Feature Idea
It seems to be a common endpoint in obesity trials to derive the Time (e.g. weeks) to achieve the weight loss plateau, which could e.g. be defined as a weight change ≤5% over a 12-week interval and all subsequent weeks.
@yurovska started to draft a derivation for this by defining the last on-treatment weight measurement as the 'baseline' for this kind of endpoint and from that 'EOT baseline' go back over the previous weight measurements and derive PBCHG.
From CDISC ADaM-IG:
I think it is a quite elegant approach, but rather unusual to define the last assessment as baseline and go back instead of forward. Therefore it could be a nice topic for a vignette. Not sure if there is actually the need for a specific function.
Maybe some of you have a totally different approach for defining the weight loss plateau. I guess one could also smooth the weight loss curve somehow? I would be curious to hear from others how you have implemented this endpoint (if you have).
So there would even be the option to present multiple way of deriving this endpoint in admiralmetabolic.
Relevant Input
No response
Relevant Output
No response
Reproducible Example/Pseudo Code
No response
Feature Idea
It seems to be a common endpoint in obesity trials to derive the Time (e.g. weeks) to achieve the weight loss plateau, which could e.g. be defined as a weight change ≤5% over a 12-week interval and all subsequent weeks.
@yurovska started to draft a derivation for this by defining the last on-treatment weight measurement as the 'baseline' for this kind of endpoint and from that 'EOT baseline' go back over the previous weight measurements and derive PBCHG.
From CDISC ADaM-IG:
I think it is a quite elegant approach, but rather unusual to define the last assessment as baseline and go back instead of forward. Therefore it could be a nice topic for a vignette. Not sure if there is actually the need for a specific function.
Maybe some of you have a totally different approach for defining the weight loss plateau. I guess one could also smooth the weight loss curve somehow? I would be curious to hear from others how you have implemented this endpoint (if you have).
So there would even be the option to present multiple way of deriving this endpoint in admiralmetabolic.
Relevant Input
No response
Relevant Output
No response
Reproducible Example/Pseudo Code
No response