ca",
       "version_major": 2,
       "version_minor": 0
      },
      "text/plain": [
       "  0%|          | 0/24 [00:00<?, ?it/s]"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "image/svg+xml": [
       "<?xml version=\"1.0\" encoding=\"utf-8\" standalone=\"no\"?>\n",
       "<!DOCTYPE svg PUBLIC \"-//W3C//DTD SVG 1.1//EN\"\n",
       "  \"http://www.w3.org/Graphics/SVG/1.1/DTD/svg11.dtd\">\n",
       "<svg xmlns:xlink=\"http://www.w3.org/1999/xlink\" width=\"712.495625pt\" height=\"997.672625pt\" viewBox=\"0 0 712.495625 997.672625\" xmlns=\"http://www.w3.org/2000/svg\" version=\"1.1\">\n",
       " <metadata>\n",
       "  <rdf:RDF xmlns:dc=\"http://purl.org/dc/elements/1.1/\" xmlns:cc=\"http://creativecommons.org/ns#\" xmlns:rdf=\"http://www.w3.org/1999/02/22-rdf-syntax-ns#\">\n",
       "   <cc:Work>\n",
       "    <dc:type rdf:resource=\"http://purl.org/dc/dcmitype/StillImage\"/>\n",
       "    <dc:date>2022-11-19T22:11:44.531132</dc:date>\n",
       "    <dc:format>image/svg+xml</dc:format>\n",
       "    <dc:creator>\n",
       "     <cc:Agent>\n",
       "      <dc:title>Matplotlib v3.6.0, https://matplotlib.org/</dc:title>\n",
       "     </cc:Agent>\n",
       "    </dc:creator>\n",
       "   </cc:Work>\n",
       "  </rdf:RDF>\n",
       " </metadata>\n",
       " <defs>\n",
       "  <style type=\"text/css\">*{stroke-linejoin: round; stroke-linecap: butt}</style>\n",
       " </defs>\n",
       " <g id=\"figure_1\">\n",
       "  <g id=\"patch_1\">\n",
       "   <path d=\"M 0 997.672625 \n",
       "L 712.495625 997.672625 \n",
       "L 712.495625 0 \n",
       "L 0 0 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "  </g>\n",
       "  <g id=\"axes_1\">\n",
       "   <g id=\"patch_2\">\n",
       "    <path d=\"M 46.965625 149.789292 \n",
       "L 173.395625 149.789292 \n",
       "L 173.395625 35.7555 \n",
       "L 46.965625 35.7555 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_3\">\n",
       "    <path d=\"M 66.070665 149.789292 \n",
       "L 73.643697 149.789292 \n",
       "L 73.643697 142.212296 \n",
       "L 66.070665 142.212296 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_4\">\n",
       "    <path d=\"M 73.643697 149.789292 \n",
       "L 81.216729 149.789292 \n",
       "L 81.216729 124.532638 \n",
       "L 73.643697 124.532638 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_5\">\n",
       "    <path d=\"M 81.216729 149.789292 \n",
       "L 88.789761 149.789292 \n",
       "L 88.789761 134.635299 \n",
       "L 81.216729 134.635299 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_6\">\n",
       "    <path d=\"M 88.789761 149.789292 \n",
       "L 96.362793 149.789292 \n",
       "L 96.362793 109.378646 \n",
       "L 88.789761 109.378646 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_7\">\n",
       "    <path d=\"M 96.362793 149.789292 \n",
       "L 103.935825 149.789292 \n",
       "L 103.935825 86.647657 \n",
       "L 96.362793 86.647657 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_8\">\n",
       "    <path d=\"M 103.935825 149.789292 \n",
       "L 111.508857 149.789292 \n",
       "L 111.508857 41.185681 \n",
       "L 103.935825 41.185681 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_9\">\n",
       "    <path d=\"M 111.508857 149.789292 \n",
       "L 119.081889 149.789292 \n",
       "L 119.081889 68.968 \n",
       "L 111.508857 68.968 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_10\">\n",
       "    <path d=\"M 119.081889 149.789292 \n",
       "L 126.654921 149.789292 \n",
       "L 126.654921 89.173323 \n",
       "L 119.081889 89.173323 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_11\">\n",
       "    <path d=\"M 126.654921 149.789292 \n",
       "L 134.227954 149.789292 \n",
       "L 134.227954 101.80165 \n",
       "L 126.654921 101.80165 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_12\">\n",
       "    <path d=\"M 134.227954 149.789292 \n",
       "L 141.800986 149.789292 \n",
       "L 141.800986 129.583969 \n",
       "L 134.227954 129.583969 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_13\">\n",
       "    <path d=\"M 141.800986 149.789292 \n",
       "L 149.374018 149.789292 \n",
       "L 149.374018 127.058303 \n",
       "L 141.800986 127.058303 \n",
       "z\n",
       "\" clip-path=\"url(#pe74d30b062)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_1\">\n",
       "    <g id=\"xtick_1\">\n",
       "     <g id=\"line2d_1\">\n",
       "      <defs>\n",
       "       <path id=\"mbd1a2dc235\" d=\"M 0 0 \n",
       "L 0 3.5 \n",
       "\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </defs>\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"64.493652\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_2\">\n",
       "     <g id=\"line2d_2\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"110.876366\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_3\">\n",
       "     <g id=\"line2d_3\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"157.259079\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_2\">\n",
       "    <g id=\"ytick_1\">\n",
       "     <g id=\"line2d_4\">\n",
       "      <defs>\n",
       "       <path id=\"m2a9f7c8a8b\" d=\"M 0 0 \n",
       "L -3.5 0 \n",
       "\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </defs>\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_1\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(33.603125 153.58851) scale(0.1 -0.1)\">\n",
       "       <defs>\n",
       "        <path id=\"DejaVuSans-30\" d=\"M 2034 4250 \n",
       "Q 1547 4250 1301 3770 \n",
       "Q 1056 3291 1056 2328 \n",
       "Q 1056 1369 1301 889 \n",
       "Q 1547 409 2034 409 \n",
       "Q 2525 409 2770 889 \n",
       "Q 3016 1369 3016 2328 \n",
       "Q 3016 3291 2770 3770 \n",
       "Q 2525 4250 2034 4250 \n",
       "z\n",
       "M 2034 4750 \n",
       "Q 2819 4750 3233 4129 \n",
       "Q 3647 3509 3647 2328 \n",
       "Q 3647 1150 3233 529 \n",
       "Q 2819 -91 2034 -91 \n",
       "Q 1250 -91 836 529 \n",
       "Q 422 1150 422 2328 \n",
       "Q 422 3509 836 4129 \n",
       "Q 1250 4750 2034 4750 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       </defs>\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_2\">\n",
       "     <g id=\"line2d_5\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"124.532638\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_2\">\n",
       "      <!-- 10 -->\n",
       "      <g transform=\"translate(27.240625 128.331857) scale(0.1 -0.1)\">\n",
       "       <defs>\n",
       "        <path id=\"DejaVuSans-31\" d=\"M 794 531 \n",
       "L 1825 531 \n",
       "L 1825 4091 \n",
       "L 703 3866 \n",
       "L 703 4441 \n",
       "L 1819 4666 \n",
       "L 2450 4666 \n",
       "L 2450 531 \n",
       "L 3481 531 \n",
       "L 3481 0 \n",
       "L 794 0 \n",
       "L 794 531 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       </defs>\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_3\">\n",
       "     <g id=\"line2d_6\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"99.275984\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_3\">\n",
       "      <!-- 20 -->\n",
       "      <g transform=\"translate(27.240625 103.075203) scale(0.1 -0.1)\">\n",
       "       <defs>\n",
       "        <path id=\"DejaVuSans-32\" d=\"M 1228 531 \n",
       "L 3431 531 \n",
       "L 3431 0 \n",
       "L 469 0 \n",
       "L 469 531 \n",
       "Q 828 903 1448 1529 \n",
       "Q 2069 2156 2228 2338 \n",
       "Q 2531 2678 2651 2914 \n",
       "Q 2772 3150 2772 3378 \n",
       "Q 2772 3750 2511 3984 \n",
       "Q 2250 4219 1831 4219 \n",
       "Q 1534 4219 1204 4116 \n",
       "Q 875 4013 500 3803 \n",
       "L 500 4441 \n",
       "Q 881 4594 1212 4672 \n",
       "Q 1544 4750 1819 4750 \n",
       "Q 2544 4750 2975 4387 \n",
       "Q 3406 4025 3406 3419 \n",
       "Q 3406 3131 3298 2873 \n",
       "Q 3191 2616 2906 2266 \n",
       "Q 2828 2175 2409 1742 \n",
       "Q 1991 1309 1228 531 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       </defs>\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_4\">\n",
       "     <g id=\"line2d_7\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"74.01933\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_4\">\n",
       "      <!-- 30 -->\n",
       "      <g transform=\"translate(27.240625 77.818549) scale(0.1 -0.1)\">\n",
       "       <defs>\n",
       "        <path id=\"DejaVuSans-33\" d=\"M 2597 2516 \n",
       "Q 3050 2419 3304 2112 \n",
       "Q 3559 1806 3559 1356 \n",
       "Q 3559 666 3084 287 \n",
       "Q 2609 -91 1734 -91 \n",
       "Q 1441 -91 1130 -33 \n",
       "Q 819 25 488 141 \n",
       "L 488 750 \n",
       "Q 750 597 1062 519 \n",
       "Q 1375 441 1716 441 \n",
       "Q 2309 441 2620 675 \n",
       "Q 2931 909 2931 1356 \n",
       "Q 2931 1769 2642 2001 \n",
       "Q 2353 2234 1838 2234 \n",
       "L 1294 2234 \n",
       "L 1294 2753 \n",
       "L 1863 2753 \n",
       "Q 2328 2753 2575 2939 \n",
       "Q 2822 3125 2822 3475 \n",
       "Q 2822 3834 2567 4026 \n",
       "Q 2313 4219 1838 4219 \n",
       "Q 1578 4219 1281 4162 \n",
       "Q 984 4106 628 3988 \n",
       "L 628 4550 \n",
       "Q 988 4650 1302 4700 \n",
       "Q 1616 4750 1894 4750 \n",
       "Q 2613 4750 3031 4423 \n",
       "Q 3450 4097 3450 3541 \n",
       "Q 3450 3153 3228 2886 \n",
       "Q 3006 2619 2597 2516 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       </defs>\n",
       "       <use xlink:href=\"#DejaVuSans-33\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_5\">\n",
       "     <g id=\"line2d_8\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"48.762677\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_5\">\n",
       "      <!-- 40 -->\n",
       "      <g transform=\"translate(27.240625 52.561895) scale(0.1 -0.1)\">\n",
       "       <defs>\n",
       "        <path id=\"DejaVuSans-34\" d=\"M 2419 4116 \n",
       "L 825 1625 \n",
       "L 2419 1625 \n",
       "L 2419 4116 \n",
       "z\n",
       "M 2253 4666 \n",
       "L 3047 4666 \n",
       "L 3047 1625 \n",
       "L 3713 1625 \n",
       "L 3713 1100 \n",
       "L 3047 1100 \n",
       "L 3047 0 \n",
       "L 2419 0 \n",
       "L 2419 1100 \n",
       "L 313 1100 \n",
       "L 313 1709 \n",
       "L 2253 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       </defs>\n",
       "       <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_6\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(21.160937 107.620833) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <defs>\n",
       "       <path id=\"DejaVuSans-43\" d=\"M 4122 4306 \n",
       "L 4122 3641 \n",
       "Q 3803 3938 3442 4084 \n",
       "Q 3081 4231 2675 4231 \n",
       "Q 1875 4231 1450 3742 \n",
       "Q 1025 3253 1025 2328 \n",
       "Q 1025 1406 1450 917 \n",
       "Q 1875 428 2675 428 \n",
       "Q 3081 428 3442 575 \n",
       "Q 3803 722 4122 1019 \n",
       "L 4122 359 \n",
       "Q 3791 134 3420 21 \n",
       "Q 3050 -91 2638 -91 \n",
       "Q 1578 -91 968 557 \n",
       "Q 359 1206 359 2328 \n",
       "Q 359 3453 968 4101 \n",
       "Q 1578 4750 2638 4750 \n",
       "Q 3056 4750 3426 4639 \n",
       "Q 3797 4528 4122 4306 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       <path id=\"DejaVuSans-6f\" d=\"M 1959 3097 \n",
       "Q 1497 3097 1228 2736 \n",
       "Q 959 2375 959 1747 \n",
       "Q 959 1119 1226 758 \n",
       "Q 1494 397 1959 397 \n",
       "Q 2419 397 2687 759 \n",
       "Q 2956 1122 2956 1747 \n",
       "Q 2956 2369 2687 2733 \n",
       "Q 2419 3097 1959 3097 \n",
       "z\n",
       "M 1959 3584 \n",
       "Q 2709 3584 3137 3096 \n",
       "Q 3566 2609 3566 1747 \n",
       "Q 3566 888 3137 398 \n",
       "Q 2709 -91 1959 -91 \n",
       "Q 1206 -91 779 398 \n",
       "Q 353 888 353 1747 \n",
       "Q 353 2609 779 3096 \n",
       "Q 1206 3584 1959 3584 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       <path id=\"DejaVuSans-75\" d=\"M 544 1381 \n",
       "L 544 3500 \n",
       "L 1119 3500 \n",
       "L 1119 1403 \n",
       "Q 1119 906 1312 657 \n",
       "Q 1506 409 1894 409 \n",
       "Q 2359 409 2629 706 \n",
       "Q 2900 1003 2900 1516 \n",
       "L 2900 3500 \n",
       "L 3475 3500 \n",
       "L 3475 0 \n",
       "L 2900 0 \n",
       "L 2900 538 \n",
       "Q 2691 219 2414 64 \n",
       "Q 2138 -91 1772 -91 \n",
       "Q 1169 -91 856 284 \n",
       "Q 544 659 544 1381 \n",
       "z\n",
       "M 1991 3584 \n",
       "L 1991 3584 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       <path id=\"DejaVuSans-6e\" d=\"M 3513 2113 \n",
       "L 3513 0 \n",
       "L 2938 0 \n",
       "L 2938 2094 \n",
       "Q 2938 2591 2744 2837 \n",
       "Q 2550 3084 2163 3084 \n",
       "Q 1697 3084 1428 2787 \n",
       "Q 1159 2491 1159 1978 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 3500 \n",
       "L 1159 3500 \n",
       "L 1159 2956 \n",
       "Q 1366 3272 1645 3428 \n",
       "Q 1925 3584 2291 3584 \n",
       "Q 2894 3584 3203 3211 \n",
       "Q 3513 2838 3513 2113 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       <path id=\"DejaVuSans-74\" d=\"M 1172 4494 \n",
       "L 1172 3500 \n",
       "L 2356 3500 \n",
       "L 2356 3053 \n",
       "L 1172 3053 \n",
       "L 1172 1153 \n",
       "Q 1172 725 1289 603 \n",
       "Q 1406 481 1766 481 \n",
       "L 2356 481 \n",
       "L 2356 0 \n",
       "L 1766 0 \n",
       "Q 1100 0 847 248 \n",
       "Q 594 497 594 1153 \n",
       "L 594 3053 \n",
       "L 172 3053 \n",
       "L 172 3500 \n",
       "L 594 3500 \n",
       "L 594 4494 \n",
       "L 1172 4494 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      </defs>\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_14\">\n",
       "    <path d=\"M 46.965625 149.789292 \n",
       "L 46.965625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_15\">\n",
       "    <path d=\"M 173.395625 149.789292 \n",
       "L 173.395625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_16\">\n",
       "    <path d=\"M 46.965625 149.789292 \n",
       "L 173.395625 149.789292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_17\">\n",
       "    <path d=\"M 46.965625 35.7555 \n",
       "L 173.395625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_7\">\n",
       "    <!-- CHEMBL1867 -->\n",
       "    <g transform=\"translate(69.780938 16.318125) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-48\" d=\"M 628 4666 \n",
       "L 1259 4666 \n",
       "L 1259 2753 \n",
       "L 3553 2753 \n",
       "L 3553 4666 \n",
       "L 4184 4666 \n",
       "L 4184 0 \n",
       "L 3553 0 \n",
       "L 3553 2222 \n",
       "L 1259 2222 \n",
       "L 1259 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-45\" d=\"M 628 4666 \n",
       "L 3578 4666 \n",
       "L 3578 4134 \n",
       "L 1259 4134 \n",
       "L 1259 2753 \n",
       "L 3481 2753 \n",
       "L 3481 2222 \n",
       "L 1259 2222 \n",
       "L 1259 531 \n",
       "L 3634 531 \n",
       "L 3634 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-4d\" d=\"M 628 4666 \n",
       "L 1569 4666 \n",
       "L 2759 1491 \n",
       "L 3956 4666 \n",
       "L 4897 4666 \n",
       "L 4897 0 \n",
       "L 4281 0 \n",
       "L 4281 4097 \n",
       "L 3078 897 \n",
       "L 2444 897 \n",
       "L 1241 4097 \n",
       "L 1241 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-42\" d=\"M 1259 2228 \n",
       "L 1259 519 \n",
       "L 2272 519 \n",
       "Q 2781 519 3026 730 \n",
       "Q 3272 941 3272 1375 \n",
       "Q 3272 1813 3026 2020 \n",
       "Q 2781 2228 2272 2228 \n",
       "L 1259 2228 \n",
       "z\n",
       "M 1259 4147 \n",
       "L 1259 2741 \n",
       "L 2194 2741 \n",
       "Q 2656 2741 2882 2914 \n",
       "Q 3109 3088 3109 3444 \n",
       "Q 3109 3797 2882 3972 \n",
       "Q 2656 4147 2194 4147 \n",
       "L 1259 4147 \n",
       "z\n",
       "M 628 4666 \n",
       "L 2241 4666 \n",
       "Q 2963 4666 3353 4366 \n",
       "Q 3744 4066 3744 3513 \n",
       "Q 3744 3084 3544 2831 \n",
       "Q 3344 2578 2956 2516 \n",
       "Q 3422 2416 3680 2098 \n",
       "Q 3938 1781 3938 1306 \n",
       "Q 3938 681 3513 340 \n",
       "Q 3088 0 2303 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-4c\" d=\"M 628 4666 \n",
       "L 1259 4666 \n",
       "L 1259 531 \n",
       "L 3531 531 \n",
       "L 3531 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-38\" d=\"M 2034 2216 \n",
       "Q 1584 2216 1326 1975 \n",
       "Q 1069 1734 1069 1313 \n",
       "Q 1069 891 1326 650 \n",
       "Q 1584 409 2034 409 \n",
       "Q 2484 409 2743 651 \n",
       "Q 3003 894 3003 1313 \n",
       "Q 3003 1734 2745 1975 \n",
       "Q 2488 2216 2034 2216 \n",
       "z\n",
       "M 1403 2484 \n",
       "Q 997 2584 770 2862 \n",
       "Q 544 3141 544 3541 \n",
       "Q 544 4100 942 4425 \n",
       "Q 1341 4750 2034 4750 \n",
       "Q 2731 4750 3128 4425 \n",
       "Q 3525 4100 3525 3541 \n",
       "Q 3525 3141 3298 2862 \n",
       "Q 3072 2584 2669 2484 \n",
       "Q 3125 2378 3379 2068 \n",
       "Q 3634 1759 3634 1313 \n",
       "Q 3634 634 3220 271 \n",
       "Q 2806 -91 2034 -91 \n",
       "Q 1263 -91 848 271 \n",
       "Q 434 634 434 1313 \n",
       "Q 434 1759 690 2068 \n",
       "Q 947 2378 1403 2484 \n",
       "z\n",
       "M 1172 3481 \n",
       "Q 1172 3119 1398 2916 \n",
       "Q 1625 2713 2034 2713 \n",
       "Q 2441 2713 2670 2916 \n",
       "Q 2900 3119 2900 3481 \n",
       "Q 2900 3844 2670 4047 \n",
       "Q 2441 4250 2034 4250 \n",
       "Q 1625 4250 1398 4047 \n",
       "Q 1172 3844 1172 3481 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-36\" d=\"M 2113 2584 \n",
       "Q 1688 2584 1439 2293 \n",
       "Q 1191 2003 1191 1497 \n",
       "Q 1191 994 1439 701 \n",
       "Q 1688 409 2113 409 \n",
       "Q 2538 409 2786 701 \n",
       "Q 3034 994 3034 1497 \n",
       "Q 3034 2003 2786 2293 \n",
       "Q 2538 2584 2113 2584 \n",
       "z\n",
       "M 3366 4563 \n",
       "L 3366 3988 \n",
       "Q 3128 4100 2886 4159 \n",
       "Q 2644 4219 2406 4219 \n",
       "Q 1781 4219 1451 3797 \n",
       "Q 1122 3375 1075 2522 \n",
       "Q 1259 2794 1537 2939 \n",
       "Q 1816 3084 2150 3084 \n",
       "Q 2853 3084 3261 2657 \n",
       "Q 3669 2231 3669 1497 \n",
       "Q 3669 778 3244 343 \n",
       "Q 2819 -91 2113 -91 \n",
       "Q 1303 -91 875 529 \n",
       "Q 447 1150 447 2328 \n",
       "Q 447 3434 972 4092 \n",
       "Q 1497 4750 2381 4750 \n",
       "Q 2619 4750 2861 4703 \n",
       "Q 3103 4656 3366 4563 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-37\" d=\"M 525 4666 \n",
       "L 3525 4666 \n",
       "L 3525 4397 \n",
       "L 1831 0 \n",
       "L 1172 0 \n",
       "L 2766 4134 \n",
       "L 525 4134 \n",
       "L 525 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- A2a (202) -->\n",
       "    <g transform=\"translate(80.540625 29.7555) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-41\" d=\"M 2188 4044 \n",
       "L 1331 1722 \n",
       "L 3047 1722 \n",
       "L 2188 4044 \n",
       "z\n",
       "M 1831 4666 \n",
       "L 2547 4666 \n",
       "L 4325 0 \n",
       "L 3669 0 \n",
       "L 3244 1197 \n",
       "L 1141 1197 \n",
       "L 716 0 \n",
       "L 50 0 \n",
       "L 1831 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-61\" d=\"M 2194 1759 \n",
       "Q 1497 1759 1228 1600 \n",
       "Q 959 1441 959 1056 \n",
       "Q 959 750 1161 570 \n",
       "Q 1363 391 1709 391 \n",
       "Q 2188 391 2477 730 \n",
       "Q 2766 1069 2766 1631 \n",
       "L 2766 1759 \n",
       "L 2194 1759 \n",
       "z\n",
       "M 3341 1997 \n",
       "L 3341 0 \n",
       "L 2766 0 \n",
       "L 2766 531 \n",
       "Q 2569 213 2275 61 \n",
       "Q 1981 -91 1556 -91 \n",
       "Q 1019 -91 701 211 \n",
       "Q 384 513 384 1019 \n",
       "Q 384 1609 779 1909 \n",
       "Q 1175 2209 1959 2209 \n",
       "L 2766 2209 \n",
       "L 2766 2266 \n",
       "Q 2766 2663 2505 2880 \n",
       "Q 2244 3097 1772 3097 \n",
       "Q 1472 3097 1187 3025 \n",
       "Q 903 2953 641 2809 \n",
       "L 641 3341 \n",
       "Q 956 3463 1253 3523 \n",
       "Q 1550 3584 1831 3584 \n",
       "Q 2591 3584 2966 3190 \n",
       "Q 3341 2797 3341 1997 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-20\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-28\" d=\"M 1984 4856 \n",
       "Q 1566 4138 1362 3434 \n",
       "Q 1159 2731 1159 2009 \n",
       "Q 1159 1288 1364 580 \n",
       "Q 1569 -128 1984 -844 \n",
       "L 1484 -844 \n",
       "Q 1016 -109 783 600 \n",
       "Q 550 1309 550 2009 \n",
       "Q 550 2706 781 3412 \n",
       "Q 1013 4119 1484 4856 \n",
       "L 1984 4856 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-29\" d=\"M 513 4856 \n",
       "L 1013 4856 \n",
       "Q 1481 4119 1714 3412 \n",
       "Q 1947 2706 1947 2009 \n",
       "Q 1947 1309 1714 600 \n",
       "Q 1481 -109 1013 -844 \n",
       "L 513 -844 \n",
       "Q 928 -128 1133 580 \n",
       "Q 1338 1288 1338 2009 \n",
       "Q 1338 2731 1133 3434 \n",
       "Q 928 4138 513 4856 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-41\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"68.408203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"132.03125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"193.310547\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"225.097656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"264.111328\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"327.734375\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"391.357422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"454.980469\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_2\">\n",
       "   <g id=\"patch_18\">\n",
       "    <path d=\"M 224.265625 149.789292 \n",
       "L 350.695625 149.789292 \n",
       "L 350.695625 35.7555 \n",
       "L 224.265625 35.7555 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_19\">\n",
       "    <path d=\"M 246.802985 149.789292 \n",
       "L 252.580946 149.789292 \n",
       "L 252.580946 139.916236 \n",
       "L 246.802985 139.916236 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_20\">\n",
       "    <path d=\"M 252.580946 149.789292 \n",
       "L 258.358907 149.789292 \n",
       "L 258.358907 136.625218 \n",
       "L 252.580946 136.625218 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_21\">\n",
       "    <path d=\"M 258.358907 149.789292 \n",
       "L 264.136868 149.789292 \n",
       "L 264.136868 113.588088 \n",
       "L 258.358907 113.588088 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_22\">\n",
       "    <path d=\"M 264.136868 149.789292 \n",
       "L 269.914829 149.789292 \n",
       "L 269.914829 90.550958 \n",
       "L 264.136868 90.550958 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_23\">\n",
       "    <path d=\"M 269.914829 149.789292 \n",
       "L 275.69279 149.789292 \n",
       "L 275.69279 82.323412 \n",
       "L 269.914829 82.323412 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_24\">\n",
       "    <path d=\"M 275.69279 149.789292 \n",
       "L 281.470751 149.789292 \n",
       "L 281.470751 88.905449 \n",
       "L 275.69279 88.905449 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_25\">\n",
       "    <path d=\"M 281.470751 149.789292 \n",
       "L 287.248711 149.789292 \n",
       "L 287.248711 64.22281 \n",
       "L 281.470751 64.22281 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_26\">\n",
       "    <path d=\"M 287.248711 149.789292 \n",
       "L 293.026672 149.789292 \n",
       "L 293.026672 41.185681 \n",
       "L 287.248711 41.185681 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_27\">\n",
       "    <path d=\"M 293.026672 149.789292 \n",
       "L 298.804633 149.789292 \n",
       "L 298.804633 64.22281 \n",
       "L 293.026672 64.22281 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_28\">\n",
       "    <path d=\"M 298.804633 149.789292 \n",
       "L 304.582594 149.789292 \n",
       "L 304.582594 74.095866 \n",
       "L 298.804633 74.095866 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_29\">\n",
       "    <path d=\"M 304.582594 149.789292 \n",
       "L 310.360555 149.789292 \n",
       "L 310.360555 92.196468 \n",
       "L 304.582594 92.196468 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_30\">\n",
       "    <path d=\"M 310.360555 149.789292 \n",
       "L 316.138516 149.789292 \n",
       "L 316.138516 97.132995 \n",
       "L 310.360555 97.132995 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_31\">\n",
       "    <path d=\"M 316.138516 149.789292 \n",
       "L 321.916477 149.789292 \n",
       "L 321.916477 128.397671 \n",
       "L 316.138516 128.397671 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_32\">\n",
       "    <path d=\"M 321.916477 149.789292 \n",
       "L 327.694437 149.789292 \n",
       "L 327.694437 136.625218 \n",
       "L 321.916477 136.625218 \n",
       "z\n",
       "\" clip-path=\"url(#pf1cbb99640)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.755628; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_3\">\n",
       "    <g id=\"xtick_4\">\n",
       "     <g id=\"line2d_9\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"241.793652\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_5\">\n",
       "     <g id=\"line2d_10\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"288.176366\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_6\">\n",
       "     <g id=\"line2d_11\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"334.559079\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_4\">\n",
       "    <g id=\"ytick_6\">\n",
       "     <g id=\"line2d_12\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_8\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(210.903125 153.58851) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_7\">\n",
       "     <g id=\"line2d_13\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"116.879106\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_9\">\n",
       "      <!-- 20 -->\n",
       "      <g transform=\"translate(204.540625 120.678325) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_8\">\n",
       "     <g id=\"line2d_14\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"83.968921\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_10\">\n",
       "      <!-- 40 -->\n",
       "      <g transform=\"translate(204.540625 87.76814) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_9\">\n",
       "     <g id=\"line2d_15\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"51.058736\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_11\">\n",
       "      <!-- 60 -->\n",
       "      <g transform=\"translate(204.540625 54.857955) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_12\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(198.460938 107.620833) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_33\">\n",
       "    <path d=\"M 224.265625 149.789292 \n",
       "L 224.265625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_34\">\n",
       "    <path d=\"M 350.695625 149.789292 \n",
       "L 350.695625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_35\">\n",
       "    <path d=\"M 224.265625 149.789292 \n",
       "L 350.695625 149.789292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_36\">\n",
       "    <path d=\"M 224.265625 35.7555 \n",
       "L 350.695625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_13\">\n",
       "    <!-- CHEMBL1862 -->\n",
       "    <g transform=\"translate(247.080938 16.318125) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- ABL1 (747) -->\n",
       "    <g transform=\"translate(254.057813 29.7555) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-41\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"68.408203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"137.011719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"192.724609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"256.347656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"288.134766\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"327.148438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"390.771484\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"454.394531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"518.017578\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_3\">\n",
       "   <g id=\"patch_37\">\n",
       "    <path d=\"M 401.565625 149.789292 \n",
       "L 527.995625 149.789292 \n",
       "L 527.995625 35.7555 \n",
       "L 401.565625 35.7555 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_38\">\n",
       "    <path d=\"M 407.312443 149.789292 \n",
       "L 410.904205 149.789292 \n",
       "L 410.904205 148.589252 \n",
       "L 407.312443 148.589252 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_39\">\n",
       "    <path d=\"M 410.904205 149.789292 \n",
       "L 414.495966 149.789292 \n",
       "L 414.495966 149.189272 \n",
       "L 410.904205 149.189272 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_40\">\n",
       "    <path d=\"M 414.495966 149.789292 \n",
       "L 418.087727 149.789292 \n",
       "L 418.087727 148.589252 \n",
       "L 414.495966 148.589252 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_41\">\n",
       "    <path d=\"M 418.087727 149.789292 \n",
       "L 421.679489 149.789292 \n",
       "L 421.679489 146.789192 \n",
       "L 418.087727 146.789192 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_42\">\n",
       "    <path d=\"M 421.679489 149.789292 \n",
       "L 425.27125 149.789292 \n",
       "L 425.27125 146.189172 \n",
       "L 421.679489 146.189172 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_43\">\n",
       "    <path d=\"M 425.27125 149.789292 \n",
       "L 428.863011 149.789292 \n",
       "L 428.863011 143.789092 \n",
       "L 425.27125 143.789092 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_44\">\n",
       "    <path d=\"M 428.863011 149.789292 \n",
       "L 432.454773 149.789292 \n",
       "L 432.454773 135.388813 \n",
       "L 428.863011 135.388813 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_45\">\n",
       "    <path d=\"M 432.454773 149.789292 \n",
       "L 436.046534 149.789292 \n",
       "L 436.046534 127.588553 \n",
       "L 432.454773 127.588553 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_46\">\n",
       "    <path d=\"M 436.046534 149.789292 \n",
       "L 439.638295 149.789292 \n",
       "L 439.638295 107.187875 \n",
       "L 436.046534 107.187875 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_47\">\n",
       "    <path d=\"M 439.638295 149.789292 \n",
       "L 443.230057 149.789292 \n",
       "L 443.230057 98.187576 \n",
       "L 439.638295 98.187576 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_48\">\n",
       "    <path d=\"M 443.230057 149.789292 \n",
       "L 446.821818 149.789292 \n",
       "L 446.821818 96.987536 \n",
       "L 443.230057 96.987536 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_49\">\n",
       "    <path d=\"M 446.821818 149.789292 \n",
       "L 450.41358 149.789292 \n",
       "L 450.41358 88.587257 \n",
       "L 446.821818 88.587257 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_50\">\n",
       "    <path d=\"M 450.41358 149.789292 \n",
       "L 454.005341 149.789292 \n",
       "L 454.005341 72.986738 \n",
       "L 450.41358 72.986738 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_51\">\n",
       "    <path d=\"M 454.005341 149.789292 \n",
       "L 457.597102 149.789292 \n",
       "L 457.597102 54.986139 \n",
       "L 454.005341 54.986139 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_52\">\n",
       "    <path d=\"M 457.597102 149.789292 \n",
       "L 461.188864 149.789292 \n",
       "L 461.188864 51.38602 \n",
       "L 457.597102 51.38602 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_53\">\n",
       "    <path d=\"M 461.188864 149.789292 \n",
       "L 464.780625 149.789292 \n",
       "L 464.780625 48.98594 \n",
       "L 461.188864 48.98594 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_54\">\n",
       "    <path d=\"M 464.780625 149.789292 \n",
       "L 468.372386 149.789292 \n",
       "L 468.372386 41.185681 \n",
       "L 464.780625 41.185681 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_55\">\n",
       "    <path d=\"M 468.372386 149.789292 \n",
       "L 471.964148 149.789292 \n",
       "L 471.964148 59.186279 \n",
       "L 468.372386 59.186279 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_56\">\n",
       "    <path d=\"M 471.964148 149.789292 \n",
       "L 475.555909 149.789292 \n",
       "L 475.555909 51.98604 \n",
       "L 471.964148 51.98604 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_57\">\n",
       "    <path d=\"M 475.555909 149.789292 \n",
       "L 479.14767 149.789292 \n",
       "L 479.14767 66.986538 \n",
       "L 475.555909 66.986538 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_58\">\n",
       "    <path d=\"M 479.14767 149.789292 \n",
       "L 482.739432 149.789292 \n",
       "L 482.739432 82.587057 \n",
       "L 479.14767 82.587057 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_59\">\n",
       "    <path d=\"M 482.739432 149.789292 \n",
       "L 486.331193 149.789292 \n",
       "L 486.331193 87.387217 \n",
       "L 482.739432 87.387217 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_60\">\n",
       "    <path d=\"M 486.331193 149.789292 \n",
       "L 489.922955 149.789292 \n",
       "L 489.922955 95.787496 \n",
       "L 486.331193 95.787496 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_61\">\n",
       "    <path d=\"M 489.922955 149.789292 \n",
       "L 493.514716 149.789292 \n",
       "L 493.514716 118.588254 \n",
       "L 489.922955 118.588254 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_62\">\n",
       "    <path d=\"M 493.514716 149.789292 \n",
       "L 497.106477 149.789292 \n",
       "L 497.106477 131.188673 \n",
       "L 493.514716 131.188673 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_63\">\n",
       "    <path d=\"M 497.106477 149.789292 \n",
       "L 500.698239 149.789292 \n",
       "L 500.698239 139.588953 \n",
       "L 497.106477 139.588953 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_64\">\n",
       "    <path d=\"M 500.698239 149.789292 \n",
       "L 504.29 149.789292 \n",
       "L 504.29 138.388913 \n",
       "L 500.698239 138.388913 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_65\">\n",
       "    <path d=\"M 504.29 149.789292 \n",
       "L 507.881761 149.789292 \n",
       "L 507.881761 146.189172 \n",
       "L 504.29 146.189172 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_66\">\n",
       "    <path d=\"M 507.881761 149.789292 \n",
       "L 511.473523 149.789292 \n",
       "L 511.473523 146.189172 \n",
       "L 507.881761 146.189172 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_67\">\n",
       "    <path d=\"M 511.473523 149.789292 \n",
       "L 515.065284 149.789292 \n",
       "L 515.065284 149.189272 \n",
       "L 511.473523 149.189272 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_68\">\n",
       "    <path d=\"M 515.065284 149.789292 \n",
       "L 518.657045 149.789292 \n",
       "L 518.657045 149.789292 \n",
       "L 515.065284 149.789292 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_69\">\n",
       "    <path d=\"M 518.657045 149.789292 \n",
       "L 522.248807 149.789292 \n",
       "L 522.248807 148.589252 \n",
       "L 518.657045 148.589252 \n",
       "z\n",
       "\" clip-path=\"url(#p7d81b5fad1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.344615; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_5\">\n",
       "    <g id=\"xtick_7\">\n",
       "     <g id=\"line2d_16\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"419.093652\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_8\">\n",
       "     <g id=\"line2d_17\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"465.476366\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_9\">\n",
       "     <g id=\"line2d_18\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"511.859079\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_6\">\n",
       "    <g id=\"ytick_10\">\n",
       "     <g id=\"line2d_19\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_14\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(388.203125 153.58851) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_11\">\n",
       "     <g id=\"line2d_20\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"119.788294\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_15\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(381.840625 123.587513) scale(0.1 -0.1)\">\n",
       "       <defs>\n",
       "        <path id=\"DejaVuSans-35\" d=\"M 691 4666 \n",
       "L 3169 4666 \n",
       "L 3169 4134 \n",
       "L 1269 4134 \n",
       "L 1269 2991 \n",
       "Q 1406 3038 1543 3061 \n",
       "Q 1681 3084 1819 3084 \n",
       "Q 2600 3084 3056 2656 \n",
       "Q 3513 2228 3513 1497 \n",
       "Q 3513 744 3044 326 \n",
       "Q 2575 -91 1722 -91 \n",
       "Q 1428 -91 1123 -41 \n",
       "Q 819 9 494 109 \n",
       "L 494 744 \n",
       "Q 775 591 1075 516 \n",
       "Q 1375 441 1709 441 \n",
       "Q 2250 441 2565 725 \n",
       "Q 2881 1009 2881 1497 \n",
       "Q 2881 1984 2565 2268 \n",
       "Q 2250 2553 1709 2553 \n",
       "Q 1456 2553 1204 2497 \n",
       "Q 953 2441 691 2322 \n",
       "L 691 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       </defs>\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_12\">\n",
       "     <g id=\"line2d_21\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"89.787297\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_16\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(375.478125 93.586515) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_13\">\n",
       "     <g id=\"line2d_22\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"59.786299\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_17\">\n",
       "      <!-- 150 -->\n",
       "      <g transform=\"translate(375.478125 63.585518) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_18\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(369.398438 107.620833) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_70\">\n",
       "    <path d=\"M 401.565625 149.789292 \n",
       "L 401.565625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_71\">\n",
       "    <path d=\"M 527.995625 149.789292 \n",
       "L 527.995625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_72\">\n",
       "    <path d=\"M 401.565625 149.789292 \n",
       "L 527.995625 149.789292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_73\">\n",
       "    <path d=\"M 401.565625 35.7555 \n",
       "L 527.995625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_19\">\n",
       "    <!-- CHEMBL220 -->\n",
       "    <g transform=\"translate(428.198438 16.318125) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Acetylcholinesterase (3,157) -->\n",
       "    <g transform=\"translate(378.722813 29.7555) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-63\" d=\"M 3122 3366 \n",
       "L 3122 2828 \n",
       "Q 2878 2963 2633 3030 \n",
       "Q 2388 3097 2138 3097 \n",
       "Q 1578 3097 1268 2742 \n",
       "Q 959 2388 959 1747 \n",
       "Q 959 1106 1268 751 \n",
       "Q 1578 397 2138 397 \n",
       "Q 2388 397 2633 464 \n",
       "Q 2878 531 3122 666 \n",
       "L 3122 134 \n",
       "Q 2881 22 2623 -34 \n",
       "Q 2366 -91 2075 -91 \n",
       "Q 1284 -91 818 406 \n",
       "Q 353 903 353 1747 \n",
       "Q 353 2603 823 3093 \n",
       "Q 1294 3584 2113 3584 \n",
       "Q 2378 3584 2631 3529 \n",
       "Q 2884 3475 3122 3366 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-65\" d=\"M 3597 1894 \n",
       "L 3597 1613 \n",
       "L 953 1613 \n",
       "Q 991 1019 1311 708 \n",
       "Q 1631 397 2203 397 \n",
       "Q 2534 397 2845 478 \n",
       "Q 3156 559 3463 722 \n",
       "L 3463 178 \n",
       "Q 3153 47 2828 -22 \n",
       "Q 2503 -91 2169 -91 \n",
       "Q 1331 -91 842 396 \n",
       "Q 353 884 353 1716 \n",
       "Q 353 2575 817 3079 \n",
       "Q 1281 3584 2069 3584 \n",
       "Q 2775 3584 3186 3129 \n",
       "Q 3597 2675 3597 1894 \n",
       "z\n",
       "M 3022 2063 \n",
       "Q 3016 2534 2758 2815 \n",
       "Q 2500 3097 2075 3097 \n",
       "Q 1594 3097 1305 2825 \n",
       "Q 1016 2553 972 2059 \n",
       "L 3022 2063 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-79\" d=\"M 2059 -325 \n",
       "Q 1816 -950 1584 -1140 \n",
       "Q 1353 -1331 966 -1331 \n",
       "L 506 -1331 \n",
       "L 506 -850 \n",
       "L 844 -850 \n",
       "Q 1081 -850 1212 -737 \n",
       "Q 1344 -625 1503 -206 \n",
       "L 1606 56 \n",
       "L 191 3500 \n",
       "L 800 3500 \n",
       "L 1894 763 \n",
       "L 2988 3500 \n",
       "L 3597 3500 \n",
       "L 2059 -325 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-6c\" d=\"M 603 4863 \n",
       "L 1178 4863 \n",
       "L 1178 0 \n",
       "L 603 0 \n",
       "L 603 4863 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-68\" d=\"M 3513 2113 \n",
       "L 3513 0 \n",
       "L 2938 0 \n",
       "L 2938 2094 \n",
       "Q 2938 2591 2744 2837 \n",
       "Q 2550 3084 2163 3084 \n",
       "Q 1697 3084 1428 2787 \n",
       "Q 1159 2491 1159 1978 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 4863 \n",
       "L 1159 4863 \n",
       "L 1159 2956 \n",
       "Q 1366 3272 1645 3428 \n",
       "Q 1925 3584 2291 3584 \n",
       "Q 2894 3584 3203 3211 \n",
       "Q 3513 2838 3513 2113 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-69\" d=\"M 603 3500 \n",
       "L 1178 3500 \n",
       "L 1178 0 \n",
       "L 603 0 \n",
       "L 603 3500 \n",
       "z\n",
       "M 603 4863 \n",
       "L 1178 4863 \n",
       "L 1178 4134 \n",
       "L 603 4134 \n",
       "L 603 4863 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-73\" d=\"M 2834 3397 \n",
       "L 2834 2853 \n",
       "Q 2591 2978 2328 3040 \n",
       "Q 2066 3103 1784 3103 \n",
       "Q 1356 3103 1142 2972 \n",
       "Q 928 2841 928 2578 \n",
       "Q 928 2378 1081 2264 \n",
       "Q 1234 2150 1697 2047 \n",
       "L 1894 2003 \n",
       "Q 2506 1872 2764 1633 \n",
       "Q 3022 1394 3022 966 \n",
       "Q 3022 478 2636 193 \n",
       "Q 2250 -91 1575 -91 \n",
       "Q 1294 -91 989 -36 \n",
       "Q 684 19 347 128 \n",
       "L 347 722 \n",
       "Q 666 556 975 473 \n",
       "Q 1284 391 1588 391 \n",
       "Q 1994 391 2212 530 \n",
       "Q 2431 669 2431 922 \n",
       "Q 2431 1156 2273 1281 \n",
       "Q 2116 1406 1581 1522 \n",
       "L 1381 1569 \n",
       "Q 847 1681 609 1914 \n",
       "Q 372 2147 372 2553 \n",
       "Q 372 3047 722 3315 \n",
       "Q 1072 3584 1716 3584 \n",
       "Q 2034 3584 2315 3537 \n",
       "Q 2597 3491 2834 3397 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-72\" d=\"M 2631 2963 \n",
       "Q 2534 3019 2420 3045 \n",
       "Q 2306 3072 2169 3072 \n",
       "Q 1681 3072 1420 2755 \n",
       "Q 1159 2438 1159 1844 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 3500 \n",
       "L 1159 3500 \n",
       "L 1159 2956 \n",
       "Q 1341 3275 1631 3429 \n",
       "Q 1922 3584 2338 3584 \n",
       "Q 2397 3584 2469 3576 \n",
       "Q 2541 3569 2628 3553 \n",
       "L 2631 2963 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-2c\" d=\"M 750 794 \n",
       "L 1409 794 \n",
       "L 1409 256 \n",
       "L 897 -744 \n",
       "L 494 -744 \n",
       "L 750 256 \n",
       "L 750 794 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-41\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"66.658203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"121.638672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"183.162109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-79\" x=\"222.371094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"281.550781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"309.333984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"364.314453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"427.693359\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"488.875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"516.658203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"544.441406\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"607.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"669.34375\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"721.443359\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"760.652344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"822.175781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"863.289062\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"924.568359\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"976.667969\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"1038.191406\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"1069.978516\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"1108.992188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"1172.615234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"1204.402344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"1268.025391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"1331.648438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"1395.271484\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_4\">\n",
       "   <g id=\"patch_74\">\n",
       "    <path d=\"M 578.865625 149.789292 \n",
       "L 705.295625 149.789292 \n",
       "L 705.295625 35.7555 \n",
       "L 578.865625 35.7555 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_75\">\n",
       "    <path d=\"M 592.59027 149.789292 \n",
       "L 596.632702 149.789292 \n",
       "L 596.632702 149.165133 \n",
       "L 592.59027 149.165133 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_76\">\n",
       "    <path d=\"M 596.632702 149.789292 \n",
       "L 600.675134 149.789292 \n",
       "L 600.675134 147.916816 \n",
       "L 596.632702 147.916816 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_77\">\n",
       "    <path d=\"M 600.675134 149.789292 \n",
       "L 604.717565 149.789292 \n",
       "L 604.717565 142.923546 \n",
       "L 600.675134 142.923546 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_78\">\n",
       "    <path d=\"M 604.717565 149.789292 \n",
       "L 608.759997 149.789292 \n",
       "L 608.759997 134.809483 \n",
       "L 604.717565 134.809483 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_79\">\n",
       "    <path d=\"M 608.759997 149.789292 \n",
       "L 612.802429 149.789292 \n",
       "L 612.802429 126.69542 \n",
       "L 608.759997 126.69542 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_80\">\n",
       "    <path d=\"M 612.802429 149.789292 \n",
       "L 616.844861 149.789292 \n",
       "L 616.844861 126.69542 \n",
       "L 612.802429 126.69542 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_81\">\n",
       "    <path d=\"M 616.844861 149.789292 \n",
       "L 620.887293 149.789292 \n",
       "L 620.887293 108.594818 \n",
       "L 616.844861 108.594818 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_82\">\n",
       "    <path d=\"M 620.887293 149.789292 \n",
       "L 624.929725 149.789292 \n",
       "L 624.929725 85.500947 \n",
       "L 620.887293 85.500947 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_83\">\n",
       "    <path d=\"M 624.929725 149.789292 \n",
       "L 628.972157 149.789292 \n",
       "L 628.972157 77.386884 \n",
       "L 624.929725 77.386884 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_84\">\n",
       "    <path d=\"M 628.972157 149.789292 \n",
       "L 633.014588 149.789292 \n",
       "L 633.014588 75.514408 \n",
       "L 628.972157 75.514408 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_85\">\n",
       "    <path d=\"M 633.014588 149.789292 \n",
       "L 637.05702 149.789292 \n",
       "L 637.05702 51.17222 \n",
       "L 633.014588 51.17222 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_86\">\n",
       "    <path d=\"M 637.05702 149.789292 \n",
       "L 641.099452 149.789292 \n",
       "L 641.099452 75.514408 \n",
       "L 637.05702 75.514408 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_87\">\n",
       "    <path d=\"M 641.099452 149.789292 \n",
       "L 645.141884 149.789292 \n",
       "L 645.141884 64.903711 \n",
       "L 641.099452 64.903711 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_88\">\n",
       "    <path d=\"M 645.141884 149.789292 \n",
       "L 649.184316 149.789292 \n",
       "L 649.184316 41.185681 \n",
       "L 645.141884 41.185681 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_89\">\n",
       "    <path d=\"M 649.184316 149.789292 \n",
       "L 653.226748 149.789292 \n",
       "L 653.226748 54.917172 \n",
       "L 649.184316 54.917172 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_90\">\n",
       "    <path d=\"M 653.226748 149.789292 \n",
       "L 657.26918 149.789292 \n",
       "L 657.26918 66.776187 \n",
       "L 653.226748 66.776187 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_91\">\n",
       "    <path d=\"M 657.26918 149.789292 \n",
       "L 661.311612 149.789292 \n",
       "L 661.311612 71.769456 \n",
       "L 657.26918 71.769456 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_92\">\n",
       "    <path d=\"M 661.311612 149.789292 \n",
       "L 665.354043 149.789292 \n",
       "L 665.354043 99.856597 \n",
       "L 661.311612 99.856597 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_93\">\n",
       "    <path d=\"M 665.354043 149.789292 \n",
       "L 669.396475 149.789292 \n",
       "L 669.396475 111.091453 \n",
       "L 665.354043 111.091453 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_94\">\n",
       "    <path d=\"M 669.396475 149.789292 \n",
       "L 673.438907 149.789292 \n",
       "L 673.438907 118.581357 \n",
       "L 669.396475 118.581357 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_95\">\n",
       "    <path d=\"M 673.438907 149.789292 \n",
       "L 677.481339 149.789292 \n",
       "L 677.481339 132.312848 \n",
       "L 673.438907 132.312848 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_96\">\n",
       "    <path d=\"M 677.481339 149.789292 \n",
       "L 681.523771 149.789292 \n",
       "L 681.523771 136.057801 \n",
       "L 677.481339 136.057801 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_97\">\n",
       "    <path d=\"M 681.523771 149.789292 \n",
       "L 685.566203 149.789292 \n",
       "L 685.566203 139.802753 \n",
       "L 681.523771 139.802753 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_98\">\n",
       "    <path d=\"M 685.566203 149.789292 \n",
       "L 689.608635 149.789292 \n",
       "L 689.608635 146.668498 \n",
       "L 685.566203 146.668498 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_99\">\n",
       "    <path d=\"M 689.608635 149.789292 \n",
       "L 693.651066 149.789292 \n",
       "L 693.651066 148.540974 \n",
       "L 689.608635 148.540974 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_100\">\n",
       "    <path d=\"M 693.651066 149.789292 \n",
       "L 697.693498 149.789292 \n",
       "L 697.693498 148.540974 \n",
       "L 693.651066 148.540974 \n",
       "z\n",
       "\" clip-path=\"url(#pfc0b2f2c16)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.387855; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_7\">\n",
       "    <g id=\"xtick_10\">\n",
       "     <g id=\"line2d_23\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"596.393652\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_11\">\n",
       "     <g id=\"line2d_24\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"642.776366\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_12\">\n",
       "     <g id=\"line2d_25\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"689.159079\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_8\">\n",
       "    <g id=\"ytick_14\">\n",
       "     <g id=\"line2d_26\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"149.789292\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_20\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(565.503125 153.58851) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_15\">\n",
       "     <g id=\"line2d_27\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"118.581357\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_21\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(559.140625 122.380576) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_16\">\n",
       "     <g id=\"line2d_28\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"87.373423\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_22\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(552.778125 91.172642) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_17\">\n",
       "     <g id=\"line2d_29\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"56.165489\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_23\">\n",
       "      <!-- 150 -->\n",
       "      <g transform=\"translate(552.778125 59.964708) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_24\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(546.698438 107.620833) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_101\">\n",
       "    <path d=\"M 578.865625 149.789292 \n",
       "L 578.865625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_102\">\n",
       "    <path d=\"M 705.295625 149.789292 \n",
       "L 705.295625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_103\">\n",
       "    <path d=\"M 578.865625 149.789292 \n",
       "L 705.295625 149.789292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_104\">\n",
       "    <path d=\"M 578.865625 35.7555 \n",
       "L 705.295625 35.7555 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_25\">\n",
       "    <!-- CHEMBL4722 -->\n",
       "    <g transform=\"translate(601.680938 16.318125) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- Aurora-A (2,122) -->\n",
       "    <g transform=\"translate(592.127813 29.7555) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-2d\" d=\"M 313 2009 \n",
       "L 1997 2009 \n",
       "L 1997 1497 \n",
       "L 313 1497 \n",
       "L 313 2009 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-41\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-75\" x=\"68.408203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"131.787109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"170.650391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"231.832031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"272.945312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2d\" x=\"334.224609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-41\" x=\"368.058594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"436.466797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"468.253906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"507.267578\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"570.890625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"602.677734\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"666.300781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"729.923828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"793.546875\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_5\">\n",
       "   <g id=\"patch_105\">\n",
       "    <path d=\"M 46.965625 311.799083 \n",
       "L 173.395625 311.799083 \n",
       "L 173.395625 197.765292 \n",
       "L 46.965625 197.765292 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_106\">\n",
       "    <path d=\"M 65.235776 311.799083 \n",
       "L 70.20388 311.799083 \n",
       "L 70.20388 310.605637 \n",
       "L 65.235776 310.605637 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_107\">\n",
       "    <path d=\"M 70.20388 311.799083 \n",
       "L 75.171984 311.799083 \n",
       "L 75.171984 303.444959 \n",
       "L 70.20388 303.444959 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_108\">\n",
       "    <path d=\"M 75.171984 311.799083 \n",
       "L 80.140088 311.799083 \n",
       "L 80.140088 301.058067 \n",
       "L 75.171984 301.058067 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_109\">\n",
       "    <path d=\"M 80.140088 311.799083 \n",
       "L 85.108192 311.799083 \n",
       "L 85.108192 278.382588 \n",
       "L 80.140088 278.382588 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_110\">\n",
       "    <path d=\"M 85.108192 311.799083 \n",
       "L 90.076296 311.799083 \n",
       "L 90.076296 259.287447 \n",
       "L 85.108192 259.287447 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_111\">\n",
       "    <path d=\"M 90.076296 311.799083 \n",
       "L 95.0444 311.799083 \n",
       "L 95.0444 241.385753 \n",
       "L 90.076296 241.385753 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_112\">\n",
       "    <path d=\"M 95.0444 311.799083 \n",
       "L 100.012504 311.799083 \n",
       "L 100.012504 227.064398 \n",
       "L 95.0444 227.064398 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_113\">\n",
       "    <path d=\"M 100.012504 311.799083 \n",
       "L 104.980607 311.799083 \n",
       "L 104.980607 203.195472 \n",
       "L 100.012504 203.195472 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_114\">\n",
       "    <path d=\"M 104.980607 311.799083 \n",
       "L 109.948711 311.799083 \n",
       "L 109.948711 210.35615 \n",
       "L 104.980607 210.35615 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_115\">\n",
       "    <path d=\"M 109.948711 311.799083 \n",
       "L 114.916815 311.799083 \n",
       "L 114.916815 213.936489 \n",
       "L 109.948711 213.936489 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_116\">\n",
       "    <path d=\"M 114.916815 311.799083 \n",
       "L 119.884919 311.799083 \n",
       "L 119.884919 207.969257 \n",
       "L 114.916815 207.969257 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_117\">\n",
       "    <path d=\"M 119.884919 311.799083 \n",
       "L 124.853023 311.799083 \n",
       "L 124.853023 216.323381 \n",
       "L 119.884919 216.323381 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_118\">\n",
       "    <path d=\"M 124.853023 311.799083 \n",
       "L 129.821127 311.799083 \n",
       "L 129.821127 243.772646 \n",
       "L 124.853023 243.772646 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_119\">\n",
       "    <path d=\"M 129.821127 311.799083 \n",
       "L 134.789231 311.799083 \n",
       "L 134.789231 275.995695 \n",
       "L 129.821127 275.995695 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_120\">\n",
       "    <path d=\"M 134.789231 311.799083 \n",
       "L 139.757335 311.799083 \n",
       "L 139.757335 278.382588 \n",
       "L 134.789231 278.382588 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_121\">\n",
       "    <path d=\"M 139.757335 311.799083 \n",
       "L 144.725439 311.799083 \n",
       "L 144.725439 295.090835 \n",
       "L 139.757335 295.090835 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_122\">\n",
       "    <path d=\"M 144.725439 311.799083 \n",
       "L 149.693543 311.799083 \n",
       "L 149.693543 295.090835 \n",
       "L 144.725439 295.090835 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_123\">\n",
       "    <path d=\"M 149.693543 311.799083 \n",
       "L 154.661647 311.799083 \n",
       "L 154.661647 309.412191 \n",
       "L 149.693543 309.412191 \n",
       "z\n",
       "\" clip-path=\"url(#pbf054e3684)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.476669; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_9\">\n",
       "    <g id=\"xtick_13\">\n",
       "     <g id=\"line2d_30\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"64.493652\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_14\">\n",
       "     <g id=\"line2d_31\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"110.876366\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_15\">\n",
       "     <g id=\"line2d_32\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"157.259079\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_10\">\n",
       "    <g id=\"ytick_18\">\n",
       "     <g id=\"line2d_33\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_26\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(33.603125 315.598302) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_19\">\n",
       "     <g id=\"line2d_34\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"287.930158\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_27\">\n",
       "      <!-- 20 -->\n",
       "      <g transform=\"translate(27.240625 291.729377) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_20\">\n",
       "     <g id=\"line2d_35\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"264.061232\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_28\">\n",
       "      <!-- 40 -->\n",
       "      <g transform=\"translate(27.240625 267.860451) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_21\">\n",
       "     <g id=\"line2d_36\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"240.192307\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_29\">\n",
       "      <!-- 60 -->\n",
       "      <g transform=\"translate(27.240625 243.991526) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_22\">\n",
       "     <g id=\"line2d_37\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"216.323381\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_30\">\n",
       "      <!-- 80 -->\n",
       "      <g transform=\"translate(27.240625 220.1226) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-38\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_31\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(21.160937 269.630625) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_124\">\n",
       "    <path d=\"M 46.965625 311.799083 \n",
       "L 46.965625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_125\">\n",
       "    <path d=\"M 173.395625 311.799083 \n",
       "L 173.395625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_126\">\n",
       "    <path d=\"M 46.965625 311.799083 \n",
       "L 173.395625 311.799083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_127\">\n",
       "    <path d=\"M 46.965625 197.765292 \n",
       "L 173.395625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_32\">\n",
       "    <!-- CHEMBL5145 -->\n",
       "    <g transform=\"translate(69.780938 178.327917) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- B-raf (1,728) -->\n",
       "    <g transform=\"translate(71.878125 191.765292) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-66\" d=\"M 2375 4863 \n",
       "L 2375 4384 \n",
       "L 1825 4384 \n",
       "Q 1516 4384 1395 4259 \n",
       "Q 1275 4134 1275 3809 \n",
       "L 1275 3500 \n",
       "L 2222 3500 \n",
       "L 2222 3053 \n",
       "L 1275 3053 \n",
       "L 1275 0 \n",
       "L 697 0 \n",
       "L 697 3053 \n",
       "L 147 3053 \n",
       "L 147 3500 \n",
       "L 697 3500 \n",
       "L 697 3744 \n",
       "Q 697 4328 969 4595 \n",
       "Q 1241 4863 1831 4863 \n",
       "L 2375 4863 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-42\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2d\" x=\"68.603516\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"104.6875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"145.800781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"207.080078\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"242.285156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"274.072266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"313.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"376.708984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"408.496094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"472.119141\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"535.742188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"599.365234\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_6\">\n",
       "   <g id=\"patch_128\">\n",
       "    <path d=\"M 224.265625 311.799083 \n",
       "L 350.695625 311.799083 \n",
       "L 350.695625 197.765292 \n",
       "L 224.265625 197.765292 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_129\">\n",
       "    <path d=\"M 248.658294 311.799083 \n",
       "L 252.620703 311.799083 \n",
       "L 252.620703 308.965946 \n",
       "L 248.658294 308.965946 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_130\">\n",
       "    <path d=\"M 252.620703 311.799083 \n",
       "L 256.583112 311.799083 \n",
       "L 256.583112 306.132808 \n",
       "L 252.620703 306.132808 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_131\">\n",
       "    <path d=\"M 256.583112 311.799083 \n",
       "L 260.545521 311.799083 \n",
       "L 260.545521 292.911499 \n",
       "L 256.583112 292.911499 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_132\">\n",
       "    <path d=\"M 260.545521 311.799083 \n",
       "L 264.50793 311.799083 \n",
       "L 264.50793 278.74581 \n",
       "L 260.545521 278.74581 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_133\">\n",
       "    <path d=\"M 264.50793 311.799083 \n",
       "L 268.470339 311.799083 \n",
       "L 268.470339 283.467707 \n",
       "L 264.50793 283.467707 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_134\">\n",
       "    <path d=\"M 268.470339 311.799083 \n",
       "L 272.432748 311.799083 \n",
       "L 272.432748 269.302018 \n",
       "L 268.470339 269.302018 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_135\">\n",
       "    <path d=\"M 272.432748 311.799083 \n",
       "L 276.395157 311.799083 \n",
       "L 276.395157 263.635743 \n",
       "L 272.432748 263.635743 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_136\">\n",
       "    <path d=\"M 276.395157 311.799083 \n",
       "L 280.357565 311.799083 \n",
       "L 280.357565 238.137504 \n",
       "L 276.395157 238.137504 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_137\">\n",
       "    <path d=\"M 280.357565 311.799083 \n",
       "L 284.319974 311.799083 \n",
       "L 284.319974 226.804953 \n",
       "L 280.357565 226.804953 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_138\">\n",
       "    <path d=\"M 284.319974 311.799083 \n",
       "L 288.282383 311.799083 \n",
       "L 288.282383 203.195472 \n",
       "L 284.319974 203.195472 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_139\">\n",
       "    <path d=\"M 288.282383 311.799083 \n",
       "L 292.244792 311.799083 \n",
       "L 292.244792 209.806127 \n",
       "L 288.282383 209.806127 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_140\">\n",
       "    <path d=\"M 292.244792 311.799083 \n",
       "L 296.207201 311.799083 \n",
       "L 296.207201 243.803779 \n",
       "L 292.244792 243.803779 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_141\">\n",
       "    <path d=\"M 296.207201 311.799083 \n",
       "L 300.16961 311.799083 \n",
       "L 300.16961 231.526849 \n",
       "L 296.207201 231.526849 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_142\">\n",
       "    <path d=\"M 300.16961 311.799083 \n",
       "L 304.132019 311.799083 \n",
       "L 304.132019 240.970641 \n",
       "L 300.16961 240.970641 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_143\">\n",
       "    <path d=\"M 304.132019 311.799083 \n",
       "L 308.094428 311.799083 \n",
       "L 308.094428 260.802605 \n",
       "L 304.132019 260.802605 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_144\">\n",
       "    <path d=\"M 308.094428 311.799083 \n",
       "L 312.056837 311.799083 \n",
       "L 312.056837 275.912673 \n",
       "L 308.094428 275.912673 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_145\">\n",
       "    <path d=\"M 312.056837 311.799083 \n",
       "L 316.019246 311.799083 \n",
       "L 316.019246 286.300844 \n",
       "L 312.056837 286.300844 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_146\">\n",
       "    <path d=\"M 316.019246 311.799083 \n",
       "L 319.981655 311.799083 \n",
       "L 319.981655 297.633395 \n",
       "L 316.019246 297.633395 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_147\">\n",
       "    <path d=\"M 319.981655 311.799083 \n",
       "L 323.944064 311.799083 \n",
       "L 323.944064 298.577774 \n",
       "L 319.981655 298.577774 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_148\">\n",
       "    <path d=\"M 323.944064 311.799083 \n",
       "L 327.906473 311.799083 \n",
       "L 327.906473 306.132808 \n",
       "L 323.944064 306.132808 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_149\">\n",
       "    <path d=\"M 327.906473 311.799083 \n",
       "L 331.868882 311.799083 \n",
       "L 331.868882 308.965946 \n",
       "L 327.906473 308.965946 \n",
       "z\n",
       "\" clip-path=\"url(#p0cc20ddfd5)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.380177; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_11\">\n",
       "    <g id=\"xtick_16\">\n",
       "     <g id=\"line2d_38\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"241.793652\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_17\">\n",
       "     <g id=\"line2d_39\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"288.176366\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_18\">\n",
       "     <g id=\"line2d_40\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"334.559079\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_12\">\n",
       "    <g id=\"ytick_23\">\n",
       "     <g id=\"line2d_41\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_33\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(210.903125 315.598302) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_24\">\n",
       "     <g id=\"line2d_42\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"288.189603\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_34\">\n",
       "      <!-- 25 -->\n",
       "      <g transform=\"translate(204.540625 291.988821) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_25\">\n",
       "     <g id=\"line2d_43\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"264.580122\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_35\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(204.540625 268.379341) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_26\">\n",
       "     <g id=\"line2d_44\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"240.970641\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_36\">\n",
       "      <!-- 75 -->\n",
       "      <g transform=\"translate(204.540625 244.76986) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-37\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_27\">\n",
       "     <g id=\"line2d_45\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"217.361161\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_37\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(198.178125 221.160379) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_38\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(192.098438 269.630625) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_150\">\n",
       "    <path d=\"M 224.265625 311.799083 \n",
       "L 224.265625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_151\">\n",
       "    <path d=\"M 350.695625 311.799083 \n",
       "L 350.695625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_152\">\n",
       "    <path d=\"M 224.265625 311.799083 \n",
       "L 350.695625 311.799083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_153\">\n",
       "    <path d=\"M 224.265625 197.765292 \n",
       "L 350.695625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_39\">\n",
       "    <!-- CHEMBL218 -->\n",
       "    <g transform=\"translate(250.898438 178.327917) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Cannabinoid (1,116) -->\n",
       "    <g transform=\"translate(226.140938 191.765292) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-62\" d=\"M 3116 1747 \n",
       "Q 3116 2381 2855 2742 \n",
       "Q 2594 3103 2138 3103 \n",
       "Q 1681 3103 1420 2742 \n",
       "Q 1159 2381 1159 1747 \n",
       "Q 1159 1113 1420 752 \n",
       "Q 1681 391 2138 391 \n",
       "Q 2594 391 2855 752 \n",
       "Q 3116 1113 3116 1747 \n",
       "z\n",
       "M 1159 2969 \n",
       "Q 1341 3281 1617 3432 \n",
       "Q 1894 3584 2278 3584 \n",
       "Q 2916 3584 3314 3078 \n",
       "Q 3713 2572 3713 1747 \n",
       "Q 3713 922 3314 415 \n",
       "Q 2916 -91 2278 -91 \n",
       "Q 1894 -91 1617 61 \n",
       "Q 1341 213 1159 525 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 4863 \n",
       "L 1159 4863 \n",
       "L 1159 2969 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-64\" d=\"M 2906 2969 \n",
       "L 2906 4863 \n",
       "L 3481 4863 \n",
       "L 3481 0 \n",
       "L 2906 0 \n",
       "L 2906 525 \n",
       "Q 2725 213 2448 61 \n",
       "Q 2172 -91 1784 -91 \n",
       "Q 1150 -91 751 415 \n",
       "Q 353 922 353 1747 \n",
       "Q 353 2572 751 3078 \n",
       "Q 1150 3584 1784 3584 \n",
       "Q 2172 3584 2448 3432 \n",
       "Q 2725 3281 2906 2969 \n",
       "z\n",
       "M 947 1747 \n",
       "Q 947 1113 1208 752 \n",
       "Q 1469 391 1925 391 \n",
       "Q 2381 391 2643 752 \n",
       "Q 2906 1113 2906 1747 \n",
       "Q 2906 2381 2643 2742 \n",
       "Q 2381 3103 1925 3103 \n",
       "Q 1469 3103 1208 2742 \n",
       "Q 947 2381 947 1747 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"131.103516\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"194.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"257.861328\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-62\" x=\"319.140625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"382.617188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"410.400391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"473.779297\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"534.960938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"562.744141\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"626.220703\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"658.007812\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"697.021484\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"760.644531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"792.431641\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"856.054688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"919.677734\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"983.300781\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_7\">\n",
       "   <g id=\"patch_154\">\n",
       "    <path d=\"M 401.565625 311.799083 \n",
       "L 527.995625 311.799083 \n",
       "L 527.995625 197.765292 \n",
       "L 401.565625 197.765292 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_155\">\n",
       "    <path d=\"M 421.227257 311.799083 \n",
       "L 425.618154 311.799083 \n",
       "L 425.618154 310.269455 \n",
       "L 421.227257 310.269455 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_156\">\n",
       "    <path d=\"M 425.618154 311.799083 \n",
       "L 430.009051 311.799083 \n",
       "L 430.009051 304.150942 \n",
       "L 425.618154 304.150942 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_157\">\n",
       "    <path d=\"M 430.009051 311.799083 \n",
       "L 434.399948 311.799083 \n",
       "L 434.399948 304.150942 \n",
       "L 430.009051 304.150942 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_158\">\n",
       "    <path d=\"M 434.399948 311.799083 \n",
       "L 438.790845 311.799083 \n",
       "L 438.790845 288.854658 \n",
       "L 434.399948 288.854658 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_159\">\n",
       "    <path d=\"M 438.790845 311.799083 \n",
       "L 443.181741 311.799083 \n",
       "L 443.181741 301.091685 \n",
       "L 438.790845 301.091685 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_160\">\n",
       "    <path d=\"M 443.181741 311.799083 \n",
       "L 447.572638 311.799083 \n",
       "L 447.572638 282.736145 \n",
       "L 443.181741 282.736145 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_161\">\n",
       "    <path d=\"M 447.572638 311.799083 \n",
       "L 451.963535 311.799083 \n",
       "L 451.963535 275.088004 \n",
       "L 447.572638 275.088004 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_162\">\n",
       "    <path d=\"M 451.963535 311.799083 \n",
       "L 456.354432 311.799083 \n",
       "L 456.354432 275.088004 \n",
       "L 451.963535 275.088004 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_163\">\n",
       "    <path d=\"M 456.354432 311.799083 \n",
       "L 460.745329 311.799083 \n",
       "L 460.745329 224.610269 \n",
       "L 456.354432 224.610269 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_164\">\n",
       "    <path d=\"M 460.745329 311.799083 \n",
       "L 465.136226 311.799083 \n",
       "L 465.136226 212.373242 \n",
       "L 460.745329 212.373242 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_165\">\n",
       "    <path d=\"M 465.136226 311.799083 \n",
       "L 469.527123 311.799083 \n",
       "L 469.527123 203.195472 \n",
       "L 465.136226 203.195472 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_166\">\n",
       "    <path d=\"M 469.527123 311.799083 \n",
       "L 473.91802 311.799083 \n",
       "L 473.91802 227.669525 \n",
       "L 469.527123 227.669525 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_167\">\n",
       "    <path d=\"M 473.91802 311.799083 \n",
       "L 478.308916 311.799083 \n",
       "L 478.308916 255.202835 \n",
       "L 473.91802 255.202835 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_168\">\n",
       "    <path d=\"M 478.308916 311.799083 \n",
       "L 482.699813 311.799083 \n",
       "L 482.699813 275.088004 \n",
       "L 478.308916 275.088004 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_169\">\n",
       "    <path d=\"M 482.699813 311.799083 \n",
       "L 487.09071 311.799083 \n",
       "L 487.09071 273.558375 \n",
       "L 482.699813 273.558375 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_170\">\n",
       "    <path d=\"M 487.09071 311.799083 \n",
       "L 491.481607 311.799083 \n",
       "L 491.481607 291.913915 \n",
       "L 487.09071 291.913915 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_171\">\n",
       "    <path d=\"M 491.481607 311.799083 \n",
       "L 495.872504 311.799083 \n",
       "L 495.872504 293.443543 \n",
       "L 491.481607 293.443543 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_172\">\n",
       "    <path d=\"M 495.872504 311.799083 \n",
       "L 500.263401 311.799083 \n",
       "L 500.263401 293.443543 \n",
       "L 495.872504 293.443543 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_173\">\n",
       "    <path d=\"M 500.263401 311.799083 \n",
       "L 504.654298 311.799083 \n",
       "L 504.654298 302.621313 \n",
       "L 500.263401 302.621313 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_174\">\n",
       "    <path d=\"M 504.654298 311.799083 \n",
       "L 509.045194 311.799083 \n",
       "L 509.045194 302.621313 \n",
       "L 504.654298 302.621313 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_175\">\n",
       "    <path d=\"M 509.045194 311.799083 \n",
       "L 513.436091 311.799083 \n",
       "L 513.436091 310.269455 \n",
       "L 509.045194 310.269455 \n",
       "z\n",
       "\" clip-path=\"url(#p9a3db44e50)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.421288; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_13\">\n",
       "    <g id=\"xtick_19\">\n",
       "     <g id=\"line2d_46\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"419.093652\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_20\">\n",
       "     <g id=\"line2d_47\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"465.476366\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_21\">\n",
       "     <g id=\"line2d_48\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"511.859079\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_14\">\n",
       "    <g id=\"ytick_28\">\n",
       "     <g id=\"line2d_49\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_40\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(388.203125 315.598302) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_29\">\n",
       "     <g id=\"line2d_50\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"281.206517\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_41\">\n",
       "      <!-- 20 -->\n",
       "      <g transform=\"translate(381.840625 285.005736) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_30\">\n",
       "     <g id=\"line2d_51\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"250.61395\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_42\">\n",
       "      <!-- 40 -->\n",
       "      <g transform=\"translate(381.840625 254.413169) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_31\">\n",
       "     <g id=\"line2d_52\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"220.021384\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_43\">\n",
       "      <!-- 60 -->\n",
       "      <g transform=\"translate(381.840625 223.820603) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_44\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(375.760938 269.630625) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_176\">\n",
       "    <path d=\"M 401.565625 311.799083 \n",
       "L 401.565625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_177\">\n",
       "    <path d=\"M 527.995625 311.799083 \n",
       "L 527.995625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_178\">\n",
       "    <path d=\"M 401.565625 311.799083 \n",
       "L 527.995625 311.799083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_179\">\n",
       "    <path d=\"M 401.565625 197.765292 \n",
       "L 527.995625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_45\">\n",
       "    <!-- CHEMBL205 -->\n",
       "    <g transform=\"translate(428.198438 178.327917) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Carbonic (603) -->\n",
       "    <g transform=\"translate(420.1575 191.765292) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"131.103516\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-62\" x=\"172.216797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"235.693359\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"296.875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"360.253906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"388.037109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"443.017578\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"474.804688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"513.818359\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"577.441406\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"641.064453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"704.6875\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_8\">\n",
       "   <g id=\"patch_180\">\n",
       "    <path d=\"M 578.865625 311.799083 \n",
       "L 705.295625 311.799083 \n",
       "L 705.295625 197.765292 \n",
       "L 578.865625 197.765292 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_181\">\n",
       "    <path d=\"M 590.54943 311.799083 \n",
       "L 593.969383 311.799083 \n",
       "L 593.969383 310.084289 \n",
       "L 590.54943 310.084289 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_182\">\n",
       "    <path d=\"M 593.969383 311.799083 \n",
       "L 597.389335 311.799083 \n",
       "L 597.389335 311.227485 \n",
       "L 593.969383 311.227485 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_183\">\n",
       "    <path d=\"M 597.389335 311.799083 \n",
       "L 600.809287 311.799083 \n",
       "L 600.809287 307.2263 \n",
       "L 597.389335 307.2263 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_184\">\n",
       "    <path d=\"M 600.809287 311.799083 \n",
       "L 604.229239 311.799083 \n",
       "L 604.229239 307.2263 \n",
       "L 600.809287 307.2263 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_185\">\n",
       "    <path d=\"M 604.229239 311.799083 \n",
       "L 607.649191 311.799083 \n",
       "L 607.649191 302.081918 \n",
       "L 604.229239 302.081918 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_186\">\n",
       "    <path d=\"M 607.649191 311.799083 \n",
       "L 611.069143 311.799083 \n",
       "L 611.069143 299.223928 \n",
       "L 607.649191 299.223928 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_187\">\n",
       "    <path d=\"M 611.069143 311.799083 \n",
       "L 614.489095 311.799083 \n",
       "L 614.489095 297.509135 \n",
       "L 611.069143 297.509135 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_188\">\n",
       "    <path d=\"M 614.489095 311.799083 \n",
       "L 617.909047 311.799083 \n",
       "L 617.909047 292.364753 \n",
       "L 614.489095 292.364753 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_189\">\n",
       "    <path d=\"M 617.909047 311.799083 \n",
       "L 621.328999 311.799083 \n",
       "L 621.328999 287.220371 \n",
       "L 617.909047 287.220371 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_190\">\n",
       "    <path d=\"M 621.328999 311.799083 \n",
       "L 624.748951 311.799083 \n",
       "L 624.748951 283.790784 \n",
       "L 621.328999 283.790784 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_191\">\n",
       "    <path d=\"M 624.748951 311.799083 \n",
       "L 628.168903 311.799083 \n",
       "L 628.168903 271.787227 \n",
       "L 624.748951 271.787227 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_192\">\n",
       "    <path d=\"M 628.168903 311.799083 \n",
       "L 631.588855 311.799083 \n",
       "L 631.588855 277.503206 \n",
       "L 628.168903 277.503206 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_193\">\n",
       "    <path d=\"M 631.588855 311.799083 \n",
       "L 635.008807 311.799083 \n",
       "L 635.008807 263.213257 \n",
       "L 631.588855 263.213257 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_194\">\n",
       "    <path d=\"M 635.008807 311.799083 \n",
       "L 638.428759 311.799083 \n",
       "L 638.428759 260.355268 \n",
       "L 635.008807 260.355268 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_195\">\n",
       "    <path d=\"M 638.428759 311.799083 \n",
       "L 641.848711 311.799083 \n",
       "L 641.848711 218.057019 \n",
       "L 638.428759 218.057019 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_196\">\n",
       "    <path d=\"M 641.848711 311.799083 \n",
       "L 645.268663 311.799083 \n",
       "L 645.268663 203.195472 \n",
       "L 641.848711 203.195472 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_197\">\n",
       "    <path d=\"M 645.268663 311.799083 \n",
       "L 648.688616 311.799083 \n",
       "L 648.688616 226.630988 \n",
       "L 645.268663 226.630988 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_198\">\n",
       "    <path d=\"M 648.688616 311.799083 \n",
       "L 652.108568 311.799083 \n",
       "L 652.108568 255.782484 \n",
       "L 648.688616 255.782484 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_199\">\n",
       "    <path d=\"M 652.108568 311.799083 \n",
       "L 655.52852 311.799083 \n",
       "L 655.52852 270.644031 \n",
       "L 652.108568 270.644031 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_200\">\n",
       "    <path d=\"M 655.52852 311.799083 \n",
       "L 658.948472 311.799083 \n",
       "L 658.948472 273.50202 \n",
       "L 655.52852 273.50202 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_201\">\n",
       "    <path d=\"M 658.948472 311.799083 \n",
       "L 662.368424 311.799083 \n",
       "L 662.368424 267.214443 \n",
       "L 658.948472 267.214443 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_202\">\n",
       "    <path d=\"M 662.368424 311.799083 \n",
       "L 665.788376 311.799083 \n",
       "L 665.788376 273.50202 \n",
       "L 662.368424 273.50202 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_203\">\n",
       "    <path d=\"M 665.788376 311.799083 \n",
       "L 669.208328 311.799083 \n",
       "L 669.208328 286.077175 \n",
       "L 665.788376 286.077175 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_204\">\n",
       "    <path d=\"M 669.208328 311.799083 \n",
       "L 672.62828 311.799083 \n",
       "L 672.62828 285.505577 \n",
       "L 669.208328 285.505577 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_205\">\n",
       "    <path d=\"M 672.62828 311.799083 \n",
       "L 676.048232 311.799083 \n",
       "L 676.048232 299.795526 \n",
       "L 672.62828 299.795526 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_206\">\n",
       "    <path d=\"M 676.048232 311.799083 \n",
       "L 679.468184 311.799083 \n",
       "L 679.468184 302.653516 \n",
       "L 676.048232 302.653516 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_207\">\n",
       "    <path d=\"M 679.468184 311.799083 \n",
       "L 682.888136 311.799083 \n",
       "L 682.888136 307.2263 \n",
       "L 679.468184 307.2263 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_208\">\n",
       "    <path d=\"M 682.888136 311.799083 \n",
       "L 686.308088 311.799083 \n",
       "L 686.308088 310.655887 \n",
       "L 682.888136 310.655887 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_209\">\n",
       "    <path d=\"M 686.308088 311.799083 \n",
       "L 689.72804 311.799083 \n",
       "L 689.72804 311.227485 \n",
       "L 686.308088 311.227485 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_210\">\n",
       "    <path d=\"M 689.72804 311.799083 \n",
       "L 693.147992 311.799083 \n",
       "L 693.147992 310.655887 \n",
       "L 689.72804 310.655887 \n",
       "z\n",
       "\" clip-path=\"url(#p29f5904bd1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.32813; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_15\">\n",
       "    <g id=\"xtick_22\">\n",
       "     <g id=\"line2d_53\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"596.393652\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_23\">\n",
       "     <g id=\"line2d_54\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"642.776366\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_24\">\n",
       "     <g id=\"line2d_55\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"689.159079\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_16\">\n",
       "    <g id=\"ytick_32\">\n",
       "     <g id=\"line2d_56\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"311.799083\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_46\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(565.503125 315.598302) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_33\">\n",
       "     <g id=\"line2d_57\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"283.219186\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_47\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(559.140625 287.018404) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_34\">\n",
       "     <g id=\"line2d_58\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"254.639288\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_48\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(552.778125 258.438507) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_35\">\n",
       "     <g id=\"line2d_59\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"226.05939\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_49\">\n",
       "      <!-- 150 -->\n",
       "      <g transform=\"translate(552.778125 229.858609) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_50\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(546.698438 269.630625) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_211\">\n",
       "    <path d=\"M 578.865625 311.799083 \n",
       "L 578.865625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_212\">\n",
       "    <path d=\"M 705.295625 311.799083 \n",
       "L 705.295625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_213\">\n",
       "    <path d=\"M 578.865625 311.799083 \n",
       "L 705.295625 311.799083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_214\">\n",
       "    <path d=\"M 578.865625 197.765292 \n",
       "L 705.295625 197.765292 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_51\">\n",
       "    <!-- CHEMBL2334 -->\n",
       "    <g transform=\"translate(601.680938 178.327917) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- Caspase (1,606) -->\n",
       "    <g transform=\"translate(593.019375 191.765292) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-70\" d=\"M 1159 525 \n",
       "L 1159 -1331 \n",
       "L 581 -1331 \n",
       "L 581 3500 \n",
       "L 1159 3500 \n",
       "L 1159 2969 \n",
       "Q 1341 3281 1617 3432 \n",
       "Q 1894 3584 2278 3584 \n",
       "Q 2916 3584 3314 3078 \n",
       "Q 3713 2572 3713 1747 \n",
       "Q 3713 922 3314 415 \n",
       "Q 2916 -91 2278 -91 \n",
       "Q 1894 -91 1617 61 \n",
       "Q 1341 213 1159 525 \n",
       "z\n",
       "M 3116 1747 \n",
       "Q 3116 2381 2855 2742 \n",
       "Q 2594 3103 2138 3103 \n",
       "Q 1681 3103 1420 2742 \n",
       "Q 1159 2381 1159 1747 \n",
       "Q 1159 1113 1420 752 \n",
       "Q 1681 391 2138 391 \n",
       "Q 2594 391 2855 752 \n",
       "Q 3116 1113 3116 1747 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"131.103516\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-70\" x=\"183.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"246.679688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"307.958984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"360.058594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"421.582031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"453.369141\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"492.382812\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"556.005859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"587.792969\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"651.416016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"715.039062\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"778.662109\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_9\">\n",
       "   <g id=\"patch_215\">\n",
       "    <path d=\"M 46.965625 473.808875 \n",
       "L 173.395625 473.808875 \n",
       "L 173.395625 359.775083 \n",
       "L 46.965625 359.775083 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_216\">\n",
       "    <path d=\"M 64.493652 473.808875 \n",
       "L 68.397222 473.808875 \n",
       "L 68.397222 470.32799 \n",
       "L 64.493652 470.32799 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_217\">\n",
       "    <path d=\"M 68.397222 473.808875 \n",
       "L 72.300791 473.808875 \n",
       "L 72.300791 467.543282 \n",
       "L 68.397222 467.543282 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_218\">\n",
       "    <path d=\"M 72.300791 473.808875 \n",
       "L 76.20436 473.808875 \n",
       "L 76.20436 466.150928 \n",
       "L 72.300791 466.150928 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_219\">\n",
       "    <path d=\"M 76.20436 473.808875 \n",
       "L 80.107929 473.808875 \n",
       "L 80.107929 452.923565 \n",
       "L 76.20436 452.923565 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_220\">\n",
       "    <path d=\"M 80.107929 473.808875 \n",
       "L 84.011498 473.808875 \n",
       "L 84.011498 444.569441 \n",
       "L 80.107929 444.569441 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_221\">\n",
       "    <path d=\"M 84.011498 473.808875 \n",
       "L 87.915067 473.808875 \n",
       "L 87.915067 439.000025 \n",
       "L 84.011498 439.000025 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_222\">\n",
       "    <path d=\"M 87.915067 473.808875 \n",
       "L 91.818636 473.808875 \n",
       "L 91.818636 428.55737 \n",
       "L 87.915067 428.55737 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_223\">\n",
       "    <path d=\"M 91.818636 473.808875 \n",
       "L 95.722206 473.808875 \n",
       "L 95.722206 420.899423 \n",
       "L 91.818636 420.899423 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_224\">\n",
       "    <path d=\"M 95.722206 473.808875 \n",
       "L 99.625775 473.808875 \n",
       "L 99.625775 408.368238 \n",
       "L 95.722206 408.368238 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_225\">\n",
       "    <path d=\"M 99.625775 473.808875 \n",
       "L 103.529344 473.808875 \n",
       "L 103.529344 395.837052 \n",
       "L 99.625775 395.837052 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_226\">\n",
       "    <path d=\"M 103.529344 473.808875 \n",
       "L 107.432913 473.808875 \n",
       "L 107.432913 391.65999 \n",
       "L 103.529344 391.65999 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_227\">\n",
       "    <path d=\"M 107.432913 473.808875 \n",
       "L 111.336482 473.808875 \n",
       "L 111.336482 375.647919 \n",
       "L 107.432913 375.647919 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_228\">\n",
       "    <path d=\"M 111.336482 473.808875 \n",
       "L 115.240051 473.808875 \n",
       "L 115.240051 365.205264 \n",
       "L 111.336482 365.205264 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_229\">\n",
       "    <path d=\"M 115.240051 473.808875 \n",
       "L 119.143621 473.808875 \n",
       "L 119.143621 394.444698 \n",
       "L 115.240051 394.444698 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_230\">\n",
       "    <path d=\"M 119.143621 473.808875 \n",
       "L 123.04719 473.808875 \n",
       "L 123.04719 385.394397 \n",
       "L 119.143621 385.394397 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_231\">\n",
       "    <path d=\"M 123.04719 473.808875 \n",
       "L 126.950759 473.808875 \n",
       "L 126.950759 406.279707 \n",
       "L 123.04719 406.279707 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_232\">\n",
       "    <path d=\"M 126.950759 473.808875 \n",
       "L 130.854328 473.808875 \n",
       "L 130.854328 403.494999 \n",
       "L 126.950759 403.494999 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_233\">\n",
       "    <path d=\"M 130.854328 473.808875 \n",
       "L 134.757897 473.808875 \n",
       "L 134.757897 425.076485 \n",
       "L 130.854328 425.076485 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_234\">\n",
       "    <path d=\"M 134.757897 473.808875 \n",
       "L 138.661466 473.808875 \n",
       "L 138.661466 439.696202 \n",
       "L 134.757897 439.696202 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_235\">\n",
       "    <path d=\"M 138.661466 473.808875 \n",
       "L 142.565035 473.808875 \n",
       "L 142.565035 450.835034 \n",
       "L 138.661466 450.835034 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_236\">\n",
       "    <path d=\"M 142.565035 473.808875 \n",
       "L 146.468605 473.808875 \n",
       "L 146.468605 457.796804 \n",
       "L 142.565035 457.796804 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_237\">\n",
       "    <path d=\"M 146.468605 473.808875 \n",
       "L 150.372174 473.808875 \n",
       "L 150.372174 469.631813 \n",
       "L 146.468605 469.631813 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_238\">\n",
       "    <path d=\"M 150.372174 473.808875 \n",
       "L 154.275743 473.808875 \n",
       "L 154.275743 470.32799 \n",
       "L 150.372174 470.32799 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_239\">\n",
       "    <path d=\"M 154.275743 473.808875 \n",
       "L 158.179312 473.808875 \n",
       "L 158.179312 472.416521 \n",
       "L 154.275743 472.416521 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_240\">\n",
       "    <path d=\"M 158.179312 473.808875 \n",
       "L 162.082881 473.808875 \n",
       "L 162.082881 473.112698 \n",
       "L 158.179312 473.112698 \n",
       "z\n",
       "\" clip-path=\"url(#pfa554f0260)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.374531; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_17\">\n",
       "    <g id=\"xtick_25\">\n",
       "     <g id=\"line2d_60\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"64.493652\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_26\">\n",
       "     <g id=\"line2d_61\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"110.876366\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_27\">\n",
       "     <g id=\"line2d_62\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"157.259079\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_18\">\n",
       "    <g id=\"ytick_36\">\n",
       "     <g id=\"line2d_63\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_52\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(33.603125 477.608094) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_37\">\n",
       "     <g id=\"line2d_64\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"439.000025\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_53\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(27.240625 442.799244) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_38\">\n",
       "     <g id=\"line2d_65\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"404.191176\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_54\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(20.878125 407.990394) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_39\">\n",
       "     <g id=\"line2d_66\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"369.382326\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_55\">\n",
       "      <!-- 150 -->\n",
       "      <g transform=\"translate(20.878125 373.181545) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_56\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(14.798437 431.640417) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_241\">\n",
       "    <path d=\"M 46.965625 473.808875 \n",
       "L 46.965625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_242\">\n",
       "    <path d=\"M 173.395625 473.808875 \n",
       "L 173.395625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_243\">\n",
       "    <path d=\"M 46.965625 473.808875 \n",
       "L 173.395625 473.808875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_244\">\n",
       "    <path d=\"M 46.965625 359.775083 \n",
       "L 173.395625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_57\">\n",
       "    <!-- CHEMBL204 -->\n",
       "    <g transform=\"translate(73.598438 340.337708) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Coagulation (1,699) -->\n",
       "    <g transform=\"translate(50.429063 353.775083) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-67\" d=\"M 2906 1791 \n",
       "Q 2906 2416 2648 2759 \n",
       "Q 2391 3103 1925 3103 \n",
       "Q 1463 3103 1205 2759 \n",
       "Q 947 2416 947 1791 \n",
       "Q 947 1169 1205 825 \n",
       "Q 1463 481 1925 481 \n",
       "Q 2391 481 2648 825 \n",
       "Q 2906 1169 2906 1791 \n",
       "z\n",
       "M 3481 434 \n",
       "Q 3481 -459 3084 -895 \n",
       "Q 2688 -1331 1869 -1331 \n",
       "Q 1566 -1331 1297 -1286 \n",
       "Q 1028 -1241 775 -1147 \n",
       "L 775 -588 \n",
       "Q 1028 -725 1275 -790 \n",
       "Q 1522 -856 1778 -856 \n",
       "Q 2344 -856 2625 -561 \n",
       "Q 2906 -266 2906 331 \n",
       "L 2906 616 \n",
       "Q 2728 306 2450 153 \n",
       "Q 2172 0 1784 0 \n",
       "Q 1141 0 747 490 \n",
       "Q 353 981 353 1791 \n",
       "Q 353 2603 747 3093 \n",
       "Q 1141 3584 1784 3584 \n",
       "Q 2172 3584 2450 3431 \n",
       "Q 2728 3278 2906 2969 \n",
       "L 2906 3500 \n",
       "L 3481 3500 \n",
       "L 3481 434 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-39\" d=\"M 703 97 \n",
       "L 703 672 \n",
       "Q 941 559 1184 500 \n",
       "Q 1428 441 1663 441 \n",
       "Q 2288 441 2617 861 \n",
       "Q 2947 1281 2994 2138 \n",
       "Q 2813 1869 2534 1725 \n",
       "Q 2256 1581 1919 1581 \n",
       "Q 1219 1581 811 2004 \n",
       "Q 403 2428 403 3163 \n",
       "Q 403 3881 828 4315 \n",
       "Q 1253 4750 1959 4750 \n",
       "Q 2769 4750 3195 4129 \n",
       "Q 3622 3509 3622 2328 \n",
       "Q 3622 1225 3098 567 \n",
       "Q 2575 -91 1691 -91 \n",
       "Q 1453 -91 1209 -44 \n",
       "Q 966 3 703 97 \n",
       "z\n",
       "M 1959 2075 \n",
       "Q 2384 2075 2632 2365 \n",
       "Q 2881 2656 2881 3163 \n",
       "Q 2881 3666 2632 3958 \n",
       "Q 2384 4250 1959 4250 \n",
       "Q 1534 4250 1286 3958 \n",
       "Q 1038 3666 1038 3163 \n",
       "Q 1038 2656 1286 2365 \n",
       "Q 1534 2075 1959 2075 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"131.005859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"192.285156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-75\" x=\"255.761719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"319.140625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"346.923828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"408.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"447.412109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"475.195312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"536.376953\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"599.755859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"631.542969\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"670.556641\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"734.179688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"765.966797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"829.589844\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"893.212891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"956.835938\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_10\">\n",
       "   <g id=\"patch_245\">\n",
       "    <path d=\"M 224.265625 473.808875 \n",
       "L 350.695625 473.808875 \n",
       "L 350.695625 359.775083 \n",
       "L 224.265625 359.775083 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_246\">\n",
       "    <path d=\"M 248.93659 473.808875 \n",
       "L 251.712927 473.808875 \n",
       "L 251.712927 472.125098 \n",
       "L 248.93659 472.125098 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_247\">\n",
       "    <path d=\"M 251.712927 473.808875 \n",
       "L 254.489264 473.808875 \n",
       "L 254.489264 472.966987 \n",
       "L 251.712927 472.966987 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_248\">\n",
       "    <path d=\"M 254.489264 473.808875 \n",
       "L 257.2656 473.808875 \n",
       "L 257.2656 469.599433 \n",
       "L 254.489264 469.599433 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_249\">\n",
       "    <path d=\"M 257.2656 473.808875 \n",
       "L 260.041937 473.808875 \n",
       "L 260.041937 472.125098 \n",
       "L 257.2656 472.125098 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_250\">\n",
       "    <path d=\"M 260.041937 473.808875 \n",
       "L 262.818274 473.808875 \n",
       "L 262.818274 467.915656 \n",
       "L 260.041937 467.915656 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_251\">\n",
       "    <path d=\"M 262.818274 473.808875 \n",
       "L 265.59461 473.808875 \n",
       "L 265.59461 459.496771 \n",
       "L 262.818274 459.496771 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_252\">\n",
       "    <path d=\"M 265.59461 473.808875 \n",
       "L 268.370947 473.808875 \n",
       "L 268.370947 454.44544 \n",
       "L 265.59461 454.44544 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_253\">\n",
       "    <path d=\"M 268.370947 473.808875 \n",
       "L 271.147284 473.808875 \n",
       "L 271.147284 451.077887 \n",
       "L 268.370947 451.077887 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_254\">\n",
       "    <path d=\"M 271.147284 473.808875 \n",
       "L 273.923621 473.808875 \n",
       "L 273.923621 446.026556 \n",
       "L 271.147284 446.026556 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_255\">\n",
       "    <path d=\"M 273.923621 473.808875 \n",
       "L 276.699957 473.808875 \n",
       "L 276.699957 408.983464 \n",
       "L 273.923621 408.983464 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_256\">\n",
       "    <path d=\"M 276.699957 473.808875 \n",
       "L 279.476294 473.808875 \n",
       "L 279.476294 413.192906 \n",
       "L 276.699957 413.192906 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_257\">\n",
       "    <path d=\"M 279.476294 473.808875 \n",
       "L 282.252631 473.808875 \n",
       "L 282.252631 397.197025 \n",
       "L 279.476294 397.197025 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_258\">\n",
       "    <path d=\"M 282.252631 473.808875 \n",
       "L 285.028967 473.808875 \n",
       "L 285.028967 390.461918 \n",
       "L 282.252631 390.461918 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_259\">\n",
       "    <path d=\"M 285.028967 473.808875 \n",
       "L 287.805304 473.808875 \n",
       "L 287.805304 365.205264 \n",
       "L 285.028967 365.205264 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_260\">\n",
       "    <path d=\"M 287.805304 473.808875 \n",
       "L 290.581641 473.808875 \n",
       "L 290.581641 377.833591 \n",
       "L 287.805304 377.833591 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_261\">\n",
       "    <path d=\"M 290.581641 473.808875 \n",
       "L 293.357977 473.808875 \n",
       "L 293.357977 377.833591 \n",
       "L 290.581641 377.833591 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_262\">\n",
       "    <path d=\"M 293.357977 473.808875 \n",
       "L 296.134314 473.808875 \n",
       "L 296.134314 400.564579 \n",
       "L 293.357977 400.564579 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_263\">\n",
       "    <path d=\"M 296.134314 473.808875 \n",
       "L 298.910651 473.808875 \n",
       "L 298.910651 403.932133 \n",
       "L 296.134314 403.932133 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_264\">\n",
       "    <path d=\"M 298.910651 473.808875 \n",
       "L 301.686987 473.808875 \n",
       "L 301.686987 422.453679 \n",
       "L 298.910651 422.453679 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_265\">\n",
       "    <path d=\"M 301.686987 473.808875 \n",
       "L 304.463324 473.808875 \n",
       "L 304.463324 434.240117 \n",
       "L 301.686987 434.240117 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_266\">\n",
       "    <path d=\"M 304.463324 473.808875 \n",
       "L 307.239661 473.808875 \n",
       "L 307.239661 445.184667 \n",
       "L 304.463324 445.184667 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_267\">\n",
       "    <path d=\"M 307.239661 473.808875 \n",
       "L 310.015998 473.808875 \n",
       "L 310.015998 457.812994 \n",
       "L 307.239661 457.812994 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_268\">\n",
       "    <path d=\"M 310.015998 473.808875 \n",
       "L 312.792334 473.808875 \n",
       "L 312.792334 465.38999 \n",
       "L 310.015998 465.38999 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_269\">\n",
       "    <path d=\"M 312.792334 473.808875 \n",
       "L 315.568671 473.808875 \n",
       "L 315.568671 462.864325 \n",
       "L 312.792334 462.864325 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_270\">\n",
       "    <path d=\"M 315.568671 473.808875 \n",
       "L 318.345008 473.808875 \n",
       "L 318.345008 467.915656 \n",
       "L 315.568671 467.915656 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_271\">\n",
       "    <path d=\"M 318.345008 473.808875 \n",
       "L 321.121344 473.808875 \n",
       "L 321.121344 471.28321 \n",
       "L 318.345008 471.28321 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_272\">\n",
       "    <path d=\"M 321.121344 473.808875 \n",
       "L 323.897681 473.808875 \n",
       "L 323.897681 472.125098 \n",
       "L 321.121344 472.125098 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_273\">\n",
       "    <path d=\"M 323.897681 473.808875 \n",
       "L 326.674018 473.808875 \n",
       "L 326.674018 470.441321 \n",
       "L 323.897681 470.441321 \n",
       "z\n",
       "\" clip-path=\"url(#p5c60187877)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.266378; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_19\">\n",
       "    <g id=\"xtick_28\">\n",
       "     <g id=\"line2d_67\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"241.793652\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_29\">\n",
       "     <g id=\"line2d_68\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"288.176366\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_30\">\n",
       "     <g id=\"line2d_69\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"334.559079\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_20\">\n",
       "    <g id=\"ytick_40\">\n",
       "     <g id=\"line2d_70\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_58\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(210.903125 477.608094) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_41\">\n",
       "     <g id=\"line2d_71\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"431.714452\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_59\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(204.540625 435.513671) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_42\">\n",
       "     <g id=\"line2d_72\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"389.620029\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_60\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(198.178125 393.419248) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_61\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(192.098438 431.640417) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_274\">\n",
       "    <path d=\"M 224.265625 473.808875 \n",
       "L 224.265625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_275\">\n",
       "    <path d=\"M 350.695625 473.808875 \n",
       "L 350.695625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_276\">\n",
       "    <path d=\"M 224.265625 473.808875 \n",
       "L 350.695625 473.808875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_277\">\n",
       "    <path d=\"M 224.265625 359.775083 \n",
       "L 350.695625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_62\">\n",
       "    <!-- CHEMBL221 -->\n",
       "    <g transform=\"translate(250.898438 340.337708) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- COX-1 (1,343) -->\n",
       "    <g transform=\"translate(245.3925 353.775083) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-4f\" d=\"M 2522 4238 \n",
       "Q 1834 4238 1429 3725 \n",
       "Q 1025 3213 1025 2328 \n",
       "Q 1025 1447 1429 934 \n",
       "Q 1834 422 2522 422 \n",
       "Q 3209 422 3611 934 \n",
       "Q 4013 1447 4013 2328 \n",
       "Q 4013 3213 3611 3725 \n",
       "Q 3209 4238 2522 4238 \n",
       "z\n",
       "M 2522 4750 \n",
       "Q 3503 4750 4090 4092 \n",
       "Q 4678 3434 4678 2328 \n",
       "Q 4678 1225 4090 567 \n",
       "Q 3503 -91 2522 -91 \n",
       "Q 1538 -91 948 565 \n",
       "Q 359 1222 359 2328 \n",
       "Q 359 3434 948 4092 \n",
       "Q 1538 4750 2522 4750 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-58\" d=\"M 403 4666 \n",
       "L 1081 4666 \n",
       "L 2241 2931 \n",
       "L 3406 4666 \n",
       "L 4084 4666 \n",
       "L 2584 2425 \n",
       "L 4184 0 \n",
       "L 3506 0 \n",
       "L 2194 1984 \n",
       "L 872 0 \n",
       "L 191 0 \n",
       "L 1856 2491 \n",
       "L 403 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4f\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-58\" x=\"142.160156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2d\" x=\"205.666016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"241.75\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"305.373047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"337.160156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"376.173828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"439.796875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"471.583984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"535.207031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"598.830078\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"662.453125\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_11\">\n",
       "   <g id=\"patch_278\">\n",
       "    <path d=\"M 401.565625 473.808875 \n",
       "L 527.995625 473.808875 \n",
       "L 527.995625 359.775083 \n",
       "L 401.565625 359.775083 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_279\">\n",
       "    <path d=\"M 414.919208 473.808875 \n",
       "L 418.139908 473.808875 \n",
       "L 418.139908 472.754471 \n",
       "L 414.919208 472.754471 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_280\">\n",
       "    <path d=\"M 418.139908 473.808875 \n",
       "L 421.360607 473.808875 \n",
       "L 421.360607 473.808875 \n",
       "L 418.139908 473.808875 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_281\">\n",
       "    <path d=\"M 421.360607 473.808875 \n",
       "L 424.581307 473.808875 \n",
       "L 424.581307 471.700067 \n",
       "L 421.360607 471.700067 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_282\">\n",
       "    <path d=\"M 424.581307 473.808875 \n",
       "L 427.802007 473.808875 \n",
       "L 427.802007 469.591259 \n",
       "L 424.581307 469.591259 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_283\">\n",
       "    <path d=\"M 427.802007 473.808875 \n",
       "L 431.022706 473.808875 \n",
       "L 431.022706 464.846441 \n",
       "L 427.802007 464.846441 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_284\">\n",
       "    <path d=\"M 431.022706 473.808875 \n",
       "L 434.243406 473.808875 \n",
       "L 434.243406 459.574421 \n",
       "L 431.022706 459.574421 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_285\">\n",
       "    <path d=\"M 434.243406 473.808875 \n",
       "L 437.464106 473.808875 \n",
       "L 437.464106 448.503179 \n",
       "L 434.243406 448.503179 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_286\">\n",
       "    <path d=\"M 437.464106 473.808875 \n",
       "L 440.684805 473.808875 \n",
       "L 440.684805 449.030381 \n",
       "L 437.464106 449.030381 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_287\">\n",
       "    <path d=\"M 440.684805 473.808875 \n",
       "L 443.905505 473.808875 \n",
       "L 443.905505 437.959139 \n",
       "L 440.684805 437.959139 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_288\">\n",
       "    <path d=\"M 443.905505 473.808875 \n",
       "L 447.126205 473.808875 \n",
       "L 447.126205 424.251887 \n",
       "L 443.905505 424.251887 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_289\">\n",
       "    <path d=\"M 447.126205 473.808875 \n",
       "L 450.346904 473.808875 \n",
       "L 450.346904 421.088675 \n",
       "L 447.126205 421.088675 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_290\">\n",
       "    <path d=\"M 450.346904 473.808875 \n",
       "L 453.567604 473.808875 \n",
       "L 453.567604 406.32702 \n",
       "L 450.346904 406.32702 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_291\">\n",
       "    <path d=\"M 453.567604 473.808875 \n",
       "L 456.788304 473.808875 \n",
       "L 456.788304 402.636606 \n",
       "L 453.567604 402.636606 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_292\">\n",
       "    <path d=\"M 456.788304 473.808875 \n",
       "L 460.009003 473.808875 \n",
       "L 460.009003 382.60293 \n",
       "L 456.788304 382.60293 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_293\">\n",
       "    <path d=\"M 460.009003 473.808875 \n",
       "L 463.229703 473.808875 \n",
       "L 463.229703 386.293344 \n",
       "L 460.009003 386.293344 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_294\">\n",
       "    <path d=\"M 463.229703 473.808875 \n",
       "L 466.450403 473.808875 \n",
       "L 466.450403 384.184536 \n",
       "L 463.229703 384.184536 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_295\">\n",
       "    <path d=\"M 466.450403 473.808875 \n",
       "L 469.671102 473.808875 \n",
       "L 469.671102 365.205264 \n",
       "L 466.450403 365.205264 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_296\">\n",
       "    <path d=\"M 469.671102 473.808875 \n",
       "L 472.891802 473.808875 \n",
       "L 472.891802 386.293344 \n",
       "L 469.671102 386.293344 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_297\">\n",
       "    <path d=\"M 472.891802 473.808875 \n",
       "L 476.112502 473.808875 \n",
       "L 476.112502 382.075728 \n",
       "L 472.891802 382.075728 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_298\">\n",
       "    <path d=\"M 476.112502 473.808875 \n",
       "L 479.333201 473.808875 \n",
       "L 479.333201 399.473394 \n",
       "L 476.112502 399.473394 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_299\">\n",
       "    <path d=\"M 479.333201 473.808875 \n",
       "L 482.553901 473.808875 \n",
       "L 482.553901 408.435828 \n",
       "L 479.333201 408.435828 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_300\">\n",
       "    <path d=\"M 482.553901 473.808875 \n",
       "L 485.774601 473.808875 \n",
       "L 485.774601 416.343857 \n",
       "L 482.553901 416.343857 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_301\">\n",
       "    <path d=\"M 485.774601 473.808875 \n",
       "L 488.9953 473.808875 \n",
       "L 488.9953 433.214321 \n",
       "L 485.774601 433.214321 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_302\">\n",
       "    <path d=\"M 488.9953 473.808875 \n",
       "L 492.216 473.808875 \n",
       "L 492.216 440.595149 \n",
       "L 488.9953 440.595149 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_303\">\n",
       "    <path d=\"M 492.216 473.808875 \n",
       "L 495.4367 473.808875 \n",
       "L 495.4367 455.356805 \n",
       "L 492.216 455.356805 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_304\">\n",
       "    <path d=\"M 495.4367 473.808875 \n",
       "L 498.657399 473.808875 \n",
       "L 498.657399 459.574421 \n",
       "L 495.4367 459.574421 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_305\">\n",
       "    <path d=\"M 498.657399 473.808875 \n",
       "L 501.878099 473.808875 \n",
       "L 501.878099 465.900845 \n",
       "L 498.657399 465.900845 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_306\">\n",
       "    <path d=\"M 501.878099 473.808875 \n",
       "L 505.098799 473.808875 \n",
       "L 505.098799 469.591259 \n",
       "L 501.878099 469.591259 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_307\">\n",
       "    <path d=\"M 505.098799 473.808875 \n",
       "L 508.319498 473.808875 \n",
       "L 508.319498 472.754471 \n",
       "L 505.098799 472.754471 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_308\">\n",
       "    <path d=\"M 508.319498 473.808875 \n",
       "L 511.540198 473.808875 \n",
       "L 511.540198 472.754471 \n",
       "L 508.319498 472.754471 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_309\">\n",
       "    <path d=\"M 511.540198 473.808875 \n",
       "L 514.760898 473.808875 \n",
       "L 514.760898 472.754471 \n",
       "L 511.540198 472.754471 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_310\">\n",
       "    <path d=\"M 514.760898 473.808875 \n",
       "L 517.981597 473.808875 \n",
       "L 517.981597 473.281673 \n",
       "L 514.760898 473.281673 \n",
       "z\n",
       "\" clip-path=\"url(#pc227c1ca20)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309013; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_21\">\n",
       "    <g id=\"xtick_31\">\n",
       "     <g id=\"line2d_73\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"419.093652\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_32\">\n",
       "     <g id=\"line2d_74\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"465.476366\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_33\">\n",
       "     <g id=\"line2d_75\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"511.859079\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_22\">\n",
       "    <g id=\"ytick_43\">\n",
       "     <g id=\"line2d_76\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_63\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(388.203125 477.608094) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_44\">\n",
       "     <g id=\"line2d_77\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"447.448775\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_64\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(381.840625 451.247994) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_45\">\n",
       "     <g id=\"line2d_78\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"421.088675\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_65\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(375.478125 424.887894) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_46\">\n",
       "     <g id=\"line2d_79\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"394.728576\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_66\">\n",
       "      <!-- 150 -->\n",
       "      <g transform=\"translate(375.478125 398.527794) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_47\">\n",
       "     <g id=\"line2d_80\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"368.368476\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_67\">\n",
       "      <!-- 200 -->\n",
       "      <g transform=\"translate(375.478125 372.167695) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_68\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(369.398438 431.640417) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_311\">\n",
       "    <path d=\"M 401.565625 473.808875 \n",
       "L 401.565625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_312\">\n",
       "    <path d=\"M 527.995625 473.808875 \n",
       "L 527.995625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_313\">\n",
       "    <path d=\"M 401.565625 473.808875 \n",
       "L 527.995625 473.808875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_314\">\n",
       "    <path d=\"M 401.565625 359.775083 \n",
       "L 527.995625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_69\">\n",
       "    <!-- CHEMBL230 -->\n",
       "    <g transform=\"translate(428.198438 340.337708) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- COX-2 (2,855) -->\n",
       "    <g transform=\"translate(422.6925 353.775083) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4f\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-58\" x=\"142.160156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2d\" x=\"205.666016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"241.75\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"305.373047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"337.160156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"376.173828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"439.796875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"471.583984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"535.207031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"598.830078\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"662.453125\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_12\">\n",
       "   <g id=\"patch_315\">\n",
       "    <path d=\"M 578.865625 473.808875 \n",
       "L 705.295625 473.808875 \n",
       "L 705.295625 359.775083 \n",
       "L 578.865625 359.775083 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_316\">\n",
       "    <path d=\"M 606.968911 473.808875 \n",
       "L 611.687579 473.808875 \n",
       "L 611.687579 457.100627 \n",
       "L 606.968911 457.100627 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_317\">\n",
       "    <path d=\"M 611.687579 473.808875 \n",
       "L 616.406247 473.808875 \n",
       "L 616.406247 463.783926 \n",
       "L 611.687579 463.783926 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_318\">\n",
       "    <path d=\"M 616.406247 473.808875 \n",
       "L 621.124915 473.808875 \n",
       "L 621.124915 450.417328 \n",
       "L 616.406247 450.417328 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_319\">\n",
       "    <path d=\"M 621.124915 473.808875 \n",
       "L 625.843583 473.808875 \n",
       "L 625.843583 433.70908 \n",
       "L 621.124915 433.70908 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_320\">\n",
       "    <path d=\"M 625.843583 473.808875 \n",
       "L 630.562251 473.808875 \n",
       "L 630.562251 410.317533 \n",
       "L 625.843583 410.317533 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_321\">\n",
       "    <path d=\"M 630.562251 473.808875 \n",
       "L 635.280919 473.808875 \n",
       "L 635.280919 386.925986 \n",
       "L 630.562251 386.925986 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_322\">\n",
       "    <path d=\"M 635.280919 473.808875 \n",
       "L 639.999587 473.808875 \n",
       "L 639.999587 365.205264 \n",
       "L 635.280919 365.205264 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_323\">\n",
       "    <path d=\"M 639.999587 473.808875 \n",
       "L 644.718255 473.808875 \n",
       "L 644.718255 400.292584 \n",
       "L 639.999587 400.292584 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_324\">\n",
       "    <path d=\"M 644.718255 473.808875 \n",
       "L 649.436923 473.808875 \n",
       "L 649.436923 375.230213 \n",
       "L 644.718255 375.230213 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_325\">\n",
       "    <path d=\"M 649.436923 473.808875 \n",
       "L 654.155591 473.808875 \n",
       "L 654.155591 375.230213 \n",
       "L 649.436923 375.230213 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_326\">\n",
       "    <path d=\"M 654.155591 473.808875 \n",
       "L 658.874259 473.808875 \n",
       "L 658.874259 417.000832 \n",
       "L 654.155591 417.000832 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_327\">\n",
       "    <path d=\"M 658.874259 473.808875 \n",
       "L 663.592927 473.808875 \n",
       "L 663.592927 415.330007 \n",
       "L 658.874259 415.330007 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_328\">\n",
       "    <path d=\"M 663.592927 473.808875 \n",
       "L 668.311595 473.808875 \n",
       "L 668.311595 455.429802 \n",
       "L 663.592927 455.429802 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_329\">\n",
       "    <path d=\"M 668.311595 473.808875 \n",
       "L 673.030264 473.808875 \n",
       "L 673.030264 460.442277 \n",
       "L 668.311595 460.442277 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_330\">\n",
       "    <path d=\"M 673.030264 473.808875 \n",
       "L 677.748932 473.808875 \n",
       "L 677.748932 460.442277 \n",
       "L 673.030264 460.442277 \n",
       "z\n",
       "\" clip-path=\"url(#ped215ec72b)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.452737; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_23\">\n",
       "    <g id=\"xtick_34\">\n",
       "     <g id=\"line2d_81\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"596.393652\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_35\">\n",
       "     <g id=\"line2d_82\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"642.776366\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_36\">\n",
       "     <g id=\"line2d_83\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"689.159079\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_24\">\n",
       "    <g id=\"ytick_48\">\n",
       "     <g id=\"line2d_84\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"473.808875\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_70\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(565.503125 477.608094) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_49\">\n",
       "     <g id=\"line2d_85\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"440.392379\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_71\">\n",
       "      <!-- 20 -->\n",
       "      <g transform=\"translate(559.140625 444.191598) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_50\">\n",
       "     <g id=\"line2d_86\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"406.975884\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_72\">\n",
       "      <!-- 40 -->\n",
       "      <g transform=\"translate(559.140625 410.775102) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_51\">\n",
       "     <g id=\"line2d_87\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"373.559388\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_73\">\n",
       "      <!-- 60 -->\n",
       "      <g transform=\"translate(559.140625 377.358607) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_74\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(553.060938 431.640417) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_331\">\n",
       "    <path d=\"M 578.865625 473.808875 \n",
       "L 578.865625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_332\">\n",
       "    <path d=\"M 705.295625 473.808875 \n",
       "L 705.295625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_333\">\n",
       "    <path d=\"M 578.865625 473.808875 \n",
       "L 705.295625 473.808875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_334\">\n",
       "    <path d=\"M 578.865625 359.775083 \n",
       "L 705.295625 359.775083 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_75\">\n",
       "    <!-- CHEMBL202 -->\n",
       "    <g transform=\"translate(605.498438 340.337708) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Dihydrofolate (584) -->\n",
       "    <g transform=\"translate(583.415625 353.775083) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-44\" d=\"M 1259 4147 \n",
       "L 1259 519 \n",
       "L 2022 519 \n",
       "Q 2988 519 3436 956 \n",
       "Q 3884 1394 3884 2338 \n",
       "Q 3884 3275 3436 3711 \n",
       "Q 2988 4147 2022 4147 \n",
       "L 1259 4147 \n",
       "z\n",
       "M 628 4666 \n",
       "L 1925 4666 \n",
       "Q 3281 4666 3915 4102 \n",
       "Q 4550 3538 4550 2338 \n",
       "Q 4550 1131 3912 565 \n",
       "Q 3275 0 1925 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-44\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"77.001953\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"104.785156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-79\" x=\"168.164062\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"227.34375\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"290.820312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"329.683594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-66\" x=\"390.865234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"426.070312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"487.251953\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"515.035156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"576.314453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"615.523438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"677.046875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"708.833984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"747.847656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"811.470703\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"875.09375\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"938.716797\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_13\">\n",
       "   <g id=\"patch_335\">\n",
       "    <path d=\"M 46.965625 635.818667 \n",
       "L 173.395625 635.818667 \n",
       "L 173.395625 521.784875 \n",
       "L 46.965625 521.784875 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_336\">\n",
       "    <path d=\"M 77.944639 635.818667 \n",
       "L 83.11096 635.818667 \n",
       "L 83.11096 619.425669 \n",
       "L 77.944639 619.425669 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_337\">\n",
       "    <path d=\"M 83.11096 635.818667 \n",
       "L 88.277281 635.818667 \n",
       "L 88.277281 611.22917 \n",
       "L 83.11096 611.22917 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_338\">\n",
       "    <path d=\"M 88.277281 635.818667 \n",
       "L 93.443601 635.818667 \n",
       "L 93.443601 592.787047 \n",
       "L 88.277281 592.787047 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_339\">\n",
       "    <path d=\"M 93.443601 635.818667 \n",
       "L 98.609922 635.818667 \n",
       "L 98.609922 588.688798 \n",
       "L 93.443601 588.688798 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_340\">\n",
       "    <path d=\"M 98.609922 635.818667 \n",
       "L 103.776243 635.818667 \n",
       "L 103.776243 574.344925 \n",
       "L 98.609922 574.344925 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_341\">\n",
       "    <path d=\"M 103.776243 635.818667 \n",
       "L 108.942563 635.818667 \n",
       "L 108.942563 543.608053 \n",
       "L 103.776243 543.608053 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_342\">\n",
       "    <path d=\"M 108.942563 635.818667 \n",
       "L 114.108884 635.818667 \n",
       "L 114.108884 527.215056 \n",
       "L 108.942563 527.215056 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_343\">\n",
       "    <path d=\"M 114.108884 635.818667 \n",
       "L 119.275205 635.818667 \n",
       "L 119.275205 549.755428 \n",
       "L 114.108884 549.755428 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_344\">\n",
       "    <path d=\"M 119.275205 635.818667 \n",
       "L 124.441525 635.818667 \n",
       "L 124.441525 551.804552 \n",
       "L 119.275205 551.804552 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_345\">\n",
       "    <path d=\"M 124.441525 635.818667 \n",
       "L 129.607846 635.818667 \n",
       "L 129.607846 584.590548 \n",
       "L 124.441525 584.590548 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_346\">\n",
       "    <path d=\"M 129.607846 635.818667 \n",
       "L 134.774167 635.818667 \n",
       "L 134.774167 613.278295 \n",
       "L 129.607846 613.278295 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_347\">\n",
       "    <path d=\"M 134.774167 635.818667 \n",
       "L 139.940487 635.818667 \n",
       "L 139.940487 617.376544 \n",
       "L 134.774167 617.376544 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_348\">\n",
       "    <path d=\"M 139.940487 635.818667 \n",
       "L 145.106808 635.818667 \n",
       "L 145.106808 615.327419 \n",
       "L 139.940487 615.327419 \n",
       "z\n",
       "\" clip-path=\"url(#p1d3cbaeb15)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.495687; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_25\">\n",
       "    <g id=\"xtick_37\">\n",
       "     <g id=\"line2d_88\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"64.493652\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_38\">\n",
       "     <g id=\"line2d_89\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"110.876366\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_39\">\n",
       "     <g id=\"line2d_90\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"157.259079\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_26\">\n",
       "    <g id=\"ytick_52\">\n",
       "     <g id=\"line2d_91\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_76\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(33.603125 639.617885) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_53\">\n",
       "     <g id=\"line2d_92\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"594.836172\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_77\">\n",
       "      <!-- 20 -->\n",
       "      <g transform=\"translate(27.240625 598.635391) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_54\">\n",
       "     <g id=\"line2d_93\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"553.853677\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_78\">\n",
       "      <!-- 40 -->\n",
       "      <g transform=\"translate(27.240625 557.652896) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_79\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(21.160937 593.650208) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_349\">\n",
       "    <path d=\"M 46.965625 635.818667 \n",
       "L 46.965625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_350\">\n",
       "    <path d=\"M 173.395625 635.818667 \n",
       "L 173.395625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_351\">\n",
       "    <path d=\"M 46.965625 635.818667 \n",
       "L 173.395625 635.818667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_352\">\n",
       "    <path d=\"M 46.965625 521.784875 \n",
       "L 173.395625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_80\">\n",
       "    <!-- CHEMBL217 -->\n",
       "    <g transform=\"translate(73.598438 502.3475) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Dopamine (479) -->\n",
       "    <g transform=\"translate(61.356563 515.784875) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-6d\" d=\"M 3328 2828 \n",
       "Q 3544 3216 3844 3400 \n",
       "Q 4144 3584 4550 3584 \n",
       "Q 5097 3584 5394 3201 \n",
       "Q 5691 2819 5691 2113 \n",
       "L 5691 0 \n",
       "L 5113 0 \n",
       "L 5113 2094 \n",
       "Q 5113 2597 4934 2840 \n",
       "Q 4756 3084 4391 3084 \n",
       "Q 3944 3084 3684 2787 \n",
       "Q 3425 2491 3425 1978 \n",
       "L 3425 0 \n",
       "L 2847 0 \n",
       "L 2847 2094 \n",
       "Q 2847 2600 2669 2842 \n",
       "Q 2491 3084 2119 3084 \n",
       "Q 1678 3084 1418 2786 \n",
       "Q 1159 2488 1159 1978 \n",
       "L 1159 0 \n",
       "L 581 0 \n",
       "L 581 3500 \n",
       "L 1159 3500 \n",
       "L 1159 2956 \n",
       "Q 1356 3278 1631 3431 \n",
       "Q 1906 3584 2284 3584 \n",
       "Q 2666 3584 2933 3390 \n",
       "Q 3200 3197 3328 2828 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-44\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"77.001953\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-70\" x=\"138.183594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"201.660156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6d\" x=\"262.939453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"360.351562\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"388.134766\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"451.513672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"513.037109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"544.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"583.837891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"647.460938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"711.083984\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"774.707031\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_14\">\n",
       "   <g id=\"patch_353\">\n",
       "    <path d=\"M 224.265625 635.818667 \n",
       "L 350.695625 635.818667 \n",
       "L 350.695625 521.784875 \n",
       "L 224.265625 521.784875 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_354\">\n",
       "    <path d=\"M 238.268566 635.818667 \n",
       "L 241.608122 635.818667 \n",
       "L 241.608122 635.113448 \n",
       "L 238.268566 635.113448 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_355\">\n",
       "    <path d=\"M 241.608122 635.818667 \n",
       "L 244.947677 635.818667 \n",
       "L 244.947677 635.818667 \n",
       "L 241.608122 635.818667 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_356\">\n",
       "    <path d=\"M 244.947677 635.818667 \n",
       "L 248.287232 635.818667 \n",
       "L 248.287232 635.818667 \n",
       "L 244.947677 635.818667 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_357\">\n",
       "    <path d=\"M 248.287232 635.818667 \n",
       "L 251.626788 635.818667 \n",
       "L 251.626788 635.113448 \n",
       "L 248.287232 635.113448 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_358\">\n",
       "    <path d=\"M 251.626788 635.818667 \n",
       "L 254.966343 635.818667 \n",
       "L 254.966343 632.997794 \n",
       "L 251.626788 632.997794 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_359\">\n",
       "    <path d=\"M 254.966343 635.818667 \n",
       "L 258.305898 635.818667 \n",
       "L 258.305898 626.650829 \n",
       "L 254.966343 626.650829 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_360\">\n",
       "    <path d=\"M 258.305898 635.818667 \n",
       "L 261.645454 635.818667 \n",
       "L 261.645454 617.482992 \n",
       "L 258.305898 617.482992 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_361\">\n",
       "    <path d=\"M 261.645454 635.818667 \n",
       "L 264.985009 635.818667 \n",
       "L 264.985009 610.43081 \n",
       "L 261.645454 610.43081 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_362\">\n",
       "    <path d=\"M 264.985009 635.818667 \n",
       "L 268.324564 635.818667 \n",
       "L 268.324564 600.557754 \n",
       "L 264.985009 600.557754 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_363\">\n",
       "    <path d=\"M 268.324564 635.818667 \n",
       "L 271.66412 635.818667 \n",
       "L 271.66412 582.222079 \n",
       "L 268.324564 582.222079 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_364\">\n",
       "    <path d=\"M 271.66412 635.818667 \n",
       "L 275.003675 635.818667 \n",
       "L 275.003675 583.632516 \n",
       "L 271.66412 583.632516 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_365\">\n",
       "    <path d=\"M 275.003675 635.818667 \n",
       "L 278.34323 635.818667 \n",
       "L 278.34323 566.00206 \n",
       "L 275.003675 566.00206 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_366\">\n",
       "    <path d=\"M 278.34323 635.818667 \n",
       "L 281.682786 635.818667 \n",
       "L 281.682786 563.886405 \n",
       "L 278.34323 563.886405 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_367\">\n",
       "    <path d=\"M 281.682786 635.818667 \n",
       "L 285.022341 635.818667 \n",
       "L 285.022341 532.151583 \n",
       "L 281.682786 532.151583 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_368\">\n",
       "    <path d=\"M 285.022341 635.818667 \n",
       "L 288.361897 635.818667 \n",
       "L 288.361897 527.215056 \n",
       "L 285.022341 527.215056 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_369\">\n",
       "    <path d=\"M 288.361897 635.818667 \n",
       "L 291.701452 635.818667 \n",
       "L 291.701452 528.625492 \n",
       "L 288.361897 528.625492 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_370\">\n",
       "    <path d=\"M 291.701452 635.818667 \n",
       "L 295.041007 635.818667 \n",
       "L 295.041007 534.267238 \n",
       "L 291.701452 534.267238 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_371\">\n",
       "    <path d=\"M 295.041007 635.818667 \n",
       "L 298.380563 635.818667 \n",
       "L 298.380563 558.949877 \n",
       "L 295.041007 558.949877 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_372\">\n",
       "    <path d=\"M 298.380563 635.818667 \n",
       "L 301.720118 635.818667 \n",
       "L 301.720118 561.065532 \n",
       "L 298.380563 561.065532 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_373\">\n",
       "    <path d=\"M 301.720118 635.818667 \n",
       "L 305.059673 635.818667 \n",
       "L 305.059673 580.106425 \n",
       "L 301.720118 580.106425 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_374\">\n",
       "    <path d=\"M 305.059673 635.818667 \n",
       "L 308.399229 635.818667 \n",
       "L 308.399229 587.158607 \n",
       "L 305.059673 587.158607 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_375\">\n",
       "    <path d=\"M 308.399229 635.818667 \n",
       "L 311.738784 635.818667 \n",
       "L 311.738784 594.21079 \n",
       "L 308.399229 594.21079 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_376\">\n",
       "    <path d=\"M 311.738784 635.818667 \n",
       "L 315.078339 635.818667 \n",
       "L 315.078339 609.020373 \n",
       "L 311.738784 609.020373 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_377\">\n",
       "    <path d=\"M 315.078339 635.818667 \n",
       "L 318.417895 635.818667 \n",
       "L 318.417895 621.009083 \n",
       "L 315.078339 621.009083 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_378\">\n",
       "    <path d=\"M 318.417895 635.818667 \n",
       "L 321.75745 635.818667 \n",
       "L 321.75745 625.945611 \n",
       "L 318.417895 625.945611 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_379\">\n",
       "    <path d=\"M 321.75745 635.818667 \n",
       "L 325.097006 635.818667 \n",
       "L 325.097006 630.882139 \n",
       "L 321.75745 630.882139 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_380\">\n",
       "    <path d=\"M 325.097006 635.818667 \n",
       "L 328.436561 635.818667 \n",
       "L 328.436561 633.703012 \n",
       "L 325.097006 633.703012 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_381\">\n",
       "    <path d=\"M 328.436561 635.818667 \n",
       "L 331.776116 635.818667 \n",
       "L 331.776116 634.40823 \n",
       "L 328.436561 634.40823 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_382\">\n",
       "    <path d=\"M 331.776116 635.818667 \n",
       "L 335.115672 635.818667 \n",
       "L 335.115672 635.113448 \n",
       "L 331.776116 635.113448 \n",
       "z\n",
       "\" clip-path=\"url(#p945f20dc37)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.320417; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_27\">\n",
       "    <g id=\"xtick_40\">\n",
       "     <g id=\"line2d_94\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"241.793652\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_41\">\n",
       "     <g id=\"line2d_95\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"288.176366\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_42\">\n",
       "     <g id=\"line2d_96\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"334.559079\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_28\">\n",
       "    <g id=\"ytick_55\">\n",
       "     <g id=\"line2d_97\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_81\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(210.903125 639.617885) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_56\">\n",
       "     <g id=\"line2d_98\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"600.557754\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_82\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(204.540625 604.356973) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_57\">\n",
       "     <g id=\"line2d_99\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"565.296841\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_83\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(198.178125 569.09606) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_58\">\n",
       "     <g id=\"line2d_100\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"530.035929\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_84\">\n",
       "      <!-- 150 -->\n",
       "      <g transform=\"translate(198.178125 533.835147) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_85\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(192.098438 593.650208) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_383\">\n",
       "    <path d=\"M 224.265625 635.818667 \n",
       "L 224.265625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_384\">\n",
       "    <path d=\"M 350.695625 635.818667 \n",
       "L 350.695625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_385\">\n",
       "    <path d=\"M 224.265625 635.818667 \n",
       "L 350.695625 635.818667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_386\">\n",
       "    <path d=\"M 224.265625 521.784875 \n",
       "L 350.695625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_86\">\n",
       "    <!-- CHEMBL222 -->\n",
       "    <g transform=\"translate(250.898438 502.3475) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Ephrin (1,737) -->\n",
       "    <g transform=\"translate(244.37625 515.784875) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-45\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-70\" x=\"63.183594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-68\" x=\"126.660156\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"190.039062\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"231.152344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"258.935547\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"322.314453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"354.101562\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"393.115234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"456.738281\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"488.525391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"552.148438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"615.771484\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"679.394531\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_15\">\n",
       "   <g id=\"patch_387\">\n",
       "    <path d=\"M 401.565625 635.818667 \n",
       "L 527.995625 635.818667 \n",
       "L 527.995625 521.784875 \n",
       "L 401.565625 521.784875 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_388\">\n",
       "    <path d=\"M 411.02306 635.818667 \n",
       "L 414.383563 635.818667 \n",
       "L 414.383563 635.37357 \n",
       "L 411.02306 635.37357 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_389\">\n",
       "    <path d=\"M 414.383563 635.818667 \n",
       "L 417.744065 635.818667 \n",
       "L 417.744065 635.37357 \n",
       "L 414.383563 635.37357 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_390\">\n",
       "    <path d=\"M 417.744065 635.818667 \n",
       "L 421.104567 635.818667 \n",
       "L 421.104567 634.928473 \n",
       "L 417.744065 634.928473 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_391\">\n",
       "    <path d=\"M 421.104567 635.818667 \n",
       "L 424.46507 635.818667 \n",
       "L 424.46507 634.483376 \n",
       "L 421.104567 634.483376 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_392\">\n",
       "    <path d=\"M 424.46507 635.818667 \n",
       "L 427.825572 635.818667 \n",
       "L 427.825572 626.916731 \n",
       "L 424.46507 626.916731 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_393\">\n",
       "    <path d=\"M 427.825572 635.818667 \n",
       "L 431.186075 635.818667 \n",
       "L 431.186075 625.581441 \n",
       "L 427.825572 625.581441 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_394\">\n",
       "    <path d=\"M 431.186075 635.818667 \n",
       "L 434.546577 635.818667 \n",
       "L 434.546577 614.454022 \n",
       "L 431.186075 614.454022 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_395\">\n",
       "    <path d=\"M 434.546577 635.818667 \n",
       "L 437.907079 635.818667 \n",
       "L 437.907079 603.771699 \n",
       "L 434.546577 603.771699 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_396\">\n",
       "    <path d=\"M 437.907079 635.818667 \n",
       "L 441.267582 635.818667 \n",
       "L 441.267582 591.754087 \n",
       "L 437.907079 591.754087 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_397\">\n",
       "    <path d=\"M 441.267582 635.818667 \n",
       "L 444.628084 635.818667 \n",
       "L 444.628084 586.858022 \n",
       "L 441.267582 586.858022 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_398\">\n",
       "    <path d=\"M 444.628084 635.818667 \n",
       "L 447.988587 635.818667 \n",
       "L 447.988587 566.828668 \n",
       "L 444.628084 566.828668 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_399\">\n",
       "    <path d=\"M 447.988587 635.818667 \n",
       "L 451.349089 635.818667 \n",
       "L 451.349089 558.371829 \n",
       "L 447.988587 558.371829 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_400\">\n",
       "    <path d=\"M 451.349089 635.818667 \n",
       "L 454.709591 635.818667 \n",
       "L 454.709591 549.469894 \n",
       "L 451.349089 549.469894 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_401\">\n",
       "    <path d=\"M 454.709591 635.818667 \n",
       "L 458.070094 635.818667 \n",
       "L 458.070094 545.018926 \n",
       "L 454.709591 545.018926 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_402\">\n",
       "    <path d=\"M 458.070094 635.818667 \n",
       "L 461.430596 635.818667 \n",
       "L 461.430596 542.348346 \n",
       "L 458.070094 542.348346 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_403\">\n",
       "    <path d=\"M 461.430596 635.818667 \n",
       "L 464.791099 635.818667 \n",
       "L 464.791099 540.567959 \n",
       "L 461.430596 540.567959 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_404\">\n",
       "    <path d=\"M 464.791099 635.818667 \n",
       "L 468.151601 635.818667 \n",
       "L 468.151601 527.215056 \n",
       "L 464.791099 527.215056 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_405\">\n",
       "    <path d=\"M 468.151601 635.818667 \n",
       "L 471.512103 635.818667 \n",
       "L 471.512103 530.77583 \n",
       "L 468.151601 530.77583 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_406\">\n",
       "    <path d=\"M 471.512103 635.818667 \n",
       "L 474.872606 635.818667 \n",
       "L 474.872606 546.799313 \n",
       "L 471.512103 546.799313 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_407\">\n",
       "    <path d=\"M 474.872606 635.818667 \n",
       "L 478.233108 635.818667 \n",
       "L 478.233108 539.232668 \n",
       "L 474.872606 539.232668 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_408\">\n",
       "    <path d=\"M 478.233108 635.818667 \n",
       "L 481.59361 635.818667 \n",
       "L 481.59361 563.71299 \n",
       "L 478.233108 563.71299 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_409\">\n",
       "    <path d=\"M 481.59361 635.818667 \n",
       "L 484.954113 635.818667 \n",
       "L 484.954113 559.262023 \n",
       "L 481.59361 559.262023 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_410\">\n",
       "    <path d=\"M 484.954113 635.818667 \n",
       "L 488.314615 635.818667 \n",
       "L 488.314615 571.279635 \n",
       "L 484.954113 571.279635 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_411\">\n",
       "    <path d=\"M 488.314615 635.818667 \n",
       "L 491.675118 635.818667 \n",
       "L 491.675118 573.505119 \n",
       "L 488.314615 573.505119 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_412\">\n",
       "    <path d=\"M 491.675118 635.818667 \n",
       "L 495.03562 635.818667 \n",
       "L 495.03562 601.546216 \n",
       "L 491.675118 601.546216 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_413\">\n",
       "    <path d=\"M 495.03562 635.818667 \n",
       "L 498.396122 635.818667 \n",
       "L 498.396122 600.210925 \n",
       "L 495.03562 600.210925 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_414\">\n",
       "    <path d=\"M 498.396122 635.818667 \n",
       "L 501.756625 635.818667 \n",
       "L 501.756625 614.899119 \n",
       "L 498.396122 614.899119 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_415\">\n",
       "    <path d=\"M 501.756625 635.818667 \n",
       "L 505.117127 635.818667 \n",
       "L 505.117127 623.355957 \n",
       "L 501.756625 623.355957 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_416\">\n",
       "    <path d=\"M 505.117127 635.818667 \n",
       "L 508.47763 635.818667 \n",
       "L 508.47763 626.916731 \n",
       "L 505.117127 626.916731 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_417\">\n",
       "    <path d=\"M 508.47763 635.818667 \n",
       "L 511.838132 635.818667 \n",
       "L 511.838132 631.812796 \n",
       "L 508.47763 631.812796 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_418\">\n",
       "    <path d=\"M 511.838132 635.818667 \n",
       "L 515.198634 635.818667 \n",
       "L 515.198634 634.483376 \n",
       "L 511.838132 634.483376 \n",
       "z\n",
       "\" clip-path=\"url(#p1fe71bebd6)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.322426; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_29\">\n",
       "    <g id=\"xtick_43\">\n",
       "     <g id=\"line2d_101\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"419.093652\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_44\">\n",
       "     <g id=\"line2d_102\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"465.476366\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_45\">\n",
       "     <g id=\"line2d_103\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"511.859079\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_30\">\n",
       "    <g id=\"ytick_59\">\n",
       "     <g id=\"line2d_104\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_87\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(388.203125 639.617885) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_60\">\n",
       "     <g id=\"line2d_105\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"591.30899\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_88\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(375.478125 595.108209) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_61\">\n",
       "     <g id=\"line2d_106\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"546.799313\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_89\">\n",
       "      <!-- 200 -->\n",
       "      <g transform=\"translate(375.478125 550.598532) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_90\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(369.398438 593.650208) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_419\">\n",
       "    <path d=\"M 401.565625 635.818667 \n",
       "L 401.565625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_420\">\n",
       "    <path d=\"M 527.995625 635.818667 \n",
       "L 527.995625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_421\">\n",
       "    <path d=\"M 401.565625 635.818667 \n",
       "L 527.995625 635.818667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_422\">\n",
       "    <path d=\"M 401.565625 521.784875 \n",
       "L 527.995625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_91\">\n",
       "    <!-- CHEMBL203 -->\n",
       "    <g transform=\"translate(428.198438 502.3475) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- erbB1 (4,860) -->\n",
       "    <g transform=\"translate(423.113438 515.784875) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-65\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"61.523438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-62\" x=\"102.636719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"166.113281\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"234.716797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"298.339844\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"330.126953\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"369.140625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"432.763672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"464.550781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"528.173828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"591.796875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"655.419922\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_16\">\n",
       "   <g id=\"patch_423\">\n",
       "    <path d=\"M 578.865625 635.818667 \n",
       "L 705.295625 635.818667 \n",
       "L 705.295625 521.784875 \n",
       "L 578.865625 521.784875 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_424\">\n",
       "    <path d=\"M 596.115356 635.818667 \n",
       "L 601.046571 635.818667 \n",
       "L 601.046571 631.474522 \n",
       "L 596.115356 631.474522 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_425\">\n",
       "    <path d=\"M 601.046571 635.818667 \n",
       "L 605.977786 635.818667 \n",
       "L 605.977786 625.39272 \n",
       "L 601.046571 625.39272 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_426\">\n",
       "    <path d=\"M 605.977786 635.818667 \n",
       "L 610.909 635.818667 \n",
       "L 610.909 624.523891 \n",
       "L 605.977786 624.523891 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_427\">\n",
       "    <path d=\"M 610.909 635.818667 \n",
       "L 615.840215 635.818667 \n",
       "L 615.840215 601.93434 \n",
       "L 610.909 601.93434 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_428\">\n",
       "    <path d=\"M 615.840215 635.818667 \n",
       "L 620.77143 635.818667 \n",
       "L 620.77143 565.443527 \n",
       "L 615.840215 565.443527 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_429\">\n",
       "    <path d=\"M 620.77143 635.818667 \n",
       "L 625.702645 635.818667 \n",
       "L 625.702645 568.918842 \n",
       "L 620.77143 568.918842 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_430\">\n",
       "    <path d=\"M 625.702645 635.818667 \n",
       "L 630.63386 635.818667 \n",
       "L 630.63386 552.411093 \n",
       "L 625.702645 552.411093 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_431\">\n",
       "    <path d=\"M 630.63386 635.818667 \n",
       "L 635.565074 635.818667 \n",
       "L 635.565074 556.755238 \n",
       "L 630.63386 556.755238 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_432\">\n",
       "    <path d=\"M 635.565074 635.818667 \n",
       "L 640.496289 635.818667 \n",
       "L 640.496289 527.215056 \n",
       "L 635.565074 527.215056 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_433\">\n",
       "    <path d=\"M 640.496289 635.818667 \n",
       "L 645.427504 635.818667 \n",
       "L 645.427504 533.296858 \n",
       "L 640.496289 533.296858 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_434\">\n",
       "    <path d=\"M 645.427504 635.818667 \n",
       "L 650.358719 635.818667 \n",
       "L 650.358719 552.411093 \n",
       "L 645.427504 552.411093 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_435\">\n",
       "    <path d=\"M 650.358719 635.818667 \n",
       "L 655.289934 635.818667 \n",
       "L 655.289934 557.624067 \n",
       "L 650.358719 557.624067 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_436\">\n",
       "    <path d=\"M 655.289934 635.818667 \n",
       "L 660.221148 635.818667 \n",
       "L 660.221148 567.181184 \n",
       "L 655.289934 567.181184 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_437\">\n",
       "    <path d=\"M 660.221148 635.818667 \n",
       "L 665.152363 635.818667 \n",
       "L 665.152363 588.033078 \n",
       "L 660.221148 588.033078 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_438\">\n",
       "    <path d=\"M 665.152363 635.818667 \n",
       "L 670.083578 635.818667 \n",
       "L 670.083578 606.278484 \n",
       "L 665.152363 606.278484 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_439\">\n",
       "    <path d=\"M 670.083578 635.818667 \n",
       "L 675.014793 635.818667 \n",
       "L 675.014793 606.278484 \n",
       "L 670.083578 606.278484 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_440\">\n",
       "    <path d=\"M 675.014793 635.818667 \n",
       "L 679.946007 635.818667 \n",
       "L 679.946007 620.179747 \n",
       "L 675.014793 620.179747 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_441\">\n",
       "    <path d=\"M 679.946007 635.818667 \n",
       "L 684.877222 635.818667 \n",
       "L 684.877222 611.491458 \n",
       "L 679.946007 611.491458 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_442\">\n",
       "    <path d=\"M 684.877222 635.818667 \n",
       "L 689.808437 635.818667 \n",
       "L 689.808437 626.261549 \n",
       "L 684.877222 626.261549 \n",
       "z\n",
       "\" clip-path=\"url(#pd14d13d4a2)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.47313; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_31\">\n",
       "    <g id=\"xtick_46\">\n",
       "     <g id=\"line2d_107\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"596.393652\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_47\">\n",
       "     <g id=\"line2d_108\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"642.776366\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_48\">\n",
       "     <g id=\"line2d_109\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"689.159079\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_32\">\n",
       "    <g id=\"ytick_62\">\n",
       "     <g id=\"line2d_110\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"635.818667\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_92\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(565.503125 639.617885) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_63\">\n",
       "     <g id=\"line2d_111\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"592.377222\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_93\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(559.140625 596.176441) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_64\">\n",
       "     <g id=\"line2d_112\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"548.935778\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_94\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(552.778125 552.734997) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_95\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(546.698438 593.650208) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_443\">\n",
       "    <path d=\"M 578.865625 635.818667 \n",
       "L 578.865625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_444\">\n",
       "    <path d=\"M 705.295625 635.818667 \n",
       "L 705.295625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_445\">\n",
       "    <path d=\"M 578.865625 635.818667 \n",
       "L 705.295625 635.818667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_446\">\n",
       "    <path d=\"M 578.865625 521.784875 \n",
       "L 705.295625 521.784875 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_96\">\n",
       "    <!-- CHEMBL206 -->\n",
       "    <g transform=\"translate(605.498438 502.3475) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Estrogen (1,702) -->\n",
       "    <g transform=\"translate(591.739688 515.784875) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-45\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-73\" x=\"63.183594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"115.283203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"154.492188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"193.355469\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"254.537109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"318.013672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"379.537109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"442.916016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"474.703125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"513.716797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"577.339844\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"609.126953\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"672.75\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"736.373047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"799.996094\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_17\">\n",
       "   <g id=\"patch_447\">\n",
       "    <path d=\"M 46.965625 797.828458 \n",
       "L 173.395625 797.828458 \n",
       "L 173.395625 683.794667 \n",
       "L 46.965625 683.794667 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_448\">\n",
       "    <path d=\"M 68.436183 797.828458 \n",
       "L 71.603003 797.828458 \n",
       "L 71.603003 797.017984 \n",
       "L 68.436183 797.017984 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_449\">\n",
       "    <path d=\"M 71.603003 797.828458 \n",
       "L 74.769822 797.828458 \n",
       "L 74.769822 795.397034 \n",
       "L 71.603003 795.397034 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_450\">\n",
       "    <path d=\"M 74.769822 797.828458 \n",
       "L 77.936642 797.828458 \n",
       "L 77.936642 797.017984 \n",
       "L 74.769822 797.017984 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_451\">\n",
       "    <path d=\"M 77.936642 797.828458 \n",
       "L 81.103462 797.828458 \n",
       "L 81.103462 792.155135 \n",
       "L 77.936642 792.155135 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_452\">\n",
       "    <path d=\"M 81.103462 797.828458 \n",
       "L 84.270282 797.828458 \n",
       "L 84.270282 789.723711 \n",
       "L 81.103462 789.723711 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_453\">\n",
       "    <path d=\"M 84.270282 797.828458 \n",
       "L 87.437101 797.828458 \n",
       "L 87.437101 777.566591 \n",
       "L 84.270282 777.566591 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_454\">\n",
       "    <path d=\"M 87.437101 797.828458 \n",
       "L 90.603921 797.828458 \n",
       "L 90.603921 774.324692 \n",
       "L 87.437101 774.324692 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_455\">\n",
       "    <path d=\"M 90.603921 797.828458 \n",
       "L 93.770741 797.828458 \n",
       "L 93.770741 764.598995 \n",
       "L 90.603921 764.598995 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_456\">\n",
       "    <path d=\"M 93.770741 797.828458 \n",
       "L 96.937561 797.828458 \n",
       "L 96.937561 749.199976 \n",
       "L 93.770741 749.199976 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_457\">\n",
       "    <path d=\"M 96.937561 797.828458 \n",
       "L 100.10438 797.828458 \n",
       "L 100.10438 741.905703 \n",
       "L 96.937561 741.905703 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_458\">\n",
       "    <path d=\"M 100.10438 797.828458 \n",
       "L 103.2712 797.828458 \n",
       "L 103.2712 714.349563 \n",
       "L 100.10438 714.349563 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_459\">\n",
       "    <path d=\"M 103.2712 797.828458 \n",
       "L 106.43802 797.828458 \n",
       "L 106.43802 707.865766 \n",
       "L 103.2712 707.865766 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_460\">\n",
       "    <path d=\"M 106.43802 797.828458 \n",
       "L 109.60484 797.828458 \n",
       "L 109.60484 689.224847 \n",
       "L 106.43802 689.224847 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_461\">\n",
       "    <path d=\"M 109.60484 797.828458 \n",
       "L 112.771659 797.828458 \n",
       "L 112.771659 694.087695 \n",
       "L 109.60484 694.087695 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_462\">\n",
       "    <path d=\"M 112.771659 797.828458 \n",
       "L 115.938479 797.828458 \n",
       "L 115.938479 697.329594 \n",
       "L 112.771659 697.329594 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_463\">\n",
       "    <path d=\"M 115.938479 797.828458 \n",
       "L 119.105299 797.828458 \n",
       "L 119.105299 728.938108 \n",
       "L 115.938479 728.938108 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_464\">\n",
       "    <path d=\"M 119.105299 797.828458 \n",
       "L 122.272119 797.828458 \n",
       "L 122.272119 725.696209 \n",
       "L 119.105299 725.696209 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_465\">\n",
       "    <path d=\"M 122.272119 797.828458 \n",
       "L 125.438938 797.828458 \n",
       "L 125.438938 731.369532 \n",
       "L 122.272119 731.369532 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_466\">\n",
       "    <path d=\"M 125.438938 797.828458 \n",
       "L 128.605758 797.828458 \n",
       "L 128.605758 746.768552 \n",
       "L 125.438938 746.768552 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_467\">\n",
       "    <path d=\"M 128.605758 797.828458 \n",
       "L 131.772578 797.828458 \n",
       "L 131.772578 767.030419 \n",
       "L 128.605758 767.030419 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_468\">\n",
       "    <path d=\"M 131.772578 797.828458 \n",
       "L 134.939397 797.828458 \n",
       "L 134.939397 779.18754 \n",
       "L 131.772578 779.18754 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_469\">\n",
       "    <path d=\"M 134.939397 797.828458 \n",
       "L 138.106217 797.828458 \n",
       "L 138.106217 779.18754 \n",
       "L 134.939397 779.18754 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_470\">\n",
       "    <path d=\"M 138.106217 797.828458 \n",
       "L 141.273037 797.828458 \n",
       "L 141.273037 785.671338 \n",
       "L 138.106217 785.671338 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_471\">\n",
       "    <path d=\"M 141.273037 797.828458 \n",
       "L 144.439857 797.828458 \n",
       "L 144.439857 791.344661 \n",
       "L 141.273037 791.344661 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_472\">\n",
       "    <path d=\"M 144.439857 797.828458 \n",
       "L 147.606676 797.828458 \n",
       "L 147.606676 794.586559 \n",
       "L 144.439857 794.586559 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_473\">\n",
       "    <path d=\"M 147.606676 797.828458 \n",
       "L 150.773496 797.828458 \n",
       "L 150.773496 795.397034 \n",
       "L 147.606676 795.397034 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_474\">\n",
       "    <path d=\"M 150.773496 797.828458 \n",
       "L 153.940316 797.828458 \n",
       "L 153.940316 797.828458 \n",
       "L 150.773496 797.828458 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_475\">\n",
       "    <path d=\"M 153.940316 797.828458 \n",
       "L 157.107136 797.828458 \n",
       "L 157.107136 797.828458 \n",
       "L 153.940316 797.828458 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_476\">\n",
       "    <path d=\"M 157.107136 797.828458 \n",
       "L 160.273955 797.828458 \n",
       "L 160.273955 797.017984 \n",
       "L 157.107136 797.017984 \n",
       "z\n",
       "\" clip-path=\"url(#p05be6a0339)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.303843; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_33\">\n",
       "    <g id=\"xtick_49\">\n",
       "     <g id=\"line2d_113\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"64.493652\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_50\">\n",
       "     <g id=\"line2d_114\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"110.876366\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_51\">\n",
       "     <g id=\"line2d_115\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"157.259079\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_34\">\n",
       "    <g id=\"ytick_65\">\n",
       "     <g id=\"line2d_116\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_97\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(33.603125 801.627677) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_66\">\n",
       "     <g id=\"line2d_117\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"757.304723\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_98\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(27.240625 761.103942) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_67\">\n",
       "     <g id=\"line2d_118\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"716.780987\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_99\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(20.878125 720.580206) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_100\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(14.798437 755.66) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_477\">\n",
       "    <path d=\"M 46.965625 797.828458 \n",
       "L 46.965625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_478\">\n",
       "    <path d=\"M 173.395625 797.828458 \n",
       "L 173.395625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_479\">\n",
       "    <path d=\"M 46.965625 797.828458 \n",
       "L 173.395625 797.828458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_480\">\n",
       "    <path d=\"M 46.965625 683.794667 \n",
       "L 173.395625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_101\">\n",
       "    <!-- CHEMBL2034 -->\n",
       "    <g transform=\"translate(69.780938 664.357292) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- Glucocorticoid (1,446) -->\n",
       "    <g transform=\"translate(43.424063 677.794667) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-47\" d=\"M 3809 666 \n",
       "L 3809 1919 \n",
       "L 2778 1919 \n",
       "L 2778 2438 \n",
       "L 4434 2438 \n",
       "L 4434 434 \n",
       "Q 4069 175 3628 42 \n",
       "Q 3188 -91 2688 -91 \n",
       "Q 1594 -91 976 548 \n",
       "Q 359 1188 359 2328 \n",
       "Q 359 3472 976 4111 \n",
       "Q 1594 4750 2688 4750 \n",
       "Q 3144 4750 3555 4637 \n",
       "Q 3966 4525 4313 4306 \n",
       "L 4313 3634 \n",
       "Q 3963 3931 3569 4081 \n",
       "Q 3175 4231 2741 4231 \n",
       "Q 1884 4231 1454 3753 \n",
       "Q 1025 3275 1025 2328 \n",
       "Q 1025 1384 1454 906 \n",
       "Q 1884 428 2741 428 \n",
       "Q 3075 428 3337 486 \n",
       "Q 3600 544 3809 666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-47\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"77.490234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-75\" x=\"105.273438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"168.652344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"223.632812\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"284.814453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"339.794922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-72\" x=\"400.976562\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-74\" x=\"442.089844\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"481.298828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"509.082031\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"564.0625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"625.244141\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"653.027344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"716.503906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"748.291016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"787.304688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"850.927734\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"882.714844\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"946.337891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"1009.960938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"1073.583984\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_18\">\n",
       "   <g id=\"patch_481\">\n",
       "    <path d=\"M 224.265625 797.828458 \n",
       "L 350.695625 797.828458 \n",
       "L 350.695625 683.794667 \n",
       "L 224.265625 683.794667 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_482\">\n",
       "    <path d=\"M 247.916171 797.828458 \n",
       "L 251.888217 797.828458 \n",
       "L 251.888217 791.145159 \n",
       "L 247.916171 791.145159 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_483\">\n",
       "    <path d=\"M 251.888217 797.828458 \n",
       "L 255.860264 797.828458 \n",
       "L 255.860264 790.309747 \n",
       "L 251.888217 790.309747 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_484\">\n",
       "    <path d=\"M 255.860264 797.828458 \n",
       "L 259.832311 797.828458 \n",
       "L 259.832311 787.80351 \n",
       "L 255.860264 787.80351 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_485\">\n",
       "    <path d=\"M 259.832311 797.828458 \n",
       "L 263.804358 797.828458 \n",
       "L 263.804358 766.082787 \n",
       "L 259.832311 766.082787 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_486\">\n",
       "    <path d=\"M 263.804358 797.828458 \n",
       "L 267.776405 797.828458 \n",
       "L 267.776405 762.741138 \n",
       "L 263.804358 762.741138 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_487\">\n",
       "    <path d=\"M 267.776405 797.828458 \n",
       "L 271.748452 797.828458 \n",
       "L 271.748452 751.045364 \n",
       "L 267.776405 751.045364 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_488\">\n",
       "    <path d=\"M 271.748452 797.828458 \n",
       "L 275.720499 797.828458 \n",
       "L 275.720499 719.299693 \n",
       "L 271.748452 719.299693 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_489\">\n",
       "    <path d=\"M 275.720499 797.828458 \n",
       "L 279.692546 797.828458 \n",
       "L 279.692546 726.818405 \n",
       "L 275.720499 726.818405 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_490\">\n",
       "    <path d=\"M 279.692546 797.828458 \n",
       "L 283.664593 797.828458 \n",
       "L 283.664593 707.60392 \n",
       "L 279.692546 707.60392 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_491\">\n",
       "    <path d=\"M 283.664593 797.828458 \n",
       "L 287.63664 797.828458 \n",
       "L 287.63664 693.401909 \n",
       "L 283.664593 693.401909 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_492\">\n",
       "    <path d=\"M 287.63664 797.828458 \n",
       "L 291.608686 797.828458 \n",
       "L 291.608686 697.578971 \n",
       "L 287.63664 697.578971 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_493\">\n",
       "    <path d=\"M 291.608686 797.828458 \n",
       "L 295.580733 797.828458 \n",
       "L 295.580733 689.224847 \n",
       "L 291.608686 689.224847 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_494\">\n",
       "    <path d=\"M 295.580733 797.828458 \n",
       "L 299.55278 797.828458 \n",
       "L 299.55278 710.945569 \n",
       "L 295.580733 710.945569 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_495\">\n",
       "    <path d=\"M 299.55278 797.828458 \n",
       "L 303.524827 797.828458 \n",
       "L 303.524827 716.793456 \n",
       "L 299.55278 716.793456 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_496\">\n",
       "    <path d=\"M 303.524827 797.828458 \n",
       "L 307.496874 797.828458 \n",
       "L 307.496874 735.172529 \n",
       "L 303.524827 735.172529 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_497\">\n",
       "    <path d=\"M 307.496874 797.828458 \n",
       "L 311.468921 797.828458 \n",
       "L 311.468921 751.045364 \n",
       "L 307.496874 751.045364 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_498\">\n",
       "    <path d=\"M 311.468921 797.828458 \n",
       "L 315.440968 797.828458 \n",
       "L 315.440968 764.411963 \n",
       "L 311.468921 764.411963 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_499\">\n",
       "    <path d=\"M 315.440968 797.828458 \n",
       "L 319.413015 797.828458 \n",
       "L 319.413015 784.46186 \n",
       "L 315.440968 784.46186 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_500\">\n",
       "    <path d=\"M 319.413015 797.828458 \n",
       "L 323.385062 797.828458 \n",
       "L 323.385062 786.968097 \n",
       "L 319.413015 786.968097 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_501\">\n",
       "    <path d=\"M 323.385062 797.828458 \n",
       "L 327.357109 797.828458 \n",
       "L 327.357109 791.980572 \n",
       "L 323.385062 791.980572 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_502\">\n",
       "    <path d=\"M 327.357109 797.828458 \n",
       "L 331.329156 797.828458 \n",
       "L 331.329156 796.157634 \n",
       "L 327.357109 796.157634 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_503\">\n",
       "    <path d=\"M 331.329156 797.828458 \n",
       "L 335.301202 797.828458 \n",
       "L 335.301202 796.993046 \n",
       "L 331.329156 796.993046 \n",
       "z\n",
       "\" clip-path=\"url(#p5e027d06e4)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.381101; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_35\">\n",
       "    <g id=\"xtick_52\">\n",
       "     <g id=\"line2d_119\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"241.793652\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_53\">\n",
       "     <g id=\"line2d_120\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"288.176366\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_54\">\n",
       "     <g id=\"line2d_121\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"334.559079\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_36\">\n",
       "    <g id=\"ytick_68\">\n",
       "     <g id=\"line2d_122\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_102\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(210.903125 801.627677) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_69\">\n",
       "     <g id=\"line2d_123\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"756.057839\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_103\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(204.540625 759.857057) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_70\">\n",
       "     <g id=\"line2d_124\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"714.287219\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_104\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(198.178125 718.086438) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_105\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(192.098438 755.66) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_504\">\n",
       "    <path d=\"M 224.265625 797.828458 \n",
       "L 224.265625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_505\">\n",
       "    <path d=\"M 350.695625 797.828458 \n",
       "L 350.695625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_506\">\n",
       "    <path d=\"M 224.265625 797.828458 \n",
       "L 350.695625 797.828458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_507\">\n",
       "    <path d=\"M 224.265625 683.794667 \n",
       "L 350.695625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_106\">\n",
       "    <!-- CHEMBL262 -->\n",
       "    <g transform=\"translate(250.898438 664.357292) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- Glycogen (1,757) -->\n",
       "    <g transform=\"translate(235.574063 677.794667) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-47\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"77.490234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-79\" x=\"105.273438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-63\" x=\"164.453125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"219.433594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-67\" x=\"280.615234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"344.091797\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"405.615234\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"468.994141\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"500.78125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"539.794922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"603.417969\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"635.205078\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"698.828125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"762.451172\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"826.074219\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_19\">\n",
       "   <g id=\"patch_508\">\n",
       "    <path d=\"M 401.565625 797.828458 \n",
       "L 527.995625 797.828458 \n",
       "L 527.995625 683.794667 \n",
       "L 401.565625 683.794667 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_509\">\n",
       "    <path d=\"M 417.702171 797.828458 \n",
       "L 419.396361 797.828458 \n",
       "L 419.396361 797.446051 \n",
       "L 417.702171 797.446051 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_510\">\n",
       "    <path d=\"M 419.396361 797.828458 \n",
       "L 421.09055 797.828458 \n",
       "L 421.09055 797.828458 \n",
       "L 419.396361 797.828458 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_511\">\n",
       "    <path d=\"M 421.09055 797.828458 \n",
       "L 422.78474 797.828458 \n",
       "L 422.78474 796.681237 \n",
       "L 421.09055 796.681237 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_512\">\n",
       "    <path d=\"M 422.78474 797.828458 \n",
       "L 424.47893 797.828458 \n",
       "L 424.47893 797.446051 \n",
       "L 422.78474 797.446051 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_513\">\n",
       "    <path d=\"M 424.47893 797.828458 \n",
       "L 426.173119 797.828458 \n",
       "L 426.173119 795.916423 \n",
       "L 424.47893 795.916423 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_514\">\n",
       "    <path d=\"M 426.173119 797.828458 \n",
       "L 427.867309 797.828458 \n",
       "L 427.867309 794.004388 \n",
       "L 426.173119 794.004388 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_515\">\n",
       "    <path d=\"M 427.867309 797.828458 \n",
       "L 429.561498 797.828458 \n",
       "L 429.561498 795.916423 \n",
       "L 427.867309 795.916423 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_516\">\n",
       "    <path d=\"M 429.561498 797.828458 \n",
       "L 431.255688 797.828458 \n",
       "L 431.255688 795.534016 \n",
       "L 429.561498 795.534016 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_517\">\n",
       "    <path d=\"M 431.255688 797.828458 \n",
       "L 432.949878 797.828458 \n",
       "L 432.949878 794.386795 \n",
       "L 431.255688 794.386795 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_518\">\n",
       "    <path d=\"M 432.949878 797.828458 \n",
       "L 434.644067 797.828458 \n",
       "L 434.644067 792.857166 \n",
       "L 432.949878 792.857166 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_519\">\n",
       "    <path d=\"M 434.644067 797.828458 \n",
       "L 436.338257 797.828458 \n",
       "L 436.338257 792.092352 \n",
       "L 434.644067 792.092352 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_520\">\n",
       "    <path d=\"M 436.338257 797.828458 \n",
       "L 438.032447 797.828458 \n",
       "L 438.032447 793.239573 \n",
       "L 436.338257 793.239573 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_521\">\n",
       "    <path d=\"M 438.032447 797.828458 \n",
       "L 439.726636 797.828458 \n",
       "L 439.726636 789.033095 \n",
       "L 438.032447 789.033095 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_522\">\n",
       "    <path d=\"M 439.726636 797.828458 \n",
       "L 441.420826 797.828458 \n",
       "L 441.420826 792.092352 \n",
       "L 439.726636 792.092352 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_523\">\n",
       "    <path d=\"M 441.420826 797.828458 \n",
       "L 443.115015 797.828458 \n",
       "L 443.115015 790.562724 \n",
       "L 441.420826 790.562724 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_524\">\n",
       "    <path d=\"M 443.115015 797.828458 \n",
       "L 444.809205 797.828458 \n",
       "L 444.809205 785.591432 \n",
       "L 443.115015 785.591432 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_525\">\n",
       "    <path d=\"M 444.809205 797.828458 \n",
       "L 446.503395 797.828458 \n",
       "L 446.503395 781.002547 \n",
       "L 444.809205 781.002547 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_526\">\n",
       "    <path d=\"M 446.503395 797.828458 \n",
       "L 448.197584 797.828458 \n",
       "L 448.197584 784.44421 \n",
       "L 446.503395 784.44421 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_527\">\n",
       "    <path d=\"M 448.197584 797.828458 \n",
       "L 449.891774 797.828458 \n",
       "L 449.891774 778.708104 \n",
       "L 448.197584 778.708104 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_528\">\n",
       "    <path d=\"M 449.891774 797.828458 \n",
       "L 451.585964 797.828458 \n",
       "L 451.585964 773.736812 \n",
       "L 449.891774 773.736812 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_529\">\n",
       "    <path d=\"M 451.585964 797.828458 \n",
       "L 453.280153 797.828458 \n",
       "L 453.280153 761.882193 \n",
       "L 451.585964 761.882193 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_530\">\n",
       "    <path d=\"M 453.280153 797.828458 \n",
       "L 454.974343 797.828458 \n",
       "L 454.974343 757.675715 \n",
       "L 453.280153 757.675715 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_531\">\n",
       "    <path d=\"M 454.974343 797.828458 \n",
       "L 456.668533 797.828458 \n",
       "L 456.668533 748.880352 \n",
       "L 454.974343 748.880352 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_532\">\n",
       "    <path d=\"M 456.668533 797.828458 \n",
       "L 458.362722 797.828458 \n",
       "L 458.362722 740.849803 \n",
       "L 456.668533 740.849803 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_533\">\n",
       "    <path d=\"M 458.362722 797.828458 \n",
       "L 460.056912 797.828458 \n",
       "L 460.056912 730.907219 \n",
       "L 458.362722 730.907219 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_534\">\n",
       "    <path d=\"M 460.056912 797.828458 \n",
       "L 461.751101 797.828458 \n",
       "L 461.751101 716.37575 \n",
       "L 460.056912 716.37575 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_535\">\n",
       "    <path d=\"M 461.751101 797.828458 \n",
       "L 463.445291 797.828458 \n",
       "L 463.445291 689.224847 \n",
       "L 461.751101 689.224847 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_536\">\n",
       "    <path d=\"M 463.445291 797.828458 \n",
       "L 465.139481 797.828458 \n",
       "L 465.139481 692.284104 \n",
       "L 463.445291 692.284104 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_537\">\n",
       "    <path d=\"M 465.139481 797.828458 \n",
       "L 466.83367 797.828458 \n",
       "L 466.83367 696.872989 \n",
       "L 465.139481 696.872989 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_538\">\n",
       "    <path d=\"M 466.83367 797.828458 \n",
       "L 468.52786 797.828458 \n",
       "L 468.52786 709.110015 \n",
       "L 466.83367 709.110015 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_539\">\n",
       "    <path d=\"M 468.52786 797.828458 \n",
       "L 470.22205 797.828458 \n",
       "L 470.22205 715.993343 \n",
       "L 468.52786 715.993343 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_540\">\n",
       "    <path d=\"M 470.22205 797.828458 \n",
       "L 471.916239 797.828458 \n",
       "L 471.916239 725.171113 \n",
       "L 470.22205 725.171113 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_541\">\n",
       "    <path d=\"M 471.916239 797.828458 \n",
       "L 473.610429 797.828458 \n",
       "L 473.610429 720.582228 \n",
       "L 471.916239 720.582228 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_542\">\n",
       "    <path d=\"M 473.610429 797.828458 \n",
       "L 475.304619 797.828458 \n",
       "L 475.304619 744.291467 \n",
       "L 473.610429 744.291467 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_543\">\n",
       "    <path d=\"M 475.304619 797.828458 \n",
       "L 476.998808 797.828458 \n",
       "L 476.998808 746.203502 \n",
       "L 475.304619 746.203502 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_544\">\n",
       "    <path d=\"M 476.998808 797.828458 \n",
       "L 478.692998 797.828458 \n",
       "L 478.692998 765.323856 \n",
       "L 476.998808 765.323856 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_545\">\n",
       "    <path d=\"M 478.692998 797.828458 \n",
       "L 480.387187 797.828458 \n",
       "L 480.387187 769.912741 \n",
       "L 478.692998 769.912741 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_546\">\n",
       "    <path d=\"M 480.387187 797.828458 \n",
       "L 482.081377 797.828458 \n",
       "L 482.081377 774.119219 \n",
       "L 480.387187 774.119219 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_547\">\n",
       "    <path d=\"M 482.081377 797.828458 \n",
       "L 483.775567 797.828458 \n",
       "L 483.775567 779.090511 \n",
       "L 482.081377 779.090511 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_548\">\n",
       "    <path d=\"M 483.775567 797.828458 \n",
       "L 485.469756 797.828458 \n",
       "L 485.469756 789.033095 \n",
       "L 483.775567 789.033095 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_549\">\n",
       "    <path d=\"M 485.469756 797.828458 \n",
       "L 487.163946 797.828458 \n",
       "L 487.163946 783.296989 \n",
       "L 485.469756 783.296989 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_550\">\n",
       "    <path d=\"M 487.163946 797.828458 \n",
       "L 488.858136 797.828458 \n",
       "L 488.858136 791.327538 \n",
       "L 487.163946 791.327538 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_551\">\n",
       "    <path d=\"M 488.858136 797.828458 \n",
       "L 490.552325 797.828458 \n",
       "L 490.552325 791.327538 \n",
       "L 488.858136 791.327538 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_552\">\n",
       "    <path d=\"M 490.552325 797.828458 \n",
       "L 492.246515 797.828458 \n",
       "L 492.246515 792.092352 \n",
       "L 490.552325 792.092352 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_553\">\n",
       "    <path d=\"M 492.246515 797.828458 \n",
       "L 493.940705 797.828458 \n",
       "L 493.940705 793.239573 \n",
       "L 492.246515 793.239573 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_554\">\n",
       "    <path d=\"M 493.940705 797.828458 \n",
       "L 495.634894 797.828458 \n",
       "L 495.634894 794.004388 \n",
       "L 493.940705 794.004388 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_555\">\n",
       "    <path d=\"M 495.634894 797.828458 \n",
       "L 497.329084 797.828458 \n",
       "L 497.329084 794.004388 \n",
       "L 495.634894 794.004388 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_556\">\n",
       "    <path d=\"M 497.329084 797.828458 \n",
       "L 499.023273 797.828458 \n",
       "L 499.023273 794.386795 \n",
       "L 497.329084 794.386795 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_557\">\n",
       "    <path d=\"M 499.023273 797.828458 \n",
       "L 500.717463 797.828458 \n",
       "L 500.717463 794.386795 \n",
       "L 499.023273 794.386795 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_558\">\n",
       "    <path d=\"M 500.717463 797.828458 \n",
       "L 502.411653 797.828458 \n",
       "L 502.411653 796.29883 \n",
       "L 500.717463 796.29883 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_559\">\n",
       "    <path d=\"M 502.411653 797.828458 \n",
       "L 504.105842 797.828458 \n",
       "L 504.105842 796.29883 \n",
       "L 502.411653 796.29883 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_560\">\n",
       "    <path d=\"M 504.105842 797.828458 \n",
       "L 505.800032 797.828458 \n",
       "L 505.800032 796.681237 \n",
       "L 504.105842 796.681237 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_561\">\n",
       "    <path d=\"M 505.800032 797.828458 \n",
       "L 507.494222 797.828458 \n",
       "L 507.494222 797.828458 \n",
       "L 505.800032 797.828458 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_562\">\n",
       "    <path d=\"M 507.494222 797.828458 \n",
       "L 509.188411 797.828458 \n",
       "L 509.188411 797.446051 \n",
       "L 507.494222 797.446051 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_563\">\n",
       "    <path d=\"M 509.188411 797.828458 \n",
       "L 510.882601 797.828458 \n",
       "L 510.882601 797.828458 \n",
       "L 509.188411 797.828458 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_564\">\n",
       "    <path d=\"M 510.882601 797.828458 \n",
       "L 512.57679 797.828458 \n",
       "L 512.57679 797.446051 \n",
       "L 510.882601 797.446051 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_565\">\n",
       "    <path d=\"M 512.57679 797.828458 \n",
       "L 514.27098 797.828458 \n",
       "L 514.27098 797.446051 \n",
       "L 512.57679 797.446051 \n",
       "z\n",
       "\" clip-path=\"url(#pf86962bd07)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.16255; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_37\">\n",
       "    <g id=\"xtick_55\">\n",
       "     <g id=\"line2d_125\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"419.093652\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_56\">\n",
       "     <g id=\"line2d_126\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"465.476366\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_57\">\n",
       "     <g id=\"line2d_127\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"511.859079\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_38\">\n",
       "    <g id=\"ytick_71\">\n",
       "     <g id=\"line2d_128\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_107\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(388.203125 801.627677) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_72\">\n",
       "     <g id=\"line2d_129\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"759.58775\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_108\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(375.478125 763.386969) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_73\">\n",
       "     <g id=\"line2d_130\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"721.347042\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_109\">\n",
       "      <!-- 200 -->\n",
       "      <g transform=\"translate(375.478125 725.146261) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_110\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(369.398438 755.66) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_566\">\n",
       "    <path d=\"M 401.565625 797.828458 \n",
       "L 401.565625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_567\">\n",
       "    <path d=\"M 527.995625 797.828458 \n",
       "L 527.995625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_568\">\n",
       "    <path d=\"M 401.565625 797.828458 \n",
       "L 527.995625 797.828458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_569\">\n",
       "    <path d=\"M 401.565625 683.794667 \n",
       "L 527.995625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_111\">\n",
       "    <!-- CHEMBL240 -->\n",
       "    <g transform=\"translate(428.198438 664.357292) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- HERG (5,203) -->\n",
       "    <g transform=\"translate(423.893438 677.794667) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-52\" d=\"M 2841 2188 \n",
       "Q 3044 2119 3236 1894 \n",
       "Q 3428 1669 3622 1275 \n",
       "L 4263 0 \n",
       "L 3584 0 \n",
       "L 2988 1197 \n",
       "Q 2756 1666 2539 1819 \n",
       "Q 2322 1972 1947 1972 \n",
       "L 1259 1972 \n",
       "L 1259 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "L 2053 4666 \n",
       "Q 2853 4666 3247 4331 \n",
       "Q 3641 3997 3641 3322 \n",
       "Q 3641 2881 3436 2590 \n",
       "Q 3231 2300 2841 2188 \n",
       "z\n",
       "M 1259 4147 \n",
       "L 1259 2491 \n",
       "L 2053 2491 \n",
       "Q 2509 2491 2742 2702 \n",
       "Q 2975 2913 2975 3322 \n",
       "Q 2975 3731 2742 3939 \n",
       "Q 2509 4147 2053 4147 \n",
       "L 1259 4147 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-48\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"75.195312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-52\" x=\"138.378906\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-47\" x=\"207.861328\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"285.351562\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"317.138672\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"356.152344\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"419.775391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"451.5625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"515.185547\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"578.808594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"642.431641\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_20\">\n",
       "   <g id=\"patch_570\">\n",
       "    <path d=\"M 578.865625 797.828458 \n",
       "L 705.295625 797.828458 \n",
       "L 705.295625 683.794667 \n",
       "L 578.865625 683.794667 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_571\">\n",
       "    <path d=\"M 594.723875 797.828458 \n",
       "L 597.999454 797.828458 \n",
       "L 597.999454 796.309527 \n",
       "L 594.723875 796.309527 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_572\">\n",
       "    <path d=\"M 597.999454 797.828458 \n",
       "L 601.275033 797.828458 \n",
       "L 601.275033 794.790595 \n",
       "L 597.999454 794.790595 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_573\">\n",
       "    <path d=\"M 601.275033 797.828458 \n",
       "L 604.550612 797.828458 \n",
       "L 604.550612 794.031129 \n",
       "L 601.275033 794.031129 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_574\">\n",
       "    <path d=\"M 604.550612 797.828458 \n",
       "L 607.826192 797.828458 \n",
       "L 607.826192 793.271663 \n",
       "L 604.550612 793.271663 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_575\">\n",
       "    <path d=\"M 607.826192 797.828458 \n",
       "L 611.101771 797.828458 \n",
       "L 611.101771 793.271663 \n",
       "L 607.826192 793.271663 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_576\">\n",
       "    <path d=\"M 611.101771 797.828458 \n",
       "L 614.37735 797.828458 \n",
       "L 614.37735 779.601279 \n",
       "L 611.101771 779.601279 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_577\">\n",
       "    <path d=\"M 614.37735 797.828458 \n",
       "L 617.652929 797.828458 \n",
       "L 617.652929 772.766087 \n",
       "L 614.37735 772.766087 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_578\">\n",
       "    <path d=\"M 617.652929 797.828458 \n",
       "L 620.928508 797.828458 \n",
       "L 620.928508 776.563416 \n",
       "L 617.652929 776.563416 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_579\">\n",
       "    <path d=\"M 620.928508 797.828458 \n",
       "L 624.204088 797.828458 \n",
       "L 624.204088 764.411963 \n",
       "L 620.928508 764.411963 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_580\">\n",
       "    <path d=\"M 624.204088 797.828458 \n",
       "L 627.479667 797.828458 \n",
       "L 627.479667 740.109057 \n",
       "L 624.204088 740.109057 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_581\">\n",
       "    <path d=\"M 627.479667 797.828458 \n",
       "L 630.755246 797.828458 \n",
       "L 630.755246 731.754933 \n",
       "L 627.479667 731.754933 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_582\">\n",
       "    <path d=\"M 630.755246 797.828458 \n",
       "L 634.030825 797.828458 \n",
       "L 634.030825 723.400809 \n",
       "L 630.755246 723.400809 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_583\">\n",
       "    <path d=\"M 634.030825 797.828458 \n",
       "L 637.306404 797.828458 \n",
       "L 637.306404 703.654698 \n",
       "L 634.030825 703.654698 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_584\">\n",
       "    <path d=\"M 637.306404 797.828458 \n",
       "L 640.581984 797.828458 \n",
       "L 640.581984 697.578971 \n",
       "L 637.306404 697.578971 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_585\">\n",
       "    <path d=\"M 640.581984 797.828458 \n",
       "L 643.857563 797.828458 \n",
       "L 643.857563 697.578971 \n",
       "L 640.581984 697.578971 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_586\">\n",
       "    <path d=\"M 643.857563 797.828458 \n",
       "L 647.133142 797.828458 \n",
       "L 647.133142 689.224847 \n",
       "L 643.857563 689.224847 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_587\">\n",
       "    <path d=\"M 647.133142 797.828458 \n",
       "L 650.408721 797.828458 \n",
       "L 650.408721 696.819505 \n",
       "L 647.133142 696.819505 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_588\">\n",
       "    <path d=\"M 650.408721 797.828458 \n",
       "L 653.6843 797.828458 \n",
       "L 653.6843 711.249356 \n",
       "L 650.408721 711.249356 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_589\">\n",
       "    <path d=\"M 653.6843 797.828458 \n",
       "L 656.95988 797.828458 \n",
       "L 656.95988 724.91974 \n",
       "L 653.6843 724.91974 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_590\">\n",
       "    <path d=\"M 656.95988 797.828458 \n",
       "L 660.235459 797.828458 \n",
       "L 660.235459 747.703715 \n",
       "L 656.95988 747.703715 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_591\">\n",
       "    <path d=\"M 660.235459 797.828458 \n",
       "L 663.511038 797.828458 \n",
       "L 663.511038 759.095702 \n",
       "L 660.235459 759.095702 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_592\">\n",
       "    <path d=\"M 663.511038 797.828458 \n",
       "L 666.786617 797.828458 \n",
       "L 666.786617 755.298373 \n",
       "L 663.511038 755.298373 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_593\">\n",
       "    <path d=\"M 666.786617 797.828458 \n",
       "L 670.062196 797.828458 \n",
       "L 670.062196 773.525552 \n",
       "L 666.786617 773.525552 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_594\">\n",
       "    <path d=\"M 670.062196 797.828458 \n",
       "L 673.337776 797.828458 \n",
       "L 673.337776 778.082347 \n",
       "L 670.062196 778.082347 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_595\">\n",
       "    <path d=\"M 673.337776 797.828458 \n",
       "L 676.613355 797.828458 \n",
       "L 676.613355 786.436471 \n",
       "L 673.337776 786.436471 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_596\">\n",
       "    <path d=\"M 676.613355 797.828458 \n",
       "L 679.888934 797.828458 \n",
       "L 679.888934 790.2338 \n",
       "L 676.613355 790.2338 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_597\">\n",
       "    <path d=\"M 679.888934 797.828458 \n",
       "L 683.164513 797.828458 \n",
       "L 683.164513 794.790595 \n",
       "L 679.888934 794.790595 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_598\">\n",
       "    <path d=\"M 683.164513 797.828458 \n",
       "L 686.440092 797.828458 \n",
       "L 686.440092 797.068993 \n",
       "L 683.164513 797.068993 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_599\">\n",
       "    <path d=\"M 686.440092 797.828458 \n",
       "L 689.715672 797.828458 \n",
       "L 689.715672 795.550061 \n",
       "L 686.440092 795.550061 \n",
       "z\n",
       "\" clip-path=\"url(#p0bcc49192d)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.314278; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_39\">\n",
       "    <g id=\"xtick_58\">\n",
       "     <g id=\"line2d_131\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"596.393652\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_59\">\n",
       "     <g id=\"line2d_132\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"642.776366\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_60\">\n",
       "     <g id=\"line2d_133\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"689.159079\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_40\">\n",
       "    <g id=\"ytick_74\">\n",
       "     <g id=\"line2d_134\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"797.828458\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_112\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(565.503125 801.627677) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_75\">\n",
       "     <g id=\"line2d_135\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"759.855168\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_113\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(559.140625 763.654386) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_76\">\n",
       "     <g id=\"line2d_136\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"721.881877\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_114\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(552.778125 725.681096) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_77\">\n",
       "     <g id=\"line2d_137\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"683.908587\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_115\">\n",
       "      <!-- 150 -->\n",
       "      <g transform=\"translate(552.778125 687.707805) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_116\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(546.698438 755.66) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_600\">\n",
       "    <path d=\"M 578.865625 797.828458 \n",
       "L 578.865625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_601\">\n",
       "    <path d=\"M 705.295625 797.828458 \n",
       "L 705.295625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_602\">\n",
       "    <path d=\"M 578.865625 797.828458 \n",
       "L 705.295625 797.828458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_603\">\n",
       "    <path d=\"M 578.865625 683.794667 \n",
       "L 705.295625 683.794667 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_117\">\n",
       "    <!-- CHEMBL2971 -->\n",
       "    <g transform=\"translate(601.680938 664.357292) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- JAK2 (2,640) -->\n",
       "    <g transform=\"translate(604.793438 677.794667) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-4a\" d=\"M 628 4666 \n",
       "L 1259 4666 \n",
       "L 1259 325 \n",
       "Q 1259 -519 939 -900 \n",
       "Q 619 -1281 -91 -1281 \n",
       "L -331 -1281 \n",
       "L -331 -750 \n",
       "L -134 -750 \n",
       "Q 284 -750 456 -515 \n",
       "Q 628 -281 628 325 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      <path id=\"DejaVuSans-4b\" d=\"M 628 4666 \n",
       "L 1259 4666 \n",
       "L 1259 2694 \n",
       "L 3353 4666 \n",
       "L 4166 4666 \n",
       "L 1850 2491 \n",
       "L 4331 0 \n",
       "L 3500 0 \n",
       "L 1259 2247 \n",
       "L 1259 0 \n",
       "L 628 0 \n",
       "L 628 4666 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-4a\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-41\" x=\"27.742188\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4b\" x=\"96.150391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"161.726562\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"225.349609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"257.136719\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"296.150391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"359.773438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-36\" x=\"391.560547\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"455.183594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"518.806641\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"582.429688\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_21\">\n",
       "   <g id=\"patch_604\">\n",
       "    <path d=\"M 46.965625 959.83825 \n",
       "L 173.395625 959.83825 \n",
       "L 173.395625 845.804458 \n",
       "L 46.965625 845.804458 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_605\">\n",
       "    <path d=\"M 64.215356 959.83825 \n",
       "L 68.281574 959.83825 \n",
       "L 68.281574 958.241138 \n",
       "L 64.215356 958.241138 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_606\">\n",
       "    <path d=\"M 68.281574 959.83825 \n",
       "L 72.347792 959.83825 \n",
       "L 72.347792 954.248358 \n",
       "L 68.281574 954.248358 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_607\">\n",
       "    <path d=\"M 72.347792 959.83825 \n",
       "L 76.41401 959.83825 \n",
       "L 76.41401 957.442582 \n",
       "L 72.347792 957.442582 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_608\">\n",
       "    <path d=\"M 76.41401 959.83825 \n",
       "L 80.480228 959.83825 \n",
       "L 80.480228 943.867131 \n",
       "L 76.41401 943.867131 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_609\">\n",
       "    <path d=\"M 80.480228 959.83825 \n",
       "L 84.546445 959.83825 \n",
       "L 84.546445 940.672907 \n",
       "L 80.480228 940.672907 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_610\">\n",
       "    <path d=\"M 84.546445 959.83825 \n",
       "L 88.612663 959.83825 \n",
       "L 88.612663 927.896011 \n",
       "L 84.546445 927.896011 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_611\">\n",
       "    <path d=\"M 88.612663 959.83825 \n",
       "L 92.678881 959.83825 \n",
       "L 92.678881 918.31334 \n",
       "L 88.612663 918.31334 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_612\">\n",
       "    <path d=\"M 92.678881 959.83825 \n",
       "L 96.745099 959.83825 \n",
       "L 96.745099 899.946553 \n",
       "L 92.678881 899.946553 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_613\">\n",
       "    <path d=\"M 96.745099 959.83825 \n",
       "L 100.811317 959.83825 \n",
       "L 100.811317 893.558105 \n",
       "L 96.745099 893.558105 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_614\">\n",
       "    <path d=\"M 100.811317 959.83825 \n",
       "L 104.877535 959.83825 \n",
       "L 104.877535 884.773989 \n",
       "L 100.811317 884.773989 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_615\">\n",
       "    <path d=\"M 104.877535 959.83825 \n",
       "L 108.943753 959.83825 \n",
       "L 108.943753 873.594206 \n",
       "L 104.877535 873.594206 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_616\">\n",
       "    <path d=\"M 108.943753 959.83825 \n",
       "L 113.009971 959.83825 \n",
       "L 113.009971 851.234639 \n",
       "L 108.943753 851.234639 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_617\">\n",
       "    <path d=\"M 113.009971 959.83825 \n",
       "L 117.076188 959.83825 \n",
       "L 117.076188 867.205758 \n",
       "L 113.009971 867.205758 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_618\">\n",
       "    <path d=\"M 117.076188 959.83825 \n",
       "L 121.142406 959.83825 \n",
       "L 121.142406 883.975433 \n",
       "L 117.076188 883.975433 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_619\">\n",
       "    <path d=\"M 121.142406 959.83825 \n",
       "L 125.208624 959.83825 \n",
       "L 125.208624 874.392762 \n",
       "L 121.142406 874.392762 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_620\">\n",
       "    <path d=\"M 125.208624 959.83825 \n",
       "L 129.274842 959.83825 \n",
       "L 129.274842 894.356661 \n",
       "L 125.208624 894.356661 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_621\">\n",
       "    <path d=\"M 129.274842 959.83825 \n",
       "L 133.34106 959.83825 \n",
       "L 133.34106 921.507564 \n",
       "L 129.274842 921.507564 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_622\">\n",
       "    <path d=\"M 133.34106 959.83825 \n",
       "L 137.407278 959.83825 \n",
       "L 137.407278 931.090235 \n",
       "L 133.34106 931.090235 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_623\">\n",
       "    <path d=\"M 137.407278 959.83825 \n",
       "L 141.473496 959.83825 \n",
       "L 141.473496 943.867131 \n",
       "L 137.407278 943.867131 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_624\">\n",
       "    <path d=\"M 141.473496 959.83825 \n",
       "L 145.539713 959.83825 \n",
       "L 145.539713 940.672907 \n",
       "L 141.473496 940.672907 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_625\">\n",
       "    <path d=\"M 145.539713 959.83825 \n",
       "L 149.605931 959.83825 \n",
       "L 149.605931 951.85269 \n",
       "L 145.539713 951.85269 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_626\">\n",
       "    <path d=\"M 149.605931 959.83825 \n",
       "L 153.672149 959.83825 \n",
       "L 153.672149 953.449802 \n",
       "L 149.605931 953.449802 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_627\">\n",
       "    <path d=\"M 153.672149 959.83825 \n",
       "L 157.738367 959.83825 \n",
       "L 157.738367 957.442582 \n",
       "L 153.672149 957.442582 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_628\">\n",
       "    <path d=\"M 157.738367 959.83825 \n",
       "L 161.804585 959.83825 \n",
       "L 161.804585 959.039694 \n",
       "L 157.738367 959.039694 \n",
       "z\n",
       "\" clip-path=\"url(#pea8ba9fbbf)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.390137; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_41\">\n",
       "    <g id=\"xtick_61\">\n",
       "     <g id=\"line2d_138\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"64.493652\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_118\">\n",
       "      <!-- −5 -->\n",
       "      <g transform=\"translate(57.122559 974.436688) scale(0.1 -0.1)\">\n",
       "       <defs>\n",
       "        <path id=\"DejaVuSans-2212\" d=\"M 678 2272 \n",
       "L 4684 2272 \n",
       "L 4684 1741 \n",
       "L 678 1741 \n",
       "L 678 2272 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       </defs>\n",
       "       <use xlink:href=\"#DejaVuSans-2212\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"83.789062\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_62\">\n",
       "     <g id=\"line2d_139\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"110.876366\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_119\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(107.695116 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_63\">\n",
       "     <g id=\"line2d_140\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"157.259079\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_120\">\n",
       "      <!-- 5 -->\n",
       "      <g transform=\"translate(154.077829 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_121\">\n",
       "     <!-- pchembl_value -->\n",
       "     <g transform=\"translate(72.420469 988.114813) scale(0.1 -0.1)\">\n",
       "      <defs>\n",
       "       <path id=\"DejaVuSans-5f\" d=\"M 3263 -1063 \n",
       "L 3263 -1509 \n",
       "L -63 -1509 \n",
       "L -63 -1063 \n",
       "L 3263 -1063 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "       <path id=\"DejaVuSans-76\" d=\"M 191 3500 \n",
       "L 800 3500 \n",
       "L 1894 563 \n",
       "L 2988 3500 \n",
       "L 3597 3500 \n",
       "L 2284 0 \n",
       "L 1503 0 \n",
       "L 191 3500 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "      </defs>\n",
       "      <use xlink:href=\"#DejaVuSans-70\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-63\" x=\"63.476562\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-68\" x=\"118.457031\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-65\" x=\"181.835938\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6d\" x=\"243.359375\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-62\" x=\"340.771484\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6c\" x=\"404.248047\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-5f\" x=\"432.03125\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-76\" x=\"482.03125\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-61\" x=\"541.210938\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6c\" x=\"602.490234\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"630.273438\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-65\" x=\"693.652344\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_42\">\n",
       "    <g id=\"ytick_78\">\n",
       "     <g id=\"line2d_141\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_122\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(33.603125 963.637469) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_79\">\n",
       "     <g id=\"line2d_142\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"919.910452\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_123\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(27.240625 923.709671) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_80\">\n",
       "     <g id=\"line2d_143\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"46.965625\" y=\"879.982654\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_124\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(20.878125 883.781872) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_125\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(14.798437 917.669792) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_629\">\n",
       "    <path d=\"M 46.965625 959.83825 \n",
       "L 46.965625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_630\">\n",
       "    <path d=\"M 173.395625 959.83825 \n",
       "L 173.395625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_631\">\n",
       "    <path d=\"M 46.965625 959.83825 \n",
       "L 173.395625 959.83825 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_632\">\n",
       "    <path d=\"M 46.965625 845.804458 \n",
       "L 173.395625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_126\">\n",
       "    <!-- CHEMBL258 -->\n",
       "    <g transform=\"translate(73.598438 826.367083) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- LCK (1,351) -->\n",
       "    <g transform=\"translate(74.9475 839.804458) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4c\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-43\" x=\"55.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4b\" x=\"125.537109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"191.113281\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"222.900391\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"261.914062\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"325.537109\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"357.324219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"420.947266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"484.570312\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"548.193359\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_22\">\n",
       "   <g id=\"patch_633\">\n",
       "    <path d=\"M 224.265625 959.83825 \n",
       "L 350.695625 959.83825 \n",
       "L 350.695625 845.804458 \n",
       "L 224.265625 845.804458 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_634\">\n",
       "    <path d=\"M 245.782566 959.83825 \n",
       "L 249.245808 959.83825 \n",
       "L 249.245808 957.451357 \n",
       "L 245.782566 957.451357 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_635\">\n",
       "    <path d=\"M 249.245808 959.83825 \n",
       "L 252.709051 959.83825 \n",
       "L 252.709051 956.257911 \n",
       "L 249.245808 956.257911 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_636\">\n",
       "    <path d=\"M 252.709051 959.83825 \n",
       "L 256.172294 959.83825 \n",
       "L 256.172294 953.871019 \n",
       "L 252.709051 953.871019 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_637\">\n",
       "    <path d=\"M 256.172294 959.83825 \n",
       "L 259.635536 959.83825 \n",
       "L 259.635536 951.484126 \n",
       "L 256.172294 951.484126 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_638\">\n",
       "    <path d=\"M 259.635536 959.83825 \n",
       "L 263.098779 959.83825 \n",
       "L 263.098779 950.29068 \n",
       "L 259.635536 950.29068 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_639\">\n",
       "    <path d=\"M 263.098779 959.83825 \n",
       "L 266.562021 959.83825 \n",
       "L 266.562021 939.549663 \n",
       "L 263.098779 939.549663 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_640\">\n",
       "    <path d=\"M 266.562021 959.83825 \n",
       "L 270.025264 959.83825 \n",
       "L 270.025264 939.549663 \n",
       "L 266.562021 939.549663 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_641\">\n",
       "    <path d=\"M 270.025264 959.83825 \n",
       "L 273.488506 959.83825 \n",
       "L 273.488506 927.615201 \n",
       "L 270.025264 927.615201 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_642\">\n",
       "    <path d=\"M 273.488506 959.83825 \n",
       "L 276.951749 959.83825 \n",
       "L 276.951749 914.487292 \n",
       "L 273.488506 914.487292 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_643\">\n",
       "    <path d=\"M 276.951749 959.83825 \n",
       "L 280.414992 959.83825 \n",
       "L 280.414992 877.490457 \n",
       "L 276.951749 877.490457 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_644\">\n",
       "    <path d=\"M 280.414992 959.83825 \n",
       "L 283.878234 959.83825 \n",
       "L 283.878234 851.234639 \n",
       "L 280.414992 851.234639 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_645\">\n",
       "    <path d=\"M 283.878234 959.83825 \n",
       "L 287.341477 959.83825 \n",
       "L 287.341477 854.814978 \n",
       "L 283.878234 854.814978 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_646\">\n",
       "    <path d=\"M 287.341477 959.83825 \n",
       "L 290.804719 959.83825 \n",
       "L 290.804719 866.74944 \n",
       "L 287.341477 866.74944 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_647\">\n",
       "    <path d=\"M 290.804719 959.83825 \n",
       "L 294.267962 959.83825 \n",
       "L 294.267962 857.20187 \n",
       "L 290.804719 857.20187 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_648\">\n",
       "    <path d=\"M 294.267962 959.83825 \n",
       "L 297.731205 959.83825 \n",
       "L 297.731205 876.297011 \n",
       "L 294.267962 876.297011 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_649\">\n",
       "    <path d=\"M 297.731205 959.83825 \n",
       "L 301.194447 959.83825 \n",
       "L 301.194447 877.490457 \n",
       "L 297.731205 877.490457 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_650\">\n",
       "    <path d=\"M 301.194447 959.83825 \n",
       "L 304.65769 959.83825 \n",
       "L 304.65769 916.874184 \n",
       "L 301.194447 916.874184 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_651\">\n",
       "    <path d=\"M 304.65769 959.83825 \n",
       "L 308.120932 959.83825 \n",
       "L 308.120932 921.647969 \n",
       "L 304.65769 921.647969 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_652\">\n",
       "    <path d=\"M 308.120932 959.83825 \n",
       "L 311.584175 959.83825 \n",
       "L 311.584175 933.582432 \n",
       "L 308.120932 933.582432 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_653\">\n",
       "    <path d=\"M 311.584175 959.83825 \n",
       "L 315.047418 959.83825 \n",
       "L 315.047418 941.936556 \n",
       "L 311.584175 941.936556 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_654\">\n",
       "    <path d=\"M 315.047418 959.83825 \n",
       "L 318.51066 959.83825 \n",
       "L 318.51066 947.903787 \n",
       "L 315.047418 947.903787 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_655\">\n",
       "    <path d=\"M 318.51066 959.83825 \n",
       "L 321.973903 959.83825 \n",
       "L 321.973903 951.484126 \n",
       "L 318.51066 951.484126 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_656\">\n",
       "    <path d=\"M 321.973903 959.83825 \n",
       "L 325.437145 959.83825 \n",
       "L 325.437145 956.257911 \n",
       "L 321.973903 956.257911 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_657\">\n",
       "    <path d=\"M 325.437145 959.83825 \n",
       "L 328.900388 959.83825 \n",
       "L 328.900388 957.451357 \n",
       "L 325.437145 957.451357 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_658\">\n",
       "    <path d=\"M 328.900388 959.83825 \n",
       "L 332.363631 959.83825 \n",
       "L 332.363631 959.83825 \n",
       "L 328.900388 959.83825 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_659\">\n",
       "    <path d=\"M 332.363631 959.83825 \n",
       "L 335.826873 959.83825 \n",
       "L 335.826873 959.83825 \n",
       "L 332.363631 959.83825 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_660\">\n",
       "    <path d=\"M 335.826873 959.83825 \n",
       "L 339.290116 959.83825 \n",
       "L 339.290116 958.644804 \n",
       "L 335.826873 958.644804 \n",
       "z\n",
       "\" clip-path=\"url(#p198a28dcb1)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.332284; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_43\">\n",
       "    <g id=\"xtick_64\">\n",
       "     <g id=\"line2d_144\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"241.793652\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_127\">\n",
       "      <!-- −5 -->\n",
       "      <g transform=\"translate(234.422559 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-2212\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"83.789062\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_65\">\n",
       "     <g id=\"line2d_145\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"288.176366\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_128\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(284.995116 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_66\">\n",
       "     <g id=\"line2d_146\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"334.559079\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_129\">\n",
       "      <!-- 5 -->\n",
       "      <g transform=\"translate(331.377829 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_130\">\n",
       "     <!-- pchembl_value -->\n",
       "     <g transform=\"translate(249.720469 988.114813) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-70\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-63\" x=\"63.476562\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-68\" x=\"118.457031\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-65\" x=\"181.835938\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6d\" x=\"243.359375\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-62\" x=\"340.771484\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6c\" x=\"404.248047\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-5f\" x=\"432.03125\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-76\" x=\"482.03125\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-61\" x=\"541.210938\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6c\" x=\"602.490234\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"630.273438\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-65\" x=\"693.652344\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_44\">\n",
       "    <g id=\"ytick_81\">\n",
       "     <g id=\"line2d_147\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_131\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(210.903125 963.637469) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_82\">\n",
       "     <g id=\"line2d_148\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"935.969324\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_132\">\n",
       "      <!-- 20 -->\n",
       "      <g transform=\"translate(204.540625 939.768543) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_83\">\n",
       "     <g id=\"line2d_149\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"912.100399\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_133\">\n",
       "      <!-- 40 -->\n",
       "      <g transform=\"translate(204.540625 915.899618) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_84\">\n",
       "     <g id=\"line2d_150\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"888.231473\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_134\">\n",
       "      <!-- 60 -->\n",
       "      <g transform=\"translate(204.540625 892.030692) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_85\">\n",
       "     <g id=\"line2d_151\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"224.265625\" y=\"864.362548\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_135\">\n",
       "      <!-- 80 -->\n",
       "      <g transform=\"translate(204.540625 868.161767) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-38\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_136\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(198.460938 917.669792) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_661\">\n",
       "    <path d=\"M 224.265625 959.83825 \n",
       "L 224.265625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_662\">\n",
       "    <path d=\"M 350.695625 959.83825 \n",
       "L 350.695625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_663\">\n",
       "    <path d=\"M 224.265625 959.83825 \n",
       "L 350.695625 959.83825 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_664\">\n",
       "    <path d=\"M 224.265625 845.804458 \n",
       "L 350.695625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_137\">\n",
       "    <!-- CHEMBL1951 -->\n",
       "    <g transform=\"translate(247.080938 826.367083) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-35\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- Monoamine (1,378) -->\n",
       "    <g transform=\"translate(228.710625 839.804458) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-4d\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"86.279297\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"147.460938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"210.839844\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"272.021484\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6d\" x=\"333.300781\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"430.712891\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"458.496094\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-65\" x=\"521.875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"583.398438\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"615.185547\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"654.199219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"717.822266\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"749.609375\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"813.232422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"876.855469\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"940.478516\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_23\">\n",
       "   <g id=\"patch_665\">\n",
       "    <path d=\"M 401.565625 959.83825 \n",
       "L 527.995625 959.83825 \n",
       "L 527.995625 845.804458 \n",
       "L 401.565625 845.804458 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_666\">\n",
       "    <path d=\"M 418.444294 959.83825 \n",
       "L 422.971247 959.83825 \n",
       "L 422.971247 957.551858 \n",
       "L 418.444294 957.551858 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_667\">\n",
       "    <path d=\"M 422.971247 959.83825 \n",
       "L 427.4982 959.83825 \n",
       "L 427.4982 958.695054 \n",
       "L 422.971247 958.695054 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_668\">\n",
       "    <path d=\"M 427.4982 959.83825 \n",
       "L 432.025153 959.83825 \n",
       "L 432.025153 952.979075 \n",
       "L 427.4982 952.979075 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_669\">\n",
       "    <path d=\"M 432.025153 959.83825 \n",
       "L 436.552106 959.83825 \n",
       "L 436.552106 934.68794 \n",
       "L 432.025153 934.68794 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_670\">\n",
       "    <path d=\"M 436.552106 959.83825 \n",
       "L 441.079058 959.83825 \n",
       "L 441.079058 930.115156 \n",
       "L 436.552106 930.115156 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_671\">\n",
       "    <path d=\"M 441.079058 959.83825 \n",
       "L 445.606011 959.83825 \n",
       "L 445.606011 934.68794 \n",
       "L 441.079058 934.68794 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_672\">\n",
       "    <path d=\"M 445.606011 959.83825 \n",
       "L 450.132964 959.83825 \n",
       "L 450.132964 923.255981 \n",
       "L 445.606011 923.255981 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_673\">\n",
       "    <path d=\"M 450.132964 959.83825 \n",
       "L 454.659917 959.83825 \n",
       "L 454.659917 902.678455 \n",
       "L 450.132964 902.678455 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_674\">\n",
       "    <path d=\"M 454.659917 959.83825 \n",
       "L 459.18687 959.83825 \n",
       "L 459.18687 864.95299 \n",
       "L 454.659917 864.95299 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_675\">\n",
       "    <path d=\"M 459.18687 959.83825 \n",
       "L 463.713823 959.83825 \n",
       "L 463.713823 851.234639 \n",
       "L 459.18687 851.234639 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_676\">\n",
       "    <path d=\"M 463.713823 959.83825 \n",
       "L 468.240775 959.83825 \n",
       "L 468.240775 872.955361 \n",
       "L 463.713823 872.955361 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_677\">\n",
       "    <path d=\"M 468.240775 959.83825 \n",
       "L 472.767728 959.83825 \n",
       "L 472.767728 885.530516 \n",
       "L 468.240775 885.530516 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_678\">\n",
       "    <path d=\"M 472.767728 959.83825 \n",
       "L 477.294681 959.83825 \n",
       "L 477.294681 883.244124 \n",
       "L 472.767728 883.244124 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_679\">\n",
       "    <path d=\"M 477.294681 959.83825 \n",
       "L 481.821634 959.83825 \n",
       "L 481.821634 902.678455 \n",
       "L 477.294681 902.678455 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_680\">\n",
       "    <path d=\"M 481.821634 959.83825 \n",
       "L 486.348587 959.83825 \n",
       "L 486.348587 909.53763 \n",
       "L 481.821634 909.53763 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_681\">\n",
       "    <path d=\"M 486.348587 959.83825 \n",
       "L 490.87554 959.83825 \n",
       "L 490.87554 933.544744 \n",
       "L 486.348587 933.544744 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_682\">\n",
       "    <path d=\"M 490.87554 959.83825 \n",
       "L 495.402492 959.83825 \n",
       "L 495.402492 938.117528 \n",
       "L 490.87554 938.117528 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_683\">\n",
       "    <path d=\"M 495.402492 959.83825 \n",
       "L 499.929445 959.83825 \n",
       "L 499.929445 942.690311 \n",
       "L 495.402492 942.690311 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_684\">\n",
       "    <path d=\"M 499.929445 959.83825 \n",
       "L 504.456398 959.83825 \n",
       "L 504.456398 952.979075 \n",
       "L 499.929445 952.979075 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_685\">\n",
       "    <path d=\"M 504.456398 959.83825 \n",
       "L 508.983351 959.83825 \n",
       "L 508.983351 957.551858 \n",
       "L 504.456398 957.551858 \n",
       "z\n",
       "\" clip-path=\"url(#p260c68cd03)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.434342; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_45\">\n",
       "    <g id=\"xtick_67\">\n",
       "     <g id=\"line2d_152\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"419.093652\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_138\">\n",
       "      <!-- −5 -->\n",
       "      <g transform=\"translate(411.722559 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-2212\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"83.789062\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_68\">\n",
       "     <g id=\"line2d_153\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"465.476366\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_139\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(462.295116 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_69\">\n",
       "     <g id=\"line2d_154\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"511.859079\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_140\">\n",
       "      <!-- 5 -->\n",
       "      <g transform=\"translate(508.677829 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_141\">\n",
       "     <!-- pchembl_value -->\n",
       "     <g transform=\"translate(427.020469 988.114813) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-70\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-63\" x=\"63.476562\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-68\" x=\"118.457031\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-65\" x=\"181.835938\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6d\" x=\"243.359375\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-62\" x=\"340.771484\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6c\" x=\"404.248047\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-5f\" x=\"432.03125\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-76\" x=\"482.03125\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-61\" x=\"541.210938\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6c\" x=\"602.490234\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"630.273438\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-65\" x=\"693.652344\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_46\">\n",
       "    <g id=\"ytick_86\">\n",
       "     <g id=\"line2d_155\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_142\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(388.203125 963.637469) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_87\">\n",
       "     <g id=\"line2d_156\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"936.974332\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_143\">\n",
       "      <!-- 20 -->\n",
       "      <g transform=\"translate(381.840625 940.773551) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-32\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_88\">\n",
       "     <g id=\"line2d_157\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"914.110414\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_144\">\n",
       "      <!-- 40 -->\n",
       "      <g transform=\"translate(381.840625 917.909632) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-34\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_89\">\n",
       "     <g id=\"line2d_158\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"891.246496\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_145\">\n",
       "      <!-- 60 -->\n",
       "      <g transform=\"translate(381.840625 895.045714) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-36\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_90\">\n",
       "     <g id=\"line2d_159\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"401.565625\" y=\"868.382577\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_146\">\n",
       "      <!-- 80 -->\n",
       "      <g transform=\"translate(381.840625 872.181796) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-38\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_147\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(375.760938 917.669792) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_686\">\n",
       "    <path d=\"M 401.565625 959.83825 \n",
       "L 401.565625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_687\">\n",
       "    <path d=\"M 527.995625 959.83825 \n",
       "L 527.995625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_688\">\n",
       "    <path d=\"M 401.565625 959.83825 \n",
       "L 527.995625 959.83825 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_689\">\n",
       "    <path d=\"M 401.565625 845.804458 \n",
       "L 527.995625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_148\">\n",
       "    <!-- CHEMBL233 -->\n",
       "    <g transform=\"translate(428.198438 826.367083) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"546.044922\"/>\n",
       "    </g>\n",
       "    <!-- opioid (830) -->\n",
       "    <g transform=\"translate(428.445 839.804458) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-6f\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-70\" x=\"61.181641\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"124.658203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"152.441406\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"213.623047\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"241.40625\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"304.882812\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"336.669922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-38\" x=\"375.683594\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"439.306641\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-30\" x=\"502.929688\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"566.552734\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       "  <g id=\"axes_24\">\n",
       "   <g id=\"patch_690\">\n",
       "    <path d=\"M 578.865625 959.83825 \n",
       "L 705.295625 959.83825 \n",
       "L 705.295625 845.804458 \n",
       "L 578.865625 845.804458 \n",
       "z\n",
       "\" style=\"fill: #ffffff\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_691\">\n",
       "    <path d=\"M 603.629356 959.83825 \n",
       "L 606.855979 959.83825 \n",
       "L 606.855979 955.815894 \n",
       "L 603.629356 955.815894 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_692\">\n",
       "    <path d=\"M 606.855979 959.83825 \n",
       "L 610.082603 959.83825 \n",
       "L 610.082603 950.989067 \n",
       "L 606.855979 950.989067 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_693\">\n",
       "    <path d=\"M 610.082603 959.83825 \n",
       "L 613.309226 959.83825 \n",
       "L 613.309226 950.184596 \n",
       "L 610.082603 950.184596 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_694\">\n",
       "    <path d=\"M 613.309226 959.83825 \n",
       "L 616.53585 959.83825 \n",
       "L 616.53585 944.553297 \n",
       "L 613.309226 944.553297 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_695\">\n",
       "    <path d=\"M 616.53585 959.83825 \n",
       "L 619.762473 959.83825 \n",
       "L 619.762473 936.508585 \n",
       "L 616.53585 936.508585 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_696\">\n",
       "    <path d=\"M 619.762473 959.83825 \n",
       "L 622.989097 959.83825 \n",
       "L 622.989097 927.659402 \n",
       "L 619.762473 927.659402 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_697\">\n",
       "    <path d=\"M 622.989097 959.83825 \n",
       "L 626.21572 959.83825 \n",
       "L 626.21572 917.201277 \n",
       "L 622.989097 917.201277 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_698\">\n",
       "    <path d=\"M 626.21572 959.83825 \n",
       "L 629.442344 959.83825 \n",
       "L 629.442344 895.480555 \n",
       "L 626.21572 895.480555 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_699\">\n",
       "    <path d=\"M 629.442344 959.83825 \n",
       "L 632.668967 959.83825 \n",
       "L 632.668967 867.324063 \n",
       "L 629.442344 867.324063 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_700\">\n",
       "    <path d=\"M 632.668967 959.83825 \n",
       "L 635.895591 959.83825 \n",
       "L 635.895591 871.346419 \n",
       "L 632.668967 871.346419 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_701\">\n",
       "    <path d=\"M 635.895591 959.83825 \n",
       "L 639.122215 959.83825 \n",
       "L 639.122215 874.564303 \n",
       "L 635.895591 874.564303 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_702\">\n",
       "    <path d=\"M 639.122215 959.83825 \n",
       "L 642.348838 959.83825 \n",
       "L 642.348838 852.03911 \n",
       "L 639.122215 852.03911 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_703\">\n",
       "    <path d=\"M 642.348838 959.83825 \n",
       "L 645.575462 959.83825 \n",
       "L 645.575462 852.843581 \n",
       "L 642.348838 852.843581 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_704\">\n",
       "    <path d=\"M 645.575462 959.83825 \n",
       "L 648.802085 959.83825 \n",
       "L 648.802085 851.234639 \n",
       "L 645.575462 851.234639 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_705\">\n",
       "    <path d=\"M 648.802085 959.83825 \n",
       "L 652.028709 959.83825 \n",
       "L 652.028709 861.692764 \n",
       "L 648.802085 861.692764 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_706\">\n",
       "    <path d=\"M 652.028709 959.83825 \n",
       "L 655.255332 959.83825 \n",
       "L 655.255332 874.564303 \n",
       "L 652.028709 874.564303 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_707\">\n",
       "    <path d=\"M 655.255332 959.83825 \n",
       "L 658.481956 959.83825 \n",
       "L 658.481956 899.50291 \n",
       "L 655.255332 899.50291 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_708\">\n",
       "    <path d=\"M 658.481956 959.83825 \n",
       "L 661.708579 959.83825 \n",
       "L 661.708579 913.178921 \n",
       "L 658.481956 913.178921 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_709\">\n",
       "    <path d=\"M 661.708579 959.83825 \n",
       "L 664.935203 959.83825 \n",
       "L 664.935203 933.290701 \n",
       "L 661.708579 933.290701 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_710\">\n",
       "    <path d=\"M 664.935203 959.83825 \n",
       "L 668.161826 959.83825 \n",
       "L 668.161826 935.704114 \n",
       "L 664.935203 935.704114 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_711\">\n",
       "    <path d=\"M 668.161826 959.83825 \n",
       "L 671.38845 959.83825 \n",
       "L 671.38845 942.944355 \n",
       "L 668.161826 942.944355 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_712\">\n",
       "    <path d=\"M 671.38845 959.83825 \n",
       "L 674.615073 959.83825 \n",
       "L 674.615073 952.598009 \n",
       "L 671.38845 952.598009 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_713\">\n",
       "    <path d=\"M 674.615073 959.83825 \n",
       "L 677.841697 959.83825 \n",
       "L 677.841697 955.815894 \n",
       "L 674.615073 955.815894 \n",
       "z\n",
       "\" clip-path=\"url(#p149a6085af)\" style=\"fill: #1f77b4; fill-opacity: 0.75; stroke: #000000; stroke-width: 0.309581; stroke-linejoin: miter\"/>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_47\">\n",
       "    <g id=\"xtick_70\">\n",
       "     <g id=\"line2d_160\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"596.393652\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_149\">\n",
       "      <!-- −5 -->\n",
       "      <g transform=\"translate(589.022559 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-2212\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-35\" x=\"83.789062\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_71\">\n",
       "     <g id=\"line2d_161\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"642.776366\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_150\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(639.595116 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"xtick_72\">\n",
       "     <g id=\"line2d_162\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#mbd1a2dc235\" x=\"689.159079\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_151\">\n",
       "      <!-- 5 -->\n",
       "      <g transform=\"translate(685.977829 974.436688) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_152\">\n",
       "     <!-- pchembl_value -->\n",
       "     <g transform=\"translate(604.320469 988.114813) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-70\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-63\" x=\"63.476562\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-68\" x=\"118.457031\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-65\" x=\"181.835938\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6d\" x=\"243.359375\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-62\" x=\"340.771484\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6c\" x=\"404.248047\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-5f\" x=\"432.03125\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-76\" x=\"482.03125\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-61\" x=\"541.210938\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6c\" x=\"602.490234\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"630.273438\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-65\" x=\"693.652344\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"matplotlib.axis_48\">\n",
       "    <g id=\"ytick_91\">\n",
       "     <g id=\"line2d_163\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"959.83825\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_153\">\n",
       "      <!-- 0 -->\n",
       "      <g transform=\"translate(565.503125 963.637469) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-30\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_92\">\n",
       "     <g id=\"line2d_164\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"919.61469\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_154\">\n",
       "      <!-- 50 -->\n",
       "      <g transform=\"translate(559.140625 923.413909) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-35\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"ytick_93\">\n",
       "     <g id=\"line2d_165\">\n",
       "      <g>\n",
       "       <use xlink:href=\"#m2a9f7c8a8b\" x=\"578.865625\" y=\"879.391131\" style=\"stroke: #000000; stroke-width: 0.8\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "     <g id=\"text_155\">\n",
       "      <!-- 100 -->\n",
       "      <g transform=\"translate(552.778125 883.190349) scale(0.1 -0.1)\">\n",
       "       <use xlink:href=\"#DejaVuSans-31\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"63.623047\"/>\n",
       "       <use xlink:href=\"#DejaVuSans-30\" x=\"127.246094\"/>\n",
       "      </g>\n",
       "     </g>\n",
       "    </g>\n",
       "    <g id=\"text_156\">\n",
       "     <!-- Count -->\n",
       "     <g transform=\"translate(546.698438 917.669792) rotate(-90) scale(0.1 -0.1)\">\n",
       "      <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6f\" x=\"69.824219\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-75\" x=\"131.005859\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-6e\" x=\"194.384766\"/>\n",
       "      <use xlink:href=\"#DejaVuSans-74\" x=\"257.763672\"/>\n",
       "     </g>\n",
       "    </g>\n",
       "   </g>\n",
       "   <g id=\"patch_714\">\n",
       "    <path d=\"M 578.865625 959.83825 \n",
       "L 578.865625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_715\">\n",
       "    <path d=\"M 705.295625 959.83825 \n",
       "L 705.295625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_716\">\n",
       "    <path d=\"M 578.865625 959.83825 \n",
       "L 705.295625 959.83825 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"patch_717\">\n",
       "    <path d=\"M 578.865625 845.804458 \n",
       "L 705.295625 845.804458 \n",
       "\" style=\"fill: none; stroke: #000000; stroke-width: 0.8; stroke-linejoin: miter; stroke-linecap: square\"/>\n",
       "   </g>\n",
       "   <g id=\"text_157\">\n",
       "    <!-- CHEMBL4794 -->\n",
       "    <g transform=\"translate(601.680938 826.367083) scale(0.12 -0.12)\">\n",
       "     <use xlink:href=\"#DejaVuSans-43\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-48\" x=\"69.824219\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-45\" x=\"145.019531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4d\" x=\"208.203125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-42\" x=\"294.482422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-4c\" x=\"363.085938\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"418.798828\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-37\" x=\"482.421875\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"546.044922\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-34\" x=\"609.667969\"/>\n",
       "    </g>\n",
       "    <!-- Vanilloid (1,923) -->\n",
       "    <g transform=\"translate(593.048438 839.804458) scale(0.12 -0.12)\">\n",
       "     <defs>\n",
       "      <path id=\"DejaVuSans-56\" d=\"M 1831 0 \n",
       "L 50 4666 \n",
       "L 709 4666 \n",
       "L 2188 738 \n",
       "L 3669 4666 \n",
       "L 4325 4666 \n",
       "L 2547 0 \n",
       "L 1831 0 \n",
       "z\n",
       "\" transform=\"scale(0.015625)\"/>\n",
       "     </defs>\n",
       "     <use xlink:href=\"#DejaVuSans-56\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-61\" x=\"60.658203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6e\" x=\"121.9375\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"185.316406\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"213.099609\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6c\" x=\"240.882812\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-6f\" x=\"268.666016\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-69\" x=\"329.847656\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-64\" x=\"357.630859\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-20\" x=\"421.107422\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-28\" x=\"452.894531\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-31\" x=\"491.908203\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-2c\" x=\"555.53125\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-39\" x=\"587.318359\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-32\" x=\"650.941406\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-33\" x=\"714.564453\"/>\n",
       "     <use xlink:href=\"#DejaVuSans-29\" x=\"778.1875\"/>\n",
       "    </g>\n",
       "   </g>\n",
       "  </g>\n",
       " </g>\n",
       " <defs>\n",
       "  <clipPath id=\"pe74d30b062\">\n",
       "   <rect x=\"46.965625\" y=\"35.7555\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pf1cbb99640\">\n",
       "   <rect x=\"224.265625\" y=\"35.7555\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p7d81b5fad1\">\n",
       "   <rect x=\"401.565625\" y=\"35.7555\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pfc0b2f2c16\">\n",
       "   <rect x=\"578.865625\" y=\"35.7555\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pbf054e3684\">\n",
       "   <rect x=\"46.965625\" y=\"197.765292\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p0cc20ddfd5\">\n",
       "   <rect x=\"224.265625\" y=\"197.765292\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p9a3db44e50\">\n",
       "   <rect x=\"401.565625\" y=\"197.765292\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p29f5904bd1\">\n",
       "   <rect x=\"578.865625\" y=\"197.765292\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pfa554f0260\">\n",
       "   <rect x=\"46.965625\" y=\"359.775083\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p5c60187877\">\n",
       "   <rect x=\"224.265625\" y=\"359.775083\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pc227c1ca20\">\n",
       "   <rect x=\"401.565625\" y=\"359.775083\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"ped215ec72b\">\n",
       "   <rect x=\"578.865625\" y=\"359.775083\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p1d3cbaeb15\">\n",
       "   <rect x=\"46.965625\" y=\"521.784875\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p945f20dc37\">\n",
       "   <rect x=\"224.265625\" y=\"521.784875\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p1fe71bebd6\">\n",
       "   <rect x=\"401.565625\" y=\"521.784875\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pd14d13d4a2\">\n",
       "   <rect x=\"578.865625\" y=\"521.784875\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p05be6a0339\">\n",
       "   <rect x=\"46.965625\" y=\"683.794667\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p5e027d06e4\">\n",
       "   <rect x=\"224.265625\" y=\"683.794667\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pf86962bd07\">\n",
       "   <rect x=\"401.565625\" y=\"683.794667\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p0bcc49192d\">\n",
       "   <rect x=\"578.865625\" y=\"683.794667\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"pea8ba9fbbf\">\n",
       "   <rect x=\"46.965625\" y=\"845.804458\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p198a28dcb1\">\n",
       "   <rect x=\"224.265625\" y=\"845.804458\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p260c68cd03\">\n",
       "   <rect x=\"401.565625\" y=\"845.804458\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       "  <clipPath id=\"p149a6085af\">\n",
       "   <rect x=\"578.865625\" y=\"845.804458\" width=\"126.43\" height=\"114.033792\"/>\n",
       "  </clipPath>\n",
       " </defs>\n",
       "</svg>\n"
      ],
      "text/plain": [
       "<Figure size 1000x1400 with 24 Axes>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "fig, axes = plt.subplots(6, 4, figsize=(10.0, 14.0), sharex=True)\n",
    "\n",
    "for (name, target_chembl_id, _), ax in zip(tqdm(mappings), axes.ravel()):\n",
    "    latest_df = latest_dfs[target_chembl_id]\n",
    "    reference_df = reference_dfs[target_chembl_id]\n",
    "\n",
    "    overlapping_molecule_chembl_ids = sorted(\n",
    "        set(latest_df.molecule_chembl_id).intersection(reference_df.molecule_chembl_id)\n",
    "    )\n",
    "\n",
    "    idx = latest_df.molecule_chembl_id.isin(overlapping_molecule_chembl_ids)\n",
    "    aa = latest_df[idx].sort_values(\"molecule_chembl_id\")\n",
    "\n",
    "    idx = reference_df.molecule_chembl_id.isin(overlapping_molecule_chembl_ids)\n",
    "    bb = reference_df[idx].sort_values(\"molecule_chembl_id\")\n",
    "\n",
    "    dist = aa.pchembl_value - bb.pchembl_value\n",
    "    sns.histplot(dist, ax=ax)\n",
    "    ax.set_title(f\"{target_chembl_id}\\n{name} ({len(overlapping_molecule_chembl_ids):,})\")\n",
    "\n",
    "fig.tight_layout()\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "134ce559",
   "metadata": {},
   "source": [
    "## Conclusion\n",
    "\n",
    "The comparison of the reference dataset to what's possible to get from ChEMBL 23 shows that without reproducible code for generating reference datasets, it's difficult to understand what's inside them.\n",
    "\n",
    "Further, it shows that as time goes on and more data becomes available, that the characteristics of the dataset can potentially drastically change. We suggest that rather than generating flat files that get redistributed wildly (without attribution nor provenance), that reproducible programmatic access should be used, e.g., with `chembl_downloader.contrib.get_target_smi_df`.\n",
    "\n",
    "This notebook doesn't do a careful investigation of the discrepancies between the reference dataset and the refreshed one with ChEMBL 23, nor does it do a careful investigation of the impact of arithmetic mean vs. geometric mean, but at least it's now possible to do some of these things in an automated way with `chembl-downloader`."
   ]
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "Python 3 (ipykernel)",
   "language": "python",
   "name": "python3"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.10.8"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 5
}