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Merge pull request #45 from broadinstitute/shntnu-patch-1
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Add everything but the license for now
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shntnu authored May 22, 2020
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# Processed Cell Painting Data for the LINCS Drug Repurposing Project
# Processed Data for the LINCS Cell Painting Project

The repository stores data and data processing scripts for **a subset** of the LINCS Drug Repurposing Project.
In this project, we perturbed A549 cells with ~1,500 compounds across 6 doses with ~4 biological replicates.
The repository stores data and data processing scripts for **a subset** of the [Broad Drug Repurposing Hub](https://clue.io/repurposing#home) collection of compounds.

For a specific list of compounds tested, see [`metadata`](https://github.com/broadinstitute/lincs-cell-painting/tree/master/metadata).
In this project, the [Connectivity Map](https://clue.io/team) team perturbed A549 cells with ~1,500 compounds across 6 doses in 5 technical replicates.
We refer to this dataset as `LINCS Pilot 1`.

For a specific list of compounds tested, see [`metadata`](https://github.com/broadinstitute/lincs-cell-painting/tree/master/metadata).
Information about the compounds can be interactively explored in the [CLUE Repurposing app](https://clue.io/repurposing-app).
The [Morphology Connectivity Hub](https://clue.io/morphology) is the primary source of this dataset.

## Image-Based Profiling

We apply a unified, image-based profiling pipeline to all Drug Repurposing Hub Cell Painting plates.
We apply a unified, image-based profiling pipeline to all 136 384-well plates from `LINCS Pilot 1` .
We use [pycytominer](https://github.com/cytomining/pycytominer) as the primary tool for image-based profiling.

The profiles are processed and stored in the [profiles/](profiles/) directory.
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