diff --git a/README.md b/README.md
index 1b614c468..cd0584787 100644
--- a/README.md
+++ b/README.md
@@ -448,6 +448,8 @@ The profile directory stores:
 
 **Tip**: Use different profile paths for different projects to keep their browser state isolated.
 
+**Sessions with profiles**: When `--session` is combined with `--profile`, each session stores its Chrome data in a separate subdirectory: `<profile>/<session>/`. This ensures that concurrent sessions using the same base profile path each get their own isolated Chrome instance. For example, `--profile ~/.myapp-profile --session work` uses `~/.myapp-profile/work/` and `--session personal` uses `~/.myapp-profile/personal/`.
+
 ## Session Persistence
 
 Alternatively, use `--session-name` to automatically save and restore cookies and localStorage across browser restarts:
diff --git a/cli/src/native/actions.rs b/cli/src/native/actions.rs
index bebffc207..ef3c77d39 100644
--- a/cli/src/native/actions.rs
+++ b/cli/src/native/actions.rs
@@ -942,6 +942,19 @@ async fn auto_launch(state: &mut DaemonState) -> Result<(), String> {
     Ok(())
 }
 
+/// Returns the effective Chrome user-data-dir path for a session.
+///
+/// Appends the session ID as a subdirectory under the base profile path so
+/// that each `--session` daemon gets its own independent Chrome instance even
+/// when `--profile` is shared across sessions. Chrome enforces a singleton
+/// constraint per `--user-data-dir`, so without this isolation the second
+/// daemon silently connects to the first daemon's Chrome instance instead of
+/// launching a new one.
+fn session_scoped_profile(profile: &str, session_id: &str) -> String {
+    let profile = profile.trim_end_matches('/');
+    format!("{}/{}", profile, session_id)
+}
+
 fn launch_options_from_env() -> LaunchOptions {
     let headed = env::var("AGENT_BROWSER_HEADED")
         .map(|v| v == "1" || v == "true")
@@ -959,7 +972,12 @@ fn launch_options_from_env() -> LaunchOptions {
         executable_path: env::var("AGENT_BROWSER_EXECUTABLE_PATH").ok(),
         proxy: env::var("AGENT_BROWSER_PROXY").ok(),
         proxy_bypass: env::var("AGENT_BROWSER_PROXY_BYPASS").ok(),
-        profile: env::var("AGENT_BROWSER_PROFILE").ok(),
+        profile: env::var("AGENT_BROWSER_PROFILE").ok().map(|p| {
+            match env::var("AGENT_BROWSER_SESSION").ok() {
+                Some(session) => session_scoped_profile(&p, &session),
+                None => p,
+            }
+        }),
         allow_file_access: env::var("AGENT_BROWSER_ALLOW_FILE_ACCESS")
             .map(|v| v == "1" || v == "true")
             .unwrap_or(false),
@@ -1148,7 +1166,7 @@ async fn handle_launch(cmd: &Value, state: &mut DaemonState) -> Result<Value, St
         profile: cmd
             .get("profile")
             .and_then(|v| v.as_str())
-            .map(|s| s.to_string()),
+            .map(|s| session_scoped_profile(s, &state.session_id)),
         allow_file_access: cmd
             .get("allowFileAccess")
             .and_then(|v| v.as_bool())
@@ -5884,6 +5902,56 @@ mod tests {
         );
     }
 
+    #[test]
+    fn test_session_scoped_profile_basic() {
+        assert_eq!(
+            session_scoped_profile("/tmp/my-profile", "first"),
+            "/tmp/my-profile/first"
+        );
+    }
+
+    #[test]
+    fn test_session_scoped_profile_default_session() {
+        assert_eq!(
+            session_scoped_profile("/tmp/my-profile", "default"),
+            "/tmp/my-profile/default"
+        );
+    }
+
+    #[test]
+    fn test_session_scoped_profile_strips_trailing_slash() {
+        assert_eq!(
+            session_scoped_profile("/tmp/my-profile/", "second"),
+            "/tmp/my-profile/second"
+        );
+    }
+
+    #[test]
+    fn test_launch_options_from_env_profile_with_session() {
+        let _guard = EnvGuard::new(&["AGENT_BROWSER_PROFILE", "AGENT_BROWSER_SESSION"]);
+        _guard.set("AGENT_BROWSER_PROFILE", "/tmp/test-profile");
+        _guard.set("AGENT_BROWSER_SESSION", "my-session");
+        let opts = launch_options_from_env();
+        assert_eq!(
+            opts.profile.as_deref(),
+            Some("/tmp/test-profile/my-session"),
+            "profile should include session subdirectory"
+        );
+    }
+
+    #[test]
+    fn test_launch_options_from_env_profile_without_session() {
+        let _guard = EnvGuard::new(&["AGENT_BROWSER_PROFILE", "AGENT_BROWSER_SESSION"]);
+        _guard.set("AGENT_BROWSER_PROFILE", "/tmp/test-profile");
+        _guard.remove("AGENT_BROWSER_SESSION"); // no session set
+        let opts = launch_options_from_env();
+        assert_eq!(
+            opts.profile.as_deref(),
+            Some("/tmp/test-profile"),
+            "profile should be unchanged when session is unset"
+        );
+    }
+
     #[test]
     fn test_har_entry_to_json_enriches_request_and_response() {
         // wall_time: 2026-03-15T12:00:00Z = 1_773_576_000
diff --git a/cli/src/output.rs b/cli/src/output.rs
index 336f28397..318056dcd 100644
--- a/cli/src/output.rs
+++ b/cli/src/output.rs
@@ -2599,6 +2599,7 @@ Snapshot Options:
 Authentication:
   --profile <path>           Persist login sessions across restarts (cookies, IndexedDB, cache)
                              (or AGENT_BROWSER_PROFILE env)
+                             When used with --session, data is stored in <path>/<session>/
   --session-name <name>      Auto-save/restore cookies and localStorage by name
                              (or AGENT_BROWSER_SESSION_NAME env)
   --state <path>             Load saved auth state (cookies + storage) from JSON file
diff --git a/docs/src/app/sessions/page.mdx b/docs/src/app/sessions/page.mdx
index 1fe44c74f..3cf0e154b 100644
--- a/docs/src/app/sessions/page.mdx
+++ b/docs/src/app/sessions/page.mdx
@@ -57,6 +57,16 @@ The profile directory stores:
 - Browser cache
 - Login sessions
 
+**Using `--profile` with `--session`**: When combining `--profile` with `--session`, each session stores its Chrome data in a separate subdirectory (`<profile>/<session>/`). This ensures that concurrent sessions sharing the same base profile path each launch their own independent Chrome instance. For example:
+
+```bash
+# Two independent Chrome instances, each with their own persisted data
+agent-browser --profile ~/.myapp-profile --session work open app.example.com
+agent-browser --profile ~/.myapp-profile --session personal open app.example.com
+# work data -> ~/.myapp-profile/work/
+# personal data -> ~/.myapp-profile/personal/
+```
+
 ## Import auth from your browser
 
 If you are already logged in to a site in Chrome, you can grab that auth state and reuse it in agent-browser. This is the fastest way to bypass login flows, OAuth, SSO, or 2FA.
diff --git a/skills/agent-browser/SKILL.md b/skills/agent-browser/SKILL.md
index 73bd7848c..fb45d9728 100644
--- a/skills/agent-browser/SKILL.md
+++ b/skills/agent-browser/SKILL.md
@@ -72,6 +72,8 @@ agent-browser --profile ~/.myapp open https://app.example.com/login
 agent-browser --profile ~/.myapp open https://app.example.com/dashboard
 ```
 
+When using `--profile` with `--session`, each session stores its Chrome data in a separate subdirectory (`<profile>/<session>/`) so that concurrent sessions with the same base profile path run independent Chrome instances without conflict.
+
 **Option 3: Session name (auto-save/restore cookies + localStorage)**
 
 ```bash