Cardiovascular models with scenarios and short-term and long-term control

Cardiovascular models

Several models of a cardiovascular system, integrated with short-term and long-term control mechanisms, are presented.

Installation

Select one option of these

• CardiovascularTotal.mo -- self contained model with the libraries mentioned above suitable for Dymola tool,
  no other requirements
  • copy this file into your preferred location and open it in Dymola.
• Cardiovascular.mo -- requires Modelica 3.2.1 and Physiolibrary 2.3.1, suitable for OpenModelica and Dymola tool
  • download Physiolibrary 2.3.1 or later from www.physiolibrary.org
  • open Physiolibrary/Physiolibrary/package.mo
  • open Cardiovascular.mo

Usage

In Modelica tool (OpenModelica or Dymola) open
Cardiovascular/Models/{Meurs,Burkhof,Smith}/

• Hemodynamics*_shallow -- the implementation of hemodynamics in one diagram
• Hemodynamics* - the identical implementation as above, but using abstract architecture model of CVS
• Hemodynamics*_control - hemodynamics with long term and short term regulation mechanism - no scenario
• AorticValveStenosis - the controlled model with scenario of aortic valve stenosis
• Bleeding - the controlled model with scenario of 500 ml blood loss.

Tested in OpenModelica 1.9.3+dev (r25502) and Dymola version 2015 FD01 and Dymola version 2016 FD01.

Cardiovascular models with scenarios and short-term and long-term control

Cardiovascular models

Several models of a cardiovascular system, integrated with short-term and long-term control mechanisms, are presented.

Installation

Select one option of these

• CardiovascularTotal.mo -- self contained model with the libraries mentioned above suitable for Dymola tool,
  no other requirements
  • copy this file into your preferred location and open it in Dymola.
• Cardiovascular.mo -- requires Modelica 3.2.1 and Physiolibrary 2.3.1, suitable for OpenModelica and Dymola tool
  • download Physiolibrary 2.3.1 or later from www.physiolibrary.org
  • open Physiolibrary/Physiolibrary/package.mo
  • open Cardiovascular.mo

Usage

In Modelica tool (OpenModelica or Dymola) open
Cardiovascular/Models/{Meurs,Burkhof,Smith}/

• Hemodynamics*_shallow -- the implementation of hemodynamics in one diagram
• Hemodynamics* - the identical implementation as above, but using abstract architecture model of CVS
• Hemodynamics*_control - hemodynamics with long term and short term regulation mechanism - no scenario
• AorticValveStenosis - the controlled model with scenario of aortic valve stenosis
• Bleeding - the controlled model with scenario of 500 ml blood loss.

Tested in OpenModelica 1.9.3+dev (r25502) and Dymola version 2015 FD01 and Dymola version 2016 FD01.

Release of Models of Cardiovascular Hemodynamics

Physiolibrary.models

Modelica models and extension libraries based on [http://www.physiolibrary.org] including supporting scripts for generating list of initial values.

Release of model based on model implementation by Meurs et al., Burkhoff et al., Fernandez de Canete et al.:

• J. Fernandez de Canete, J. Luque, J. Barbancho, V. Munoz, Modelling of long-term and short-term mechanisms of arterial pressure control in the cardiovascular system: An objectoriented approach., Computers in biology and medicine 47 (2014) 104{12. doi:10.1016/j.compbiomed.2014.01.006.
• W. P. Santamore, D. Burkhoff, Hemodynamic consequences of ventricular interaction as assessed by model analysis., The American journal of physiology 260 (1 Pt 2) (1991) H146{H157.
• D. Burkhoff, J. V. Tyberg, Why does pulmonary venous pressure rise after onset of LV dysfunction: a theoretical analysis. The American journal of physiology 265 (5 Pt 2) (1993) H1819{H1828.
• J. A. Goodwin, W. L. van Meurs, C. D. S�a Couto, J. E. W. Beneken, S. A. Graves, A model for educational simulation of infant cardiovascular physiology., Anesthesia and analgesia 99 (6) (2004) 1655{1664, table of contents. doi:10.1213/01.ANE.0000134797.52793.AF.
• C. D. S�a Couto, W. L. van Meurs, J. A. Goodwin, P. Andriessen, A Model for Educational Simulation of Neonatal Cardiovascular Pathophysiology, Simulation in Healthcare 1 (Inaugural) (2006) 4{12.
• W. van Meurs, Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology, McGraw-Hill Professional, 2011.

Installation

Unzip and open the Modelica files in the following order:

• Physiolibrary.mo special release of library to support modelling of physiology in Modelica (www.physiolibrary.org)
• Cardiovascular.mo extension to Physiolibrary regarding Cariovascular system
• FernandezModel.mo
• MeursModel.mo
• BurkhoffModel.mo

Usage

In Modelica tool (OpenModelica or Dymola) open
FernandezModel/Models

• Hemodynamics_pure -- the implementation of hemodynamics without any regulation
• Hemodynamics_stenosiswithbarocontrol - hemodynamics and baroreceptor control mechanism connected with prepared scenario changing the vena cava elastance (stenosis)
• Hemodynamics_stenosiswithoutbaro- hemodynamics without any control mechanism with prepared scenario changing the vena cava elastance (stenosis)
  MeursModel/Models
• Hemodynamics -- the implementaiton of hemodynamics without any regulation
  MeursModel/Experiment
• Hemodynamics_volumecontrol - change the blood volume during simulation
  BurkhoffModel/Models
• Hemodynamics -- the implementation of hemodynamics without any regulation

Model of hemodynamics

Physiolibrary.models/FernandezModel

Modelica models and extension libraries based on [http://www.physiolibrary.org].

Release of model based on model implementation by Fernandez de Canete et al.
J. Fernandez de Canete, J. Luque, J. Barbancho, V. Munoz, Modelling of long-term and short-term mechanisms of arterial pressure control in the cardiovascular system: An objectoriented approach., Computers in biology and medicine 47 (2014) 104{12. doi:10.1016/j.compbiomed.2014.01.006.

Installation

Requires Modelica 3.2 (3.2.1) standard library. Open the Modelica files in the following order:

• Physiolibrary.mo -- basic library to model physiology in Modelica from, special custom release from www.physiolibrary.org
• Cardiovascular.mo -- extension to Physiolibrary regarding Cariovascular system
• FernandezModel.mo

Usage

In Modelica tool (OpenModelica or Dymola) open
FernandezModel/Models

• Hemodynamics_pure -- the implementation of hemodynamics without any regulation
• Hemodynamics_stenosiswithbarocontrol - hemodynamics and baroreceptor control mechanism connected with prepared scenario changing the vena cava elastance (stenosis)
• Hemodynamics_stenosiswithoutbaro- hemodynamics without any control mechanism with prepared scenario changing the vena cava elastance (stenosis)

Tested in OpenModelica 1.9.1+dev (r20369) (RML version) and Dymola version 2014 FD01.