diff --git a/flake.lock b/flake.lock
index 83a6ab6143..05683a524a 100644
--- a/flake.lock
+++ b/flake.lock
@@ -33,11 +33,11 @@
     },
     "nixpkgs": {
       "locked": {
-        "lastModified": 1778036283,
-        "narHash": "sha256-62EWg6lI0qyzm7oAx5cAnGkLutvJsRBe0KkEW2JDZCE=",
+        "lastModified": 1784555310,
+        "narHash": "sha256-/FCliTPgiuV1owejZFNx3Ch9irdvkOfOFl+HHZ+DrtM=",
         "owner": "NixOS",
         "repo": "nixpkgs",
-        "rev": "ed67bc86e84e51d4a88e73c7fd36006dc876476f",
+        "rev": "421eebfd0ec7bccd4abe826ce62d7e6e83129493",
         "type": "github"
       },
       "original": {
@@ -47,11 +47,28 @@
         "type": "github"
       }
     },
+    "nixpkgs-x86_64-darwin": {
+      "locked": {
+        "lastModified": 1784707089,
+        "narHash": "sha256-2V/6imsUgB7mPZlHY54oeVBRDoZbPKnvzwkAHUSSufk=",
+        "owner": "NixOS",
+        "repo": "nixpkgs",
+        "rev": "b3fe9581c9061c749abef42b6d4ee7b7c05c33fa",
+        "type": "github"
+      },
+      "original": {
+        "owner": "NixOS",
+        "ref": "nixos-26.05",
+        "repo": "nixpkgs",
+        "type": "github"
+      }
+    },
     "root": {
       "inputs": {
         "filter": "filter",
         "flake-compat": "flake-compat",
         "nixpkgs": "nixpkgs",
+        "nixpkgs-x86_64-darwin": "nixpkgs-x86_64-darwin",
         "shell-hooks": "shell-hooks"
       }
     },
diff --git a/flake.nix b/flake.nix
index 6364834388..5e5049759a 100644
--- a/flake.nix
+++ b/flake.nix
@@ -2,6 +2,9 @@
   description = "Extract files from any kind of container formats";
 
   inputs.nixpkgs.url = "github:NixOS/nixpkgs/nixpkgs-unstable";
+  # nixpkgs 26.11 no longer has an x86_64-darwin stdenv. Keep this input
+  # only while that platform remains in unblob's CI matrix.
+  inputs.nixpkgs-x86_64-darwin.url = "github:NixOS/nixpkgs/nixos-26.05";
   inputs.filter.url = "github:numtide/nix-filter";
   inputs.flake-compat = {
     url = "github:edolstra/flake-compat";
@@ -21,6 +24,7 @@
     {
       self,
       nixpkgs,
+      nixpkgs-x86_64-darwin,
       shell-hooks,
       filter,
       ...
@@ -36,6 +40,7 @@
 
       # Temporary patches for nixpkgs required for current unblob
       nixpkgsPatches = [
+        ./nix/patches/fs-python-3.14.patch
       ];
 
       # Helper function to generate an attrset '{ x86_64-linux = f "x86_64-linux"; ... }'.
@@ -45,27 +50,50 @@
       nixpkgsFor = forAllSystems (
         system:
         let
+          nixpkgsSource = if system == "x86_64-darwin" then nixpkgs-x86_64-darwin else nixpkgs;
+          systemNixpkgsPatches = if system == "x86_64-darwin" then [ ] else nixpkgsPatches;
+
           importPkgs =
-            nixpkgs:
-            import nixpkgs {
+            nixpkgsSource: extraOverlays:
+            import nixpkgsSource {
               inherit system;
               overlays = [
                 self.overlays.default
                 shell-hooks.overlays.default
-              ];
+              ]
+              ++ extraOverlays;
             };
 
-          bootstrapPkgs = importPkgs nixpkgs;
+          bootstrapPkgs = importPkgs nixpkgsSource [ ];
 
           patchedNixpkgs = bootstrapPkgs.applyPatches {
             name = "nixpkgs-patched";
-            src = nixpkgs;
-            patches = map bootstrapPkgs.fetchpatch nixpkgsPatches;
+            src = nixpkgsSource;
+            patches = map (
+              patch: if builtins.isPath patch then patch else bootstrapPkgs.fetchpatch patch
+            ) systemNixpkgsPatches;
           };
 
-          finalPkgs = importPkgs patchedNixpkgs;
+          finalPkgs = importPkgs patchedNixpkgs [
+            (final: prev: {
+              # Preserve the derivation context so consumers of `pkgs.path`
+              # retain the patched nixpkgs source as a build dependency.
+              path = "${patchedNixpkgs}";
+
+              # nix-shell-hooks currently references the former nixpkgs source
+              # location of auto-patchelf.sh. Use the packaged setup hook until
+              # it switches to a stable package path.
+              pythonPackagesExtensions = prev.pythonPackagesExtensions ++ [
+                (_pythonFinal: pythonPrev: {
+                  autoPatchelfVenvShellHook = pythonPrev.autoPatchelfVenvShellHook.overrideAttrs (_old: {
+                    autoPatchelfHook = "${final.autoPatchelfHook}/nix-support/setup-hook";
+                  });
+                })
+              ];
+            })
+          ];
         in
-        if builtins.length nixpkgsPatches != 0 then finalPkgs else bootstrapPkgs
+        if builtins.length systemNixpkgsPatches != 0 then finalPkgs else bootstrapPkgs
       );
     in
     {
diff --git a/nix/patches/fs-python-3.14.patch b/nix/patches/fs-python-3.14.patch
new file mode 100644
index 0000000000..25b61eb29d
--- /dev/null
+++ b/nix/patches/fs-python-3.14.patch
@@ -0,0 +1,53 @@
+diff --git a/pkgs/development/python-modules/fs/default.nix b/pkgs/development/python-modules/fs/default.nix
+index f77d02801153..97eea4e5be7c 100644
+--- a/pkgs/development/python-modules/fs/default.nix
++++ b/pkgs/development/python-modules/fs/default.nix
+@@ -6,0 +7 @@
++  fetchpatch,
+@@ -24,3 +24,0 @@
+-  # https://github.com/PyFilesystem/pyfilesystem2/issues/596
+-  disabled = pythonAtLeast "3.14";
+-
+@@ -32,5 +29,32 @@
+-  postPatch = ''
+-    # https://github.com/PyFilesystem/pyfilesystem2/pull/591
+-    substituteInPlace tests/test_ftpfs.py \
+-      --replace ThreadedTestFTPd FtpdThreadWrapper
+-  '';
++  # Temporary compatibility fixes for Python 3.14 and setuptools 82.
++  # Remove once PyFilesystem and nixpkgs ship equivalent fixes.
++  patches = [
++    (fetchpatch {
++      # https://github.com/PyFilesystem/pyfilesystem2/pull/588
++      url = "https://github.com/PyFilesystem/pyfilesystem2/commit/5c4bde407300dc7b4af6019c19219eaad59d93ee.patch";
++      hash = "sha256-rH0sOq19KPoXFLmIZdwP2/dZAFmGwViE1e+XYdVdUb0=";
++    })
++    (fetchpatch {
++      # https://github.com/PyFilesystem/pyfilesystem2/pull/589
++      url = "https://github.com/PyFilesystem/pyfilesystem2/commit/136e7e257eebfcd1f561a6b2f897eb8bfd44574e.patch";
++      hash = "sha256-AGeT8GUlbI1O7EFhuS9zzqPTE2lVXOzj8/JPjUnpNPk=";
++    })
++    (fetchpatch {
++      # https://github.com/PyFilesystem/pyfilesystem2/pull/590
++      url = "https://github.com/PyFilesystem/pyfilesystem2/commit/c009996c7f4a9ac3bd98cdd86b354c08a68d36c0.patch";
++      excludes = [ "setup.cfg" ];
++      hash = "sha256-Pw30ofLvxMm5dfY3XrjYsWcPKf3rLWMLbREsrB2tuZw=";
++    })
++  ];
++
++  postPatch = ''
++    # https://github.com/PyFilesystem/pyfilesystem2/pull/591
++    substituteInPlace tests/test_ftpfs.py \
++      --replace ThreadedTestFTPd FtpdThreadWrapper
++  ''
++  + lib.optionalString (pythonAtLeast "3.14") ''
++    # https://github.com/PyFilesystem/pyfilesystem2/issues/596
++    substituteInPlace fs/_url_tools.py \
++      --replace 'import platform' $'import platform\nimport sys' \
++      --replace '    return path_snippet' $'    if sys.version_info >= (3, 14):\n        path_snippet = path_snippet.removeprefix("//")\n    return path_snippet'
++  '';
+@@ -41 +65,0 @@
+-    setuptools
+@@ -91,2 +114,0 @@
+-    # https://github.com/PyFilesystem/pyfilesystem2/issues/577
+-    broken = lib.versionAtLeast setuptools.version "82";