v3.0.0
It is now possible to run a pre-processing step PanGenie-index
prior to PanGenie
to pre-compute data structures needed later during the genotyping step. The pre-processing step does not depend on any sample-specific data. It only needs the input VCF. When genotyping the same set of variants across multiple samples, PanGenie-index
needs to be run only once. Afterwards, the pre-computed data can be provided to PanGenie
with option -f
in order to genotype a specific sample. Running genotyping in this way reduces the runtime and especially the memory usage, and is the recommended way of running PanGenie.