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2024_BlockCourse

This repository is used for the acquisition, pre-processing, and analysis of IMC data during the DQBM Block-Course 2024. It is explicitly tailored to handle acquisition of the same ROIs from consecutive sections using the compressed and uncompressed antibody panels.

## Structure: The repository is structured into three major directories.

Region Selection:

  • Contains the bio-image analysis scripts to perform semi-automated region-selection for IMC acquisition using IF images.

Pre-processing:

  • Contains Python-Scripts to pre-process IMC data and perform cell segmentation.

Analysis:

  • Contains R-scripts to analyze data.
  • Spillover Compensation, Data Transformation, Quality Control, Cell Annotation
  • Comparison of compressed and Uncompressed dataset.

Setup:

Check DirectoryStructure.md for how to organize your directory structure including data and code!

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