The CTPR (Cross-Trait / Cross-eThnic Penalized Regression) software was originally developed for multi-trait polygenic risk prediction in large cohorts and is subsequently being extended for multi-ethnic polygenic risk prediction.
In order to download CTPR, you should clone this repository via the commands
git clone https://github.com/wonilchung/CTPR.git
cd CTPR
Short tutorials describing how to install and run CTPR can be found in the following wiki: https://github.com/wonilchung/CTPR/wiki/CTPR-User-Manual.
The CTPR algorithm is described in the following reference:
Wonil Chung, Jun Chen, Constance Turman, Sara Lindstrom, Zhaozhong Zhu, Po-Ru Loh, Peter Kraft and Liming Liang (2019), Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes. Nature Communications, 10(1), 569. Link
If you have any questions on CTPR software, please email to Wonil Chung ([email protected]).