HML Examples

HML Examples

NGS examples

Locus	Method	Interpretation Format	HML	Other info
A B	NGS Sanger	GL String	0.9.5	NGS used for HLA-A Sanger used for HLA-B
A B	NGS Sanger	GL Resource	0.9.5	Same as above, except format for interpretation is GL Resource instead of GL String. This is an example of why GL Resource shouldn't be used.
DRB1	NGS	GL String	0.9.5

Examples of older technologies in HML 0.95

Locus	Method	Interpretation Format	HML	Other info
A B C		Haploid	0.9.5	three samples; no primary data or interpretation Note: while the schema shows that at least one typing-method is required, typing-method is an abstract type that requires a choice. In this case the choice is none. Yes, it can be confusing.
DRB1 DQB1 DPB1	SBT	Haploid (allele code and allele)	0.9.5
A B C	SBT	Haploid (allele code and allele)	0.9.5
DPA1 DPB1	SSO	Haploid (allele)	0.9.5

Examples from previous versions of HML converted to v0.93

| Locus | Method | Interpretation
Format | HML | Other info | | ----- | ------ | --------------------- | ------- | ------- || | A | DNA | allele code | 0.3.0 | Lab 999 typed a sample for center 123 for the ABDR project for NMDP ID: 444-333-2. The typing was performed on Jan 23, 2004. The results are:
A0102, A0103
A0103, A0106 | | A | DNA | genotype list | 0.3.0
0.9.3 | (same as above, but reported as genotype list instead of allele code)<br >Lab 999 typed a sample for center 123 for the ABDR project for NMDP ID: 444-333-2. The typing was performed on Jan 23, 2004. The results are:
A0102, A0103
A0103, A0106 | | B | SBT | genotype list | 0.3.3
0.9.3| In this case there is an intronic or exon1 gSSP reagent that is uninformative for our local interpretation. The gssp tag with no contents is an indicator of a hemizygous product | | B | SBT | genotype list | 0.3.3
0.9.3| In this case there is an intronic or exon1 gSSP reagent that is uninformative for our local interpretation. The gssp tag with no contents is an indicator of a hemizygous product | | B | SBT | genotype list | 0.3.3<br > 0.9.3| example showing GSSP as sequence instead of registered-name | | DRB1 | SBT | genotype list | 0.3.3
0.9.3| There is no generic sequence in this example. It contains GSSPs that are specific for DRB113 and DRB115 | | DRB1 | SBT | genotype list | 0.3.3
0.9.3| This is a homozygous sample with no generic sequence. This is up-front GSSP that is DR13 specific. | | 2DL1
2DL2
2DL3
2DL4
2DL5
2DS1
2DS2
2DS3
2DS4
2DS5
3DL1
3DL2
3DL3
3DS1
| SSO | genotype list | 0.3.0
0.9.3| Lab 999 typed a sample for center 789 for a project entitled "KIR". The typing was performed on Sep 8, 2008. They tested fourteen KIR genes and reported presence/absence for each,along with the probe information. Each locus was reported in its own 'typing' HML element. | | 2DL1
2DL2
2DL3
2DL4
2DL5
2DS1
2DS2
2DS3
2DS4
2DS5
3DL1
3DL2
3DL3
3DS1
| SSO | genotype list | 0.3.0
0.9.3| Same as above (6.1) except for each sample (one, in this case), all loci were reported in a single 'interpretation' element. |