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about merging multiallelics #104

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vicbp1 opened this issue Jun 19, 2024 · 0 comments
Open

about merging multiallelics #104

vicbp1 opened this issue Jun 19, 2024 · 0 comments

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@vicbp1
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vicbp1 commented Jun 19, 2024

Hi,
Thank you for developing this amazing tool.
I understand that splitting multiallelic is needed before phasing. However, I observed a weird pattern after phasing: I have unphased variants with two alternative alleles.

Unphased
chr21 5292305 G A 1/0
chr21 5292305 G T 0/1

Phased

chr21 5292305 . G A 1|0
chr21 5292305 . G T 1|0

I observed this for several multiallelics, and when I collapse into one variant, this genotype becomes unphased because of the incompatibility of phases: 1/2

How do you think I should avoid this problem?

Thanks

Vic

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