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<!DOCTYPE html>
<html>
<title>Direct Signal Control & Sequence Level PTx</title>
<xmp theme=spacelab style=display:none;>
# Sequence Level PTx optimization
#### This set of methods is based on designing entire sequences of RF pulses together. A major theme of this work is to focus on using PTx degrees of freedom to optimize more than just the homogeneity of the B1+ field.
## Contents
* [**Optimal Control EPG**](#optepg)
* [**Extended RF shimming for cardiac bSSFP**](#cardiac_shim)
<a name="optepg"></a>
## [Optimal Control EPG](https://github.com/mriphysics/optimal-control-EPG/#readme)
This is an efficient implementation of the *Direct Signal Control* (DSC) framework, a method for optimizing Turbo Spin Echo sequences, directly aiming to achieve uniform *signal* properties by dynamically switching RF shims throughout the echo train (see [this](http://dx.doi.org/10.1002/mrm.25192) paper, and [this](http://dx.doi.org/10.1002/mrm.25192) one).
This work by [Alessandro Sbrizzi (UMCU)](http://www.umcutrecht.nl/en/Research/Research-programs/UMC-Utrecht-Center-for-Image-Sciences/Research-programs/Ultra-high-field-MRI-7-Tesla/High-Precision-Medical-Imaging) treats the design problem using optimal control methods, rather than simple numerical optimization. The result is highly accelerated and much stabler calculation.
<a name="cardiac_shim"></a>
## [Extended RF shimming for cardiac bSSFP](https://github.com/mriphysics/cardiac_RF_shimming/#readme)
RF shimming with the aim of directly minimizing the TR of bSSFP sequences. This is achieved by directly minimizing the SAR (requires Q-matrices) in addition to searching for the optimal RF pulse duration to allow maximum efficiency within specified constraints.
</xmp>
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