diff --git a/autoload/gist.vim b/autoload/gist.vim
index 6727bc0..9f19598 100644
--- a/autoload/gist.vim
+++ b/autoload/gist.vim
@@ -32,17 +32,22 @@ else
   call webapi#json#true()
 endif
 
-let s:gist_token_file = expand(get(g:, 'gist_token_file', '~/.gist-vim'))
+" a profile defines: gist_api_url, github_user and the gist_token_file
+let s:gist_profiles = get(g:, 'gist_profiles', {})
 let s:system = function(get(g:, 'webapi#system_function', 'system'))
 
-if !exists('g:github_user')
-  let g:github_user = substitute(s:system('git config --get github.user'), "\n", '', '')
-  if strlen(g:github_user) == 0
-    let g:github_user = $GITHUB_USER
-  end
-endif
+function! s:set_default_github_user()
+    let g:github_user = substitute(s:system('git config --get github.user'), "\n", '', '')
+    if strlen(g:github_user) == 0
+      let g:github_user = $GITHUB_USER
+    end
+endfunction
+
+function! gist#list_profiles(arg_lead,cmdline,cursor_pos)
+  return keys(s:gist_profiles)
+endfunction
 
-if !exists('g:gist_api_url')
+function! s:set_default_api_url()
   let g:gist_api_url = substitute(s:system('git config --get github.apiurl'), "\n", '', '')
   if strlen(g:gist_api_url) == 0
     let g:gist_api_url = 'https://api.github.com/'
@@ -61,10 +66,38 @@ if !exists('g:gist_api_url')
       redraw!
     endif
   endif
-endif
-if g:gist_api_url !~# '/$'
-  let g:gist_api_url .= '/'
-endif
+endfunction
+
+function! gist#select_profile(...) abort
+  let profile_name = a:0 ? a:1 : get(g:, 'gist_default_profile', '')
+  let profile = get(s:gist_profiles, profile_name, [])
+  if len(profile) == 2
+    let [g:gist_api_url, g:github_user] = profile
+    let g:gist_token_dir = expand(get(g:, 'gist_token_dir', '~/.config/gist-vim'))
+    if !isdirectory(g:gist_token_dir)
+      call mkdir(g:gist_token_dir)
+    endif
+    let g:gist_token_file = expand(simplify(g:gist_token_dir . '/' . profile_name))
+  else
+    echomsg 'gist: profile ' . profile_name . ' does not exist, fallback to default'
+    let g:gist_api_url = ''
+    let g:github_user = ''
+    let g:gist_token_file = '~/.gist-vim'
+  endif
+  if g:gist_api_url is ''
+    call s:set_default_api_url()
+  endif
+  if g:github_user is ''
+    call s:set_default_github_user()
+  endif
+  if g:gist_api_url !~# '/$'
+    let g:gist_api_url .= '/'
+  endif
+  echom 'g:gist_api_url:' . g:gist_api_url
+  echom 'g:github_user:' . g:github_user
+  echom 'g:gist_token_file:' . g:gist_token_file
+endfunction
+call gist#select_profile()
 
 if !exists('g:gist_update_on_write')
   let g:gist_update_on_write = 1
@@ -228,7 +261,7 @@ function! s:GistList(gistls, page) abort
     redraw
     echohl ErrorMsg | echomsg content.message | echohl None
     if content.message ==# 'Bad credentials'
-      call delete(s:gist_token_file)
+      call delete(g:gist_token_file)
     endif
     return
   endif
@@ -783,6 +816,8 @@ function! gist#Gist(count, bang, line1, line2, ...) abort
     if arg =~# '^\(-h\|--help\)$\C'
       help :Gist
       return
+    elseif arg =~# '^\(--profile\|-f\)'
+      call call('gist#select_profile', a:000[1:])
     elseif arg =~# '^\(-g\|--git\)$\C' && gistidbuf !=# '' && g:gist_api_url ==# 'https://api.github.com/' && has_key(b:, 'gist') && has_key(b:gist, 'id')
       echo printf('git clone git@github.com:%s', b:gist['id'])
       return
@@ -962,8 +997,8 @@ function! s:GistGetAuthHeader() abort
     return printf('basic %s', webapi#base64#b64encode(g:github_user.':'.password))
   endif
   let auth = ''
-  if filereadable(s:gist_token_file)
-    let str = join(readfile(s:gist_token_file), '')
+  if filereadable(g:gist_token_file)
+    let str = join(readfile(g:gist_token_file), '')
     if type(str) == 1
       let auth = str
     endif
@@ -974,7 +1009,7 @@ function! s:GistGetAuthHeader() abort
 
   redraw
   echohl WarningMsg
-  echo 'Gist.vim requires authorization to use the GitHub API. These settings are stored in "~/.gist-vim". If you want to revoke, do "rm ~/.gist-vim".'
+  echo 'Gist.vim requires authorization to use the GitHub API. These settings are stored in "' . g:gist_token_file . '". If you want to revoke, do "rm ' . g:gist_token_file . '".'
   echohl None
   let password = inputsecret('GitHub Password for '.g:github_user.':')
   if len(password) == 0
@@ -1012,9 +1047,9 @@ function! s:GistGetAuthHeader() abort
   let authorization = webapi#json#decode(res.content)
   if has_key(authorization, 'token')
     let secret = printf('token %s', authorization.token)
-    call writefile([secret], s:gist_token_file)
+    call writefile([secret], g:gist_token_file)
     if !(has('win32') || has('win64'))
-      call system('chmod go= '.s:gist_token_file)
+      call system('chmod go= '.g:gist_token_file)
     endif
   elseif has_key(authorization, 'message')
     let secret = ''
diff --git a/doc/gist-vim.txt b/doc/gist-vim.txt
index c7005a7..4a045c4 100644
--- a/doc/gist-vim.txt
+++ b/doc/gist-vim.txt
@@ -15,6 +15,10 @@ For the latest version please see https://github.com/mattn/gist-vim.
 ==============================================================================
 USAGE                                                 *:Gist* *gist-vim-usage*
 
+- Select profile (see also |gist-vim-setup|) >
+
+    :Gist --profile [profilename]
+>
 - Post current buffer to gist, using default privacy option. >
 
     :Gist
@@ -293,10 +297,55 @@ REQUIREMENTS                                           *gist-vim-requirements*
   - and, if you want to use your git profile, the git command-line client.
 
 ==============================================================================
-SETUP                                                       *gist-vim-setup*
+SETUP                                                         *gist-vim-setup*
+
+This plugin uses GitHub API v3. gist-vim provides two ways to authenticate
+against the GitHub APIs.
+
+                                                      *gist-vim-setup-profile*
+Method 1~
+
+You define the following variables
+>
+    let g:gist_profiles = {
+        \ 'github'     : ['', 'username'],
+        \ 'enterprise' : ['https://mycompany.com/api/v3', 'employeeid']
+    }
 
-This plugin uses GitHub API v3. The authentication value is stored in `~/.gist-vim`.
-gist-vim provides two ways to authenticate against the GitHub APIs.
+    let g:gist_token_dir = '~/.config/gist-vim/'   (default value)
+
+    let g:gist_default_profile = 'enterprise'      (no default value)
+<
+and use
+>
+    :Gist --profile [profilename]
+<
+to select one profile. If `profilename` is not given, it fallbacks to
+`g:gist_default_profile` if it is defined. Otherwise, |gist-vim-setup-old| will
+be used. `:Gist --profile` is implicitly called when the script is autoloaded.
+
+Each profile defines the github api url and the login
+username. If the api url is `''`, it defaults to ` 'https://api.github.com/'`
+
+Then, gist.vim will ask for your password to create an authorization when you
+first use it.  The password is not stored and only the OAuth access token will
+be kept for later use. The token will be stored at
+>
+    g:gist_token_dir/profilename
+<
+You can revoke the token at any time from the list of
+"Authorized applications" on GitHub's "Account Settings" page.
+(https://github.com/settings/applications)
+
+If the profile is not correctly defined, for example, key does not exists or
+the list does not contain two elements, `:Gist --profile [profilename]` will
+fallback to the |gist-vim-setup-old| method.
+
+
+                                                      *gist-vim-setup-old*
+Method 2~
+
+This method does not allow you to have more than one profile.
 
 First, you need to set your GitHub username in global git config:
 >
@@ -304,8 +353,8 @@ First, you need to set your GitHub username in global git config:
 <
 Then, gist.vim will ask for your password to create an authorization when you
 first use it.  The password is not stored and only the OAuth access token will
-be kept for later use.  You can revoke the token at any time from the list of
-"Authorized applications" on GitHub's "Account Settings" page.
+be kept at `~/.gist-vim` for later use. You can revoke the token at any time
+from the list of "Authorized applications" on GitHub's "Account Settings" page.
 (https://github.com/settings/applications)
 
 If you have two-factor authentication enabled on GitHub, you'll see the message
diff --git a/plugin/gist.vim b/plugin/gist.vim
index 4aa674d..9a0ada1 100644
--- a/plugin/gist.vim
+++ b/plugin/gist.vim
@@ -19,5 +19,6 @@ function! s:CompleteArgs(arg_lead,cmdline,cursor_pos)
 endfunction
 
 command! -nargs=? -range=% -bang -complete=customlist,s:CompleteArgs Gist :call gist#Gist(<count>, "<bang>", <line1>, <line2>, <f-args>)
+command! -nargs=? -complete=customlist,gist#list_profiles GistProfile call gist#select_profile(<q-args>)
 
 " vim:set et: