diff --git a/deps/ncrypto/ncrypto.cc b/deps/ncrypto/ncrypto.cc
index 82da0d34cba4b6..0a0da0263676d9 100644
--- a/deps/ncrypto/ncrypto.cc
+++ b/deps/ncrypto/ncrypto.cc
@@ -1,4 +1,5 @@
 #include "ncrypto.h"
+#include <openssl/asn1.h>
 #include <openssl/bn.h>
 #include <openssl/dh.h>
 #include <openssl/evp.h>
@@ -99,7 +100,15 @@ std::optional<std::string> CryptoErrorList::pop_front() {
 
 // ============================================================================
 DataPointer DataPointer::Alloc(size_t len) {
+#ifdef OPENSSL_IS_BORINGSSL
+  // Boringssl does not implement OPENSSL_zalloc
+  auto ptr = OPENSSL_malloc(len);
+  if (ptr == nullptr) return {};
+  memset(ptr, 0, len);
+  return DataPointer(ptr, len);
+#else
   return DataPointer(OPENSSL_zalloc(len), len);
+#endif
 }
 
 DataPointer DataPointer::Copy(const Buffer<const void>& buffer) {
@@ -218,7 +227,12 @@ BignumPointer BignumPointer::New() {
 }
 
 BignumPointer BignumPointer::NewSecure() {
+#ifdef OPENSSL_IS_BORINGSSL
+  // Boringssl does not implement BN_secure_new.
+  return New();
+#else
   return BignumPointer(BN_secure_new());
+#endif
 }
 
 BignumPointer& BignumPointer::operator=(BignumPointer&& other) noexcept {
@@ -492,6 +506,7 @@ constexpr int days_from_epoch(int y, unsigned m, unsigned d) {
   return era * 146097 + static_cast<int>(doe) - 719468;
 }
 
+#ifndef OPENSSL_IS_BORINGSSL
 // tm must be in UTC
 // using time_t causes problems on 32-bit systems and windows x64.
 int64_t PortableTimeGM(struct tm* t) {
@@ -512,6 +527,7 @@ int64_t PortableTimeGM(struct tm* t) {
                t->tm_min) +
          t->tm_sec;
 }
+#endif
 
 // ============================================================================
 // SPKAC
@@ -822,7 +838,7 @@ bool SafeX509SubjectAltNamePrint(const BIOPointer& out, X509_EXTENSION* ext) {
 
   bool ok = true;
 
-  for (int i = 0; i < sk_GENERAL_NAME_num(names); i++) {
+  for (OPENSSL_SIZE_T i = 0; i < sk_GENERAL_NAME_num(names); i++) {
     GENERAL_NAME* gen = sk_GENERAL_NAME_value(names, i);
 
     if (i != 0) BIO_write(out.get(), ", ", 2);
@@ -846,7 +862,7 @@ bool SafeX509InfoAccessPrint(const BIOPointer& out, X509_EXTENSION* ext) {
 
   bool ok = true;
 
-  for (int i = 0; i < sk_ACCESS_DESCRIPTION_num(descs); i++) {
+  for (OPENSSL_SIZE_T i = 0; i < sk_ACCESS_DESCRIPTION_num(descs); i++) {
     ACCESS_DESCRIPTION* desc = sk_ACCESS_DESCRIPTION_value(descs, i);
 
     if (i != 0) BIO_write(out.get(), "\n", 1);
@@ -999,15 +1015,31 @@ BIOPointer X509View::getValidTo() const {
 }
 
 int64_t X509View::getValidToTime() const {
+#ifdef OPENSSL_IS_BORINGSSL
+  // Boringssl does not implement ASN1_TIME_to_tm in a public way,
+  // and only recently added ASN1_TIME_to_posix. Some boringssl
+  // users on older version may still need to patch around this
+  // or use a different implementation.
+  int64_t tp;
+  ASN1_TIME_to_posix(X509_get0_notAfter(cert_), &tp);
+  return tp;
+#else
   struct tm tp;
   ASN1_TIME_to_tm(X509_get0_notAfter(cert_), &tp);
   return PortableTimeGM(&tp);
+#endif
 }
 
 int64_t X509View::getValidFromTime() const {
+#ifdef OPENSSL_IS_BORINGSSL
+  int64_t tp;
+  ASN1_TIME_to_posix(X509_get0_notBefore(cert_), &tp);
+  return tp;
+#else
   struct tm tp;
   ASN1_TIME_to_tm(X509_get0_notBefore(cert_), &tp);
   return PortableTimeGM(&tp);
+#endif
 }
 
 DataPointer X509View::getSerialNumber() const {
@@ -1324,7 +1356,12 @@ BIOPointer BIOPointer::NewMem() {
 }
 
 BIOPointer BIOPointer::NewSecMem() {
+#ifdef OPENSSL_IS_BORINGSSL
+  // Boringssl does not implement the BIO_s_secmem API.
+  return BIOPointer(BIO_new(BIO_s_mem()));
+#else
   return BIOPointer(BIO_new(BIO_s_secmem()));
+#endif
 }
 
 BIOPointer BIOPointer::New(const BIO_METHOD* method) {
@@ -1394,8 +1431,11 @@ BignumPointer DHPointer::FindGroup(const std::string_view name,
 #define V(n, p)                                                                \
   if (EqualNoCase(name, n)) return BignumPointer(p(nullptr));
   if (option != FindGroupOption::NO_SMALL_PRIMES) {
+#ifndef OPENSSL_IS_BORINGSSL
+    // Boringssl does not support the 768 and 1024 small primes
     V("modp1", BN_get_rfc2409_prime_768);
     V("modp2", BN_get_rfc2409_prime_1024);
+#endif
     V("modp5", BN_get_rfc3526_prime_1536);
   }
   V("modp14", BN_get_rfc3526_prime_2048);
@@ -1467,15 +1507,22 @@ DHPointer::CheckResult DHPointer::check() {
 DHPointer::CheckPublicKeyResult DHPointer::checkPublicKey(
     const BignumPointer& pub_key) {
   ClearErrorOnReturn clearErrorOnReturn;
-  if (!pub_key || !dh_) return DHPointer::CheckPublicKeyResult::CHECK_FAILED;
+  if (!pub_key || !dh_) {
+    return DHPointer::CheckPublicKeyResult::CHECK_FAILED;
+  }
   int codes = 0;
-  if (DH_check_pub_key(dh_.get(), pub_key.get(), &codes) != 1)
+  if (DH_check_pub_key(dh_.get(), pub_key.get(), &codes) != 1) {
     return DHPointer::CheckPublicKeyResult::CHECK_FAILED;
+  }
+#ifndef OPENSSL_IS_BORINGSSL
+  // Boringssl does not define DH_CHECK_PUBKEY_TOO_SMALL or TOO_LARGE
   if (codes & DH_CHECK_PUBKEY_TOO_SMALL) {
     return DHPointer::CheckPublicKeyResult::TOO_SMALL;
-  } else if (codes & DH_CHECK_PUBKEY_TOO_SMALL) {
+  } else if (codes & DH_CHECK_PUBKEY_TOO_LARGE) {
     return DHPointer::CheckPublicKeyResult::TOO_LARGE;
-  } else if (codes != 0) {
+  }
+#endif
+  if (codes != 0) {
     return DHPointer::CheckPublicKeyResult::INVALID;
   }
   return CheckPublicKeyResult::NONE;
@@ -2530,6 +2577,7 @@ std::optional<uint32_t> SSLPointer::verifyPeerCertificate() const {
 
 const std::string_view SSLPointer::getClientHelloAlpn() const {
   if (ssl_ == nullptr) return {};
+#ifndef OPENSSL_IS_BORINGSSL
   const unsigned char* buf;
   size_t len;
   size_t rem;
@@ -2546,10 +2594,15 @@ const std::string_view SSLPointer::getClientHelloAlpn() const {
   len = (buf[0] << 8) | buf[1];
   if (len + 2 != rem) return {};
   return reinterpret_cast<const char*>(buf + 3);
+#else
+  // Boringssl doesn't have a public API for this.
+  return {};
+#endif
 }
 
 const std::string_view SSLPointer::getClientHelloServerName() const {
   if (ssl_ == nullptr) return {};
+#ifndef OPENSSL_IS_BORINGSSL
   const unsigned char* buf;
   size_t len;
   size_t rem;
@@ -2569,6 +2622,10 @@ const std::string_view SSLPointer::getClientHelloServerName() const {
   len = (*(buf + 3) << 8) | *(buf + 4);
   if (len + 2 > rem) return {};
   return reinterpret_cast<const char*>(buf + 5);
+#else
+  // Boringssl doesn't have a public API for this.
+  return {};
+#endif
 }
 
 std::optional<const std::string_view> SSLPointer::GetServerName(
@@ -2602,7 +2659,11 @@ bool SSLPointer::isServer() const {
 EVPKeyPointer SSLPointer::getPeerTempKey() const {
   if (!ssl_) return {};
   EVP_PKEY* raw_key = nullptr;
+#ifndef OPENSSL_IS_BORINGSSL
   if (!SSL_get_peer_tmp_key(get(), &raw_key)) return {};
+#else
+  if (!SSL_get_server_tmp_key(get(), &raw_key)) return {};
+#endif
   return EVPKeyPointer(raw_key);
 }
 
@@ -3167,9 +3228,15 @@ int EVPKeyCtxPointer::initForSign() {
 }
 
 bool EVPKeyCtxPointer::setDhParameters(int prime_size, uint32_t generator) {
+#ifndef OPENSSL_IS_BORINGSSL
   if (!ctx_) return false;
   return EVP_PKEY_CTX_set_dh_paramgen_prime_len(ctx_.get(), prime_size) == 1 &&
          EVP_PKEY_CTX_set_dh_paramgen_generator(ctx_.get(), generator) == 1;
+#else
+  // TODO(jasnell): Boringssl appears not to support this operation.
+  // Is there an alternative approach that Boringssl does support?
+  return false;
+#endif
 }
 
 bool EVPKeyCtxPointer::setDsaParameters(uint32_t bits,
@@ -3249,6 +3316,7 @@ bool EVPKeyCtxPointer::setRsaPssSaltlen(int salt_len) {
 }
 
 bool EVPKeyCtxPointer::setRsaImplicitRejection() {
+#ifndef OPENSSL_IS_BORINGSSL
   if (!ctx_) return false;
   return EVP_PKEY_CTX_ctrl_str(
              ctx_.get(), "rsa_pkcs1_implicit_rejection", "1") > 0;
@@ -3259,6 +3327,11 @@ bool EVPKeyCtxPointer::setRsaImplicitRejection() {
   // of how it is set. The call to set the value
   // will not affect what is used since a different context is
   // used in the call if the option is supported
+#else
+  // TODO(jasnell): Boringssl appears not to support this operation.
+  // Is there an alternative approach that Boringssl does support?
+  return true;
+#endif
 }
 
 bool EVPKeyCtxPointer::setRsaOaepLabel(DataPointer&& data) {
@@ -3311,16 +3384,31 @@ EVPKeyPointer EVPKeyCtxPointer::paramgen() const {
 
 bool EVPKeyCtxPointer::publicCheck() const {
   if (!ctx_) return false;
+#ifndef OPENSSL_IS_BORINGSSL
+  return EVP_PKEY_public_check(ctx_.get()) == 1;
 #if OPENSSL_VERSION_MAJOR >= 3
   return EVP_PKEY_public_check_quick(ctx_.get()) == 1;
 #else
   return EVP_PKEY_public_check(ctx_.get()) == 1;
 #endif
+#else  // OPENSSL_IS_BORINGSSL
+  // Boringssl appears not to support this operation.
+  // TODO(jasnell): Is there an alternative approach that Boringssl does
+  // support?
+  return true;
+#endif
 }
 
 bool EVPKeyCtxPointer::privateCheck() const {
   if (!ctx_) return false;
+#ifndef OPENSSL_IS_BORINGSSL
   return EVP_PKEY_check(ctx_.get()) == 1;
+#else
+  // Boringssl appears not to support this operation.
+  // TODO(jasnell): Is there an alternative approach that Boringssl does
+  // support?
+  return true;
+#endif
 }
 
 bool EVPKeyCtxPointer::verify(const Buffer<const unsigned char>& sig,
diff --git a/deps/ncrypto/ncrypto.h b/deps/ncrypto/ncrypto.h
index 31d999d3e7e235..f73c84edce20bf 100644
--- a/deps/ncrypto/ncrypto.h
+++ b/deps/ncrypto/ncrypto.h
@@ -40,6 +40,14 @@
 #define NCRYPTO_MUST_USE_RESULT
 #endif
 
+#ifdef OPENSSL_IS_BORINGSSL
+// Boringssl has opted to use size_t for some size related
+// APIs while Openssl is still using ints
+using OPENSSL_SIZE_T = size_t;
+#else
+using OPENSSL_SIZE_T = int;
+#endif
+
 namespace ncrypto {
 
 // ============================================================================
@@ -845,17 +853,25 @@ class DHPointer final {
     UNABLE_TO_CHECK_GENERATOR = DH_UNABLE_TO_CHECK_GENERATOR,
     NOT_SUITABLE_GENERATOR = DH_NOT_SUITABLE_GENERATOR,
     Q_NOT_PRIME = DH_CHECK_Q_NOT_PRIME,
+#ifndef OPENSSL_IS_BORINGSSL
+    // Boringssl does not define the DH_CHECK_INVALID_[Q or J]_VALUE
     INVALID_Q = DH_CHECK_INVALID_Q_VALUE,
     INVALID_J = DH_CHECK_INVALID_J_VALUE,
+#endif
     CHECK_FAILED = 512,
   };
   CheckResult check();
 
   enum class CheckPublicKeyResult {
     NONE,
+#ifndef OPENSSL_IS_BORINGSSL
+    // Boringssl does not define DH_R_CHECK_PUBKEY_TOO_SMALL or TOO_LARGE
     TOO_SMALL = DH_R_CHECK_PUBKEY_TOO_SMALL,
     TOO_LARGE = DH_R_CHECK_PUBKEY_TOO_LARGE,
     INVALID = DH_R_CHECK_PUBKEY_INVALID,
+#else
+    INVALID = DH_R_INVALID_PUBKEY,
+#endif
     CHECK_FAILED = 512,
   };
   // Check to see if the given public key is suitable for this DH instance.