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Pyronaridine
Swapnil Jha edited this page Oct 5, 2020
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Pyronaridine was first synthesized in the 1970s at the Institute of Chinese Parasitic Disease [53, 54]. It has been found to be efficacious against chloroquine-resistant strains and has been in use for over 40 years, sold under the trade name Pyramax® (in combination with artesunate). Like lumefantrine, pyronaridine has been found to act through the inhibition of β-haematin formation [55].
Keywords: Malaria, Plasmodium, Mechanism of action, Drug discovery, Drug development
Original online version of this article (DOI: 10.1186/s12936-019-2724-z).